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STK11 [nucleoplasm]
Stable Identifier
R-HSA-164119
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LKB-1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
NUAK1 phosphorylates TP53 (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
TP53 binds STK11 and NUAK1 (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
AMPK inhibits chREBP transcriptional activation activity (Homo sapiens)
LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)
STK11 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15831 STK11
Gene Names
STK11, LKB1, PJS
Chain
chain:1-430, propeptide:431-433
Reference Genes
BioGPS Gene:6794 STK11
COSMIC (genes):STK11 STK11
CTD Gene:6794 STK11
dbSNP Gene:6794 STK11
ENSEMBL:ENSG00000118046 STK11
HGNC:11389 STK11
KEGG Gene (Homo sapiens):6794 STK11
Monarch:6794 STK11
NCBI Gene:6794 STK11
OMIM:602216 STK11
UCSC:Q15831 STK11
Reference Transcript
RefSeq:XM_005259618.3 STK11
RefSeq:NM_000455.4 STK11
Other Identifiers
0005050725
11735699_x_at
16856463
204292_x_at
231017_at
3815579
3815580
3815581
3815582
3815588
3815589
3815591
3815593
3815595
3815596
3815597
3815598
3815600
3815602
3815603
3815604
3815605
41657_at
6794
8024204
86312_at
A_23_P16483
A_24_P159866
A_33_P3389148
GE60471
GO:0000003
GO:0000166
GO:0000287
GO:0000902
GO:0001558
GO:0001894
GO:0001944
GO:0002039
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006464
GO:0006468
GO:0006470
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006974
GO:0007049
GO:0007050
GO:0007165
GO:0007267
GO:0007283
GO:0007409
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0010212
GO:0010508
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0030010
GO:0030111
GO:0030154
GO:0030234
GO:0030275
GO:0030295
GO:0030308
GO:0030511
GO:0030705
GO:0032147
GO:0040007
GO:0042592
GO:0042593
GO:0043167
GO:0043226
GO:0043276
GO:0045059
GO:0046777
GO:0046872
GO:0048814
GO:0048856
GO:0050772
GO:0050852
GO:0051645
GO:0051896
GO:0060070
GO:0060770
GO:0070062
GO:0071493
GO:0072332
GO:0090090
GO:0097484
GO:0106310
GO:0106311
GO:0120163
GO:1900182
GO:1901610
GO:1901796
GO:1904262
HMNXSV003049229
HMNXSV003056543
Hs.155647.0.S1_3p_at
ILMN_1751871
PH_hs_0015564
TC19001930.hg
TC19002617.hg
g4507270_3p_s_at
Participates
as an output of
STK11 gene transcription is stimulated by FOXO3,FOXO4 (Homo sapiens)
NUAK1 phosphorylates TP53 (Homo sapiens)
as an input of
TP53 binds STK11 and NUAK1 (Homo sapiens)
as a component of
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
STK11 [cytosol]
Inferred To
samkD [nucleoplasm]
(Dictyostelium discoideum)
Stk11 [nucleoplasm]
(Mus musculus)
Stk11 [nucleoplasm]
(Rattus norvegicus)
ppk34 [nucleoplasm]
(Schizosaccharomyces pombe)
STK11 [nucleoplasm]
(Bos taurus)
STK11 [nucleoplasm]
(Canis familiaris)
STK11 [nucleoplasm]
(Gallus gallus)
STK11 [nucleoplasm]
(Plasmodium falciparum)
STK11 [nucleoplasm]
(Sus scrofa)
TOS3 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
XP_005259675.1
,
NP_000446.1
ZINC - World Drugs
STK11_HUMAN
Guide to Pharmacology - Targets
2212
OpenTargets
ENSG00000118046
ZINC - FDA approved
STK11_HUMAN
ZINC - Substances
STK11_HUMAN
ZINC - Biogenic
STK11_HUMAN
ZINC target
Q15831
PRO
Q15831
GlyGen
Q15831
PDB
2WTK
,
5WXN
,
4ZDR
ZINC - Investigational
STK11_HUMAN
HPA
ENSG00000118046-STK11
GeneCards
Q15831
Ensembl
ENSG00000118046
,
ENST00000652231
,
ENST00000326873
,
ENSP00000324856
,
ENSP00000498804
Pharos - Targets
Q15831
ZINC - Predictions - Purchasable
STK11_HUMAN
Orphanet
15565
HMDB Protein
HMDBP01530
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7RTN6 STRADA
1
STRADA [cytosol]
(R-HSA-380960)
0.941
16
UniProt:Q9Y376 CAB39
4
CAB39 [secretory granule lumen]
(R-HSA-6801288)
CAB39 [extracellular region]
(R-HSA-6806462)
CAB39 [ficolin-1-rich granule lumen]
(R-HSA-6801287)
CAB39 [cytosol]
(R-HSA-380969)
0.924
16
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.848
6
UniProt:Q9C0K7 STRADB
1
STRADB [cytosol]
(R-HSA-380976)
0.76
8
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.744
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.723
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.683
5
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.669
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.61
6
UniProt:Q7RTN6-1 STRADA
0.564
3
UniProt:Q9BT78 COPS4
2
COPS4 [cytosol]
(R-HSA-416965)
COPS4 [nucleoplasm]
(R-HSA-5697020)
0.564
3
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.544
2
UniProt:Q9NNW5 WDR6
1
WDR6 [cytosol]
(R-HSA-9715165)
0.543
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.536
3
UniProt:P48426 PIP4K2A
2
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
PIP4K2A [cytosol]
(R-HSA-1604641)
0.527
2
UniProt:Q9UNS2 COPS3
2
COPS3 [cytosol]
(R-HSA-416973)
COPS3 [nucleoplasm]
(R-HSA-5697017)
0.527
2
UniProt:O95835 LATS1
2
p-S909,T1097-LATS1 [cytosol]
(R-HSA-2028551)
LATS1 [cytosol]
(R-HSA-2028562)
0.499
2
UniProt:P26927 MST1
3
MST1(19-483) [extracellular region]
(R-HSA-6800207)
MST1(484-711) [extracellular region]
(R-HSA-6800230)
pro-MST1 [extracellular region]
(R-HSA-6800227)
0.499
2
UniProt:Q8TEW0 PARD3
3
PARD3 [plasma membrane]
(R-HSA-419980)
PARD3 [cytosol]
(R-HSA-419993)
PARD3 [cell junction]
(R-HSA-2134481)
0.463
2
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