Reactome | CXXC1 [nucleoplasm]

CXXC1 [nucleoplasm]

Stable Identifier

R-HSA-535610

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CpG-binding protein, CXXC1_HUMAN, CFP1

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of CXXC1 (Homo sapiens)
        
        CXXC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0U4 CXXC1

Gene Names

CXXC1, CFP1, CGBP, PCCX1, PHF18

Chain

chain:1-656

Reference Genes

BioGPS Gene:30827 CXXC1

COSMIC (genes):CXXC1 CXXC1

CTD Gene:30827 CXXC1

dbSNP Gene:30827 CXXC1

ENSEMBL:ENSG00000154832 CXXC1

HGNC:24343 CXXC1

Monarch:30827 CXXC1

NCBI Gene:30827 CXXC1

OMIM:609150 CXXC1

UCSC:Q9P0U4 CXXC1

Reference Transcript

Other Identifiers

11756831_a_at

11756929_a_at

16855283

218058_3p_at

218058_PM_at

218058_at

30827

3807804

3807805

3807806

3807807

3807808

3807810

3807811

3807812

3807813

3807814

3807815

3807816

3807817

3807818

3807819

3807820

3807821

3807822

3807823

3807824

3807825

3807826

3807827

3807828

3807829

3807830

3807831

3807832

3807833

3807834

3807835

3807836

3807837

3807838

3807839

3807840

3807841

3807842

3807843

3807844

3807845

3807846

3807847

3807848

3807849

3807850

3807851

3807852

3807853

3807854

3807855

48580_PM_at

48580_at

8023344

A_23_P141779

GE62202

GO:0000987

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0008270

GO:0016363

GO:0016607

GO:0035064

GO:0035097

GO:0042393

GO:0043226

GO:0045322

GO:0045893

GO:0046872

GO:0048188

HMNXSV003013130

ILMN_1691276

PH_hs_0010708

PH_hs_0032027

TC18000513.hg

g7656974_3p_at

g7656974_3p_s_at

Participates

as a component of

as an input of

as an output of

Expression of CXXC1 (Homo sapiens)

Inferred To

cxxc1b [nucleoplasm] (Danio rerio)

Cxxc1 [nucleoplasm] (Rattus norvegicus)

gflC [nucleoplasm] (Dictyostelium discoideum)

CXXC1 [nucleoplasm] (Bos taurus)

CXXC1 [nucleoplasm] (Canis familiaris)

CXXC1 [nucleoplasm] (Drosophila melanogaster)

CXXC1 [nucleoplasm] (Mus musculus)

CXXC1 [nucleoplasm] (Saccharomyces cerevisiae)

CXXC1 [nucleoplasm] (Sus scrofa)

cfp-1 [nucleoplasm] (Caenorhabditis elegans)

spp1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000412036, ENST00000285106, ENSP00000390475, ENSP00000285106

OpenTargets

ENSG00000154832

HPA

ENSG00000154832-CXXC1

PRO

Q9P0U4

Pharos - Targets

Q9P0U4

PDB

3QMH, 3QMD, 3QMG, 3QMC, 3QMI, 3QMB

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.812	7
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.758	8
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.737	8
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.69	6
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.643	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.597	7
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q96IK1 BOD1	1	BOD1 [nucleoplasm] (R-HSA-9821926)	0.527	2
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.527	2
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.527	3
UniProt:Q8NFC6 BOD1L1	1	BOD1L1 [nucleoplasm] (R-HSA-8954547)	0.527	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.508	2
UniProt:Q6UXN9 WDR82	1	WDR82 [nucleoplasm] (R-HSA-9821474)	0.462	3
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.462	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.462	2

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