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SREBF2(1-522) [Golgi membrane]
Stable Identifier
R-HSA-1655752
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
SREBP2(1-522), SREBF2 cleaved by S1P, Sterol regulatory element-binding protein 2, SRBP2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
SREBF1A,1C,2 cleaved by S1P [Golgi membrane] (Homo sapiens)
SREBF2(1-522) [Golgi membrane] (Homo sapiens)
S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)
SREBF1A,1C,2 cleaved by S1P [Golgi membrane] (Homo sapiens)
SREBF2(1-522) [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12772 SREBF2
Gene Names
SREBF2, BHLHD2, SREBP2
Chain
chain:1-1141, chain:1-484
Reference Genes
BioGPS Gene:6721 SREBF2
COSMIC (genes):SREBF2 SREBF2
CTD Gene:6721 SREBF2
dbSNP Gene:6721 SREBF2
ENSEMBL:ENSG00000198911 SREBF2
ENSEMBL_homo_sapiens_GENE:ENSG00000198911.13 SREBF2
HGNC:11290 SREBF2
KEGG Gene (Homo sapiens):6721 SREBF2
Monarch:6721 SREBF2
NCBI Gene:6721 SREBF2
OMIM:600481 SREBF2
UCSC:Q12772 SREBF2
Reference Transcript
RefSeq:NM_004599.3 SREBF2
Other Identifiers
11723664_a_at
11752012_a_at
11759548_a_at
16930768
201247_PM_at
201247_at
201248_PM_s_at
201248_s_at
38713_at
3947124
3947125
3947137
3947138
3947142
3947143
3947144
3947148
3947149
3947151
3947154
3947155
3947156
3947158
3947165
3947166
3947179
3947180
3947181
3947183
3947188
3947189
3947192
3947194
3947195
3947196
3947197
3947198
3947199
3947200
6721
78554_at
8073522
A_14_P129067
A_23_P166502
A_23_P419602
GE58852
GE85795
GO:0000122
GO:0000139
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001227
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006886
GO:0006914
GO:0007005
GO:0008202
GO:0008203
GO:0008593
GO:0009267
GO:0010886
GO:0012507
GO:0016020
GO:0023052
GO:0031410
GO:0032933
GO:0032937
GO:0042632
GO:0043226
GO:0043231
GO:0045542
GO:0045944
GO:0046983
GO:0070888
GO:0071404
GO:0071499
GO:0090370
GO:0140110
GO:1901524
GO:1902895
GO:1903955
GO:1990837
HMNXSV003036456
Hs.108689.0.A2_3p_at
ILMN_2217661
PH_hs_0006017
TC22000347.hg
U02031_at
g4759169_3p_s_at
Participates
as a member of
SREBF1A,1C,2 cleaved by S1P [Golgi membrane] (Homo sapiens)
Other forms of this molecule
SREBF2(1-1141) [Golgi membrane]
SREBF2(1-484) [cytosol]
SREBF2(1-1141) [endoplasmic reticulum membrane]
SREBF2(1-484) [nucleoplasm]
Inferred To
SREBP [Golgi membrane]
(Drosophila melanogaster)
SREBF2 [Golgi membrane]
(Bos taurus)
SREBF2 [Golgi membrane]
(Canis familiaris)
SREBF2 [Golgi membrane]
(Sus scrofa)
sbp-1 [Golgi membrane]
(Caenorhabditis elegans)
srebf2 [Golgi membrane]
(Danio rerio)
srebf2 [Golgi membrane]
(Xenopus tropicalis)
Srebf2 [Golgi membrane]
(Mus musculus)
Srebf2 [Golgi membrane]
(Rattus norvegicus)
SREBF2(1-522) [Golgi membrane]
(Gallus gallus)
Cross References
RefSeq
NP_004590.2
OpenTargets
ENSG00000198911
ZINC - Substances
SRBP2_HUMAN
ZINC - Biogenic
SRBP2_HUMAN
ZINC target
Q12772
PRO
Q12772
PDB
1UKL
ZINC - Metabolites
SRBP2_HUMAN
GeneCards
Q12772
HPA
ENSG00000198911-SREBF2
Ensembl
ENST00000361204
,
ENSP00000354476
,
ENSG00000198911
Pharos - Targets
Q12772
ZINC - Predictions - Purchasable
SRBP2_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.666
5
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.635
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.524
3
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.499
2
UniProt:Q96RN5 MED15
1
MED15 [nucleoplasm]
(R-HSA-556827)
0.499
2
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