Reactome | polySUMO3-K65,K160,K490-PML [nucleoplasm]

polySUMO3-K65,K160,K490-PML [nucleoplasm]

Stable Identifier

R-HSA-3000386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO3 N-glycyl-lys65,160,490 PML, Protein PML, PML_HUMAN

Locations in the PathwayBrowser

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General

Fu et al. (2005) report that only lysine-160 is conjugated to SUMO3. Gong and Yeh (2006) report that lysine-65, lysine-160, and lysine-490 are conjugated to SUMO3.

Literature References

PubMed ID	Title	Journal	Year
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Gong, L, Yeh, ET	J. Biol. Chem.	2006
15940266	Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3 Fu, C, Ahmed, K, Ding, H, Ding, X, Lan, J, Yang, Z, Miao, Y, Zhu, Y, Shi, Y, Zhu, J, Huang, H, Yao, X	Oncogene	2005

External Reference Information

External Reference

UniProt:P29590 PML

Gene Names

PML, MYL, PP8675, RNF71, TRIM19

Chain

chain:1-882

Reference Genes

COSMIC (genes):PML PML

dbSNP Gene:5371 PML

ENSEMBL:ENSG00000140464 PML

Participates

as an output of

SUMOylation of PML with SUMO3 (Homo sapiens)

Other forms of this molecule

polySUMO2-K65,K160,K490-PML [nucleoplasm]

monoSUMO1-K65,160,490-PML [nucleoplasm]

PML [nucleoplasm]

PML [cytosol]

Inferred To

Pml [nucleoplasm] (Rattus norvegicus)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Danio rerio)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Dictyostelium discoideum)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Mus musculus)

mei-P26 [nucleoplasm] (Drosophila melanogaster)

PML [nucleoplasm] (Bos taurus)

PML [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 65

Coordinate

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 160

Coordinate

160

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 490

Coordinate

490

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.832	6
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.813	11
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.791	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.7	4
UniProt:P03243-1			0.621	3
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.611	7
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.609	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.589	3
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.571	6
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:Q8UN00 Q8UN00			0.556	4
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.553	2
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.527	2
UniProt:Q9Y5W9 SNX11			0.527	2
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.527	2
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.527	2
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.527	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.527	2
UniProt:P02585 TNNC2	1	TNNC2 [cytosol] (R-HSA-390531)	0.527	2
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.524	4
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.508	2
UniProt:P03255-1			0.463	2
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.463	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.463	2
UniProt:P27958-PRO_0000037566			0.463	6
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.463	2
UniProt:O15055 PER2	5	PER2 [cytosol] (R-HSA-400399) p-7S-PER2 [nucleoplasm] (R-HSA-9920680) p-7S-PER2 [cytosol] (R-HSA-9920710) p-S396-PER2 [cytosol] (R-HSA-9920705) K48polyUb-K,p-7S-PER2 [cytosol] (R-HSA-9932526)	0.463	3

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