p-S465,S467-SMAD2 D300A [cytosol]

Stable Identifier
R-HSA-3315064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Ser465,Ser467-SMAD2 Asp300Ala
Icon
p-S465,S467-SMAD2 D300A [cytosol] icon
p-S465,S467-SMAD2 D300A [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
23139211 SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Fleming, NI, Jorissen, RN, Mouradov, D, Christie, M, Sakthianandeswaren, A, Palmieri, M, Day, F, Li, S, Tsui, C, Lipton, L, Desai, J, Jones, IT, McLaughlin, S, Ward, RL, Hawkins, NJ, Ruszkiewicz, AR, Moore, J, Zhu, HJ, Mariadason, JM, Burgess, AW, Busam, D, Zhao, Q, Strausberg, RL, Gibbs, P, Sieber, OM

Cancer Res. 2013
External Reference Information
External Reference
UniProt:Q15796 SMAD2
Gene Names
SMAD2, MADH2, MADR2
Chain
initiator methionine:1, chain:2-467
Reference Genes
BioGPS Gene:4087 SMAD2
COSMIC (genes):SMAD2 SMAD2
CTD Gene:4087 SMAD2
dbSNP Gene:4087 SMAD2
ENSEMBL:ENSG00000175387 SMAD2
HGNC:6768 SMAD2
KEGG Gene (Homo sapiens):4087 SMAD2
Monarch:4087 SMAD2
NCBI Gene:4087 SMAD2
OMIM:601366 SMAD2
UCSC:Q15796 SMAD2
Reference Transcript
Other Identifiers
0004570408
0100510537
11729653_a_at
11729654_a_at
11729655_a_at
11729656_s_at
11734014_a_at
11734015_a_at
11746820_a_at
1453_at
16855090
16855093
1928_s_at
1DEV
1KHX
1U7V
203075_at
203076_s_at
203077_s_at
226563_at
235598_at
239271_at
25507
2LB3
3096426
3806892
3806894
3806896
3806898
3806900
3806902
3806904
3806906
3806907
3806908
3806909
3806910
3806911
3806912
3806914
3806915
3806916
3806917
3806918
3806919
3806924
3806926
3806928
3806929
3806931
3806933
3806937
3806938
3806939
3806946
3806947
3806948
3806956
3806957
3806958
3806959
3806960
3806961
4087
50764_at
53730_at
57493_at
5XOD
5ZOJ
67203
70271_at
73546
8023191
8023195
81545_at
90267_at
A_19_P00331466
A_19_P00811827
A_21_P0009555
A_23_P15937
A_24_P202527
A_32_P109002
A_32_P12580
AAB17054
AAB17087
AAC39657
AAC50789
AAC51918
AAH14840
AAH25699
AAP36090
AF027964
AK312963
B7Z5N5
BAG35802
BC014840
BC025699
BT007422
CAB025507
CAB073546
CCDS11934
CH471096
EAW62915
EAW62916
EAW62917
ENSG00000175387
ENSP00000262160
ENSP00000349282
ENSP00000384449
ENSP00000466193
ENST00000262160
ENST00000262160.10
ENST00000356825
ENST00000356825.8
ENST00000402690
ENST00000402690.6
ENST00000586040
ENST00000586040.5
EntrezGene:4087
EntrezGene:SMAD2
g1575529_3p_a_at
g5174510_3p_a_at
GE59354
GE846664
GO:0000122
GO:0000228
GO:0000790
GO:0000978
GO:0000981
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0003723
GO:0005160
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0007179
GO:0007182
GO:0007183
GO:0007267
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008134
GO:0008150
GO:0008283
GO:0008285
GO:0009058
GO:0009749
GO:0009790
GO:0009791
GO:0009880
GO:0009952
GO:0010628
GO:0010629
GO:0010718
GO:0015031
GO:0016579
GO:0017015
GO:0019899
GO:0019902
GO:0022607
GO:0023019
GO:0030073
GO:0030154
GO:0030324
GO:0030325
GO:0030512
GO:0030513
GO:0030618
GO:0031016
GO:0031053
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0033613
GO:0034641
GO:0034713
GO:0035019
GO:0035265
GO:0035326
GO:0035556
GO:0038092
GO:0040007
GO:0042060
GO:0042803
GO:0043167
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048646
GO:0048701
GO:0048856
GO:0051098
GO:0060039
GO:0060395
GO:0062009
GO:0065003
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0070878
GO:0071141
GO:0071144
GO:0097718
GO:1900224
HGNC:6768
HPA067203
Hs.110741.0.A1_3p_at
Hs.12253.0.A1_3p_at
Hs.204129.0.A1_3p_at
Hs.82483.0.A3_3p_at
ILMN_1751036
ILMN_1754521
ILMN_1771203
ILMN_1914072
IPR001132
IPR003619
IPR008984
IPR013019
IPR013790
IPR017855
IPR036578
K7EJX0
K7EL92
K7ERC7
K7ESI8
MIM:601366
NM_001003652
NM_001135937
NM_005901
NP_001003652
NP_001129409
NP_005892
PF03165
PF03166
PH_hs_0020771
PH_hs_0022288
PH_hs_0033969
PH_hs_0038510
Q53XR6
SM00523
SM00524
SMAD2
SMAD2-201
SMAD2-202
SMAD2-203
SMAD2-205
TC18000496.hg
TC18000918.hg
TC18000919.hg
U59911
U65019
U68018
U68018_at
U78727
U78728
U78729
U78730
U78731
U78732
U78733
UPI0000032EE7
UPI00001EC3AA
XM_005258259
XM_006722451
XM_011525984
XM_011525985
XM_017025745
XM_017025746
XM_017025747
XM_017025748
XM_017025750
XM_024451173
XP_005258316
XP_006722514
XP_011524286
XP_011524287
XP_016881234
XP_016881235
XP_016881236
XP_016881237
XP_016881239
XP_024306941
Participant Of
hasMember
Other forms of this molecule
Ub-SMAD2 [cytosol]
p-S465,S467-SMAD2 P305L [cytosol]
p-S465,S467-SMAD2 D300N [cytosol]
p-S465,S467-SMAD2 A354T [cytosol]
p-S465,S467-SMAD2 P305Q [cytosol]
p-S465,S467-SMAD2 D300V [cytosol]
SMAD2 S464* [cytosol]
p-S465,S467-SMAD2 [nucleoplasm]
p-S465,S467-SMAD2 [cytosol]
SMAD2 [cytosol]
p-T220,S465,S467-SMAD2 [nucleoplasm]
SMAD2 [nucleoplasm]
SMAD2 S467P [cytosol]
SMAD2 S464L [cytosol]
Modified Residues
Name
L-aspartic acid residue 300 replaced with L-alanine
Coordinate
300
PsiMod
L-aspartic acid residue [MOD:00013]
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
L-alanine residue [MOD:00010]
A protein modification that effectively converts a source amino acid residue to an L-alanine.
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
large intestine cancer 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Orphanet
PDB
Interactors (22)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13485 SMAD4  18 0.957 21
 UniProt:P12755 SKI  1 0.834 10
 UniProt:Q9HAU4 SMURF2  2 0.811 6
 UniProt:P04637 TP53  27 0.702 7
 UniProt:Q9UPN9 TRIM33  1 0.662 6
 UniProt:O00308 WWP2  1 0.656 4
 UniProt:Q13573 SNW1  1 0.646 3
 UniProt:O75593 FOXH1  1 0.635 3
 UniProt:P12757-1 SKIL      0.589 2
 UniProt:Q9H3D4 TP63  1 0.589 3
 UniProt:Q9BZ29 DOCK9  1 0.576 3
 UniProt:Q12955 ANK3  1 0.573 2
 UniProt:O95405 ZFYVE9      0.573 2
 UniProt:P84022 SMAD3  12 0.573 2
 UniProt:P05412 JUN  4 0.564 3
 UniProt:P35813 PPM1A  2 0.544 2
 UniProt:O15111 CHUK  3 0.524 2
 UniProt:P98082 DAB2  3 0.524 4
 UniProt:P61586 RHOA  6 0.524 2
 UniProt:Q9NYA4 MTMR4  2 0.524 2
 UniProt:P70056 FOXH1      0.499 4
 UniProt:P10070 GLI2  11 0.462 2