Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Stable Identifier
Reaction [transition]
Homo sapiens
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PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Literature References
PubMed ID Title Journal Year
18759926 Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

Fife, BT, Bluestone, JA

Immunol Rev 2008
15358536 PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

Jussif, JM, Benander, C, Carter, LL, Wooters, J, Fitz, LJ, Qiu, Y, Chaudhary, D, George, JA, Sheppard, KA, Wood, CR, Lee, JM

FEBS Lett 2004
18173375 PD-1 and its ligands in tolerance and immunity

Keir, ME, Sharpe, AH, Freeman, GJ, Butte, MJ

Annu Rev Immunol 2008
12947224 Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation

Carter, LL, Carreno, BM

Immunol Res 2003
Catalyst Activity

protein tyrosine phosphatase activity of PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane]

Orthologous Events
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