Reactome | ASH2L [nucleoplasm]

ASH2L [nucleoplasm]

Stable Identifier

R-HSA-1629834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UBL3 ASH2L

Gene Names

ASH2L, ASH2L1

Chain

chain:1-628

Reference Genes

BioGPS Gene:9070 ASH2L

COSMIC (genes):ASH2L ASH2L

CTD Gene:9070 ASH2L

dbSNP Gene:9070 ASH2L

ENSEMBL:ENSG00000129691 ASH2L

HGNC:744 ASH2L

KEGG Gene (Homo sapiens):9070 ASH2L

Monarch:9070 ASH2L

NCBI Gene:9070 ASH2L

OMIM:604782 ASH2L

UCSC:Q9UBL3 ASH2L

Reference Transcript

Other Identifiers

0003390670

11739012_a_at

11739013_s_at

17067970

209517_s_at

3094448

3094449

3094450

3094451

3094452

3094453

3094457

3094458

3094460

3094462

3094465

3094466

3094468

3094469

3094472

3094473

3094474

3094476

3094480

3094481

3094482

3094483

3094484

35804_at

8145894

9070

A_14_P119074

A_23_P134827

GE54534

GO:0000976

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006325

GO:0006464

GO:0006950

GO:0006974

GO:0008013

GO:0008150

GO:0008168

GO:0008283

GO:0008284

GO:0022607

GO:0030097

GO:0030154

GO:0032991

GO:0035097

GO:0042800

GO:0043167

GO:0043226

GO:0043627

GO:0044666

GO:0045652

GO:0046872

GO:0048188

GO:0048856

GO:0051276

GO:0051568

GO:0065003

GO:1904837

HMNXSV003045628

ILMN_1666933

PH_hs_0000696

TC08000283.hg

g4417209_3p_a_at

Participates

as a component of

as an input of

Recruitment of SET1 methyltransferase complex (Homo sapiens)

as an output of

APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)

Inferred To

ash-2 [nucleoplasm] (Caenorhabditis elegans)

Ash2l [nucleoplasm] (Mus musculus)

Ash2l [nucleoplasm] (Rattus norvegicus)

ash2 [nucleoplasm] (Drosophila melanogaster)

ash2 [nucleoplasm] (Schizosaccharomyces pombe)

ash2l [nucleoplasm] (Danio rerio)

ASH2L [nucleoplasm] (Bos taurus)

ASH2L [nucleoplasm] (Canis familiaris)

ASH2L [nucleoplasm] (Dictyostelium discoideum)

ASH2L [nucleoplasm] (Gallus gallus)

ASH2L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001248761.1, NP_004665.2, NP_001098684.1

OpenTargets

ENSG00000129691

HPA

ENSG00000129691-ASH2L

GeneCards

Q9UBL3

Ensembl

ENSP00000340896, ENSP00000395310, ENST00000428278, ENSG00000129691, ENST00000521652, ENST00000343823, ENSP00000430259

PRO

Q9UBL3

PDB

3TOJ, 6KIV, 3S32, 6KIW, 7BRE, 5F6K, 3RSN, 4RIQ, 5F6L, 6KIX, 4X8N, 6KIZ, 6KIU, 4X8P, 6E2H, 6PWV

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.977	37
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.965	22
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.942	15
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.918	14
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.845	8
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.812	9
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.794	12
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.773	5
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.748	6
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.69	7
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.643	7
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.623	5
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619395) Paxip1 [nucleoplasm] (R-MMU-5619398)	0.623	4
UniProt:Q9UMN6 KMT2B	1	KMT2B [nucleoplasm] (R-HSA-1183216)	0.597	3
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.597	3
UniProt:Q6UXN9 WDR82			0.597	3
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.597	5
UniProt:O43823 AKAP8			0.576	3
UniProt:O75460-2 ERN1			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.536	2
UniProt:Q9H4Z2 ZNF335	1	ZNF335 [nucleoplasm] (R-HSA-6810129)	0.532	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	4
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.527	2
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.499	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) SUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.499	3
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.499	2
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.462	3

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