Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Stable Identifier
R-HSA-389758
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Literature References
PubMed ID Title Journal Year
15358536 PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

Sheppard, KA, Fitz, LJ, Lee, JM, Benander, C, George, JA, Wooters, J, Qiu, Y, Jussif, JM, Carter, LL, Wood, CR, Chaudhary, D

FEBS Lett 2004
18759926 Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

Fife, BT, Bluestone, JA

Immunol Rev 2008
18173375 PD-1 and its ligands in tolerance and immunity

Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH

Annu Rev Immunol 2008
12947224 Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Carter, LL, Carreno, BM

Immunol Res 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created