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MEN1 [nucleoplasm]
Stable Identifier
R-HSA-2186626
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Menin, SCG2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
MEN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00255 MEN1
Gene Names
MEN1, SCG2
Chain
chain:1-615
Reference Genes
BioGPS Gene:4221 MEN1
COSMIC (genes):MEN1 MEN1
CTD Gene:4221 MEN1
dbSNP Gene:4221 MEN1
ENSEMBL:ENSG00000133895 MEN1
HGNC:7010 MEN1
KEGG Gene (Homo sapiens):4221 MEN1
Monarch:4221 MEN1
NCBI Gene:4221 MEN1
OMIM:613733 MEN1
UCSC:O00255 MEN1
Reference Transcript
RefSeq:NM_000244.3 MEN1
RefSeq:XM_017017769.1 MEN1
RefSeq:XM_005274001.4 MEN1
RefSeq:NM_130800.2 MEN1
RefSeq:NM_130799.2 MEN1
RefSeq:XM_017017770.1 MEN1
RefSeq:NM_130802.2 MEN1
RefSeq:NM_130801.2 MEN1
RefSeq:NM_130804.2 MEN1
RefSeq:NM_130803.2 MEN1
Other Identifiers
0001580563
0002190132
0004070398
11717609_a_at
16740074
202645_s_at
3377144
3377145
3377146
3377147
3377148
3377150
3377151
3377152
3377153
3377154
3377155
3377158
3377160
3377161
3377162
3377163
3377164
3377165
3377166
3377167
3377168
3377169
3377170
3377171
3377172
3377173
3377174
4221
448_s_at
7949206
A_23_P75453
A_24_P153898
A_33_P3414058
GE80542
GO:0000003
GO:0000122
GO:0000165
GO:0000278
GO:0000400
GO:0000403
GO:0000781
GO:0000785
GO:0000976
GO:0001933
GO:0002076
GO:0003309
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0006259
GO:0006281
GO:0006325
GO:0006357
GO:0006464
GO:0006950
GO:0006974
GO:0007049
GO:0007155
GO:0007165
GO:0007420
GO:0008150
GO:0008168
GO:0008283
GO:0008285
GO:0009058
GO:0009411
GO:0010332
GO:0010812
GO:0016363
GO:0018024
GO:0022607
GO:0030154
GO:0030511
GO:0030674
GO:0032092
GO:0032154
GO:0032925
GO:0032991
GO:0034641
GO:0034968
GO:0035097
GO:0042592
GO:0043226
GO:0043433
GO:0043687
GO:0044267
GO:0045668
GO:0045736
GO:0045786
GO:0045892
GO:0045944
GO:0046329
GO:0046697
GO:0047485
GO:0048856
GO:0050680
GO:0051276
GO:0051974
GO:0061469
GO:0065003
GO:0070412
GO:0071333
GO:0071375
GO:0071559
GO:1902807
GO:1904837
HMNXSV003032890
ILMN_1683298
ILMN_1721963
ILMN_2277877
ILMN_2340877
TC11001913.hg
U93237_rna2_at
g4557744_3p_a_at
Participates
as an input of
Recruitment of SET1 methyltransferase complex (Homo sapiens)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
as a component of
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-MEN1 [endoplasmic reticulum lumen]
MEN1 [endoplasmic reticulum lumen]
MEN1 [cytosol]
Inferred To
Ghost homologue of MEN1 [nucleoplasm]
(Bos taurus)
Ghost homologue of MEN1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of MEN1 [nucleoplasm]
(Gallus gallus)
Ghost homologue of MEN1 [nucleoplasm]
(Xenopus tropicalis)
Men1 [nucleoplasm]
(Mus musculus)
Men1 [nucleoplasm]
(Rattus norvegicus)
Mnn1 [nucleoplasm]
(Drosophila melanogaster)
men1 [nucleoplasm]
(Danio rerio)
MEN1 [nucleoplasm]
(Canis familiaris)
MEN1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_570714.1
,
XP_016873259.1
,
NP_570713.1
,
NP_000235.2
,
XP_016873258.1
,
NP_570712.1
,
XP_005274058.1
,
NP_570711.1
,
NP_570716.1
,
NP_570715.1
OpenTargets
ENSG00000133895
ZINC - Substances
MEN1_HUMAN
GeneCards
O00255
HPA
ENSG00000133895-MEN1
Ensembl
ENST00000394374
,
ENST00000394376
,
ENST00000315422
,
ENSP00000413944
,
ENSP00000377899
,
ENSP00000377901
,
ENST00000440873
,
ENSP00000394933
,
ENSP00000366538
,
ENSP00000308975
,
ENST00000377326
,
ENST00000377313
,
ENSG00000133895
,
ENST00000377321
,
ENST00000312049
,
ENST00000450708
,
ENSP00000366530
,
ENSP00000366543
,
ENSP00000323747
ZINC target
O00255
PRO
O00255
Pharos - Targets
O00255
Orphanet
16390
ZINC - Predictions - Purchasable
MEN1_HUMAN
PDB
3U84
,
4I80
,
4GQ4
,
5DDA
,
6O5I
,
3U85
,
5DD9
,
4GQ6
,
6BY8
,
6BXY
,
5DDD
,
6OPJ
,
3U86
,
5DDE
,
5DDB
,
3U88
,
5DDC
,
4OG5
,
6WNH
,
4OG4
,
4OG6
,
5DB0
,
4OG3
,
5DDF
,
7M4T
,
4X5Z
,
4GPQ
,
5DB3
,
6PKC
,
6B41
,
6E1A
,
4OG7
,
4GQ3
,
4X5Y
,
5DB1
,
6BXH
,
4OG8
,
5DB2
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.708
4
UniProt:Q03164 KMT2A
1
KMT2A [nucleoplasm]
(R-HSA-1183223)
0.643
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.556
3
UniProt:Q9BXW9 FANCD2
3
FANCD2 [nucleoplasm]
(R-HSA-419522)
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
0.524
4
UniProt:P19838-PRO_0000030311 NFKB1
0.524
2
UniProt:Q9UMN6 KMT2B
1
KMT2B [nucleoplasm]
(R-HSA-1183216)
0.462
2
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