PIK3CA E545K [cytosol]

Stable Identifier
R-HSA-1500706
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
PIK3CA Glu545Lys
PIK3CA E545K [cytosol] icon
Locations in the PathwayBrowser
General
Substitution of glutamic acid residue at position 545 of PIK3CA with lysine disrupts inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1. The PI3K complex containing PIK3CA E545K mutant is constitutively active under serum starved conditions (Miled et al. 2007, Huang et al. 2007, Zhao et al. 2005).
Literature References
PubMed ID Title Journal Year
18079394 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Samuels, Y, Mandelker, D, Schmidt-Kittler, O, Kinzler, KW, Vogelstein, B, Amzel, LM, Gabelli, SB, Velculescu, VE, Huang, CH

Science 2007
17626883 Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Inbar, Y, Miled, N, Hon, WC, Williams, RL, Yan, Y, Backer, JM, Zvelebil, M, Wolfson, HJ, Schneidman-Duhovny, D, Perisic, O

Science 2007
16339315 The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

Liu, Z, Shin, E, Roberts, TM, Wang, L, Loda, MF, Zhao, JJ

Proc. Natl. Acad. Sci. U.S.A. 2005
15016963 High frequency of mutations of the PIK3CA gene in human cancers

Ptak, J, Samuels, Y, Silliman, N, Yan, H, Gazdar, A, Riggins, GJ, Markowitz, S, Powell, SM, Szabo, S, Wang, Z, Willson, JKV, Bardelli, A, Kinzler, KW, Vogelstein, B, Velculescu, VE

Science 2004
External Reference Information
External Reference
Gene Names
PIK3CA
Chain
chain:1-1068
Other Identifiers
11745214_a_at
11763283_at
16948209
17122920
17122922
204369_PM_at
204369_at
231854_PM_at
231854_at
235980_PM_at
235980_at
2653841
2653852
2653853
2653855
2653856
2653857
2653858
2653860
2653861
2653862
2653864
2653865
2653866
2653867
2653868
2653869
2653871
2653872
2653873
2653875
2653876
2653877
2653879
2653880
2653881
2653882
2653883
2653884
2653885
2653890
3935885
3935887
3935891
3935893
3935895
3935897
40704_at
41969_at
5290
55954_at
8084016
81516_at
81657_at
83177_at
90039_at
A_14_P113684
A_14_P127878
A_14_P128410
A_21_P0012238
A_23_P92057
GE60386
GE88555
GO:0000166
GO:0001525
GO:0001889
GO:0001932
GO:0001944
GO:0002376
GO:0003012
GO:0003013
GO:0003824
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0005944
GO:0005975
GO:0006006
GO:0006091
GO:0006629
GO:0006909
GO:0006914
GO:0007010
GO:0007155
GO:0007173
GO:0008286
GO:0010468
GO:0010592
GO:0010629
GO:0012501
GO:0014065
GO:0014704
GO:0014823
GO:0014870
GO:0016192
GO:0016242
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030027
GO:0030036
GO:0030168
GO:0030295
GO:0030835
GO:0031295
GO:0032008
GO:0032869
GO:0035004
GO:0035005
GO:0035994
GO:0036092
GO:0036211
GO:0038084
GO:0040014
GO:0042060
GO:0043201
GO:0043276
GO:0043457
GO:0043491
GO:0043524
GO:0043542
GO:0043560
GO:0046854
GO:0046934
GO:0048009
GO:0048015
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050852
GO:0051897
GO:0055119
GO:0060048
GO:0060612
GO:0071333
GO:0071464
GO:0071548
GO:0086003
GO:0097009
GO:0098772
GO:0106310
GO:0110053
GO:0140096
GO:0141068
GO:1903544
GO:1905477
GO:2000270
GO:2000811
HMNXSV003040760
Hs.120905.0.S1_3p_at
Hs.122419.0.S1_3p_at
ILMN_1705396
ILMN_1705468
PH_hs_0031379
TC03000951.hg
TC03002674.hg
TC22000929.hg
Z29090_at
g5453891_3p_at
p28442
Participates
Other forms of this molecule
Modified Residues
Name
L-glutamic acid 545 replaced with L-lysine
Coordinate
545
PsiMod
A protein modification that effectively converts a source amino acid residue to L-lysine.
A protein modification that effectively removes or replaces an L-glutamic acid.
Disease
Name Identifier Synonyms
thyroid cancer DOID:1781 Thyroid gland neoplasm, thyroid cancer, thyroid neoplasm, neoplasm of thyroid gland, thyroid neoplasm, Thyroid neoplasm, malignant tumour of thyroid gland, malignant neoplasm of thyroid gland
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
tongue cancer DOID:8649 malignant neoplasm of fixed part of tongue NOS, malignant neoplasm of anterior two-thirds of tongue, part unspecified, malignant tumor of lingual tonsil (disorder), malignant neoplasm of tongue, NOS, malignant neoplasm of tip and lateral border of tongue, malignant neoplasm of anterior 2/3 of tongue unspecified (disorder), malignant neoplasm of tip and/or lateral border of tongue, malignant neoplasm of tongue NOS, malignant neoplasm of tongue, tip and lateral border (disorder), malignant neoplasm of dorsum of tongue NOS (disorder), malignant neoplasm of dorsal surface of tongue, malignant neoplasm of tongue NOS (disorder), malignant neoplasm of tongue, malignant neoplasm of ventral surface of tongue, malignant neoplasm of fixed part of tongue NOS (disorder), malignant neoplasm of dorsal tongue NOS, malignant tumor of lingual tonsil, malignant tumor of anterior two-thirds of tongue (disorder), malignant neoplasm of other sites of tongue, malignant neoplasm of tongue, malignant neoplasm of ventral tongue surface NOS (disorder), malignant neoplasm of base of tongue, malignant tumor of Posterior Tongue, malignant tumor of mobile part of tongue, malignant neoplasm of lingual tonsil, malignant neoplasm of border of tongue, malignant tumor of tongue (disorder), malignant neoplasm of mobile part of tongue NOS, malignant neoplasm of other sites of tongue (disorder), malignant tumor of base of tongue (disorder), malignant neoplasm of junctional zone of tongue, Tongue neoplasm malignant stage Unspecified
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
myeloma DOID:0070004
eccrine sweat gland cancer DOID:4921 malignant eccrine skin neoplasm, malignant Eccrine tumor
pituitary adenoma DOID:3829 Pituitary adenoma - disorder, Pituitary adenoma, no ICD-O subtype (morphologic abnormality), Pituitary adenoma, Pituitary adenoma, Pituitary adenoma (disorder), adenoma of the Pituitary gland, Pituitary adenoma
renal pelvis carcinoma DOID:4919 malignant renal Pelvis neoplasm, malignant tumor of renal pelvis (disorder), malignant neoplasm of renal pelvis, malignant neoplasm of renal pelvis NOS (disorder), carcinoma of kidney Pelvis, renal pelvis cancer
pancreatic cancer DOID:1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
kidney cancer DOID:263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
basal cell carcinoma DOID:2513 malignant Basal cell neoplasm, malignant basal cell tumor, malignant basal cell tumor (morphologic abnormality), Basal cell cancer, BASAL CELL carcinoma OF SKIN, Rodent ulcer, Rodent ulcer, Basal cell carcinoma NOS (morphologic abnormality), Basal cell neoplasm NOS (morphologic abnormality), Rodent ulcer, basal cell carcinoma, Basal cell carcinoma (morphologic abnormality), Epithelioma basal cell (disorder), basal cell neoplasm, Basal cell neoplasm (morphologic abnormality), Basal cell tumor (morphologic abnormality), Rodent ulcer, Basal cell carcinoma of skin (disorder), Basal cell tumor
gum cancer DOID:8602 malignant neoplasm of other sites of gum, malignant neoplasm of gum NOS (disorder), malignant neoplasm of gum, malignant Gingival tumor, malignant neoplasm of other sites of gum (disorder), malignant tumor of gum (disorder), malignant tumour of gingiva
skin squamous cell carcinoma DOID:3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
gallbladder carcinoma DOID:4948 cancer of the gallbladder, carcinoma gallbladder, carcinoma gallbladder, carcinoma gallbladder, carcinoma of gallbladder (disorder)
pharynx cancer DOID:0060119
esophageal carcinoma DOID:1107 carcinoma OF ESOPHAGUS, carcinoma of oesophagus, cancer of esophagus, cancer of oesophagus, carcinoma of esophagus (disorder), carcinoma of esophagus (disorder)
penis carcinoma DOID:3449 Penile carcinoma, carcinoma of penis (disorder)
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
bile duct carcinoma DOID:4897
medulloblastoma DOID:0050902
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung cancer DOID:1324
seborrheic keratosis DOID:6498
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cervical cancer DOID:4362 neoplasm of uterine cervix (disorder), tumor of the Cervix Uteri, cervix uteri cancer, cervical neoplasm, cervix cancer
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
brain glioma DOID:0060108
glioblastoma multiforme DOID:3068 GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P27986 PIK3R1  16 0.965 63
 UniProt:O00459 PIK3R2  2 0.864 48
 UniProt:P35568 IRS1  5 0.853 42
 UniProt:Q92569 PIK3R3  2 0.845 45
 UniProt:P62993 GRB2  1 0.742 5
 UniProt:P21860 ERBB3      0.723 18
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:P01100 FOS  2 0.556 3
 UniProt:P54253 ATX1      0.556 3
 UniProt:P54252 ATXN3  2 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:P03496 NS  2 0.527 7
 UniProt:P42336 PIK3CA  20 0.462 3
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