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What is Reactome ?
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Team
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
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How do I search ?
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Analysis Data
Analysis Gene Expression
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Citing us
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Analyse gene expression
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ASH2L [nucleoplasm]
Stable Identifier
R-HSA-1629834
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA2 chromatin is activated (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA2 gene is transcribed (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA3 chromatin is activated (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXA3 gene is transcribed (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXA2 expression (Homo sapiens)
HOXA2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1 activates HOXB2 expression (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB2 chromatin is activated (Homo sapiens)
HOXB2 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB2 gene is transcribed (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB3 chromatin is activated (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB3 gene is transcribed (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXB4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXC4 chromatin is activated (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXC4 gene is transcribed (Homo sapiens)
HOXC4 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)
HOXA3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
HOXB3 active chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
MLL2,3 complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
ASH2L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBL3 ASH2L
Gene Names
ASH2L, ASH2L1
Chain
chain:1-628
Reference Genes
BioGPS Gene:9070 ASH2L
COSMIC (genes):ASH2L ASH2L
CTD Gene:9070 ASH2L
dbSNP Gene:9070 ASH2L
ENSEMBL:ENSG00000129691 ASH2L
HGNC:744 ASH2L
KEGG Gene (Homo sapiens):9070 ASH2L
Monarch:9070 ASH2L
NCBI Gene:9070 ASH2L
OMIM:604782 ASH2L
UCSC:Q9UBL3 ASH2L
Reference Transcript
RefSeq:NM_001261832.1 ASH2L
RefSeq:NM_001105214.2 ASH2L
RefSeq:NM_004674.4 ASH2L
Other Identifiers
0003390670
11739012_a_at
11739013_s_at
17067970
209517_s_at
3094448
3094449
3094450
3094451
3094452
3094453
3094457
3094458
3094460
3094462
3094465
3094466
3094468
3094469
3094472
3094473
3094474
3094476
3094480
3094481
3094482
3094483
3094484
35804_at
8145894
9070
A_14_P119074
A_23_P134827
GE54534
GO:0000976
GO:0002376
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006325
GO:0006464
GO:0006950
GO:0006974
GO:0008013
GO:0008150
GO:0008168
GO:0008283
GO:0008284
GO:0022607
GO:0030097
GO:0030154
GO:0032991
GO:0035097
GO:0042800
GO:0043167
GO:0043226
GO:0043627
GO:0044666
GO:0045652
GO:0046872
GO:0048188
GO:0048856
GO:0051276
GO:0051568
GO:0065003
GO:1904837
HMNXSV003045628
ILMN_1666933
PH_hs_0000696
TC08000283.hg
g4417209_3p_a_at
Participates
as a component of
MLL2,3 complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
as an input of
Recruitment of SET1 methyltransferase complex (Homo sapiens)
as an output of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
Inferred To
ash-2 [nucleoplasm]
(Caenorhabditis elegans)
Ash2l [nucleoplasm]
(Mus musculus)
Ash2l [nucleoplasm]
(Rattus norvegicus)
BRE2 [nucleoplasm]
(Saccharomyces cerevisiae)
ash2 [nucleoplasm]
(Drosophila melanogaster)
ash2l [nucleoplasm]
(Danio rerio)
ash2l [nucleoplasm]
(Xenopus tropicalis)
ASH2L [nucleoplasm]
(Bos taurus)
ASH2L [nucleoplasm]
(Canis familiaris)
ASH2L [nucleoplasm]
(Dictyostelium discoideum)
ASH2L [nucleoplasm]
(Gallus gallus)
ASH2L [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_004665.2
,
NP_001098684.1
,
NP_001248761.1
OpenTargets
ENSG00000129691
GeneCards
Q9UBL3
HPA
ENSG00000129691-ASH2L
Ensembl
ENSP00000340896
,
ENSP00000395310
,
ENST00000343823
,
ENST00000521652
,
ENSG00000129691
,
ENSP00000430259
,
ENST00000428278
PRO
Q9UBL3
Pharos - Targets
Q9UBL3
GlyGen
Q9UBL3
PDB
6W5I
,
5F6K
,
6KIU
,
6PWV
,
6E2H
,
5F6L
,
6KIV
,
6KIW
,
6W5M
,
4RIQ
,
4X8N
,
3S32
,
7BRE
,
3TOJ
,
4X8P
,
3RSN
,
6KIX
,
6W5N
,
6KIZ
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.977
37
UniProt:Q9C005 DPY30
1
DPY30 [nucleoplasm]
(R-HSA-5669104)
0.965
22
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.942
15
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.918
14
UniProt:Q03164 KMT2A
1
KMT2A [nucleoplasm]
(R-HSA-1183223)
0.845
8
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.812
9
UniProt:Q6ZW49 PAXIP1
1
PAXIP1 [nucleoplasm]
(R-HSA-5619395)
0.794
12
UniProt:Q8NEZ4 KMT2C
1
KMT2C [nucleoplasm]
(R-HSA-1183224)
0.773
5
UniProt:P51610 HCFC1
2
HCFC1 [nucleoplasm]
(R-HSA-1592209)
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
0.748
6
UniProt:Q9P0U4 CXXC1
1
CXXC1 [nucleoplasm]
(R-HSA-535610)
0.69
7
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.643
7
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.623
5
UniProt:Q6NZQ4 Paxip1
2
Paxip1 [nucleoplasm]
(R-MMU-5619398)
Paxip1 [nucleoplasm]
(R-MMU-5619395)
0.623
4
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.604
3
UniProt:Q9UMN6 KMT2B
1
KMT2B [nucleoplasm]
(R-HSA-1183216)
0.597
3
UniProt:O15047 SETD1A
1
SETD1A [nucleoplasm]
(R-HSA-3239027)
0.597
3
UniProt:Q6UXN9 WDR82
0.597
3
UniProt:O15550 KDM6A
1
KDM6A [nucleoplasm]
(R-HSA-4754224)
0.597
5
UniProt:O43823 AKAP8
0.576
3
UniProt:O75460-2 ERN1
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:Q14696 MESD
0.556
3
UniProt:P54652 HSPA2
2
HSPA2 [nucleoplasm]
(R-HSA-912480)
HSPA2 [cytosol]
(R-HSA-3371408)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
0.536
2
UniProt:Q9H4Z2 ZNF335
1
ZNF335 [nucleoplasm]
(R-HSA-6810129)
0.532
3
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.527
2
UniProt:Q9UPS6 SETD1B
1
SETD1B [nucleoplasm]
(R-HSA-5244714)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
4
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.499
2
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.499
3
UniProt:Q9BTK6 PAGR1
1
PAGR1 [nucleoplasm]
(R-HSA-5619374)
0.462
3
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