2xPPCS ligates PPanK with Cys

Stable Identifier
R-HSA-196753
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Condensation of phosphopantothenate with cysteine
Locations in the PathwayBrowser
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The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).

Literature References
PubMed ID Title Journal Year
11923312 Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

Daugherty, M, Polanuyer, B, Farrell, M, Scholle, M, Lykidis, A, de Crecy-Lagard, V, Osterman, A

J Biol Chem 2002
12906824 Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.

Manoj, N, Strauss, E, Begley, TP, Ealick, SE

Structure 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphopantothenate--cysteine ligase activity of 2xPPCS [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created
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