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CABLES1 [nucleoplasm]
Stable Identifier
R-HSA-1013870
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CDK5 and ABL1 enzyme substrate 1, CABL1_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables1 links CDK2 and WEE1 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDN4 CABLES1
Gene Names
CABLES1, CABLES
Chain
chain:1-633
Reference Genes
BioGPS Gene:91768 CABLES1
COSMIC (genes):CABLES1 CABLES1
CTD Gene:91768 CABLES1
dbSNP Gene:91768 CABLES1
ENSEMBL:ENSG00000134508 CABLES1
HGNC:25097 CABLES1
KEGG:hsa:91768 CABLES1
Monarch:91768 CABLES1
NCBI Gene:91768 CABLES1
OMIM:609194 CABLES1
UCSC:Q8TDN4 CABLES1
Reference Transcript
RefSeq:NM_138375.2 CABLES1
RefSeq:NM_001100619.2 CABLES1
RefSeq:NM_001256438.1 CABLES1
Other Identifiers
11732905_a_at
11739575_a_at
11751156_a_at
11754455_a_at
11763465_at
1558621_PM_at
1558621_at
16851427
225531_PM_at
225531_at
225532_PM_at
225532_at
3781541
3781543
3781544
3781545
3781546
3781547
3781560
3781561
3781566
3781567
3781568
3781569
3781570
3781571
3781576
3781577
3781579
3781580
3781583
3781584
3781596
3781597
3781599
3781609
3781610
3781612
3781613
3781614
3781615
3781616
3781624
48558_at
72819_r_at
77248_at
8020495
91768
A_14_P106670
A_14_P112719
A_23_P422851
GE56999
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0007399
GO:0043226
GO:0048856
GO:0051301
GO:0051726
HMNXSV003025348
Hs.17901.0.S1_3p_at
Hs.17901.0.S2_3p_at
Hs2.334574.1.A1_3p_at
ILMN_1653001
PH_hs_0001608
TC18000099.hg
TC18000653.hg
Participates
as a component of
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
as an input of
Cables1 links CDK2 and WEE1 (Homo sapiens)
This entity regulates
Positively
Phosphorylation of Cyclin A:Cdk2 at Tyr 15
(Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1
(Homo sapiens)
Other forms of this molecule
CABLES1 [cytosol]
Inferred To
cables1 [nucleoplasm]
(Danio rerio)
cables1 [nucleoplasm]
(Xenopus tropicalis)
Cables1 [nucleoplasm]
(Drosophila melanogaster)
Cables1 [nucleoplasm]
(Mus musculus)
Cables1 [nucleoplasm]
(Rattus norvegicus)
CABLES1 [nucleoplasm]
(Bos taurus)
CABLES1 [nucleoplasm]
(Canis familiaris)
CABLES1 [nucleoplasm]
(Gallus gallus)
CABLES1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001243367.1
,
NP_612384.1
,
NP_001094089.1
ENSEMBL
ENST00000420687
,
ENST00000256925
,
ENSP00000256925
,
ENSP00000383321
,
ENST00000400473
,
ENSP00000413851
,
ENSG00000134508
OpenTargets
ENSG00000134508
GeneCards
CABLES1
HPA
ENSG00000134508-CABLES1
PRO
Q8TDN4
Pharos - Targets
Q8TDN4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00535 CDK5
4
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.886
8
UniProt:P80370 DLK1
1
DLK1 [plasma membrane]
(R-HSA-1604447)
0.527
2
UniProt:Q9H3D4-1 TP63
0.471
7
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