PIK3CA R38G [cytosol]

Stable Identifier
R-HSA-2395950
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
PIK3CA Arg38Gly
PIK3CA R38G [cytosol] icon
Locations in the PathwayBrowser
General

The arginine residue at position 38 of PIK3CA (R38) is located at a contact site between the ABD and kinase domains of PIK3CA. Substitution of this arginine residue with glycine in PIK3CA R38G mutant is likely to disrupt the interaction between the ABD domain and the kinase domain, causing a confomrational change of the kinase domain that leads to increased enzymatic activity (Huang et al. 2007).

Literature References
PubMed ID Title Journal Year
18079394 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Samuels, Y, Mandelker, D, Schmidt-Kittler, O, Kinzler, KW, Vogelstein, B, Amzel, LM, Gabelli, SB, Velculescu, VE, Huang, CH

Science 2007
External Reference Information
External Reference
Gene Names
PIK3CA
Chain
chain:1-1068
Other Identifiers
11745214_a_at
11763283_at
16948209
17122920
17122922
204369_PM_at
204369_at
231854_PM_at
231854_at
235980_PM_at
235980_at
2653841
2653852
2653853
2653855
2653856
2653857
2653858
2653860
2653861
2653862
2653864
2653865
2653866
2653867
2653868
2653869
2653871
2653872
2653873
2653875
2653876
2653877
2653879
2653880
2653881
2653882
2653883
2653884
2653885
2653890
3935885
3935887
3935891
3935893
3935895
3935897
40704_at
41969_at
5290
55954_at
8084016
81516_at
81657_at
83177_at
90039_at
A_14_P113684
A_14_P127878
A_14_P128410
A_21_P0012238
A_23_P92057
GE60386
GE88555
GO:0000166
GO:0001525
GO:0001889
GO:0001932
GO:0001944
GO:0002376
GO:0003012
GO:0003013
GO:0003824
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0005944
GO:0005975
GO:0006006
GO:0006091
GO:0006325
GO:0006629
GO:0006909
GO:0006914
GO:0007010
GO:0007155
GO:0007173
GO:0008286
GO:0010468
GO:0010592
GO:0010629
GO:0012501
GO:0014065
GO:0014704
GO:0014823
GO:0014870
GO:0016192
GO:0016242
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0030027
GO:0030036
GO:0030168
GO:0030295
GO:0030835
GO:0031295
GO:0032008
GO:0033138
GO:0035004
GO:0035005
GO:0035994
GO:0036092
GO:0036211
GO:0038028
GO:0038084
GO:0040014
GO:0042060
GO:0043201
GO:0043276
GO:0043457
GO:0043491
GO:0043524
GO:0043542
GO:0043560
GO:0044029
GO:0046854
GO:0046934
GO:0048009
GO:0048015
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050852
GO:0051897
GO:0052812
GO:0055119
GO:0060048
GO:0060612
GO:0071333
GO:0071464
GO:0071514
GO:0071548
GO:0086003
GO:0097009
GO:0098772
GO:0106310
GO:0110053
GO:0140096
GO:1903544
GO:2000270
GO:2000811
HMNXSV003040760
Hs.120905.0.S1_3p_at
Hs.122419.0.S1_3p_at
ILMN_1705396
ILMN_1705468
PH_hs_0031379
TC03000951.hg
TC03002674.hg
TC22000929.hg
Z29090_at
g5453891_3p_at
p28442
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 38 replaced with glycine
Coordinate
38
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to a glycine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
glioblastoma multiforme DOID:3068 GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P27986 PIK3R1  16 0.965 63
 UniProt:O00459 PIK3R2  2 0.864 48
 UniProt:P35568 IRS1  5 0.853 42
 UniProt:Q92569 PIK3R3  2 0.845 45
 UniProt:P62993 GRB2  1 0.742 5
 UniProt:P21860 ERBB3      0.723 18
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:P01100 FOS  2 0.556 3
 UniProt:P54253 ATX1      0.556 3
 UniProt:P54252 ATXN3  2 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:P03496 NS  2 0.527 7
 UniProt:P42336 PIK3CA  20 0.462 3
Cite Us!