Reactome | CEBPB [nucleoplasm]

CEBPB [nucleoplasm]

Stable Identifier

R-HSA-381378

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CCAAT/enhancer-binding protein beta, CEBPB_HUMAN, C/EBP beta, LAP, NF-IL6, TCF5

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        NPM-ALK-dependent CEBPB gene expression (Homo sapiens)
        
        CEBPB [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17676 CEBPB

Gene Names

CEBPB, TCF5, PP9092

Chain

chain:1-345

Reference Genes

BioGPS Gene:1051 CEBPB

COSMIC (genes):CEBPB CEBPB

CTD Gene:1051 CEBPB

dbSNP Gene:1051 CEBPB

ENSEMBL:ENSG00000172216.6 CEBPB

HGNC:1834 CEBPB

KEGG Gene (Homo sapiens):1051 CEBPB

Monarch:1051 CEBPB

NCBI Gene:1051 CEBPB

OMIM:189965 CEBPB

UCSC:P17676 CEBPB

Reference Transcript

Other Identifiers

1051

11743077_s_at

16914812

212501_PM_at

212501_at

38354_at

3888614

3888615

3888616

3888617

3888618

3888619

3888620

3888621

3888622

3888623

43806_at

8063386

A_14_P109564

A_14_P113115

A_14_P134847

A_23_P143242

A_23_P411296

GE59775

GE85855

GO:0000122

GO:0000779

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000979

GO:0000981

GO:0001227

GO:0001228

GO:0001541

GO:0001889

GO:0001892

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006953

GO:0006954

GO:0006955

GO:0007155

GO:0007613

GO:0010628

GO:0012501

GO:0016363

GO:0019900

GO:0022414

GO:0023052

GO:0030154

GO:0030182

GO:0031490

GO:0032496

GO:0032675

GO:0032753

GO:0033598

GO:0034976

GO:0035035

GO:0035259

GO:0036488

GO:0042130

GO:0042742

GO:0042802

GO:0042803

GO:0042826

GO:0043226

GO:0043524

GO:0043565

GO:0044389

GO:0045444

GO:0045595

GO:0045600

GO:0045669

GO:0045670

GO:0045892

GO:0045893

GO:0045944

GO:0046982

GO:0048856

GO:0050729

GO:0050873

GO:0050877

GO:0060644

GO:0061515

GO:0061629

GO:0070059

GO:0070169

GO:0071222

GO:0071230

GO:0071347

GO:0071407

GO:0072574

GO:0090575

GO:0097421

GO:0098542

GO:0120162

GO:0140110

GO:0140297

GO:0140467

GO:1901329

GO:1990440

GO:1990647

GO:1990837

GO:2000120

GO:2001198

HMNXSV003050518

Hs.99029.0.S2_3p_at

ILMN_1693014

PH_hs_0005496

TC20000399.hg

TC20001277.hg

Participates

as an output of

as a component of

as an input of

as a member of

This entity regulates

Positively

Other forms of this molecule

p-T235, S321-CEBPB [nucleoplasm]

p-T235-CEBPB [nucleoplasm]

Inferred To

CEBPB [nucleoplasm] (Bos taurus)

CEBPB [nucleoplasm] (Canis familiaris)

CEBPB [nucleoplasm] (Danio rerio)

CEBPB [nucleoplasm] (Gallus gallus)

CEBPB [nucleoplasm] (Sus scrofa)

CEBPB [nucleoplasm] (Xenopus tropicalis)

cebp-2 [nucleoplasm] (Caenorhabditis elegans)

Cebpb [nucleoplasm] (Mus musculus)

Cebpb [nucleoplasm] (Rattus norvegicus)

slbo [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001272807.1, NP_005185.2, NP_001272808.1

OpenTargets

ENSG00000172216

HPA

ENSG00000172216-CEBPB

GeneCards

P17676

Ensembl

ENST00000303004, ENSP00000305422, ENSG00000172216

PRO

P17676

Pharos - Targets

P17676

PDB

1IO4, 1H88, 2E43, 7L4V, 6MG2, 1GU5, 2E42, 6MG1, 1GTW, 1H8A, 1HJB, 1GU4, 1H89, 6MG3

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.609	2
UniProt:P06422 VE2			0.602	4
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.59	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.556	4
UniProt:P06790 VE2			0.544	4
UniProt:P03122 VE2			0.544	3
UniProt:P03120 VE2			0.544	2
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.544	3
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.524	2
IntAct:EBI-9996975 MMP1			0.499	2
UniProt:P15941-PRO_0000317447 MUC1			0.463	8
IntAct:EBI-9981598 3BHS2			0.462	3

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