nsp12 guanylates nsp7

Stable Identifier
R-HSA-9765952
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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nsp12 guanylates nsp7
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The nucleotidyl transferase in the N-terminal (NiRAN) domain of the SARS-CoV-2 nonstructural protein (nsp12) transfers guanosine-5'-monophosphate onto lysine-2 of nsp7. Nsp7 Lys-2 is well-conserved within the Coronavirinae subfamily. The SARS-CoV-2 RNA-dependent RNA Polymerase (RdRP) structure shows nsp7 Lys-2 located at the interface between nsp8 and nsp12. Similar modiication of nsp8 was observed, with the exact site modified being unknown. Nsp12 possibly also acts as nucleotidyl transferase to mediate viral RNA capping (Conti et al, 2021).
Literature References
PubMed ID Title Journal Year
34189273 Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

Kirchdoerfer, RN, Leicht, AS, Sussman, MR, Conti, BJ

Commun Chem 2021
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Catalyst Activity

protein guanylyltransferase activity of pp1ab-nsp12 [cytosol]

Physical Entity
pp1ab-nsp12 [cytosol] (Severe acute respiratory syndrome coronavirus 2)
Activity
protein guanylyltransferase activity (GO:0044600)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2022-02-17)
Created
Stephan, R  (2022-02-17)
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