Rap1 signal termination by Rap1GAPs

Stable Identifier
Reaction [transition]
Homo sapiens
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Rap1 signalling is terminated by the hydrolysis of bound GTP to GDP. The intrinsic GTPase activity of Rap1 is greatly enhanced by GTP-ase activating proteins (GAPs).

Literature References
PubMed ID Title Journal Year
1846040 Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells

McCormick, F, Polakis, PG, Evans, T, Rubinfeld, B

Proc Natl Acad Sci U S A 1991
9346962 Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product

Tsukamoto, N, Kurachi, H, Kubota, H, Wada, Y, Hattori, M, Minato, N, Iwai, K, Maeda, M

J Biol Chem 1997
15632203 Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets

Schultess, J, Danielewski, O, Smolenski, AP

Blood 2005
Catalyst Activity

GTPase activator activity of Rap1 GTPase-activating proteins [cytosol]

This event is regulated
Orthologous Events
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