Reactome | p-S337-PPP2R5C [cytosol]

p-S337-PPP2R5C [cytosol]

Stable Identifier

R-HSA-6811447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        MAPKs phosphorylate PP2A (Homo sapiens)
        
        p-S368-PPP2R5B,p-S337-PPP2R5C [cytosol] (Homo sapiens)
        
        p-S337-PPP2R5C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13362 PPP2R5C

Gene Names

PPP2R5C, KIAA0044

Chain

chain:1-524

Reference Genes

BioGPS Gene:5527 PPP2R5C

COSMIC (genes):PPP2R5C PPP2R5C

CTD Gene:5527 PPP2R5C

dbSNP Gene:5527 PPP2R5C

ENSEMBL:ENSG00000078304 PPP2R5C

HGNC:9311 PPP2R5C

KEGG:hsa:5527 PPP2R5C

Monarch:5527 PPP2R5C

NCBI Gene:5527 PPP2R5C

OMIM:601645 PPP2R5C

UCSC:Q13362 PPP2R5C

Reference Transcript

Participates

as a member of

p-S368-PPP2R5B,p-S337-PPP2R5C [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2R5C [cytosol]

PPP2R5C [nucleoplasm]

Inferred To

phospho-ppp2r5cb [cytosol] (Danio rerio)

phospho-p-S337-PPP2R5C [cytosol] (Bos taurus)

phospho-p-S337-PPP2R5C [cytosol] (Canis familiaris)

phospho-PPP2R5C [cytosol] (Sus scrofa)

phospho-Ppp2r5c [cytosol] (Mus musculus)

phospho-Ppp2r5c [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 337

Coordinate

337

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001155197.1, NP_848702.1, NP_848701.1, XP_011535222.1, XP_005267884.1, NP_001339841.1, NP_002710.2, NP_001155198.1

OpenTargets

ENSG00000078304

ENSEMBL

ENSP00000329009, ENSP00000408389, ENSP00000333905, ENSG00000078304, ENST00000445439, ENSP00000262239, ENST00000422945, ENSP00000412324, ENST00000350249, ENST00000328724, ENST00000334743

HPA

ENSG00000078304-PPP2R5C

GeneCards

PPP2R5C

PRO

Q13362

Pharos - Targets

Q13362

GlyGen

Q13362

PDB

2NYL, 2IAE, 7SOY, 2NYM, 6VRO, 6OYL, 3FGA, 5SWF, 5JJA, 6TOQ, 5K6S, 7PEL, 2NPP, 6VOY, 7OUF, 7OUH, 2JAK, 5SW9, 7OUG

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.934	11
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.65	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.558	5
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.544	2
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.527	2
UniProt:Q5FBB7 SGO1	3	SGOL1 [cytosol] (R-HSA-376227) SGO1 [nucleoplasm] (R-HSA-2468161) p-S-SGO1 [nucleoplasm] (R-HSA-9929718)	0.527	3
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	2

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