p-S465,S467-SMAD2 P305L [cytosol]

Stable Identifier
R-HSA-3315471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-Ser465,Ser467-SMAD2 Pro305Leu
p-S465,S467-SMAD2 P305L [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
23139211 SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Mouradov, D, Jorissen, RN, Jones, IT, Tsui, C, Palmieri, M, Sieber, OM, Ward, RL, Fleming, NI, Mariadason, JM, Sakthianandeswaren, A, Lipton, L, Moore, J, Ruszkiewicz, AR, Busam, D, Christie, M, McLaughlin, S, Gibbs, P, Zhu, HJ, Strausberg, RL, Day, F, Li, S, Burgess, AW, Hawkins, NJ, Desai, J, Zhao, Q

Cancer Res. 2013
External Reference Information
External Reference
Gene Names
SMAD2, MADH2, MADR2
Chain
initiator methionine:, chain:2-467
Other Identifiers
11729653_a_at
11729654_a_at
11729655_a_at
11729656_s_at
11734014_a_at
11734015_a_at
11746820_a_at
1453_at
16855090
16855093
1928_s_at
203075_PM_at
203075_at
203076_PM_s_at
203076_s_at
203077_PM_s_at
203077_s_at
226563_PM_at
226563_at
235598_PM_at
235598_at
239271_PM_at
239271_at
3096426
3806892
3806894
3806896
3806898
3806900
3806902
3806904
3806906
3806907
3806908
3806909
3806910
3806911
3806912
3806914
3806915
3806916
3806917
3806918
3806919
3806924
3806926
3806928
3806929
3806931
3806933
3806937
3806938
3806939
3806946
3806947
3806948
3806956
3806957
3806958
3806959
3806960
3806961
4087
50764_at
53730_at
57493_at
70271_at
8023191
8023195
81545_at
90267_at
A_19_P00331466
A_19_P00811827
A_21_P0009555
A_23_P15937
A_24_P202527
A_32_P109002
A_32_P12580
GE59354
GE846664
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0007179
GO:0007182
GO:0007183
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008285
GO:0009653
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0017015
GO:0019902
GO:0023019
GO:0023052
GO:0030073
GO:0030154
GO:0030324
GO:0030325
GO:0030513
GO:0031016
GO:0031047
GO:0031053
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0036211
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0051098
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0065003
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071142
GO:0071144
GO:0097718
GO:0140110
GO:0140297
GO:1900224
HMNXSV003021861
HMNXSV003023211
HMNXSV003024357
Hs.110741.0.A1_3p_at
Hs.12253.0.A1_3p_at
Hs.204129.0.A1_3p_at
Hs.82483.0.A3_3p_at
ILMN_1751036
ILMN_1754521
ILMN_1771203
PH_hs_0020771
PH_hs_0022288
PH_hs_0033969
PH_hs_0038510
TC18000496.hg
TC18000918.hg
TC18000919.hg
U68018_at
g1575529_3p_a_at
g5174510_3p_a_at
p20421
Participates
Other forms of this molecule
Modified Residues
Name
L-proline 305 replaced with L-leucine
Coordinate
305
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-leucine.
A protein modification that effectively removes or replaces an L-proline.
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467
Coordinate
467
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Interactors (24)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13485 SMAD4  20 0.962 23
 UniProt:P12755 SKI  1 0.826 10
 UniProt:Q9HAU4 SMURF2  2 0.811 6
 UniProt:O95405 ZFYVE9      0.783 6
 UniProt:O75593 FOXH1  1 0.675 4
 UniProt:P04637 TP53  20 0.674 7
 UniProt:Q9UPN9 TRIM33  1 0.662 6
 UniProt:O00308 WWP2  1 0.656 4
 UniProt:Q13573 SNW1  1 0.646 3
 UniProt:Q9H3D4 TP63  1 0.589 3
 UniProt:Q9BZ29 DOCK9  1 0.576 3
 UniProt:Q12955 ANK3  1 0.573 2
 UniProt:P84022 SMAD3  20 0.573 2
 UniProt:P05412 JUN  4 0.564 3
 UniProt:P35813 PPM1A  2 0.544 2
 UniProt:P12757-1 SKIL      0.536 2
 UniProt:Q15796 SMAD2  20 0.524 2
 UniProt:P98082 DAB2  3 0.524 4
 UniProt:O15111 CHUK  3 0.524 2
 UniProt:Q9NYA4 MTMR4  2 0.524 2
 UniProt:P61586 RHOA  6 0.524 2
 UniProt:P70056 FOXH1      0.499 4
 UniProt:P36801 VE6      0.488 2
 UniProt:P10070 GLI2  11 0.462 2
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