Reactome | ASH2L [nucleoplasm]

ASH2L

Stable Identifier

R-HSA-1629834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UBL3 ASH2L

Gene Names

ASH2L, ASH2L1

Chain

chain:1-628

Reference Genes

BioGPS Gene:9070 ASH2L

COSMIC (genes):ASH2L ASH2L

CTD Gene:9070 ASH2L

dbSNP Gene:9070 ASH2L

ENSEMBL:ENSG00000129691 ASH2L

HGNC:744 ASH2L

KEGG Gene (Homo sapiens):hsa:9070 ASH2L

Monarch:9070 ASH2L

NCBI Gene:9070 ASH2L

OMIM:604782 ASH2L

UCSC:Q9UBL3 ASH2L

Reference Transcript

Other Identifiers

0003390670

11739012_a_at

11739013_s_at

17067970

209517_s_at

3094448

3094449

3094450

3094451

3094452

3094453

3094457

3094458

3094460

3094462

3094465

3094466

3094468

3094469

3094472

3094473

3094474

3094476

3094480

3094481

3094482

3094483

35804_at

3RSN

3S32

3TOJ

42289

4RIQ

4X8N

4X8P

5F6K

5F6L

8145894

9070

A_14_P119074

A_23_P134827

AAC13563

AAC13564

AAH15936

AB020982

AB022785

AF056717

AF056718

AK291938

ASH2L

ASH2L-201

ASH2L-202

ASH2L-207

BAA35127

BAA74520

BAF84627

BC015936

CCDS47840

CCDS59100

CCDS6101

CH471080

E5RFH5

E5RHM1

EAW63336

EAW63337

EAW63340

ENSG00000129691

ENSP00000340896

ENSP00000395310

ENSP00000430259

ENST00000343823

ENST00000428278

ENST00000521652

EntrezGene:9070

F5H8F7

g4417209_3p_a_at

GE54534

GO:0000228

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005719

GO:0006325

GO:0006351

GO:0006355

GO:0006464

GO:0006950

GO:0006974

GO:0008013

GO:0008150

GO:0008168

GO:0008283

GO:0008284

GO:0009058

GO:0018024

GO:0022607

GO:0030097

GO:0030154

GO:0032991

GO:0034641

GO:0035097

GO:0042800

GO:0043167

GO:0043226

GO:0043627

GO:0044212

GO:0044666

GO:0045652

GO:0045944

GO:0046872

GO:0048188

GO:0048856

GO:0051276

GO:0051568

GO:0065003

GO:0071339

GO:1904837

GO:1990188

HGNC:744

HPA042289

ILMN_1666933

IPR001870

IPR003877

IPR013320

IPR037353

MIM:604782

NM_001105214

NM_001261832

NM_004674

NP_001098684

NP_001248761

NP_004665

PF00622

PH_hs_0000696

SM00449

TC08000283.hg

uc003xkt.6

uc003xku.6

uc010lwa.5

UPI0000038D65

UPI000013CCC6

UPI0000169F6C

XM_005273682

XM_005273683

XM_006716412

XM_006716413

XP_005273739

XP_005273740

XP_006716475

XP_006716476

Participant Of

input

Recruitment of SET1 methyltransferase complex

output

APC promotes disassembly of beta-catenin transactivation complex

hasComponent

Inferred To

Homologues of ASH2L [nucleoplasm] (Danio rerio)

Homologues of ASH2L [nucleoplasm] (Oryza sativa)

Homologues of ASH2L [nucleoplasm] (Rattus norvegicus)

Homologues of ASH2L [nucleoplasm] (Sus scrofa)

ASH2L [nucleoplasm] (Arabidopsis thaliana)

ASH2L [nucleoplasm] (Bos taurus)

ASH2L [nucleoplasm] (Caenorhabditis elegans)

ASH2L [nucleoplasm] (Canis familiaris)

ASH2L [nucleoplasm] (Danio rerio)

ASH2L [nucleoplasm] (Dictyostelium discoideum)

ASH2L [nucleoplasm] (Drosophila melanogaster)

ASH2L [nucleoplasm] (Gallus gallus)

ASH2L [nucleoplasm] (Mus musculus)

ASH2L [nucleoplasm] (Oryza sativa)

ASH2L [nucleoplasm] (Plasmodium falciparum)

ASH2L [nucleoplasm] (Rattus norvegicus)

ASH2L [nucleoplasm] (Schizosaccharomyces pombe)

ASH2L [nucleoplasm] (Sus scrofa)

ASH2L [nucleoplasm] (Taeniopygia guttata)

ASH2L [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001098684.1, NP_004665.2, NP_001248761.1

GeneCards

Q9UBL3

PRO

Q9UBL3

BRENDA (Homo sapiens)

2.1.1.43

PDB

4X8P, 5F6K, 5F6L, 4RIQ, 3RSN, 4X8N, 3TOJ, 3S32

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.973	32
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.957	18
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.932	13
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.909	13
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.8	7
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.758	8
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.737	11
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.708	4
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.677	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.643	7
UniProt:Q6NZQ4 Paxip1	2	PAXIP1 [nucleoplasm] (R-MMU-5619395) Paxip1 [nucleoplasm] (R-MMU-5619398)	0.623	4
UniProt:Q09472 EP300	3	p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) EP300 [nucleoplasm] (R-HSA-381325)	0.623	5
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.597	6
UniProt:O43823 AKAP8			0.576	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.564	2
UniProt:O15294 OGT	1	OGT [nucleoplasm] (R-HSA-3321845)	0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.499	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) SUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.499	3
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.499	2
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.488	2
UniProt:Q14696 MESD			0.488	2
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.488	2
UniProt:Q9UMN6 KMT2B	1	KMT2B [nucleoplasm] (R-HSA-1183216)	0.462	2
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.462	2
UniProt:Q6UXN9 WDR82			0.462	2
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.462	4
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.462	3