Reactome | p-S465,S467-SMAD2 D300A [cytosol]

p-S465,S467-SMAD2 D300A [cytosol]

Stable Identifier

R-HSA-3315064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Ser465,Ser467-SMAD2 Asp300Ala

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
    - Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
      - SMAD2/3 MH2 Domain Mutants in Cancer (Homo sapiens)
        
        Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)
        
        p-2S-SMAD2/3 MH2 Domain Mutants [cytosol] (Homo sapiens)
        
        p-2S-SMAD2 MH2 Domain Mutants [cytosol] (Homo sapiens)
        
        p-S465,S467-SMAD2 D300A [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
23139211	SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer Mouradov, D, Jorissen, RN, Jones, IT, Tsui, C, Palmieri, M, Sieber, OM, Ward, RL, Fleming, NI, Mariadason, JM, Sakthianandeswaren, A, Lipton, L, Moore, J, Ruszkiewicz, AR, Busam, D, Christie, M, McLaughlin, S, Gibbs, P, Zhu, HJ, Strausberg, RL, Day, F, Li, S, Burgess, AW, Hawkins, NJ, Desai, J, Zhao, Q	Cancer Res.	2013

External Reference Information

External Reference

UniProt:Q15796 SMAD2

Gene Names

SMAD2, MADH2, MADR2

Chain

initiator methionine:1, chain:2-467

Reference Genes

BioGPS Gene:4087 SMAD2

COSMIC (genes):SMAD2 SMAD2

CTD Gene:4087 SMAD2

dbSNP Gene:4087 SMAD2

ENSEMBL:ENSG00000175387.16 SMAD2

HGNC:6768 SMAD2

KEGG Gene (Homo sapiens):4087 SMAD2

Monarch:4087 SMAD2

NCBI Gene:4087 SMAD2

OMIM:601366 SMAD2

UCSC:Q15796 SMAD2

Reference Transcript

Other Identifiers

0004570408

0100510537

11729653_a_at

11729654_a_at

11729655_a_at

11729656_s_at

11734014_a_at

11734015_a_at

11746820_a_at

1453_at

16855090

16855093

1928_s_at

203075_PM_at

203075_at

203076_PM_s_at

203076_s_at

203077_PM_s_at

203077_s_at

226563_PM_at

226563_at

235598_PM_at

235598_at

239271_PM_at

239271_at

3096426

3806892

3806894

3806896

3806898

3806900

3806902

3806904

3806906

3806907

3806908

3806909

3806910

3806911

3806912

3806914

3806915

3806916

3806917

3806918

3806919

3806924

3806926

3806928

3806929

3806931

3806933

3806937

3806938

3806939

3806946

3806947

3806948

3806956

3806957

3806958

3806959

3806960

3806961

4087

50764_at

53730_at

57493_at

70271_at

8023191

8023195

81545_at

90267_at

A_19_P00331466

A_19_P00811827

A_21_P0009555

A_23_P15937

A_24_P202527

A_32_P109002

A_32_P12580

GE59354

GE846664

GO:0000785

GO:0000978

GO:0000981

GO:0000987

GO:0001228

GO:0001657

GO:0001701

GO:0001706

GO:0001707

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005160

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0007179

GO:0007182

GO:0007183

GO:0007352

GO:0007369

GO:0007389

GO:0007492

GO:0007507

GO:0008092

GO:0008285

GO:0009653

GO:0009749

GO:0009791

GO:0009880

GO:0009952

GO:0010628

GO:0010629

GO:0010718

GO:0017015

GO:0019902

GO:0023019

GO:0023052

GO:0030073

GO:0030154

GO:0030324

GO:0030325

GO:0030509

GO:0030513

GO:0031016

GO:0031047

GO:0031053

GO:0031625

GO:0032444

GO:0032924

GO:0032991

GO:0034713

GO:0035265

GO:0035556

GO:0036211

GO:0038092

GO:0042060

GO:0042802

GO:0043226

GO:0045165

GO:0045892

GO:0045893

GO:0045944

GO:0046332

GO:0046872

GO:0048156

GO:0048340

GO:0048589

GO:0048617

GO:0048701

GO:0048856

GO:0051098

GO:0060039

GO:0060395

GO:0061629

GO:0062009

GO:0065003

GO:0070410

GO:0070411

GO:0070412

GO:0070723

GO:0071141

GO:0071142

GO:0071144

GO:0097718

GO:0140297

GO:1900224

HMNXSV003021861

HMNXSV003023211

HMNXSV003024357

Hs.110741.0.A1_3p_at

Hs.12253.0.A1_3p_at

Hs.204129.0.A1_3p_at

Hs.82483.0.A3_3p_at

ILMN_1751036

ILMN_1754521

ILMN_1771203

ILMN_1914072

PH_hs_0020771

PH_hs_0022288

PH_hs_0033969

PH_hs_0038510

TC18000496.hg

TC18000918.hg

TC18000919.hg

U68018_at

g1575529_3p_a_at

g5174510_3p_a_at

p20421

Participates

as a member of

p-2S-SMAD2 MH2 Domain Mutants [cytosol] (Homo sapiens)

Other forms of this molecule

Ub-SMAD2 [cytosol]

p-S465,S467-SMAD2 P305L [cytosol]

p-S465,S467-SMAD2 D300N [cytosol]

p-S465,S467-SMAD2 A354T [cytosol]

p-S465,S467-SMAD2 P305Q [cytosol]

p-S465,S467-SMAD2 D300V [cytosol]

SMAD2 S464* [cytosol]

SMAD2 W422* [cytosol]

SMAD2 S308* [cytosol]

SMAD2 R427* [cytosol]

SMAD2 W448* [cytosol]

SMAD2 S464L [cytosol]

SMAD2 C463* [cytosol]

SMAD2 R321* [cytosol]

SMAD2 S296* [cytosol]

SMAD2 S306* [cytosol]

SMAD2 Q455* [cytosol]

SMAD2 E439* [cytosol]

SMAD2 L315* [cytosol]

SMAD2 S467P [cytosol]

SMAD2 Q429* [cytosol]

p-S250-SMAD2 [cytosol]

SMAD2 [nucleoplasm]

Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]

p-T220,S465,S467-SMAD2 [nucleoplasm]

SMAD2 [cytosol]

p-S465,S467-SMAD2 [cytosol]

p-S465,S467-SMAD2 [nucleoplasm]

Modified Residues

Name

L-aspartic acid 300 replaced with L-alanine

Coordinate

300

PsiMod

L-alanine residue [MOD:00010]

A protein modification that effectively converts a source amino acid residue to an L-alanine.

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

Name

O-phospho-L-serine at 465

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
large intestine cancer	DOID:5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS

Cross References

RefSeq

XP_006722514.1, XP_016881234.1, XP_016881235.1, XP_005258316.1, NP_005892.1, NP_001003652.1

OpenTargets

ENSG00000175387

GeneCards

Q15796

HPA

ENSG00000175387-SMAD2

Ensembl

ENST00000262160, ENST00000356825, ENSP00000466193, ENSP00000384449, ENSP00000349282, ENST00000402690, ENSP00000262160, ENST00000586040, ENSG00000175387

PRO

Q15796

Pharos - Targets

Q15796

Orphanet

24927

HMDB Protein

HMDBP14506

PDB

2LB3, 1KHX, 5ZOJ, 6ZVQ, 1DEV, 7CO1, 6YIA, 5XOD, 1U7V, 6M64

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.959	22
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.826	10
UniProt:Q9HAU4 SMURF2	2	SMURF2 [cytosol] (R-HSA-173537) SMURF2 [nucleoplasm] (R-HSA-178202)	0.811	6
UniProt:O95405 ZFYVE9			0.783	6
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.675	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.674	7
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.662	6
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.656	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.646	3
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.589	3
UniProt:Q9BZ29 DOCK9	1	DOCK9 [cytosol] (R-HSA-1012981)	0.576	3
UniProt:Q12955 ANK3	1	ANK3 [cytosol] (R-HSA-374562)	0.573	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.573	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.544	2
UniProt:P12757-1 SKIL			0.536	2
UniProt:P98082 DAB2	3	DAB2 [cytosol] (R-HSA-8862456) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [plasma membrane] (R-HSA-2980808)	0.524	4
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.524	2
UniProt:Q9NYA4 MTMR4	2	MTMR4 [early endosome membrane] (R-HSA-2187404) MTMR4 [cytosol] (R-HSA-1604658)	0.524	2
UniProt:P61586 RHOA	6	RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.524	2
UniProt:P70056 FOXH1			0.499	4
UniProt:P36801 VE6			0.488	2
UniProt:P10070 GLI2	11	ub-2p-GLI2 [nucleoplasm] (R-HSA-5635059) p4S-GLI2 [ciliary base] (R-HSA-5610487) p8S-GLI2 [ciliary base] (R-HSA-5610494) GLI2 [ciliary tip] (R-HSA-5610363) GLI2 [ciliary base] (R-HSA-5610361) 2p-GLI2 [nucleoplasm] (R-HSA-5635055) p-GLI2 [nucleoplasm] (R-HSA-5635047) p-GLI2 [ciliary tip] (R-HSA-5635044) GLI2 [cytosol] (R-HSA-445451) ub-p11S-GLI2 [ciliary base] (R-HSA-5610501) p11S-GLI2 [ciliary base] (R-HSA-5610471)	0.462	2

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