Reactome | HNF4A [nucleoplasm]

HNF4A [nucleoplasm]

Stable Identifier

R-HSA-446162

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Hepatocyte nuclear factor 4-alpha, HNF4A_HUMAN

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External Reference Information

External Reference

UniProt:P41235 HNF4A

Gene Names

HNF4A, HNF4, NR2A1, TCF14

Chain

chain:1-474

Reference Genes

BioGPS Gene:3172 HNF4A

COSMIC (genes):HNF4A HNF4A

CTD Gene:3172 HNF4A

dbSNP Gene:3172 HNF4A

ENSEMBL:ENSG00000101076 HNF4A

HGNC:5024 HNF4A

KEGG:hsa:3172 HNF4A

Monarch:3172 HNF4A

NCBI Gene:3172 HNF4A

OMIM:600281 HNF4A

UCSC:P41235 HNF4A

Reference Transcript

Participates

as a member of

NR [nucleoplasm] (Homo sapiens)

as an output of

Expression of HNF4A during nephron development (Homo sapiens)

Inferred To

nhr-114 [nucleoplasm] (Caenorhabditis elegans)

nhr-69 [nucleoplasm] (Caenorhabditis elegans)

Hnf4a [nucleoplasm] (Mus musculus)

Hnf4a [nucleoplasm] (Rattus norvegicus)

nhr-47 [nucleoplasm] (Caenorhabditis elegans)

nhr-68 [nucleoplasm] (Caenorhabditis elegans)

nhr-64 [nucleoplasm] (Caenorhabditis elegans)

nhr-40 [nucleoplasm] (Caenorhabditis elegans)

nhr-49 [nucleoplasm] (Caenorhabditis elegans)

nhr-14 [nucleoplasm] (Caenorhabditis elegans)

nhr-35 [nucleoplasm] (Caenorhabditis elegans)

Hnf4 [nucleoplasm] (Drosophila melanogaster)

nhr-76 [nucleoplasm] (Caenorhabditis elegans)

hnf4a [nucleoplasm] (Xenopus tropicalis)

nhr-118 [nucleoplasm] (Caenorhabditis elegans)

nhr-17 [nucleoplasm] (Caenorhabditis elegans)

nhr-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of HNF4A [nucleoplasm] (Caenorhabditis elegans)

nhr-100 [nucleoplasm] (Caenorhabditis elegans)

HNF4A [nucleoplasm] (Bos taurus)

HNF4A [nucleoplasm] (Canis familiaris)

HNF4A [nucleoplasm] (Gallus gallus)

HNF4A [nucleoplasm] (Sus scrofa)

nhr-10 [nucleoplasm] (Caenorhabditis elegans)

nhr-101 [nucleoplasm] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

608

OpenTargets

ENSG00000101076

ENSEMBL

ENSP00000476609, ENST00000316673, ENST00000609795, ENST00000316099, ENST00000415691, ENSP00000312987, ENST00000457232, ENSP00000410911, ENSP00000396216, ENSP00000315180, ENSG00000101076, ENSP00000412111, ENST00000443598

ZINC - Substances

HNF4A_HUMAN

ZINC target

P41235

PRO

P41235

GlyGen

P41235

PDB

3CBB, 1PZL, 3FS1, 4B7W, 6CHT, 4IQR, 8C1L

HPA

ENSG00000101076-HNF4A

GeneCards

HNF4A

Pharos - Targets

P41235

Orphanet

HNF4A

ZINC - Predictions - Purchasable

HNF4A_HUMAN

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.655	4
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.604	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.604	3
UniProt:Q92786 PROX1			0.581	3
IntAct:EBI-10050241 ST2A1			0.576	4
IntAct:EBI-10050232 ST2A1			0.576	4
IntAct:EBI-10051521 CP2C9			0.576	5
IntAct:EBI-9980932 UD19			0.576	4
IntAct:EBI-10055672 CP2C8			0.576	3
IntAct:EBI-10051518 CP2C9			0.576	5
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.543	3
IntAct:EBI-10050213 HNF4A-RE			0.524	2
IntAct:EBI-9973444 CP2A6			0.499	2
IntAct:EBI-9992455 HYEP			0.499	2
IntAct:EBI-10034984 GUC2C			0.499	2
IntAct:EBI-10039585 CO3			0.499	2
IntAct:EBI-10039564 CO3			0.499	2

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