Reactome | p-S465,S467-SMAD2 D300A [cytosol]

p-S465,S467-SMAD2 D300A

Stable Identifier

R-HSA-3315064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Ser465,Ser467-SMAD2 Asp300Ala

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
23139211	SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer	Cancer Res.	2013

External Reference Information

External Reference

UniProt:Q15796 SMAD2

Gene Names

SMAD2, MADH2, MADR2

Chain

initiator methionine:1, chain:2-467

Reference Genes

BioGPS Gene:4087 SMAD2

COSMIC (genes):SMAD2 SMAD2

CTD Gene:4087 SMAD2

dbSNP Gene:4087 SMAD2

ENSEMBL:ENSG00000175387 SMAD2

HGNC:6768 SMAD2

KEGG Gene (Homo sapiens):hsa:4087 SMAD2

Monarch:4087 SMAD2

NCBI Gene:4087 SMAD2

OMIM:601366 SMAD2

UCSC:Q15796 SMAD2

Reference Transcript

Other Identifiers

0004570408

0100510537

11729653_a_at

11729654_a_at

11729655_a_at

11729656_s_at

11734014_a_at

11734015_a_at

11746820_a_at

1453_at

16855090

16855093

1928_s_at

1DEV

1KHX

1U7V

203075_at

203076_s_at

203077_s_at

226563_at

235598_at

239271_at

25507

2LB3

4087

50764_at

53730_at

57493_at

67203

70271_at

73546

8023191

8023195

81545_at

90267_at

A_19_P00331466

A_19_P00811827

A_21_P0009555

A_23_P15937

A_24_P202527

A_32_P109002

A_32_P12580

AAB17054

AAB17087

AAC39657

AAC50789

AAC51918

AAH14840

AAH25699

AAP36090

AF027964

AK312963

B7Z5N5

BAG35802

BC014840

BC025699

BT007422

CAB025507

CAB073546

CCDS11934

CH471096

EAW62915

EAW62916

EAW62917

ENSG00000175387

ENSP00000262160

ENSP00000349282

ENSP00000384449

ENSP00000466193

ENST00000262160

ENST00000356825

ENST00000402690

ENST00000586040

EntrezGene:4087

g1575529_3p_a_at

g5174510_3p_a_at

GE59354

GE846664

GO:0000122

GO:0000228

GO:0000790

GO:0000978

GO:0001071

GO:0001077

GO:0001657

GO:0001701

GO:0001706

GO:0001707

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0003723

GO:0004871

GO:0005160

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0006412

GO:0006461

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007165

GO:0007179

GO:0007182

GO:0007183

GO:0007267

GO:0007352

GO:0007369

GO:0007389

GO:0007492

GO:0007507

GO:0008134

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0009749

GO:0009790

GO:0009791

GO:0009880

GO:0009952

GO:0010628

GO:0010629

GO:0010718

GO:0016579

GO:0017015

GO:0019899

GO:0019902

GO:0022607

GO:0023019

GO:0030073

GO:0030154

GO:0030324

GO:0030512

GO:0030513

GO:0030618

GO:0031016

GO:0031053

GO:0031625

GO:0032444

GO:0032924

GO:0033613

GO:0034641

GO:0034713

GO:0035019

GO:0035265

GO:0035326

GO:0035556

GO:0038092

GO:0040007

GO:0042060

GO:0042803

GO:0043167

GO:0043226

GO:0043234

GO:0045165

GO:0045892

GO:0045893

GO:0045944

GO:0046332

GO:0046872

GO:0046982

GO:0048340

GO:0048589

GO:0048617

GO:0048646

GO:0048701

GO:0048856

GO:0051098

GO:0060021

GO:0060039

GO:0060395

GO:0065003

GO:0070410

GO:0070411

GO:0070412

GO:0070723

GO:0070878

GO:0071141

GO:0071144

GO:0097718

GO:1900224

HGNC:6768

HPA067203

Hs.110741.0.A1_3p_at

Hs.12253.0.A1_3p_at

Hs.204129.0.A1_3p_at

Hs.741342

Hs.82483.0.A3_3p_at

ILMN_1751036

ILMN_1754521

ILMN_1771203

ILMN_1914072

IPR001132

IPR003619

IPR008984

IPR013019

IPR013790

IPR017855

MIM:601366

NM_001003652

NM_001135937

NM_005901

NP_001003652

NP_001129409

NP_005892

PF03165

PF03166

PH_hs_0020771

PH_hs_0022288

PH_hs_0033969

PH_hs_0038510

Q53XR6

SM00523

SM00524

SMAD2

SMAD2-201

SMAD2-202

SMAD2-203

SMAD2-205

TC18000496.hg

TC18000918.hg

TC18000919.hg

U59911

U65019

U68018

U68018_at

U78727

U78728

U78729

U78730

U78731

U78732

U78733

uc002lcy.5

uc002lcz.5

uc010xdc.4

uc060oxx.1

UPI0000032EE7

UPI00001EC3AA

XM_005258259

XM_006722451

XM_011525984

XM_011525985

XM_017025745

XM_017025746

XM_017025747

XM_017025748

XM_017025750

XP_005258316

XP_006722514

XP_011524286

XP_011524287

XP_016881234

XP_016881235

XP_016881236

XP_016881237

XP_016881239

Participant Of

hasMember

p-2S-SMAD2 MH2 Domain Mutants [cytosol]

Other forms of this molecule

Ub-SMAD2 [cytosol]

p-S465,S467-SMAD2 P305L [cytosol]

p-S465,S467-SMAD2 D300N [cytosol]

p-S465,S467-SMAD2 A354T [cytosol]

p-S465,S467-SMAD2 P305Q [cytosol]

p-S465,S467-SMAD2 D300V [cytosol]

SMAD2 A354T [cytosol]

SMAD2 D300A [cytosol]

SMAD2 D300N [cytosol]

SMAD2 P305L [cytosol]

SMAD2 D300V [cytosol]

SMAD2 P305Q [cytosol]

SMAD2 S464* [cytosol]

p-S465,S467-SMAD2 [nucleoplasm]

p-S465,S467-SMAD2 [cytosol]

SMAD2 [cytosol]

SMAD2 [nucleoplasm]

p-T220,S465,S467-SMAD2 [nucleoplasm]

SMAD2 S467P [cytosol]

SMAD2 S464L [cytosol]

Modified Residues

Name

O-phospho-L-serine at 465

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

L-aspartic acid residue 300 replaced with L-alanine

Coordinate

300

PsiMod HEY

L-aspartic acid residue [MOD:00013]

A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.

L-alanine residue [MOD:00010]

A protein modification that effectively converts a source amino acid residue to an L-alanine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
malignant neoplasm of large intestine	5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001003652.1, XP_016881234.1, XP_006722514.1, XP_005258316.1, NP_005892.1, XP_016881235.1

GeneCards

Q15796

DOCK Blaster

1DEV, 1U7V, 1KHX

PRO

Q15796

Orphanet

24927

PDB

1DEV, 2LB3, 1U7V, 1KHX

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 K428R [cytosol] (R-HSA-3311001)	0.957	21
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.834	10
UniProt:Q9HAU4 SMURF2	2	SMURF2 [cytosol] (R-HSA-173537) SMURF2 [nucleoplasm] (R-HSA-178202)	0.811	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb-TP53 [cytosol] (R-HSA-6793681) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.702	7
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.662	6
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.656	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.646	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.635	3
UniProt:P12757-1 SKIL			0.589	2
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.589	3
UniProt:Q9BZ29 DOCK9	1	DOCK9 [cytosol] (R-HSA-1012981)	0.576	3
UniProt:Q12955 ANK3	1	ANK3 [cytosol] (R-HSA-374562)	0.573	2
UniProt:O95405 ZFYVE9			0.573	2
UniProt:P84022 SMAD3	15	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 R268C [cytosol] (R-HSA-3702149) SMAD3 D258N [cytosol] (R-HSA-3702147) SMAD3 R268H [cytosol] (R-HSA-3702148) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326)	0.573	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.544	2
UniProt:P61586 RHOA	6	RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510) RHOA [cytosol] (R-HSA-194866)	0.524	2
UniProt:P98082 DAB2	3	DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.524	4
UniProt:O15111 CHUK	3	p-T23-CHUK [cytosol] (R-HSA-198615) CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667)	0.524	2
UniProt:Q9NYA4 MTMR4	2	MTMR4 [early endosome membrane] (R-HSA-2187404) MTMR4 [cytosol] (R-HSA-1604658)	0.524	2
UniProt:P70056 FOXH1			0.499	4
UniProt:P10070 GLI2	11	p4S-GLI2 [ciliary base] (R-HSA-5610487) ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059) p8S-GLI2 [ciliary base] (R-HSA-5610494) p11S-GLI2 [ciliary base] (R-HSA-5610471) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) GLI2 [cytosol] (R-HSA-445451) p-GLI2 [ciliary tip] (R-HSA-5635044) p-GLI2 [nucleoplasm] (R-HSA-5635047) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) GLI2 [ciliary base] (R-HSA-5610361) GLI2 [ciliary tip] (R-HSA-5610363)	0.462	2