Reactome | Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Stable Identifier

R-HSA-389758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

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PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Literature References

PubMed ID	Title	Journal	Year
18759926	Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Fife, BT, Bluestone, JA	Immunol Rev	2008
12947224	Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation Carter, LL, Carreno, BM	Immunol Res	2003
18173375	PD-1 and its ligands in tolerance and immunity Keir, ME, Sharpe, AH, Freeman, GJ, Butte, MJ	Annu Rev Immunol	2008
15358536	PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta Jussif, JM, Benander, C, Carter, LL, Wooters, J, Fitz, LJ, Qiu, Y, Chaudhary, D, George, JA, Sheppard, KA, Wood, CR, Lee, JM	FEBS Lett	2004