Reactome | VRK1 [cytosol]

VRK1

Stable Identifier

R-HSA-2995381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope Reformation (Homo sapiens)
        
        ANKLE2 binds VRK1 or VRK2 (Homo sapiens)
        
        ANKLE2:VRK1/VRK2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        VRK1/VRK2 [cytosol] (Homo sapiens)
        
        VRK1 [cytosol] (Homo sapiens)
        
        VRK1/VRK2 [cytosol] (Homo sapiens)
        
        VRK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99986 VRK1

Gene Names

VRK1

Chain

chain:1-396

Reference Genes

BioGPS Gene:7443 VRK1

COSMIC (genes):VRK1 VRK1

CTD Gene:7443 VRK1

dbSNP Gene:7443 VRK1

ENSEMBL:ENSG00000100749 VRK1

HGNC:12718 VRK1

KEGG Gene (Homo sapiens):hsa:7443 VRK1

Monarch:7443 VRK1

NCBI Gene:7443 VRK1

OMIM:602168 VRK1

UCSC:Q99986 VRK1

Reference Transcript

RefSeq:NM_003384.2 VRK1

Other Identifiers

0005570129

11743536_at

16788142

17929

203856_at

2KTY

2KUL

2LAV

2RSV

3550527

3550536

3550537

3550538

3550540

3550541

3550543

3550544

3550545

3550546

3550547

3550554

3550562

3550563

3550564

39980_at

3OP5

5UKF

5UVF

660

7443

7976621

A_14_P125646

A_14_P139143

A_23_P76761

AB000449_at

CCDS9947

ENSG00000100749

ENSP00000216639

ENST00000216639

EntrezGene:7443

g4507902_3p_at

GE53012

GO:0000166

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005795

GO:0005819

GO:0005829

GO:0005856

GO:0006468

GO:0007049

GO:0007077

GO:0007084

GO:0008360

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0031493

GO:0035175

GO:0043987

GO:0046777

GO:0051301

GO:0072354

GO:0072355

GO:0090166

HGNC:12718

HPA000660

HPA017929

Hs.422662

ILMN_1805828

MIM:602168

MIM:607596

NM_003384

NP_003375

PF00069

PH_hs_0025158

SM00220

TC14000608.hg

uc001yft.4

UPI0000073867

VRK1

VRK1-201

XM_006720247

XM_011537132

XM_017021622

XM_017021624

XM_017021625

XM_017021626

XP_006720310

XP_011535434

XP_016877111

XP_016877113

XP_016877114

XP_016877115

XR_001750539

Participant Of

hasMember

VRK1/VRK2 [cytosol]

Other forms of this molecule

VRK1 [nucleoplasm]

Inferred To

Homologues of VRK1 [cytosol] (Drosophila melanogaster)

VRK1 [cytosol] (Bos taurus)

VRK1 [cytosol] (Caenorhabditis elegans)

VRK1 [cytosol] (Canis familiaris)

VRK1 [cytosol] (Danio rerio)

VRK1 [cytosol] (Drosophila melanogaster)

VRK1 [cytosol] (Gallus gallus)

VRK1 [cytosol] (Mus musculus)

VRK1 [cytosol] (Rattus norvegicus)

VRK1 [cytosol] (Sus scrofa)

VRK1 [cytosol] (Taeniopygia guttata)

VRK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003375.1

Brenda

2.7.11.1

GeneCards

Q99986

DOCK Blaster

3OP5, 5UKF, 5UVF

ZINC target

Q99986

PRO

Q99986

Orphanet

18602

HMDB Protein

HMDBP01270

PDB

6BTW, 6BU6, 5UKF, 5UVF, 2KUL, 2LAV, 6BW7, 6BP0, 6BRU, 2RSV, 3OP5, 2KTY

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
ATP [ChEBI:15422]	13	ATP [mitochondrial intermembrane space] (R-ALL-5696069) ATP [phagocytic vesicle] (R-ALL-6798184) ATP [peroxisomal matrix] (R-ALL-389573) ATP [platelet dense granule lumen] (R-ALL-114571) ATP [endoplasmic reticulum lumen] (R-ALL-8931885) ATP [endosome] (R-ALL-190078) ATP [plasma membrane] (R-ALL-139836) ATP [mitochondrial matrix] (R-ALL-113593) ATP [cilium] (R-ALL-5632460) ATP [endoplasmic reticulum membrane] (R-ALL-211579) ATP [extracellular region] (R-ALL-114570) ATP [cytosol] (R-ALL-113592) ATP [nucleoplasm] (R-ALL-29358)	0.73	9
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb-TP53 [cytosol] (R-HSA-6793681) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.675	9
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.675	5
UniProt:O60934 NBN	3	NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.65	13
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.65	12
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.61	14
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.602	8
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.571	5