Reactome | Rap1 signal termination by Rap1GAPs

Rap1 signal termination by Rap1GAPs

Stable Identifier

R-HSA-392513

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Rap1 signalling is terminated by the hydrolysis of bound GTP to GDP. The intrinsic GTPase activity of Rap1 is greatly enhanced by GTP-ase activating proteins (GAPs).

Literature References

PubMed ID	Title	Journal	Year
1846040	Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells Polakis, PG, Rubinfeld, B, Evans, T, McCormick, F	Proc Natl Acad Sci U S A	1991
9346962	Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Kurachi, H, Wada, Y, Tsukamoto, N, Maeda, M, Kubota, H, Hattori, M, Iwai, K, Minato, N	J Biol Chem	1997
15632203	Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets Schultess, J, Danielewski, O, Smolenski, AP	Blood	2005