Reactome | TCF4 [nucleoplasm]

TCF4 [nucleoplasm]

Stable Identifier

R-HSA-445672

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E2-2/ITF-2, Transcription factor 4, ITF2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGFBR3 (Homo sapiens)
    - TGFBR3 expression (Homo sapiens)
      - Binding of MyoD to TGFBR3 gene promoter (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
      - TGFBR3 transcription (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15884 TCF4

Gene Names

TCF4, BHLHB19, ITF2, SEF2

Chain

chain:1-667

Reference Genes

BioGPS Gene:6925 TCF4

COSMIC - genes:TCF4 TCF7L2

CTD Gene:6925 TCF4

dbSNP Gene:6925 TCF4

ENSEMBL:ENSG00000196628 TCF4

HGNC:11634 TCF4

KEGG:hsa:6925 TCF4

Monarch:6925 TCF4

NCBI Gene:6925 TCF4

OMIM:602272 TCF4

UCSC:P15884 TCF4

Reference Transcript

Participates

as a candidate of

phospho-E proteins [nucleoplasm] (Homo sapiens)

Inferred To

da [nucleoplasm] (Drosophila melanogaster)

Tcf4 [nucleoplasm] (Mus musculus)

Tcf4 [nucleoplasm] (Rattus norvegicus)

TCF4 [nucleoplasm] (Bos taurus)

TCF4 [nucleoplasm] (Canis familiaris)

TCF4 [nucleoplasm] (Gallus gallus)

TCF4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003190.1, NP_001356511.1, NP_001230156.1, NP_001356512.1, NP_001335149.1, NP_001230155.2, NP_001230157.1, NP_001230159.1, NP_001293136.1, NP_001335141.1, NP_001335147.1, NP_001335145.1, NP_001335146.1, NP_001335143.1, NP_001335142.1, NP_001335144.1, NP_001335148.1, NP_001356497.1, NP_001356496.1, NP_001335140.1, NP_001077431.1, NP_001230163.1, NP_001356500.1, NP_001356501.1, NP_001356504.1, NP_001230165.1, NP_001230161.1, NP_001230164.1, NP_001230162.1, NP_001230160.1, NP_001293137.1

OpenTargets

ENSG00000196628

ENSEMBL

ENSP00000455179, ENST00000629387, ENSP00000454366, ENST00000457482, ENSP00000455135, ENST00000537578, ENST00000537856, ENSP00000455261, ENSP00000409447, ENSP00000346440, ENST00000566279, ENST00000356073, ENST00000636400, ENST00000564999, ENST00000567880, ENST00000568673, ENST00000616053, ENSP00000445202, ENST00000544241, ENST00000570177, ENSP00000441562, ENSP00000457649, ENSP00000455763, ENST00000626584, ENST00000354452, ENSP00000478549, ENSP00000490006, ENSP00000439656, ENSP00000486072, ENSP00000486670, ENSP00000440731, ENSP00000455984, ENSP00000457765, ENSP00000439827, ENST00000540999, ENSP00000348374, ENST00000565018, ENST00000564228, ENSP00000456125, ENSP00000455418, ENST00000566286, ENST00000570287, ENST00000561992, ENST00000561831, ENST00000543082, ENSG00000196628, ENSP00000454647

GeneCards

TCF4

HPA

ENSG00000196628-TCF4

PRO

P15884

Pharos - Targets

P15884

Orphanet

TCF4

PDB

8OSB, 6OD5, 2KWF, 6OD3, 6OD4

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.94	22
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.845	9
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.845	8
UniProt:Q8WVJ9 TWIST2	1	TWIST2 [nucleoplasm] (R-HSA-445444)	0.742	5
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.725	8
UniProt:P47928 ID4	1	ID4 [nucleoplasm] (R-HSA-3701048)	0.725	5
UniProt:P17542 TAL1	2	TAL1 [nucleoplasm] (R-HSA-8956511) TAL1 [cytosol] (R-HSA-9921881)	0.689	5
UniProt:P61296 HAND2	1	HAND2 [nucleoplasm] (R-HSA-9007820)	0.666	4
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.659	4
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.643	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	2
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.558	6
UniProt:Q9GZQ4 NMUR2	1	NMUR2 [plasma membrane] (R-HSA-964816)	0.556	3
UniProt:P54646 PRKAA2	5	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) p-T172-PRKAA2 [endoplasmic reticulum lumen] (R-HSA-9931258) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.556	3
UniProt:Q9UIL1 SCOC	1	SCOC [cytosol] (R-HSA-6813911)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.556	3
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.556	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q92888 ARHGEF1	1	ARHGEF1 [cytosol] (R-HSA-114526)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.556	3
UniProt:Q9H5Z6 FAM124B	1	FAM124B [nucleoplasm] (R-HSA-9944443)	0.556	3
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:P38936 CDKN1A	5	CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.527	3
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.527	3
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.527	2
UniProt:Q0VG99 MESP2	1	MESP2 [nucleoplasm] (R-HSA-9793805)	0.527	2
UniProt:P15173 MYOG	1	MYOG [nucleoplasm] (R-HSA-445160)	0.527	2
UniProt:Q61473 Sox17	2	Sox17 [nucleoplasm] (R-MMU-9823740) Sox17 [nucleoplasm] (R-MMU-5625834)	0.499	5
UniProt:P26233 ctnnb1	1	ctnnb1 [nucleoplasm] (R-XLA-9835531)	0.499	2

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