Reactome | ASH2L [nucleoplasm]

ASH2L [nucleoplasm]

Stable Identifier

R-HSA-1629834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UBL3 ASH2L

Gene Names

ASH2L, ASH2L1

Chain

chain:1-628

Reference Genes

BioGPS Gene:9070 ASH2L

COSMIC (genes):ASH2L ASH2L

CTD Gene:9070 ASH2L

dbSNP Gene:9070 ASH2L

ENSEMBL:ENSG00000129691 ASH2L

HGNC:744 ASH2L

KEGG Gene (Homo sapiens):9070 ASH2L

Monarch:9070 ASH2L

NCBI Gene:9070 ASH2L

OMIM:604782 ASH2L

UCSC:Q9UBL3 ASH2L

Reference Transcript

Other Identifiers

0003390670

11739012_a_at

11739013_s_at

17067970

209517_s_at

3094448

3094449

3094450

3094451

3094452

3094453

3094457

3094458

3094460

3094462

3094465

3094466

3094468

3094469

3094472

3094473

3094474

3094476

3094480

3094481

3094482

3094483

3094484

35804_at

3RSN

3S32

3TOJ

42289

4RIQ

4X8N

4X8P

5F6K

5F6L

6E2H

8145894

9070

A_14_P119074

A_23_P134827

AAC13563

AAC13564

AAH15936

AB020982

AB022785

AF056717

AF056718

AK291938

ASH2L

ASH2L-201

ASH2L-202

ASH2L-207

BAA35127

BAA74520

BAF84627

BC015936

CCDS47840

CCDS59100

CCDS6101

CH471080

E5RFH5

E5RHM1

EAW63336

EAW63337

EAW63340

ENSG00000129691

ENSP00000340896

ENSP00000395310

ENSP00000430259

ENST00000343823

ENST00000343823.10

ENST00000428278

ENST00000428278.6

ENST00000521652

ENST00000521652.5

EntrezGene:9070

EntrezGene:ASH2L

F5H8F7

g4417209_3p_a_at

GE54534

GO:0000228

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005719

GO:0006325

GO:0006351

GO:0006355

GO:0006464

GO:0006950

GO:0006974

GO:0008013

GO:0008150

GO:0008168

GO:0008283

GO:0008284

GO:0009058

GO:0022607

GO:0030097

GO:0030154

GO:0032991

GO:0034641

GO:0035097

GO:0042800

GO:0043167

GO:0043226

GO:0043627

GO:0044212

GO:0044666

GO:0045652

GO:0045944

GO:0046872

GO:0048188

GO:0048856

GO:0051276

GO:0051568

GO:0065003

GO:0071339

GO:1904837

GO:1990188

HGNC:744

HPA042289

ILMN_1666933

IPR001870

IPR003877

IPR013320

IPR037353

MIM:604782

NM_001105214

NM_001261832

NM_004674

NP_001098684

NP_001248761

NP_004665

PF00622

PH_hs_0000696

SM00449

TC08000283.hg

UPI0000038D65

UPI000013CCC6

UPI0000169F6C

XM_005273682

XM_005273683

XM_006716412

XM_006716413

XP_005273739

XP_005273740

XP_006716475

XP_006716476

Participant Of

hasComponent

input

Recruitment of SET1 methyltransferase complex

output

APC promotes disassembly of beta-catenin transactivation complex

Inferred To

ash-2 [nucleoplasm] (Caenorhabditis elegans)

Ash2l [nucleoplasm] (Mus musculus)

Ash2l [nucleoplasm] (Rattus norvegicus)

ash2 [nucleoplasm] (Drosophila melanogaster)

ash2l [nucleoplasm] (Danio rerio)

ash2l [nucleoplasm] (Xenopus tropicalis)

ASH2L [nucleoplasm] (Bos taurus)

ASH2L [nucleoplasm] (Canis familiaris)

ASH2L [nucleoplasm] (Dictyostelium discoideum)

ASH2L [nucleoplasm] (Gallus gallus)

ASH2L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004665.2, NP_001248761.1, NP_001098684.1

OpenTargets

ENSG00000129691

HPA

ENSG00000129691-ASH2L

GeneCards

Q9UBL3

Ensembl

ENST00000428278, ENSP00000430259, ENSG00000129691, ENST00000343823, ENST00000521652, ENSP00000395310, ENSP00000340896

PRO

Q9UBL3

PDB

6KIX, 4X8P, 3RSN, 4X8N, 5F6L, 4RIQ, 5F6K, 6KIW, 6KIV, 3TOJ, 3S32, 6E2H, 6KIU, 6KIZ

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.974	34
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.963	21
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.932	13
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.909	13
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.8	7
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.758	8
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.737	11
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.708	4
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.677	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.643	7
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619395) Paxip1 [nucleoplasm] (R-MMU-5619398)	0.623	4
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.623	5
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.597	6
UniProt:O43823 AKAP8			0.576	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.564	2
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	4
UniProt:O15294 OGT	1	OGT [nucleoplasm] (R-HSA-3321845)	0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.499	2
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.499	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) SUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.499	3
UniProt:Q9UMN6 KMT2B	1	KMT2B [nucleoplasm] (R-HSA-1183216)	0.462	2
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.462	2
UniProt:Q6UXN9 WDR82			0.462	2
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.462	4
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.462	3

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