PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.
Sheppard, KA, Fitz, LJ, Lee, JM, Benander, C, George, JA, Wooters, J, Qiu, Y, Jussif, JM, Carter, LL, Wood, CR, Chaudhary, D
Fife, BT, Bluestone, JA
Keir, ME, Butte, MJ, Freeman, GJ, Sharpe, AH
Carter, LL, Carreno, BM
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