Reactome | TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol]

TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol]

Stable Identifier

R-HSA-1839012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRIM24-p-2Y-FGFR1 fusion, t(7;8) TRIM24-p-FGFR1 fusion

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15609342	8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes Di Fiore, PP, Gasparini, P, Belloni, E, Trubia, M, Tapinassi, C, Nuciforo, P, Micucci, C, Martino, B, Pelicci, PG, Confalonieri, S, Lo-Coco, F	Genes Chromosomes Cancer	2005

External Reference Information

External Reference

UniProt:O15164 TRIM24

Gene Names

TRIM24, RNF82, TIF1, TIF1A

Chain

chain:1-1050

Reference Genes

BioGPS Gene:8805 TRIM24

COSMIC (genes):TRIM24 TRIM24

CTD Gene:8805 TRIM24

dbSNP Gene:8805 TRIM24

ENSEMBL:ENSG00000122779 TRIM24

HGNC:11812 TRIM24

KEGG:hsa:8805 TRIM24

Monarch:8805 TRIM24

NCBI Gene:8805 TRIM24

OMIM:603406 TRIM24

UCSC:O15164 TRIM24

Reference Transcript

Other Identifiers

11729816_x_at

11749468_a_at

11758692_s_at

1569316_PM_at

1569316_at

17052115

204391_PM_x_at

204391_x_at

213301_PM_x_at

213301_x_at

3026603

3026604

3026605

3026606

3026607

3026608

3026609

3026622

3026626

3026628

3026633

3026634

3026636

3026637

3026642

3026643

3026644

3026645

3026647

3026648

3026649

3026650

3026651

3026653

3026654

3026656

3026657

3026658

3026660

3026661

3026662

3026663

3026664

3026665

3026666

3026667

3026668

3026670

3026672

39292_r_at

66615_at

8136473

83662_at

8805

A_14_P122921

A_14_P124392

A_14_P131860

A_14_P138691

A_23_P93629

A_33_P3259028

GE62625

GE863285

GO:0000785

GO:0000791

GO:0001673

GO:0002039

GO:0003677

GO:0003682

GO:0003713

GO:0003824

GO:0004672

GO:0004842

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005726

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0008270

GO:0010628

GO:0016567

GO:0016740

GO:0016922

GO:0030163

GO:0031647

GO:0034056

GO:0042393

GO:0042981

GO:0043226

GO:0043434

GO:0043565

GO:0045892

GO:0045893

GO:0050673

GO:0050680

GO:0055074

GO:0060090

GO:0061630

GO:0070562

GO:0070577

GO:0071391

GO:0140096

GO:0140110

GO:1901796

HMNXSV003048357

HMNXSV003050282

Hs2.125798.1.S1_3p_at

ILMN_1711247

ILMN_1799642

ILMN_2405031

PH_hs_0010837

TC07000868.hg

g7706233_3p_a_at

Participates

as a component of

TRIM24-p-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)

Other forms of this molecule

TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol]

TRIM24(1-510)-BRAF(381-766) fusion [cytosol]

TRIM24(1-626)-FGFR1(429-822) fusion [cytosol]

Modified Residues

Name

Insertion of residues 429 to 822 at 627 from UniProt:P11362 FGFR1

Coordinate

627

Name

O4'-phospho-L-tyrosine at 766

Coordinate

766

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
subacute leukemia	DOID:3264
myelodysplastic myeloproliferative cancer	DOID:4972	Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
acute lymphocytic leukemia	DOID:9952

Cross References

RefSeq

NP_056989.2, NP_003843.3

Guide to Pharmacology - Targets

2252

OpenTargets

ENSG00000122779

ENSEMBL

ENSP00000340507, ENSG00000122779, ENSP00000390829, ENST00000415680, ENST00000343526

ZINC - Substances

TIF1A_HUMAN

ZINC target

O15164

PRO

O15164

GlyGen

O15164

PDB

4ZQL, 4YAD, 4YAB, 7B9X, 4YAT, 4YBM, 5H1V, 3O37, 5H1U, 3O33, 5H1T, 4YBT, 2YYN, 3O36, 4YC9, 3O35, 4YBS, 3O34, 4YAX

IntEnz

2.3.2.27

HPA

ENSG00000122779-TRIM24

GeneCards

TRIM24

Pharos - Targets

O15164

Orphanet

TRIM24

ZINC - Predictions - Purchasable

TIF1A_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.794	6
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.641	3
UniProt:Q13263 TRIM28	3	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.597	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3

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