Reactome | STK11 [nucleoplasm]

STK11 [nucleoplasm]

Stable Identifier

R-HSA-164119

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

LKB-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15831 STK11

Gene Names

STK11, LKB1, PJS

Chain

chain:1-430, propeptide:431-433

Reference Genes

BioGPS Gene:6794 STK11

COSMIC (genes):STK11 STK11

CTD Gene:6794 STK11

dbSNP Gene:6794 STK11

ENSEMBL:ENSG00000118046 STK11

HGNC:11389 STK11

KEGG Gene (Homo sapiens):6794 STK11

Monarch:6794 STK11

NCBI Gene:6794 STK11

OMIM:602216 STK11

UCSC:Q15831 STK11

Reference Transcript

Other Identifiers

0005050725

11735699_x_at

16856463

204292_x_at

231017_at

3815579

3815580

3815581

3815582

3815588

3815589

3815591

3815593

3815595

3815596

3815597

3815598

3815600

3815602

3815603

3815604

3815605

41657_at

6794

8024204

86312_at

A_23_P16483

A_24_P159866

A_33_P3389148

GE60471

GO:0000003

GO:0000166

GO:0000287

GO:0000902

GO:0001558

GO:0001894

GO:0001944

GO:0002039

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006464

GO:0006468

GO:0006470

GO:0006810

GO:0006914

GO:0006915

GO:0006950

GO:0006974

GO:0007049

GO:0007050

GO:0007165

GO:0007267

GO:0007283

GO:0007409

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009056

GO:0010212

GO:0010508

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0030010

GO:0030111

GO:0030154

GO:0030234

GO:0030275

GO:0030295

GO:0030308

GO:0030511

GO:0030705

GO:0032147

GO:0040007

GO:0042592

GO:0042593

GO:0043167

GO:0043226

GO:0043276

GO:0045059

GO:0046777

GO:0046872

GO:0048814

GO:0048856

GO:0050772

GO:0050852

GO:0051645

GO:0051896

GO:0060070

GO:0060770

GO:0070062

GO:0071493

GO:0072332

GO:0090090

GO:0097484

GO:0106310

GO:0106311

GO:0120163

GO:1900182

GO:1901610

GO:1901796

GO:1904262

HMNXSV003049229

HMNXSV003056543

Hs.155647.0.S1_3p_at

ILMN_1751871

PH_hs_0015564

TC19001930.hg

TC19002617.hg

g4507270_3p_s_at

Participates

as an output of

as an input of

TP53 binds STK11 and NUAK1 (Homo sapiens)

as a component of

Other forms of this molecule

STK11 [cytosol]

Inferred To

samkD [nucleoplasm] (Dictyostelium discoideum)

Stk11 [nucleoplasm] (Mus musculus)

Stk11 [nucleoplasm] (Rattus norvegicus)

ppk34 [nucleoplasm] (Schizosaccharomyces pombe)

STK11 [nucleoplasm] (Bos taurus)

STK11 [nucleoplasm] (Canis familiaris)

STK11 [nucleoplasm] (Gallus gallus)

STK11 [nucleoplasm] (Plasmodium falciparum)

STK11 [nucleoplasm] (Sus scrofa)

TOS3 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_005259675.1, NP_000446.1

ZINC - World Drugs

STK11_HUMAN

Guide to Pharmacology - Targets

2212

OpenTargets

ENSG00000118046

ZINC - FDA approved

STK11_HUMAN

ZINC - Substances

STK11_HUMAN

ZINC - Biogenic

STK11_HUMAN

ZINC target

Q15831

PRO

Q15831

GlyGen

Q15831

PDB

2WTK, 5WXN, 4ZDR

ZINC - Investigational

STK11_HUMAN

HPA

ENSG00000118046-STK11

GeneCards

Q15831

Ensembl

ENSG00000118046, ENST00000652231, ENST00000326873, ENSP00000324856, ENSP00000498804

Pharos - Targets

Q15831

ZINC - Predictions - Purchasable

STK11_HUMAN

Orphanet

15565

HMDB Protein

HMDBP01530

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7RTN6 STRADA	1	STRADA [cytosol] (R-HSA-380960)	0.941	16
UniProt:Q9Y376 CAB39	4	CAB39 [secretory granule lumen] (R-HSA-6801288) CAB39 [extracellular region] (R-HSA-6806462) CAB39 [ficolin-1-rich granule lumen] (R-HSA-6801287) CAB39 [cytosol] (R-HSA-380969)	0.924	16
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.848	6
UniProt:Q9C0K7 STRADB	1	STRADB [cytosol] (R-HSA-380976)	0.76	8
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.744	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.723	5
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.683	5
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.669	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.61	6
UniProt:Q7RTN6-1 STRADA			0.564	3
UniProt:Q9BT78 COPS4	2	COPS4 [cytosol] (R-HSA-416965) COPS4 [nucleoplasm] (R-HSA-5697020)	0.564	3
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.544	2
UniProt:Q9NNW5 WDR6	1	WDR6 [cytosol] (R-HSA-9715165)	0.543	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.536	3
UniProt:P48426 PIP4K2A	2	PIP4K2A [nucleoplasm] (R-HSA-6811484) PIP4K2A [cytosol] (R-HSA-1604641)	0.527	2
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.527	2
UniProt:O95835 LATS1	2	p-S909,T1097-LATS1 [cytosol] (R-HSA-2028551) LATS1 [cytosol] (R-HSA-2028562)	0.499	2
UniProt:P26927 MST1	3	MST1(19-483) [extracellular region] (R-HSA-6800207) MST1(484-711) [extracellular region] (R-HSA-6800230) pro-MST1 [extracellular region] (R-HSA-6800227)	0.499	2
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.463	2

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