Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
VRK1 [cytosol]
Stable Identifier
R-HSA-2995381
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
ANKLE2 binds VRK1,(VRK2) (Homo sapiens)
ANKLE2:VRK1/VRK2 [endoplasmic reticulum membrane] (Homo sapiens)
VRK1,(VRK2) [cytosol] (Homo sapiens)
VRK1 [cytosol] (Homo sapiens)
VRK1,(VRK2) [cytosol] (Homo sapiens)
VRK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99986 VRK1
Gene Names
VRK1
Chain
chain:1-396
Reference Genes
BioGPS Gene:7443 VRK1
COSMIC (genes):VRK1 VRK1
CTD Gene:7443 VRK1
dbSNP Gene:7443 VRK1
ENSEMBL:ENSG00000100749 VRK1
HGNC:12718 VRK1
KEGG Gene (Homo sapiens):7443 VRK1
Monarch:7443 VRK1
NCBI Gene:7443 VRK1
OMIM:602168 VRK1
UCSC:Q99986 VRK1
Reference Transcript
RefSeq:NM_003384.2 VRK1
Other Identifiers
11743536_at
16788142
203856_at
3550527
3550536
3550537
3550538
3550540
3550541
3550543
3550544
3550545
3550546
3550547
3550554
3550562
3550563
3550564
3550565
39980_at
7443
7976621
AB000449_at
A_14_P125646
A_14_P139143
A_23_P76761
GO:0000166
GO:0000278
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0005795
GO:0005819
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0007049
GO:0007077
GO:0007084
GO:0008150
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0019901
GO:0031493
GO:0035175
GO:0042393
GO:0043167
GO:0043226
GO:0043987
GO:0046777
GO:0051276
GO:0051301
GO:0061024
GO:0072354
GO:0072355
GO:0090166
GO:0106310
GO:0106311
PH_hs_0025158
TC14000608.hg
g4507902_3p_at
Participates
as a member of
VRK1,(VRK2) [cytosol] (Homo sapiens)
Other forms of this molecule
VRK1 [nucleoplasm]
Inferred To
Vrk1 [cytosol]
(Mus musculus)
Vrk1 [cytosol]
(Rattus norvegicus)
Homologues of VRK1 [cytosol]
(Drosophila melanogaster)
vrk-1 [cytosol]
(Caenorhabditis elegans)
VRK1 [cytosol]
(Canis familiaris)
VRK1 [cytosol]
(Gallus gallus)
VRK1 [cytosol]
(Sus scrofa)
BcDNA.LD23371 [cytosol]
(Drosophila melanogaster)
vrk1 [cytosol]
(Danio rerio)
ball [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003375.1
OpenTargets
ENSG00000100749
GeneCards
Q99986
HPA
ENSG00000100749-VRK1
ZINC target
Q99986
Ensembl
ENSG00000100749
,
ENST00000216639
,
ENSP00000216639
PRO
Q99986
Orphanet
18602
HMDB Protein
HMDBP01270
PDB
6BP0
,
5UKF
,
6NPN
,
6BU6
,
6CNX
,
6VZH
,
2KUL
,
2RSV
,
6DD4
,
5UVF
,
6BTW
,
2KTY
,
2LAV
,
3OP5
,
6CQH
,
6AC9
,
6BRU
,
6CFM
,
6CSW
,
6CMM
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.761
11
UniProt:P05412 JUN
4
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [nucleoplasm]
(R-HSA-450250)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.675
5
UniProt:O60934 NBN
3
NBN [nucleoplasm]
(R-HSA-75163)
NBN [cytosol]
(R-HSA-5684005)
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
0.65
13
UniProt:Q96GD4 AURKB
3
AURKB [nucleoplasm]
(R-HSA-4655360)
SUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [cytosol]
(R-HSA-174231)
0.65
14
UniProt:Q9H4B4 PLK3
1
PLK3 [nucleoplasm]
(R-HSA-3222161)
0.65
12
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.645
6
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.61
14
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
SUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
0.602
8
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.571
5
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text