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BRAF D638E [cytosol]
Stable Identifier
R-HSA-9651125
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
B-RAF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
kinase dead BRAF mutants [cytosol] (Homo sapiens)
BRAF D638E [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18413255
Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome
Rodriguez-Viciana, P
,
Rauen, KA
Meth. Enzymol.
2008
External Reference Information
External Reference
UniProt:P15056 BRAF
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:, chain:2-766
Reference Genes
BioGPS Gene:673 BRAF
COSMIC (genes):BRAF BRAF
CTD Gene:673 BRAF
dbSNP Gene:673 BRAF
ENSEMBL:ENSG00000157764 BRAF
HGNC:1097 BRAF
KEGG:hsa:673 BRAF
Monarch:673 BRAF
NCBI Gene:673 BRAF
OMIM:164757 BRAF
UCSC:P15056 BRAF
Reference Transcript
RefSeq:NM_004333.4 BRAF
Other Identifiers
11732491_s_at
1654_at
17063631
206044_PM_s_at
206044_s_at
226391_PM_at
226391_at
236402_PM_at
236402_at
243829_PM_at
243829_at
3076354
3076355
3076356
3076357
3076358
3076359
3076360
3076361
3076362
3076363
3076364
3076365
3076366
3076367
3076368
3076370
3076371
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076385
3076386
3076388
3076390
3076391
3076392
3076393
3076396
3076397
3076398
3076399
3076406
3076411
3076412
3076413
3076414
3076415
3076416
3076439
3076440
3076441
3076442
3982166
3982173
40306_at
55694_at
673
72299_r_at
75931_at
8143417
86199_r_at
91686_at
A_23_P42935
A_24_P567502
GE58163
GE766137
GO:0000165
GO:0002318
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0004677
GO:0004679
GO:0004694
GO:0004708
GO:0004709
GO:0004711
GO:0004713
GO:0005509
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005815
GO:0005829
GO:0005886
GO:0005929
GO:0006325
GO:0006338
GO:0006468
GO:0007010
GO:0007155
GO:0007165
GO:0007173
GO:0008270
GO:0008542
GO:0009887
GO:0010628
GO:0010764
GO:0010828
GO:0012501
GO:0016079
GO:0016192
GO:0016740
GO:0030154
GO:0030878
GO:0033077
GO:0033138
GO:0034446
GO:0034451
GO:0035019
GO:0035175
GO:0035402
GO:0035403
GO:0035979
GO:0036064
GO:0036211
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043149
GO:0043226
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043524
GO:0044022
GO:0044023
GO:0044024
GO:0044025
GO:0044297
GO:0045580
GO:0046632
GO:0046872
GO:0048538
GO:0048679
GO:0048680
GO:0048856
GO:0050772
GO:0050852
GO:0050877
GO:0051496
GO:0060291
GO:0060323
GO:0060324
GO:0070371
GO:0070374
GO:0071277
GO:0071466
GO:0072354
GO:0072371
GO:0072518
GO:0072577
GO:0090150
GO:0097110
GO:0098793
GO:0098978
GO:0099170
GO:0106310
GO:0140096
GO:0140823
GO:0140855
GO:0140857
GO:1900026
GO:1990244
GO:2000301
GO:2000352
HMNXSV003020754
HMNXSV003038238
Hs.162967.0.A1_3p_at
Hs.299137.0.A1_3p_at
Hs.96566.0.S1_3p_at
ILMN_1652472
ILMN_1836469
M95712_at
PH_hs_0027912
PH_hs_0038106
TC07001926.hg
TC07001927.hg
TC07003197.hg
g4757867_3p_a_at
p26408
Participates
as a member of
kinase dead BRAF mutants [cytosol] (Homo sapiens)
Other forms of this molecule
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
BRAF E501G [cytosol]
BRAF D594N [cytosol]
BRAF G596R [cytosol]
BRAF D594V [cytosol]
BRAF G596V [cytosol]
BRAF G466E [cytosol]
BRAF D594G [cytosol]
BRAF L505H [cytosol]
BRAF F595L [cytosol]
BRAF L597V [cytosol]
BRAF G464E [cytosol]
BRAF N581D [cytosol]
BRAF E586K [cytosol]
BRAF V600K [cytosol]
BRAF A246P [cytosol]
BRAF G469V [cytosol]
BRAF T244P [cytosol]
BRAF G469R [cytosol]
BRAF L597R [cytosol]
BRAF G469E [cytosol]
BRAF L597Q [cytosol]
BRAF G466A [cytosol]
BRAF G466V [cytosol]
BRAF N581S [cytosol]
BRAF G464V [cytosol]
p-BRAF L597V [plasma membrane]
p-BRAF L505H [plasma membrane]
p-BRAF G464E [plasma membrane]
p-BRAF F595L [plasma membrane]
p-BRAF A246P [plasma membrane]
p-BRAF E586K [plasma membrane]
p-BRAF N581D [plasma membrane]
p-BRAF V600K [plasma membrane]
p-BRAF G464V [plasma membrane]
p-BRAF T244P [plasma membrane]
p-BRAF G469E [plasma membrane]
p-BRAF G466V [plasma membrane]
p-BRAF G469V [plasma membrane]
p-BRAF G466A [plasma membrane]
p-BRAF L597Q [plasma membrane]
p-BRAF L597R [plasma membrane]
p-BRAF N581S [plasma membrane]
p-BRAF G469R [plasma membrane]
BRAF T599dup [cytosol]
p-S446,T599,S602,S729 BRAF [cytosol]
p-S446,S729-BRAF [cytosol]
p-S446,T599,S602,S729 BRAF [plasma membrane]
BRAF [cytosol]
p-S,T-BRAF [cytosol]
p-S365,S446,S729 BRAF [cytosol]
hyperphosphorylated BRAF [plasma membrane]
p-S446,S729-BRAF [plasma membrane]
BRAF V600E;V169_D380del [cytosol]
BRAF V600E;V47_M438del [cytosol]
BRAF V600E;V47_D380del [cytosol]
BRAF V600E;V169_M438del [cytosol]
BRAF K601E [cytosol]
BRAF V600E [cytosol]
BRAF K499E [cytosol]
BRAF Q257R [cytosol]
BRAF L485F [cytosol]
BRAF G469A [cytosol]
BRAF K601N [cytosol]
BRAF S467A [cytosol]
BRAF G534R [cytosol]
Modified Residues
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
L-aspartic acid 638 replaced with L-glutamic acid
Coordinate
638
PsiMod
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
L-glutamic acid residue [MOD:00015]
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
Disease
Name
Identifier
Synonyms
cardiofaciocutaneous syndrome
DOID:0060233
CFC syndrome, cardio-facial-cutaneous syndrome
Cross References
RefSeq
NP_004324.2
ZINC - World Drugs
BRAF_HUMAN
Guide to Pharmacology - Targets
1943
ClinGen
CA279981
,
CA280051
OpenTargets
ENSG00000157764
ENSEMBL
ENSG00000157764
,
ENST00000646891
,
ENSP00000493543
ZINC - FDA approved
BRAF_HUMAN
ZINC - Substances
BRAF_HUMAN
ZINC - Biogenic
BRAF_HUMAN
ZINC target
P15056
PRO
P15056
PDB
4CQE
,
3Q4C
,
5CSW
,
4H58
,
7M0X
,
8QQG
,
6N0P
,
7ZR5
,
7M0W
,
5HI2
,
2L05
,
4XV2
,
6P3D
,
4FK3
,
4EHE
,
6V2U
,
6UAN
,
4EHG
,
6V2W
,
9BFB
,
3PRI
,
9AXX
,
5VAL
,
5JRQ
,
7MFF
,
7P3V
,
5HIE
,
1UWJ
,
4MNE
,
8F7O
,
7M0T
,
4XV1
,
3PSD
,
5J18
,
6XLO
,
4E26
,
7K0V
,
4KSQ
,
7ZR6
,
8DGS
,
3C4C
,
6U2H
,
6V34
,
4RZV
,
3D4Q
,
3SKC
,
8C7X
,
4XV9
,
4DBN
,
4MBJ
,
9AXY
,
3NY5
,
6NSQ
,
5HID
,
2FB8
,
4MNF
,
6NYB
,
5CT7
,
8F7P
,
5CSX
,
7M0U
,
3II5
,
3IDP
,
7M0Y
,
8DGT
,
4E4X
,
3PPK
,
4KSP
,
4RZW
,
6U2G
,
4XV3
,
6P7G
,
5JT2
,
5JSM
,
8C7Y
,
5J2R
,
7M0Z
,
4WO5
,
5FD2
,
3PRF
,
7MFD
,
6UUO
,
6XFP
,
6XAG
,
6Q0K
,
1UWH
,
3TV6
,
7SHV
,
3PSB
,
4R5Y
,
6B8U
,
5J17
,
5VYK
,
7ZR0
,
3PPJ
,
7M0V
,
6N0Q
,
4YHT
,
4FC0
,
4G9C
,
4JVG
,
6PP9
,
3OG7
,
5C9C
,
5VR3
,
3TV4
,
5ITA
,
6CAD
,
5VAM
,
6Q0J
,
3Q96
,
6Q0T
,
7MFE
,
4PP7
,
4G9R
ZINC - Investigational
BRAF_HUMAN
ZINC - Metabolites
BRAF_HUMAN
GeneCards
BRAF
HPA
ENSG00000157764-BRAF
Pharos - Targets
P15056
Orphanet
BRAF
ZINC - Predictions - Purchasable
BRAF_HUMAN
HMDB Protein
HMDBP02597
Interactors (127)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
MAP2K1 [cytosol]
(R-HSA-59502)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
0.98
65
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.968
73
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.941
15
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.932
14
UniProt:P01112 HRAS
20
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
HRAS [plasma membrane]
(R-HSA-62717)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
0.931
9
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.927
14
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.912
12
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.908
12
UniProt:P36507 MAP2K2
12
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
0.894
13
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.889
9
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.889
11
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.879
12
UniProt:P01111 NRAS
20
S-Farn-Me PalmS NRAS [plasma membrane]
(R-HSA-9647910)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-HSA-9647782)
S-Farn-Me NRAS [endoplasmic reticulum membrane]
(R-HSA-9647891)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-HSA-9647928)
proNRAS [cytosol]
(R-HSA-9647758)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
NRAS [plasma membrane]
(R-HSA-62725)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
0.863
8
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.767
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
0.731
5
UniProt:Q8N122 RPTOR
3
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [cytosol]
(R-HSA-3006727)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.695
4
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.681
16
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.68
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.643
6
UniProt:Q13233 MAP3K1
2
MAP3K1 [cytosol]
(R-HSA-166866)
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
0.609
2
UniProt:Q07817 BCL2L1
2
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
BCL2L1 [cytosol]
(R-HSA-50771)
0.596
7
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.596
6
UniProt:P17174 GOT1
1
PXLP-K259-GOT1 [cytosol]
(R-HSA-1295497)
0.596
5
UniProt:P40337 VHL
3
VHL [cytosol]
(R-HSA-391423)
VHL [nucleoplasm]
(R-HSA-1234127)
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
0.596
7
UniProt:O00255 MEN1
4
MEN1 [nucleoplasm]
(R-HSA-2186626)
MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956785)
p-MEN1 [endoplasmic reticulum lumen]
(R-HSA-8956901)
MEN1 [cytosol]
(R-HSA-5672315)
0.596
4
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.596
4
UniProt:Q07864 POLE
1
POLE [nucleoplasm]
(R-HSA-68473)
0.596
6
UniProt:Q13164 MAPK7
4
p-T218,Y221-MAPK7 [nucleoplasm]
(R-HSA-198738)
p-T218,Y221-MAPK7 [cytosol]
(R-HSA-198721)
MAPK7 [cytosol]
(R-HSA-198754)
MAPK7 [nucleoplasm]
(R-HSA-199961)
0.596
5
UniProt:Q9BRP1 PDD2L
0.596
6
UniProt:P27987 ITPKB
1
ITPKB [cytosol]
(R-HSA-1604605)
0.596
4
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.596
5
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.596
5
UniProt:O43524 FOXO3
11
FOXO3 [nucleoplasm]
(R-HSA-199305)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
0.596
5
UniProt:Q02156 PRKCE
2
PRKCE [cytosol]
(R-HSA-58202)
p-T566,T710,S729-PRKCE [plasma membrane]
(R-HSA-198260)
0.589
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.577
4
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.553
4
UniProt:Q9GZV4 EIF5A2
3
Hyp-K50-EIF5A2 [cytosol]
(R-HSA-204650)
EIF5A2 [cytosol]
(R-HSA-204612)
Dhp-K50-EIF5A2 [cytosol]
(R-HSA-3149584)
0.553
4
UniProt:Q12967 RALGDS
1
RALGDS [cytosol]
(R-HSA-171001)
0.553
4
UniProt:P21399 ACO1
1
ACO1 [cytosol]
(R-HSA-5690899)
0.553
4
UniProt:P57735 RAB25
2
GGC-RAB25 [cytosol]
(R-HSA-8873780)
RAB25 [cytosol]
(R-HSA-8873683)
0.553
4
UniProt:P48736 PIK3CG
1
PIK3CG [cytosol]
(R-HSA-392286)
0.553
4
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.553
4
UniProt:P18074 ERCC2
2
ERCC2 [nucleoplasm]
(R-HSA-67443)
ERCC2 [cytosol]
(R-HSA-2564770)
0.553
3
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
MAPK11 [cytosol]
(R-HSA-170989)
MAPK11 [nucleoplasm]
(R-HSA-203790)
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
0.553
4
UniProt:P25311 AZGP1
1
AZGP1 [extracellular region]
(R-HSA-5215961)
0.553
3
UniProt:Q92843 B2CL2
0.553
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.553
4
UniProt:Q7Z589 EMSY
0.553
4
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.553
4
UniProt:P40259 CD79B
2
CD79B [plasma membrane]
(R-HSA-197156)
p-Y196,Y207-CD79B [plasma membrane]
(R-HSA-983634)
0.553
3
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.553
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.553
4
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.553
3
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.553
4
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.553
4
UniProt:Q8IYM1 SEP12
0.553
4
UniProt:P28715 ERCC5
1
ERCC5 [nucleoplasm]
(R-HSA-67447)
0.553
3
UniProt:Q92560 BAP1
1
BAP1 [nucleoplasm]
(R-HSA-5689665)
0.553
4
UniProt:P35221 CTNNA1
2
CTNNA1 [plasma membrane]
(R-HSA-191735)
CTNNA1 [cytosol]
(R-HSA-191697)
0.553
4
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.553
4
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.553
4
UniProt:P61224 RAP1B
2
RAP1B [plasma membrane]
(R-HSA-377590)
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
0.553
4
UniProt:P42772 CDKN2B
1
CDKN2B [cytosol]
(R-HSA-182586)
0.553
4
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.553
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.544
4
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.539
3
UniProt:P07098 LIPF
1
LIPF [extracellular region]
(R-HSA-6789323)
0.527
2
UniProt:Q15042 RAB3GAP1
2
RAB3GAP1 [endoplasmic reticulum membrane]
(R-HSA-508581)
RAB3GAP1 [cytosol]
(R-HSA-8877982)
0.527
2
UniProt:Q9UH62 ARMCX3
1
ARMCX3 [mitochondrial outer membrane]
(R-HSA-9714514)
0.527
2
UniProt:Q14154 DELE1
3
DELE1 [mitochondrial inner membrane]
(R-HSA-9840377)
DELE1(143-515) [cytosol]
(R-HSA-9840380)
DELE1(143-515) [mitochondrial inner membrane]
(R-HSA-9840386)
0.527
2
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
3
UniProt:Q9UIM3 FKBPL
1
FKBPL [cytosol]
(R-HSA-8852374)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:P38646 HSPA9
6
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [cytosol]
(R-HSA-5251993)
0.527
2
UniProt:Q99N57
11
phospho-Raf1 [cytosol]
(R-MMU-5672664)
phospho-Raf1 [plasma membrane]
(R-MMU-5672665)
phospho-Raf1 [cytosol]
(R-MMU-206028)
phospho-Raf1 [cytosol]
(R-MMU-9732747)
Raf1 [cytosol]
(R-MMU-167205)
phospho-Raf1 [cytosol]
(R-MMU-109786)
phospho-Raf1 [plasma membrane]
(R-MMU-5675420)
phospho-Raf1 [plasma membrane]
(R-MMU-206222)
phospho-Raf1 [plasma membrane]
(R-MMU-5675193)
phospho-Raf1 [cytosol]
(R-MMU-5624469)
phospho-Raf1 [cytosol]
(R-MMU-5624465)
0.499
3
UniProt:Q61097
5
phospho-Ksr1 [cytosol]
(R-MMU-5672654)
Ksr1 [cytosol]
(R-MMU-5672587)
phospho-Ksr1 [cytosol]
(R-MMU-5672652)
phospho-Ksr1 [plasma membrane]
(R-MMU-5672659)
phospho-Ksr1 [cytosol]
(R-MMU-5672656)
0.499
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
0.483
3
UniProt:Q16651 PRSS8
2
PRSS8(33-44) [plasma membrane]
(R-HSA-8849805)
PRSS8(45-322) [plasma membrane]
(R-HSA-8849789)
0.471
2
UniProt:Q6W2J9 BCOR
0.471
2
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.471
2
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.471
2
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.471
2
UniProt:P52333 JAK3
6
JAK3 [cytosol]
(R-HSA-451893)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
0.471
2
UniProt:P28347 TEAD1
1
TEAD1 [nucleoplasm]
(R-HSA-2032774)
0.471
2
UniProt:Q03181 PPARD
1
PPARD [nucleoplasm]
(R-HSA-446176)
0.471
2
UniProt:P19367 HK1
4
HK1 [cytosol]
(R-HSA-70395)
HK1 L529S [cytosol]
(R-HSA-5621861)
HK1 H577_C672del [cytosol]
(R-HSA-5621873)
HK1 T680S [cytosol]
(R-HSA-5621880)
0.471
2
UniProt:Q92800 EZH1
0.471
2
UniProt:P23458 JAK1
6
p-Y-JAK1 [cytosol]
(R-HSA-451921)
JAK1 [cytosol]
(R-HSA-451898)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
p-JAK1 [cytosol]
(R-HSA-8950711)
JAK1 [endosome]
(R-HSA-8983168)
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
0.471
2
UniProt:P08476 INHBA
1
INHBA [extracellular region]
(R-HSA-205926)
0.471
2
UniProt:Q00597 FANCC
2
FANCC [nucleoplasm]
(R-HSA-419530)
FANCC [cytosol]
(R-HSA-420801)
0.471
2
UniProt:Q06187 BTK
6
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
Active BTK [cytosol]
(R-HSA-8964323)
0.471
2
UniProt:O43741 PRKAB2
2
PRKAB2 [cytosol]
(R-HSA-200413)
PRKAB2 [nucleoplasm]
(R-HSA-164096)
0.471
2
UniProt:Q969H4 CNKSR1
1
CNKSR1 [cytosol]
(R-HSA-5672629)
0.471
2
UniProt:Q15382 RHEB
2
RHEB [endosome membrane]
(R-HSA-5656350)
RHEB [lysosomal membrane]
(R-HSA-165190)
0.471
2
UniProt:Q14209 E2F2
1
E2F2 [nucleoplasm]
(R-HSA-68649)
0.471
2
UniProt:Q92747 ARPC1A
1
ARPC1A [cytosol]
(R-HSA-200807)
0.471
2
UniProt:P08236 GUSB
9
GUSB [lysosomal lumen]
(R-HSA-1678846)
GUSB [ficolin-1-rich granule lumen]
(R-HSA-6800967)
GUSB [extracellular region]
(R-HSA-6806207)
GUSB [azurophil granule lumen]
(R-HSA-6799122)
GUSB S52F [lysosomal lumen]
(R-HSA-2318391)
GUSB R356* [lysosomal lumen]
(R-HSA-2318372)
GUSB A354V [lysosomal lumen]
(R-HSA-2318376)
GUSB R216W [lysosomal lumen]
(R-HSA-2318584)
GUSB R611W [lysosomal lumen]
(R-HSA-2318382)
0.471
2
UniProt:Q96HB5 CC120
0.471
2
UniProt:A1E959 ODAM
1
ODAM [extracellular region]
(R-HSA-977149)
0.471
2
UniProt:P30260 CDC27
2
CDC27 [cytosol]
(R-HSA-174073)
CDC27 [nucleoplasm]
(R-HSA-174175)
0.471
2
UniProt:P53779 MAPK10
3
p-T221,Y223-MAPK10 [nucleoplasm]
(R-HSA-450311)
p-T221,Y223-MAPK10 [cytosol]
(R-HSA-450214)
MAPK10 [cytosol]
(R-HSA-450352)
0.471
2
UniProt:P53778 MAPK12
3
MAPK12 [cytosol]
(R-HSA-171025)
p-T183,Y185-MAPK12 [cytosol]
(R-HSA-171021)
MAPK12 [nucleoplasm]
(R-HSA-448833)
0.471
2
UniProt:Q96AV8 E2F7
1
E2F7 [nucleoplasm]
(R-HSA-6798305)
0.471
2
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
0.471
2
UniProt:Q9BZK7 TBL1XR1
1
TBL1XR1 [nucleoplasm]
(R-HSA-351643)
0.471
2
UniProt:Q16633 OBF1
0.471
2
UniProt:Q9NRM7 LATS2
2
p-S872,T1041-LATS2 [cytosol]
(R-HSA-2028565)
LATS2 [cytosol]
(R-HSA-2028580)
0.471
2
UniProt:Q9Y6E7 SIRT4
1
SIRT4 [mitochondrial matrix]
(R-HSA-5687775)
0.471
2
UniProt:O95389 CCN6
0.471
2
UniProt:Q9HB63 NTN4
1
NTN4 [plasma membrane]
(R-HSA-561258)
0.471
2
UniProt:P46777 RPL5
1
RPL5 [cytosol]
(R-HSA-72482)
0.471
2
UniProt:Q9UIV8 SERPINB13
1
SERPINB13 [lysosomal lumen]
(R-HSA-8938045)
0.471
2
UniProt:P21912 SDHB
2
SDHB [mitochondrial matrix]
(R-HSA-9854983)
SDHB [mitochondrial inner membrane]
(R-HSA-70985)
0.471
2
UniProt:P36222 CHI3L1
2
CHI3L1 [extracellular region]
(R-HSA-6806319)
CHI3L1 [specific granule lumen]
(R-HSA-6799507)
0.471
2
UniProt:P29992 GNA11
1
GNA11 [plasma membrane]
(R-HSA-167446)
0.471
2
UniProt:P21860 ERBB3
0.471
2
UniProt:Q70Z35 PREX2
1
PREX2 [cytosol]
(R-HSA-8850949)
0.471
2
UniProt:P30291 WEE1
4
WEE1 [nucleoplasm]
(R-HSA-69253)
p-WEE1 [nucleoplasm]
(R-HSA-156491)
p-S53-WEE1 [nucleoplasm]
(R-HSA-156694)
p-T187,T190-WEE1 [nucleoplasm]
(R-HSA-9929669)
0.471
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.471
2
UniProt:O95754 SEMA4F
1
SEMA4F [plasma membrane]
(R-HSA-3006460)
0.471
2
UniProt:Q86WJ1 CHD1L
1
CHD1L [nucleoplasm]
(R-HSA-5688916)
0.471
2
UniProt:P78333 GPC5
20
HS(4)-GPC5 [plasma membrane]
(R-HSA-2076696)
HS(6)-GPC5 [plasma membrane]
(R-HSA-2076676)
HS(2)-GPC5 [plasma membrane]
(R-HSA-2076649)
HS(1)-GPC5 [plasma membrane]
(R-HSA-2076689)
HS(3)-GPC5 [plasma membrane]
(R-HSA-2076628)
HS(5)-GPC5 [plasma membrane]
(R-HSA-2076646)
GPC5(25-?) [Golgi lumen]
(R-HSA-2054103)
XylS-GPC5(25-?) [Golgi lumen]
(R-HSA-2064160)
Gal-Xyl-GPC5 [Golgi lumen]
(R-HSA-2064133)
Gal-Gal-Xyl-GPC5 [Golgi lumen]
(R-HSA-2064053)
GlcA-Gal-Gal-Xyl-GPC5 [Golgi lumen]
(R-HSA-2064087)
Heparan-GPC5 [Golgi lumen]
(R-HSA-2076472)
Heparan(1)-GPC5 [Golgi lumen]
(R-HSA-2076584)
Heparan(2)-GPC5 [Golgi lumen]
(R-HSA-2076482)
Heparan(3)-GPC5 [Golgi lumen]
(R-HSA-2076376)
Heparan(4)-GPC5 [Golgi lumen]
(R-HSA-2076556)
HS(1)-GPC5 [Golgi lumen]
(R-HSA-2076486)
HS(2)-GPC5 [Golgi lumen]
(R-HSA-2076459)
HS(3)-GPC5 [Golgi lumen]
(R-HSA-2076544)
HS(5)-GPC5 [Golgi lumen]
(R-HSA-2076457)
0.471
2
UniProt:Q6ZNE5 ATG14
3
ATG14 [phagophore assembly site membrane]
(R-HSA-5682389)
ATG14 [endoplasmic reticulum membrane]
(R-HSA-5679263)
ATG14 [cytosol]
(R-HSA-5668893)
0.471
2
UniProt:Q9NW38 FANCL
2
FANCL [nucleoplasm]
(R-HSA-419520)
FANCL [cytosol]
(R-HSA-420789)
0.471
2
UniProt:P31040 SDHA
2
FAD-SDHA [mitochondrial matrix]
(R-HSA-70983)
SDHA [mitochondrial matrix]
(R-HSA-9854690)
0.471
2
UniProt:Q00534 CDK6
3
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
CDK6 [nucleoplasm]
(R-HSA-141283)
CDK6 [cytosol]
(R-HSA-68336)
0.471
2
UniProt:Q9NXR7 BRE
2
BRE [nucleoplasm]
(R-HSA-5682579)
BRE [cytosol]
(R-HSA-5691413)
0.471
2
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