TP53 P77Rfs*71 [nucleoplasm]

Stable Identifier
R-HSA-9722093
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TP53 P77Rfs*71 [nucleoplasm] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
TP53, P53
Chain
chain:1-393
Other Identifiers
11738335_x_at
11748319_x_at
11748599_a_at
11750514_x_at
11751536_a_at
11751537_x_at
16840732
1939_at
1974_s_at
201746_PM_at
201746_at
211300_PM_s_at
211300_s_at
31618_at
3743907
3743908
3743909
3743912
3743913
3743915
3743917
3743918
3743919
3743920
3743922
3743923
3743924
3743925
3743926
3743933
7157
8012257
A_23_P26810
A_33_P3315764
GE58227
GO:0000122
GO:0000278
GO:0000423
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001046
GO:0001094
GO:0001227
GO:0001228
GO:0001701
GO:0001756
GO:0001836
GO:0002020
GO:0002039
GO:0002244
GO:0002309
GO:0002326
GO:0002360
GO:0002376
GO:0002931
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0003730
GO:0005507
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005783
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006260
GO:0006281
GO:0006289
GO:0006302
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006974
GO:0006977
GO:0006978
GO:0006979
GO:0006983
GO:0007005
GO:0007049
GO:0007179
GO:0007265
GO:0007346
GO:0007369
GO:0007405
GO:0007406
GO:0007417
GO:0007507
GO:0007623
GO:0008104
GO:0008156
GO:0008270
GO:0008283
GO:0008285
GO:0008340
GO:0009299
GO:0009303
GO:0009410
GO:0009411
GO:0009651
GO:0009792
GO:0010035
GO:0010165
GO:0010332
GO:0010628
GO:0010629
GO:0010659
GO:0010666
GO:0012501
GO:0014009
GO:0016032
GO:0016071
GO:0016363
GO:0016604
GO:0016605
GO:0017053
GO:0019661
GO:0019899
GO:0021549
GO:0023052
GO:0030154
GO:0030308
GO:0030330
GO:0030512
GO:0030971
GO:0031047
GO:0031571
GO:0031625
GO:0032991
GO:0033077
GO:0033209
GO:0034103
GO:0034644
GO:0035033
GO:0035264
GO:0035794
GO:0035861
GO:0036003
GO:0036211
GO:0036310
GO:0042127
GO:0042149
GO:0042771
GO:0042802
GO:0042826
GO:0042981
GO:0043065
GO:0043066
GO:0043073
GO:0043153
GO:0043226
GO:0043504
GO:0043516
GO:0043523
GO:0043525
GO:0043565
GO:0043621
GO:0045815
GO:0045861
GO:0045892
GO:0045893
GO:0045899
GO:0045930
GO:0045944
GO:0046677
GO:0046872
GO:0046982
GO:0048144
GO:0048147
GO:0048511
GO:0048512
GO:0048539
GO:0048568
GO:0048856
GO:0050731
GO:0050821
GO:0051087
GO:0051097
GO:0051262
GO:0051276
GO:0051402
GO:0051721
GO:0051726
GO:0051974
GO:0055086
GO:0060218
GO:0060253
GO:0060333
GO:0060411
GO:0061024
GO:0061419
GO:0061629
GO:0062100
GO:0065003
GO:0070059
GO:0070242
GO:0070243
GO:0070245
GO:0070266
GO:0071456
GO:0071466
GO:0071479
GO:0071480
GO:0071494
GO:0071889
GO:0072089
GO:0072331
GO:0072332
GO:0072593
GO:0072717
GO:0090200
GO:0090398
GO:0090399
GO:0090403
GO:0097193
GO:0097252
GO:0097371
GO:0097718
GO:0098542
GO:0098772
GO:0140110
GO:0140296
GO:0140657
GO:0140677
GO:1900119
GO:1901135
GO:1901525
GO:1902108
GO:1902253
GO:1902749
GO:1902895
GO:1903451
GO:1903799
GO:1904024
GO:1905856
GO:1990144
GO:1990440
GO:1990841
GO:2000269
GO:2000378
GO:2000379
GO:2000647
GO:2000772
GO:2000774
GO:2001244
HMNXSV003011219
ILMN_1779356
M22898_at
PH_hs_0019846
TC17001094.hg
TC17002468.hg
g189478_3p_a_at
g8400737_3p_at
g8400737_3p_x_at
Participates
Other forms of this molecule
Modified Residues
Name
Replacement of residues 77 to 146 by RSSYTGGPCTSPLLAPVIFCPFPENLPGQLRFPSGLLAFWDSQVCDLHVLPCPQQDVLPTGQDLPCAAVG
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
6SL6, 2H2D, 2X0W, 6RKK, 6W51, 4AGM, 2X0V, 4AGL, 1YC5, 5MCU, 1XQH, 2X0U, 5BUA, 4BV2, 6RKM, 4KVP, 8F2H, 4IJT, 6RM7, 8E7A, 5O1E, 2BIN, 2J1Z, 4AGO, 4ZZJ, 7B4N, 3PDH, 2J20, 6SIO, 4AGN, 5MHC, 6V4F, 5G4N, 2J10, 3IGL, 2Z5T, 5UN8, 5O1B, 1SAF, 2MZD, 5G4O, 2Z5S, 1MA3, 3IGK, 4HJE, 8A31, 7XZX, 7V97, 4LOF, 3DAC, 8A32, 8DC4, 6T58, 7XZZ, 6V4H, 5O1C, 3DAB, 4BUZ, 5MCV, 6XRE, 6VR1, 1UOL, 6GGA, 6VRN, 6VQO, 2BIQ, 1AIE, 5HPD, 2J21, 6LHD, 2L14, 4MZR, 6SIQ, 4RP6, 3D09, 7NMI, 6RKI, 2YBG, 6RM5, 2MWY, 4RP7, 5MG7, 1KZY, 6VRM, 5MCT, 7EDS, 3D07, 6S40, 6GGF, 5AOM, 7B4H, 6RK8, 2H1L, 6SIN, 6RWH, 7B4G, 2MWP, 3D05, 7B4B, 2AC0, 3SAK, 2J1Y, 5ECG, 6RWI, 1OLH, 5O1H, 6SI4, 2YDR, 6SI3, 2BIM, 3TG5, 3TS8, 1SAE, 5O1A, 5O1I, 4LOE, 7B4F, 5AOK, 4X34, 5HP0, 5AOL, 7B4E, 5HOU, 4HFZ, 3Q06, 7DVD, 5MOC, 7YGI, 3ZME, 3Q05, 2GS0, 8DC8, 6FF9, 6VR5, 4LO9, 3D0A, 7B4A, 5G4M, 2H2F, 2ATA, 3OQ5, 6GGE, 2FOO, 4IBU, 3KMD, 2H59, 6GGD, 2J1W, 1PET, 7EL4, 5XZC, 6RZ3, 3D08, 7B48, 2FOJ, 4QO1, 6RJZ, 2H4J, 1SAL, 2MWO, 7B49, 4IBQ, 2AHI, 6SI2, 4IBS, 2F1X, 6RL6, 5LAP, 2J11, 7B4D, 5AOI, 2J1X, 7DHZ, 5AOJ, 8DC7, 7DHY, 6R5L, 8E7B, 6RX2, 1OLG, 8A92, 1GZH, 2FEJ, 3D06, 1TUP, 4IBY, 4XR8, 2PCX, 1DT7, 1YCS, 6SIP, 6S3C, 7EAX, 3Q01, 6ZNC, 4MZI, 6SI0, 5OL0, 6SHZ, 4IBT, 5LGY, 8DC6, 7B46, 1PES, 2J0Z, 5AB9, 2XWR, 2WGX, 7B47, 3LW1, 5ABA, 6S9Q, 2BIP, 6RL4, 2ADY, 6S39, 4AGQ, 1TSR, 5MF7, 6RL3, 2H4H, 4AGP, 4IBZ, 2H4F, 2VUK, 7RM4, 5O1F, 6SI1, 1SAK, 2BIO, 6SLV, 5O1G, 1C26, 1JSP, 2OCJ, 2RUK, 7B4C, 6RWS, 7EEU, 1A1U, 4IBV, 5O1D, 6RWU, 4IBW, 2K8F, 2LY4, 1YCR, 1HS5, 5MCW, 8F2I, 2MEJ, 7BWN, 6FJ5, 6GGB, 6GGC, 1H26, 3KZ8, 5A7B, 2B3G, 1YCQ
COSMIC
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (228)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q00987 MDM2  11 0.995 115
 UniProt:P04637 TP53  20 0.98 33
 UniProt:Q09472 EP300  5 0.976 22
 IntAct:EBI-4399559 UBIQ      0.973 21
 UniProt:P03070 LT      0.97 25
 UniProt:Q93009 USP7  2 0.969 23
 UniProt:O15151 MDM4  5 0.964 19
 UniProt:P0CG48 UBC  20 0.96 15
 UniProt:Q92793 CREBBP  4 0.96 17
 UniProt:Q96EB6 SIRT1  1 0.957 18
 IntAct:EBI-1550784 CDKN1A      0.929 22
 UniProt:Q8WTS6 SETD7  1 0.922 11
 UniProt:Q13625 TP53BP2  1 0.903 9
 UniProt:Q96PM5 RCHY1  2 0.892 13
 UniProt:Q14999 CUL7  1 0.888 16
 UniProt:Q8IWT3 CUL9  2 0.887 13
 UniProt:Q07817-1 BCL2L1      0.881 26
 UniProt:Q12888-1 TP53BP1      0.879 17
 UniProt:Q12888 TP53BP1  3 0.87 8
 UniProt:P26447 S10A4      0.848 9
 UniProt:Q13526 PIN1  2 0.846 14
 UniProt:P45481 Crebbp  4 0.845 10
 UniProt:P06463 VE6      0.84 5
 UniProt:Q9UER7 DAXX  13 0.84 12
 UniProt:Q15672 TWIST1  1 0.817 10
 UniProt:Q8WUF5 PPP1R13L  1 0.815 12
 UniProt:P38646 HSP9  6 0.811 6
 UniProt:P03126 VE6      0.807 5
 UniProt:Q9NRG4 SMYD2  1 0.806 6
 UniProt:O14641 DVL2  5 0.778 6
 UniProt:P38936 CDKN1A  5 0.778 5
 UniProt:Q05086 UBE3A  1 0.77 6
 UniProt:Q923E4 Sirt1  2 0.766 4
 UniProt:Q99986 VRK1  2 0.761 11
 UniProt:Q05397 PTK2  11 0.751 13
 UniProt:P09874 PARP1  4 0.75 5
 UniProt:P09429 HMGB1  5 0.74 9
 UniProt:P31947 SFN  1 0.738 5
 UniProt:P53350 PLK1  4 0.737 6
 UniProt:P63279 UBE2I  9 0.737 5
 UniProt:P43356 MAGA2      0.729 7
 UniProt:Q9NPI1 BRD7  1 0.729 9
 UniProt:O14503 BHLHE40  1 0.728 11
 UniProt:Q8N3Y1 FBXW8  1 0.725 7
 UniProt:P63165 SUMO1  11 0.722 3
 UniProt:P32776  1 0.719 7
 UniProt:P32780 GTF2H1  1 0.719 12
 UniProt:Q8NHY2 RFWD2  3 0.717 5
 UniProt:Q96KB5 TOPK      0.715 7
 UniProt:P13693 TCTP      0.715 7
 UniProt:Q16666-2 IFI16      0.715 6
 UniProt:Q13547 HDAC1  2 0.713 7
 UniProt:Q9H2X6 HIPK2  3 0.713 3
 UniProt:P42858 HTT  1 0.709 19
 UniProt:P13569 CFTR  17 0.706 18
 UniProt:P29590 PML  5 0.7 4
 UniProt:Q9BUJ2 HNRNPUL1  1 0.697 12
 UniProt:O95376 ARIH2  1 0.691 5
 UniProt:P61964 WDR5  1 0.69 5
 UniProt:Q15291 RBBP5  1 0.69 5
 UniProt:P02829  11 0.678 8
 UniProt:Q9NRR4 DROSHA  1 0.677 5
 UniProt:P06703 S10A6      0.676 3
 UniProt:P29034 S10A2      0.676 4
 UniProt:P06748 NPM1  11 0.676 6
 UniProt:Q15796 SMAD2  20 0.674 7
 UniProt:Q96M61 MAGBI      0.668 3
 UniProt:P31948 STIP1  1 0.666 4
 UniProt:P04792 HSBP1  3 0.665 3
 UniProt:O60341-1 KDM1A      0.664 6
 UniProt:P26663-PRO_0000037536      0.664 9
 UniProt:P48643 CCT5  1 0.659 3
 UniProt:P03120 VE2      0.658 3
 UniProt:P49841 GSK3B  4 0.658 3
 UniProt:P17844 DDX5  4 0.656 6
 UniProt:P51587 BRCA2  20 0.655 7
 UniProt:Q13362 PPP2R5C  3 0.65 4
 UniProt:Q06587 RING1  1 0.65 7
 UniProt:Q14191 WRN  2 0.647 5
 UniProt:O96017 CHEK2  3 0.646 3
 UniProt:Q9BV47 DUS26      0.645 9
 UniProt:Q86XK2 FBXO11  1 0.645 4
 UniProt:Q06330 RBPJ  1 0.645 5
 UniProt:Q9Y618 NCOR2  2 0.645 7
 UniProt:Q92569 PIK3R3  2 0.644 5
 UniProt:P19784 CSNK2A2  2 0.643 3
 UniProt:Q99615 DNAJC7  2 0.643 4
 UniProt:P61981 YWHAG  1 0.643 5
 IntAct:EBI-1550787 MDM2      0.643 3
 UniProt:O95816 BAG2  1 0.643 4
 UniProt:Q9UPR3 SMG5  1 0.643 3
 UniProt:Q9UBL3 ASH2L  1 0.643 7
 UniProt:P30405 PPIF      0.639 4
 UniProt:Q6NYC1 JMJD6  1 0.639 7
 UniProt:Q96FW1 OTUB1  2 0.632 8
 UniProt:Q9Y3T9 NOC2L  1 0.632 8
 UniProt:P49757 NUMB  1 0.632 5
 UniProt:P30153 PPP2R1A  2 0.628 3
 UniProt:P04019 VE6      0.623 2
 UniProt:Q8N488 RYBP  1 0.623 4
 UniProt:P23297 S100A1  1 0.623 3
 UniProt:Q6PCD5 RFWD3      0.623 5
 UniProt:Q8N726 CDKN2A  12 0.623 3
 UniProt:P04271 S100B  1 0.623 3
 UniProt:P35232 PHB  2 0.619 6
 UniProt:Q9Y265 RUVBL1  1 0.619 10
 UniProt:Q86TM6 SYVN1  1 0.61 5
 UniProt:O14920 IKBKB  3 0.609 2
 UniProt:Q9BWC9 CC106      0.608 3
 UniProt:P89055 P89055      0.602 6
 UniProt:Q05655 PRKCD  12 0.602 4
 UniProt:Q9UHH9 IP6K2  1 0.602 4
 UniProt:P15036 ETS2  2 0.602 4
 UniProt:Q9UHC7 MKRN1  2 0.602 8
 UniProt:Q9P0U4 CXXC1  1 0.597 7
 UniProt:Q13155 AIMP2  1 0.593 6
 UniProt:Q96SB4 SRPK1  2 0.591 3
 UniProt:Q06945 SOX4  1 0.591 4
 UniProt:Q8TAQ5 ZNF420  2 0.591 4
 UniProt:Q9UBF1 MAGC2      0.591 3
 UniProt:O60285 NUAK1  2 0.591 5
 UniProt:P23396 RPS3  2 0.59 4
 UniProt:Q9H3D4 TP63  1 0.589 5
 UniProt:P61978 HNRNPK  2 0.589 2
 UniProt:O14980 XPO1  2 0.589 3
 UniProt:Q96ST3 SIN3A  2 0.589 2
 UniProt:P08047 SP1  1 0.589 6
 UniProt:P22736 NR4A1  2 0.581 6
 UniProt:Q96GM8 TOE1      0.577 3
 UniProt:P61289 PSME3  2 0.576 7
 UniProt:O43847 NRDC      0.576 6
 UniProt:P68400 CSNK2A1  2 0.571 2
 UniProt:O75925 PIAS1  1 0.571 4
 UniProt:Q9H7Z6 KAT8  1 0.564 2
 UniProt:P15884 TCF4  1 0.564 2
 UniProt:P25208 NFYB  1 0.564 6
 UniProt:P06748-1 NPM1      0.564 3
 UniProt:P10415 BCL2  1 0.564 5
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:P19338 NCL  3 0.558 2
 UniProt:Q7Z412 PEX26  2 0.556 3
 UniProt:P13473-2 P134732      0.556 3
 IntAct:EBI-25865403 EHD27213144      0.556 3
 UniProt:P21333-2 FLNA      0.556 3
 IntAct:EBI-16429055 CCSB ISOFORM ID      0.556 3
 UniProt:D3DTS7 D3DTS7      0.556 3
 UniProt:P09936 UCHL1  1 0.556 3
 UniProt:P17676 CEBPB  3 0.556 4
 UniProt:Q15424 SAFB  3 0.556 5
 UniProt:P46821 MAP1B  1 0.556 6
 UniProt:P55212 CASP6  5 0.556 3
 UniProt:Q9BQA5 HINFP      0.553 2
 UniProt:P04183 TK1  1 0.553 2
 UniProt:Q99608 NDN  1 0.547 4
 UniProt:P55060 XPO2      0.544 5
 UniProt:O60936 NOL3      0.544 3
 UniProt:Q9PST7 Q9PST7      0.544 3
 UniProt:P33763 S10A5      0.544 2
 UniProt:P25815 S100P  2 0.544 2
 UniProt:P31949 S100A11  2 0.544 2
 UniProt:Q9H9J4-2 USP42      0.544 2
 UniProt:P29066  5 0.544 3
 UniProt:Q8R5A0  1 0.544 3
 UniProt:P04731 MT1A  1 0.544 3
 UniProt:P38398 BRCA1  20 0.544 2
 UniProt:P11473 VDR  2 0.537 6
 UniProt:P23511 NFYA  1 0.537 11
 UniProt:P34931 HSPA1L  2 0.536 2
 UniProt:O43524 FOXO3  9 0.536 2
 UniProt:O15047 SETD1A  1 0.532 4
 UniProt:P27958-PRO_0000037566      0.528 2
 UniProt:Q99832 CCT7  1 0.527 2
 UniProt:Q9NTK5 OLA1  2 0.527 2
 UniProt:P40227 CCT6A  1 0.527 2
 UniProt:Q9H0W5 CCDC8  1 0.527 2
 UniProt:Q8TBX8 PIP4K2C  2 0.527 2
 UniProt:P50991 CCT4  1 0.527 2
 UniProt:O75147 OBSL1  1 0.527 2
 IntAct:EBI-1550792 TP53I3      0.527 3
 UniProt:Q9UNE7 STUB1  1 0.527 3
 UniProt:P78371 CCT2  3 0.527 2
 UniProt:P49368 CCT3  1 0.527 2
 UniProt:P46777 RPL5  1 0.527 2
 UniProt:Q9UL15 BAG5  1 0.527 4
 UniProt:P06400 RB1  20 0.527 2
 UniProt:P17987 TCP1  1 0.527 2
 IntAct:EBI-6620336 CD44      0.525 2
 UniProt:Q8IZD2 KMT2E      0.524 4
 UniProt:O95352-2 ATG7      0.524 4
 UniProt:Q7Z6Z7 HUWE1  4 0.524 3
 UniProt:Q7L7W2 Q7L7W2      0.524 2
 UniProt:P61978-2 HNRNPK      0.524 2
 UniProt:P26687 Twist1  2 0.524 4
 UniProt:Q96PU4 UHRF2  1 0.524 3
 UniProt:Q08619 IFI5B      0.524 2
 UniProt:P36873-1 PPP1CC      0.524 2
 UniProt:Q03701 CEBPZ      0.524 2
 UniProt:Q12772 SREBF2  5 0.524 3
 UniProt:O15169 AXIN1  11 0.524 4
 UniProt:O15164 TRIM24  4 0.524 3
 UniProt:Q15466 NR0B2  1 0.524 3
 UniProt:Q15648 MED1  1 0.524 3
 UniProt:Q92841 DDX17  2 0.524 3
 UniProt:O95863 SNAI1  1 0.524 2
 UniProt:P11274 BCR  4 0.519 2
 UniProt:Q16363 LAMA4  1 0.519 2
 UniProt:O75928 PIAS2  1 0.519 2
 UniProt:Q9BX70 BTBD2      0.508 2
 UniProt:P51114 FXR1  2 0.508 2
 UniProt:Q9NZN9 AIPL1      0.508 2
 UniProt:Q8N2W9 PIAS4  2 0.508 2
 UniProt:Q86Z02 HIPK1  1 0.508 2
 UniProt:O75970 MPDZ      0.499 3
 UniProt:Q8TEW0 PARD3  3 0.499 3
 UniProt:Q60953-2 PML      0.499 3
 UniProt:Q92993 KAT5  1 0.499 3
 UniProt:P49407 ARRB1  5 0.499 5
 UniProt:Q8N9N5 BANP  1 0.499 3
 UniProt:P29590-5 PML      0.491 2
 UniProt:O43741 PRKAB2  2 0.488 2
 UniProt:P24830 VE2      0.488 2
 UniProt:Q96CJ1 EAF2  1 0.488 2
 UniProt:P16885 PLCG2  8 0.488 2
 UniProt:Q16666 IFI16  1 0.488 2
 UniProt:Q8QVZ0 Q8QVZ0      0.463 2
 UniProt:O70445  4 0.463 2
 IntAct:EBI-1800051 CDKN1A      0.462 2
 UniProt:Q7Z2E3 APTX      0.462 4
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