Reactome | EAF2 [nucleoplasm]

EAF2 [nucleoplasm]

Stable Identifier

R-HSA-8932790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ELL-associated factor 2, EAF2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96CJ1 EAF2

Gene Names

EAF2, TRAITS, BM-040

Chain

chain:1-260

Reference Genes

BioGPS Gene:55840 EAF2

COSMIC (genes):EAF2 EAF2

CTD Gene:55840 EAF2

dbSNP Gene:55840 EAF2

ENSEMBL:ENSG00000145088 EAF2

ENSEMBL_homo_sapiens_GENE:ENSG00000145088.9 EAF2

HGNC:23115 EAF2

KEGG Gene (Homo sapiens):55840 EAF2

Monarch:55840 EAF2

NCBI Gene:55840 EAF2

OMIM:607659 EAF2

UCSC:Q96CJ1 EAF2

Reference Transcript

Other Identifiers

11751698_a_at

16944574

219551_PM_at

219551_at

2638688

2638689

2638698

2638704

2638706

2638708

2638714

2638715

2638716

43990_at

55840

8082003

A_14_P119916

A_23_P252201

GE61955

GO:0003711

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006368

GO:0006915

GO:0008023

GO:0012501

GO:0016607

GO:0022414

GO:0030308

GO:0032783

GO:0034243

GO:0043226

GO:0045893

GO:0045944

GO:0048856

GO:0060767

GO:0060770

GO:0140110

HMNXSV003016612

ILMN_1708798

PH_hs_0018693

TC03000624.hg

g8922098_3p_at

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

eaf2 [nucleoplasm] (Xenopus tropicalis)

eaf1 [nucleoplasm] (Schizosaccharomyces pombe)

Eaf2 [nucleoplasm] (Mus musculus)

Eaf2 [nucleoplasm] (Rattus norvegicus)

eaf-1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of EAF2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of EAF2 [nucleoplasm] (Saccharomyces cerevisiae)

EAF2 [nucleoplasm] (Bos taurus)

EAF2 [nucleoplasm] (Canis familiaris)

EAF2 [nucleoplasm] (Gallus gallus)

EAF2 [nucleoplasm] (Sus scrofa)

Eaf [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_060926.2, XP_016862350.1, NP_001306970.1, XP_016862351.1

OpenTargets

ENSG00000145088

HPA

ENSG00000145088-EAF2

GeneCards

Q96CJ1

Ensembl

ENSP00000273668, ENSG00000145088, ENST00000273668

PRO

Q96CJ1

Pharos - Targets

Q96CJ1

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N7W2-2 BEND7			0.696	5
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.643	3
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.621	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.527	2
UniProt:P48426 PIP4K2A	2	PIP4K2A [nucleoplasm] (R-HSA-6811484) PIP4K2A [cytosol] (R-HSA-1604641)	0.527	2
UniProt:Q9HB65 ELL3	1	ELL3 [nucleoplasm] (R-HSA-6807497)	0.527	3
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.524	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.508	4
UniProt:Q96MF2 STAC3			0.488	2
UniProt:Q7Z6G3-2 NECAB2			0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q8ND90 PNMA1			0.488	2
UniProt:Q8N448 LNX2			0.488	2

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