Reactome | MEN1 [nucleoplasm]

MEN1 [nucleoplasm]

Stable Identifier

R-HSA-2186626

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Menin, SCG2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00255 MEN1

Gene Names

MEN1, SCG2

Chain

chain:1-610

Reference Genes

BioGPS Gene:4221 MEN1

COSMIC (genes):MEN1 MEN1

COSMIC (genes):SCG2 MEN1

CTD Gene:4221 MEN1

dbSNP Gene:4221 MEN1

ENSEMBL:ENSG00000133895 MEN1

HGNC:7010 MEN1

KEGG:hsa:4221 MEN1

Monarch:4221 MEN1

NCBI Gene:4221 MEN1

OMIM:613733 MEN1

UCSC:O00255 MEN1

Reference Transcript

Participates

as an input of

as a component of

as an output of

APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)

Other forms of this molecule

MEN1 [endoplasmic reticulum lumen]

p-MEN1 [endoplasmic reticulum lumen]

MEN1 [cytosol]

Inferred To

Ghost homologue of MEN1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of MEN1 [nucleoplasm] (Gallus gallus)

Men1 [nucleoplasm] (Mus musculus)

Men1 [nucleoplasm] (Rattus norvegicus)

Mnn1 [nucleoplasm] (Drosophila melanogaster)

men1 [nucleoplasm] (Danio rerio)

MEN1 [nucleoplasm] (Bos taurus)

MEN1 [nucleoplasm] (Canis familiaris)

MEN1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_570715.1, NP_570712.1, XP_005274058.1, XP_016873259.1, NP_570713.1, XP_016873258.1, NP_000235.2, NP_570711.1, NP_570714.1, NP_570716.1

OpenTargets

ENSG00000133895

ENSEMBL

ENST00000440873, ENSP00000518530, ENST00000424912, ENSG00000133895, ENSP00000388016, ENST00000377326, ENST00000377313, ENST00000710881, ENST00000413626, ENSP00000402752, ENST00000429702, ENSP00000394933, ENSP00000413944, ENSP00000411218, ENSP00000366530, ENSP00000366543, ENSP00000308975, ENST00000450708, ENST00000315422, ENSP00000323747, ENST00000312049

HPA

ENSG00000133895-MEN1

GeneCards

MEN1

ZINC - Substances

MEN1_HUMAN

ZINC target

O00255

PRO

O00255

Pharos - Targets

O00255

Orphanet

MEN1

ZINC - Predictions - Purchasable

MEN1_HUMAN

PDB

8IG0, 6BXY, 4GQ6, 6BY8, 6OPJ, 4I80, 4GPQ, 7M4T, 4GQ3, 6O5I, 6WNH, 4GQ4, 5DB0, 5DB1, 5DB2, 4X5Z, 7O9Z, 7UJ4, 4OG5, 5DDE, 5DDF, 4OG6, 5DB3, 8E90, 5DD9, 6BXH, 6PKC, 4OG7, 7O9T, 5DDA, 5DDB, 3U86, 6S2K, 4OG3, 7O9X, 4OG8, 3U84, 3U85, 5DDC, 5DDD, 7OA9, 6E1A, 6B41, 3U88, 4OG4, 4X5Y, 8GPN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.708	4
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.643	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	3
UniProt:P19838-PRO_0000030311 NFKB1			0.524	2
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.524	4
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.462	2

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