Reactome | 2xPPCS ligates PPanK with Cys

2xPPCS ligates PPanK with Cys

Stable Identifier

R-HSA-196753

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-((R)-4-phosphopantothenoyl)-L-cysteine

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12906824	Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Manoj, N, Begley, TP, Strauss, E, Ealick, SE	Structure	2003
11923312	Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics Osterman, A, Farrell, M, Daugherty, M, de Crecy-Lagard, V, Scholle, M, Polanuyer, B, Lykidis, A	J Biol Chem	2002