Reactome | MEN1 [nucleoplasm]

MEN1 [nucleoplasm]

Stable Identifier

R-HSA-2186626

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Menin, SCG2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00255 MEN1

Gene Names

MEN1, SCG2

Chain

chain:1-615

Reference Genes

BioGPS Gene:4221 MEN1

COSMIC (genes):MEN1 MEN1

CTD Gene:4221 MEN1

dbSNP Gene:4221 MEN1

ENSEMBL:ENSG00000133895 MEN1

ENSEMBL:ENSG00000133895.18 MEN1

HGNC:7010 MEN1

KEGG Gene (Homo sapiens):4221 MEN1

Monarch:4221 MEN1

NCBI Gene:4221 MEN1

OMIM:613733 MEN1

UCSC:O00255 MEN1

Reference Transcript

Other Identifiers

11717609_a_at

16740074

202645_PM_s_at

202645_s_at

3377144

3377145

3377146

3377147

3377148

3377150

3377151

3377152

3377153

3377154

3377155

3377158

3377160

3377161

3377162

3377163

3377164

3377165

3377166

3377167

3377168

3377169

3377170

3377171

3377172

3377173

3377174

4221

448_s_at

7949206

A_23_P75453

A_24_P153898

A_33_P3414058

GE80542

GO:0000122

GO:0000165

GO:0000400

GO:0000403

GO:0000781

GO:0000785

GO:0000976

GO:0001933

GO:0002076

GO:0002376

GO:0003677

GO:0003682

GO:0003690

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005783

GO:0005788

GO:0005829

GO:0005886

GO:0006281

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0008285

GO:0009411

GO:0010332

GO:0016363

GO:0017053

GO:0023052

GO:0030154

GO:0030511

GO:0030674

GO:0032154

GO:0032991

GO:0035097

GO:0036211

GO:0043226

GO:0043433

GO:0044665

GO:0045064

GO:0045668

GO:0045736

GO:0045786

GO:0045815

GO:0045892

GO:0045944

GO:0046329

GO:0048856

GO:0051219

GO:0051568

GO:0051974

GO:0060090

GO:0070412

GO:0071339

HMNXSV003032890

ILMN_1683298

ILMN_1721963

ILMN_2277877

ILMN_2340877

TC11001913.hg

U93237_rna2_at

g4557744_3p_a_at

Participates

as an input of

as a component of

as an output of

APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)

Other forms of this molecule

MEN1 [cytosol]

p-MEN1 [endoplasmic reticulum lumen]

MEN1 [endoplasmic reticulum lumen]

Inferred To

Ghost homologue of MEN1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of MEN1 [nucleoplasm] (Gallus gallus)

Men1 [nucleoplasm] (Mus musculus)

Men1 [nucleoplasm] (Rattus norvegicus)

Mnn1 [nucleoplasm] (Drosophila melanogaster)

men1 [nucleoplasm] (Xenopus tropicalis)

MEN1 [nucleoplasm] (Bos taurus)

MEN1 [nucleoplasm] (Canis familiaris)

MEN1 [nucleoplasm] (Danio rerio)

MEN1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_570714.1, NP_570712.1, NP_570713.1, NP_570716.1, NP_570711.1, XP_016873258.1, XP_016873259.1, XP_005274058.1, NP_570715.1, NP_000235.2

OpenTargets

ENSG00000133895

GeneCards

O00255

ZINC - Substances

MEN1_HUMAN

HPA

ENSG00000133895-MEN1

ZINC target

O00255

Ensembl

ENST00000450708, ENST00000377321, ENST00000377313, ENST00000377326, ENSP00000366530, ENSP00000366543, ENST00000315422, ENSP00000413944, ENST00000312049, ENST00000440873, ENSG00000133895, ENSP00000308975, ENSP00000394933, ENSP00000366538, ENSP00000323747

PRO

O00255

Pharos - Targets

O00255

Orphanet

16390

ZINC - Predictions - Purchasable

MEN1_HUMAN

PDB

5DD9, 4GQ4, 4OG6, 6OPJ, 3U84, 3U85, 4GQ6, 4I80, 6BXH, 5DDA, 4OG8, 4X5Y, 3U86, 6B41, 4OG7, 6WNH, 3U88, 4X5Z, 5DB0, 5DDB, 5DDC, 6BXY, 6E1A, 6BY8, 6PKC, 7OA9, 4OG3, 7M4T, 5DDD, 8GPN, 5DB1, 8IG0, 6S2K, 5DDE, 5DB2, 4GPQ, 4OG4, 6O5I, 5DDF, 4GQ3, 4OG5, 5DB3

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.708	4
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.643	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	3
UniProt:P19838-PRO_0000030311 NFKB1			0.524	2
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) FANCD2 [nucleoplasm] (R-HSA-419522)	0.524	4
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.462	2