Reactome | Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Stable Identifier

R-HSA-389758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

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PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Literature References

PubMed ID	Title	Journal	Year
15358536	PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta Sheppard, KA, Fitz, LJ, Lee, JM, Benander, C, George, JA, Wooters, J, Qiu, Y, Jussif, JM, Carter, LL, Wood, CR, Chaudhary, D	FEBS Lett	2004
18759926	Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways Fife, BT, Bluestone, JA	Immunol Rev	2008
18173375	PD-1 and its ligands in tolerance and immunity Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH	Annu Rev Immunol	2008
12947224	Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation Carter, LL, Carreno, BM	Immunol Res	2003