Reactome | SMARCA4 [nucleoplasm]

SMARCA4 [nucleoplasm]

Stable Identifier

R-HSA-201686

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRG1, BAF190A, SNF2B

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        ZEB1 recruits SMARCA4 to CDH1 gene promoter (Homo sapiens)
        
        SMARCA4 [nucleoplasm] (Homo sapiens)
        
        SMARCA4:ZEB1:CDH1 gene [nucleoplasm] (Homo sapiens)
        
        SMARCA4 [nucleoplasm] (Homo sapiens)
        
        ZEB1 represses CDH1 gene transcription (Homo sapiens)
        
        SMARCA4 [nucleoplasm] (Homo sapiens)
        
        ZEB1:CDH1 gene, SMARCA4:ZEB1:CDH1 gene, HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene, (SETD8:ZEB1:CDH1 gene, SIRT1:MPHOSPH8:ZEB1:CDH1 gene) [nucleoplasm] (Homo sapiens)
        
        SMARCA4:ZEB1:CDH1 gene [nucleoplasm] (Homo sapiens)
        
        SMARCA4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51532 SMARCA4

Gene Names

SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4

Chain

chain:1-1647

Reference Genes

BioGPS Gene:6597 SMARCA4

COSMIC (genes):SMARCA4 SMARCA4

CTD Gene:6597 SMARCA4

dbSNP Gene:6597 SMARCA4

ENSEMBL:ENSG00000127616 SMARCA4

HGNC:11100 SMARCA4

KEGG:hsa:6597 SMARCA4

Monarch:6597 SMARCA4

NCBI Gene:6597 SMARCA4

OMIM:603254 SMARCA4

UCSC:P51532 SMARCA4

Reference Transcript

Other Identifiers

11740886_a_at

11742957_a_at

11742958_x_at

11742959_a_at

11754590_x_at

11756305_a_at

1569073_3p_x_at

1569073_PM_x_at

1569073_x_at

16858344

208793_PM_x_at

208793_x_at

208794_PM_s_at

208794_s_at

212520_PM_s_at

212520_s_at

213720_PM_s_at

213720_s_at

214360_3p_at

214360_PM_at

214360_at

214728_PM_x_at

214728_x_at

215714_PM_s_at

215714_s_at

32579_at

3820920

3820922

3820923

3820927

3820928

3820929

3820930

3820931

3820932

3820935

3820936

3820937

3820938

3820939

3820940

3820943

3820944

3820945

3820946

3820949

3820951

3820952

3820953

3820954

3820955

3820956

3820957

3820958

3820959

3820960

3820965

3820966

3820967

3820968

3820969

3820970

3820971

3820972

3820973

3820974

3820975

3820976

3820977

3820978

3820983

3820984

3820985

3820986

3820987

3820988

3820989

3820990

3820991

3820999

3821000

3821001

3821003

3821004

3821005

3821006

3821007

3821008

3821009

3821010

3821012

57257_s_at

6597

8025788

88069_s_at

A_14_P116631

A_14_P134129

A_23_P39034

A_23_P39040

A_24_P212851

D26156_s_at

GE59059

GE84765

GO:0000122

GO:0000166

GO:0000776

GO:0000785

GO:0001164

GO:0001188

GO:0001221

GO:0001650

GO:0002039

GO:0003407

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0003723

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006325

GO:0006337

GO:0006338

GO:0006355

GO:0006357

GO:0007399

GO:0008094

GO:0008284

GO:0016020

GO:0016363

GO:0016514

GO:0016586

GO:0016787

GO:0016887

GO:0030071

GO:0030177

GO:0030308

GO:0030957

GO:0031492

GO:0031507

GO:0032991

GO:0042393

GO:0042802

GO:0043226

GO:0043923

GO:0045582

GO:0045596

GO:0045597

GO:0045663

GO:0045815

GO:0045892

GO:0045893

GO:0045944

GO:0048856

GO:0050681

GO:0060766

GO:0065003

GO:0070182

GO:0070316

GO:0071564

GO:0071565

GO:0120162

GO:0140092

GO:0140097

GO:0140288

GO:0140657

GO:0140658

GO:0140750

GO:1901798

GO:1901838

GO:1902459

GO:1902661

GO:1902895

GO:2000045

GO:2000781

GO:2000819

HMNXSV003057489

Hs.78202.0.S1_3p_a_at

Hs.78202.1.S1_3p_a_at

Hs.78202.3.S1_3p_a_at

Hs.78202.3.S1_3p_at

Hs.78202.4.S1_3p_a_at

Hs.78202.5.S1_3p_a_at

Hs2.407212.1.S1_3p_at

Hs2.407212.1.S1_3p_x_at

ILMN_1814173

PH_hs_0004515

TC19000190.hg

U29175_at

Participates

as a component of

as an input of

as a member of

SMARCA2,SMARCA4 [nucleoplasm] (Homo sapiens)

Inferred To

swsn-4 [nucleoplasm] (Caenorhabditis elegans)

snf21 [nucleoplasm] (Schizosaccharomyces pombe)

SMARCA4 [nucleoplasm] (Bos taurus)

SMARCA4 [nucleoplasm] (Canis familiaris)

SMARCA4 [nucleoplasm] (Dictyostelium discoideum)

SMARCA4 [nucleoplasm] (Gallus gallus)

SMARCA4 [nucleoplasm] (Plasmodium falciparum)

SMARCA4 [nucleoplasm] (Sus scrofa)

SNF2 [nucleoplasm] (Saccharomyces cerevisiae)

Smarca4 [nucleoplasm] (Mus musculus)

Smarca4 [nucleoplasm] (Rattus norvegicus)

brm [nucleoplasm] (Drosophila melanogaster)

smarca4 [nucleoplasm] (Xenopus tropicalis)

smarca4a [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_024307435.1, NP_001122317.1, NP_001122316.1, XP_047295203.1, NP_003063.2, XP_047295204.1, XP_047295200.1, XP_016882657.1, XP_016882655.1, XP_016882654.1, XP_016882656.1, NP_001361386.1, NP_001122320.1, XP_054177799.1, XP_054177798.1, XP_054177797.1, XP_054177801.1, XP_047295206.1, NP_001122318.1, XP_054177800.1, XP_047295207.1, XP_047295205.1, XP_054177796.1, NP_001122319.1, XP_054177792.1

Guide to Pharmacology - Targets

2740

OpenTargets

ENSG00000127616

ENSEMBL

ENST00000647230, ENST00000643296, ENST00000541122, ENST00000590574, ENST00000646484, ENSP00000496635, ENSP00000343896, ENSP00000395654, ENSP00000495548, ENSP00000495536, ENSP00000494676, ENST00000429416, ENST00000344626, ENSP00000392837, ENSP00000494772, ENSP00000466963, ENSG00000127616, ENST00000646510, ENST00000645460, ENST00000444061, ENST00000589677, ENSP00000464778, ENST00000644737, ENSP00000445036, ENSP00000494463

ZINC - Substances

SMCA4_HUMAN

ZINC target

P51532

PRO

P51532

GlyGen

P51532

PDB

5DKD, 6ZS2, 7TD9, 2GRC, 5EA1, 6HR2, 7VRB, 8EB1, 6LTJ, 8G1Q, 7Y8R, 7VDT, 6LTH, 7TAB, 6SY2, 7VDV, 6BGH, 3UVD, 2H60, 8QJR

GeneCards

SMARCA4

HPA

ENSG00000127616-SMARCA4

Pharos - Targets

P51532

Orphanet

SMARCA4

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.955	43
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.942	28
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.934	29
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.905	15
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.877	21
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.837	9
UniProt:Q92785 DPF2	1	DPF2 [nucleoplasm] (R-HSA-9727509)	0.837	15
UniProt:Q86U86 PBRM1	1	PBRM1 [nucleoplasm] (R-HSA-389254)	0.802	7
UniProt:Q68CP9 ARID2	1	ARID2 [nucleoplasm] (R-HSA-5225613)	0.767	10
UniProt:Q15532 SS18	1	SS18 [nucleoplasm] (R-HSA-9727441)	0.758	24
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.742	8
UniProt:Q8NFD5 ARID1B	1	ARID1B [nucleoplasm] (R-HSA-5225635)	0.723	5
UniProt:Q92784-2 DPF3			0.69	7
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.669	6
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.646	7
UniProt:Q92782 DPF1	1	DPF1 [nucleoplasm] (R-HSA-8855001)	0.643	4
UniProt:Q4VC05 BCL7A	1	BCL7A [nucleoplasm] (R-HSA-9727449)	0.643	4
UniProt:Q8WUB8 PHF10	1	PHF10 [nucleoplasm] (R-HSA-9932814)	0.643	4
UniProt:A4PIV7 A4PIV7			0.637	14
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.628	6
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.615	7
UniProt:Q92784-1 DPF3			0.597	5
UniProt:Q9UHA2 S18L2			0.569	5
UniProt:Q969G3-2 SMARCE1			0.564	2
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.537	9
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.536	5
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.536	5
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.536	5
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.536	5
UniProt:Q6STE5 SMARCD3	1	SMARCD3 [nucleoplasm] (R-HSA-400141)	0.527	2
UniProt:Q12824-1 SMARCB1			0.527	4
UniProt:O14497-1 ARID1A			0.527	3
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.527	4
UniProt:Q92784 DPF3	1	DPF3 [nucleoplasm] (R-HSA-9727469)	0.527	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.527	5
UniProt:Q92925 SMARCD2	1	SMARCD2 [nucleoplasm] (R-HSA-5225626)	0.527	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.512	3
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:Q9Y466 NR2E1	1	NR2E1 [nucleoplasm] (R-HSA-376207)	0.484	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.484	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.483	5
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.483	5
UniProt:O95644 NFATC1	3	p-12S-NFATC1 [cytosol] (R-HSA-2025953) p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935)	0.483	5
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.483	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.483	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.483	7
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.483	5
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.483	5
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.483	5
UniProt:P04040 CAT	5	CAT [peroxisomal matrix] (R-HSA-51417) CAT [secretory granule lumen] (R-HSA-6801311) CAT [extracellular region] (R-HSA-6806458) CAT [ficolin-1-rich granule lumen] (R-HSA-6801279) CAT [cytosol] (R-HSA-9033141)	0.483	2
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.483	5
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.471	5
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.471	5
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.471	2
UniProt:P52333 JAK3	6	JAK3 [cytosol] (R-HSA-451893) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y980 JAK3 [cytosol] (R-HSA-9701438)	0.471	5
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	5

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