Reactome | ASH2L [nucleoplasm]

ASH2L [nucleoplasm]

Stable Identifier

R-HSA-1629834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein, ASH2L1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UBL3 ASH2L

Gene Names

ASH2L, ASH2L1

Chain

chain:1-628

Reference Genes

BioGPS Gene:9070 ASH2L

COSMIC (genes):ASH2L ASH2L

CTD Gene:9070 ASH2L

dbSNP Gene:9070 ASH2L

ENSEMBL:ENSG00000129691 ASH2L

HGNC:744 ASH2L

KEGG Gene (Homo sapiens):9070 ASH2L

Monarch:9070 ASH2L

NCBI Gene:9070 ASH2L

OMIM:604782 ASH2L

UCSC:Q9UBL3 ASH2L

Reference Transcript

Other Identifiers

0003390670

11739012_a_at

11739013_s_at

17067970

209517_s_at

3094448

3094449

3094450

3094451

3094452

3094453

3094457

3094458

3094460

3094462

3094465

3094466

3094468

3094469

3094472

3094473

3094474

3094476

3094480

3094481

3094482

3094483

3094484

35804_at

8145894

9070

A_14_P119074

A_23_P134827

GE54534

GO:0000976

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006325

GO:0006464

GO:0006950

GO:0006974

GO:0008013

GO:0008150

GO:0008168

GO:0008283

GO:0008284

GO:0022607

GO:0030097

GO:0030154

GO:0032991

GO:0035097

GO:0042800

GO:0043167

GO:0043226

GO:0043627

GO:0044666

GO:0045652

GO:0046872

GO:0048188

GO:0048856

GO:0051276

GO:0051568

GO:0065003

GO:1904837

HMNXSV003045628

ILMN_1666933

PH_hs_0000696

TC08000283.hg

g4417209_3p_a_at

Participates

as a component of

as an input of

Recruitment of SET1 methyltransferase complex (Homo sapiens)

as an output of

APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)

Inferred To

ash-2 [nucleoplasm] (Caenorhabditis elegans)

Ash2l [nucleoplasm] (Mus musculus)

Ash2l [nucleoplasm] (Rattus norvegicus)

BRE2 [nucleoplasm] (Saccharomyces cerevisiae)

ash2 [nucleoplasm] (Drosophila melanogaster)

ash2l [nucleoplasm] (Danio rerio)

ash2l [nucleoplasm] (Xenopus tropicalis)

ASH2L [nucleoplasm] (Bos taurus)

ASH2L [nucleoplasm] (Canis familiaris)

ASH2L [nucleoplasm] (Dictyostelium discoideum)

ASH2L [nucleoplasm] (Gallus gallus)

ASH2L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004665.2, NP_001098684.1, NP_001248761.1

OpenTargets

ENSG00000129691

GeneCards

Q9UBL3

HPA

ENSG00000129691-ASH2L

Ensembl

ENSP00000340896, ENSP00000395310, ENST00000343823, ENST00000521652, ENSG00000129691, ENSP00000430259, ENST00000428278

PRO

Q9UBL3

Pharos - Targets

Q9UBL3

GlyGen

Q9UBL3

PDB

6W5I, 5F6K, 6KIU, 6PWV, 6E2H, 5F6L, 6KIV, 6KIW, 6W5M, 4RIQ, 4X8N, 3S32, 7BRE, 3TOJ, 4X8P, 3RSN, 6KIX, 6W5N, 6KIZ

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.977	37
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.965	22
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.942	15
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.918	14
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.845	8
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.812	9
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.794	12
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.773	5
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.748	6
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.69	7
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.643	7
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.623	5
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619398) Paxip1 [nucleoplasm] (R-MMU-5619395)	0.623	4
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.604	3
UniProt:Q9UMN6 KMT2B	1	KMT2B [nucleoplasm] (R-HSA-1183216)	0.597	3
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.597	3
UniProt:Q6UXN9 WDR82			0.597	3
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.597	5
UniProt:O43823 AKAP8			0.576	3
UniProt:O75460-2 ERN1			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [nucleoplasm] (R-HSA-912480) HSPA2 [cytosol] (R-HSA-3371408)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.536	2
UniProt:Q9H4Z2 ZNF335	1	ZNF335 [nucleoplasm] (R-HSA-6810129)	0.532	3
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.527	2
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	4
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.499	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.499	3
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.462	3

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