PIK3CA H1047R [cytosol]

Stable Identifier
R-HSA-1500716
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
PIK3CA His1047Arg
PIK3CA H1047R [cytosol] icon
Locations in the PathwayBrowser
General

Substitution of histidine residue with arginine at position 1047 in the kinase domain of PIK3CA is predicted, based on PIK3CA crystal structure, to change the conformation of the activation loop (Huang et al. 2007). The PI3K complex containing PIK3CA H1047R mutant is constitutively active, in the absence of growth factors (Zhao et al. 2005, Horn et al. 2008), but its activity may be additional boosted by binding of PIK3R1 regulatory subunit to phosphopeptides generated by activated receptor tyrosine kinases (Hon et al. 2011).

Literature References
PubMed ID Title Journal Year
22120714 Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

Williams, RL, Hon, WC, Berndt, A

Oncogene 2011
18079394 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Samuels, Y, Mandelker, D, Schmidt-Kittler, O, Kinzler, KW, Vogelstein, B, Amzel, LM, Gabelli, SB, Velculescu, VE, Huang, CH

Science 2007
18317450 Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells

Stocking, C, Bäsecke, J, Bergholz, U, Trümper, L, Horn, S, McCubrey, JA, Jücker, M

Oncogene 2008
16339315 The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

Liu, Z, Shin, E, Roberts, TM, Wang, L, Loda, MF, Zhao, JJ

Proc. Natl. Acad. Sci. U.S.A. 2005
15016963 High frequency of mutations of the PIK3CA gene in human cancers

Ptak, J, Samuels, Y, Silliman, N, Yan, H, Gazdar, A, Riggins, GJ, Markowitz, S, Powell, SM, Szabo, S, Wang, Z, Willson, JKV, Bardelli, A, Kinzler, KW, Vogelstein, B, Velculescu, VE

Science 2004
External Reference Information
External Reference
Gene Names
PIK3CA
Chain
chain:1-1068
Other Identifiers
11745214_a_at
11763283_at
16948209
17122920
17122922
204369_PM_at
204369_at
231854_PM_at
231854_at
235980_PM_at
235980_at
2653841
2653852
2653853
2653855
2653856
2653857
2653858
2653860
2653861
2653862
2653864
2653865
2653866
2653867
2653868
2653869
2653871
2653872
2653873
2653875
2653876
2653877
2653879
2653880
2653881
2653882
2653883
2653884
2653885
2653890
3935885
3935887
3935891
3935893
3935895
3935897
40704_at
41969_at
5290
55954_at
8084016
81516_at
81657_at
83177_at
90039_at
A_14_P113684
A_14_P127878
A_14_P128410
A_21_P0012238
A_23_P92057
GE60386
GE88555
GO:0000166
GO:0001525
GO:0001889
GO:0001932
GO:0001944
GO:0002376
GO:0003012
GO:0003013
GO:0003824
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0005944
GO:0005975
GO:0006006
GO:0006091
GO:0006325
GO:0006629
GO:0006909
GO:0006914
GO:0007010
GO:0007155
GO:0007173
GO:0008286
GO:0010468
GO:0010592
GO:0010629
GO:0012501
GO:0014065
GO:0014704
GO:0014823
GO:0014870
GO:0016192
GO:0016242
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0030027
GO:0030036
GO:0030168
GO:0030295
GO:0030835
GO:0031295
GO:0032008
GO:0033138
GO:0035004
GO:0035005
GO:0035994
GO:0036092
GO:0036211
GO:0038028
GO:0038084
GO:0040014
GO:0042060
GO:0043201
GO:0043276
GO:0043457
GO:0043491
GO:0043524
GO:0043542
GO:0043560
GO:0044029
GO:0046854
GO:0046934
GO:0048009
GO:0048015
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050852
GO:0051897
GO:0052812
GO:0055119
GO:0060048
GO:0060612
GO:0071333
GO:0071464
GO:0071514
GO:0071548
GO:0086003
GO:0097009
GO:0098772
GO:0106310
GO:0110053
GO:0140096
GO:1903544
GO:2000270
GO:2000811
HMNXSV003040760
Hs.120905.0.S1_3p_at
Hs.122419.0.S1_3p_at
ILMN_1705396
ILMN_1705468
PH_hs_0031379
TC03000951.hg
TC03002674.hg
TC22000929.hg
Z29090_at
g5453891_3p_at
p28442
Participates
Other forms of this molecule
Modified Residues
Name
L-histidine 1047 replaced with L-arginine
Coordinate
1047
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-arginine.
A protein modification that effectively removes or replaces an L-histidine.
Disease
Name Identifier Synonyms
dysembryoplastic neuroepithelial tumor DOID:2679 Dysembryoplastic Neuroepithelial neoplasm, Dysembryoplastic neuroepithelial tumor (morphologic abnormality)
brain meningioma DOID:0060106
peripheral primitive neuroectodermal tumor DOID:3369 Ewings sarcoma-primitive neuroectodermal tumor, Ewing's sarcoma/peripheral primitive neuroectodermal tumor, Ewing's tumor, Ewing's tumor, Ewings sarcoma, Ewing sarcoma, PNET of Thoracopulmonary Region
thyroid cancer DOID:1781 Thyroid gland neoplasm, thyroid cancer, thyroid neoplasm, neoplasm of thyroid gland, thyroid neoplasm, Thyroid neoplasm, malignant tumour of thyroid gland, malignant neoplasm of thyroid gland
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
non-Hodgkin lymphoma DOID:0060060
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
pituitary adenoma DOID:3829 Pituitary adenoma - disorder, Pituitary adenoma, no ICD-O subtype (morphologic abnormality), Pituitary adenoma, Pituitary adenoma, Pituitary adenoma (disorder), adenoma of the Pituitary gland, Pituitary adenoma
pancreatic cancer DOID:1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
gallbladder carcinoma DOID:4948 cancer of the gallbladder, carcinoma gallbladder, carcinoma gallbladder, carcinoma gallbladder, carcinoma of gallbladder (disorder)
pharynx cancer DOID:0060119
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
ovarian endometrioid neoplasm DOID:6212 malignant ovarian endometrioid tumor, endometrioid neoplasm of Ovary
medulloblastoma DOID:0050902
oral cavity cancer DOID:8618 malignant tumor of lateral floor of mouth (disorder), malignant tumor of anterior floor of mouth (disorder), malignant neoplasm of other sites of floor of mouth, malignant tumor of floor of mouth (disorder), malignant neoplasm of anterior portion of floor of mouth, malignant neoplasm of lateral floor of mouth, malignant neoplasm of floor of mouth, NOS, malignant neoplasm of other sites of floor of mouth (disorder), malignant neoplasm of floor of mouth NOS (disorder), malignant neoplasm of floor of mouth, oral cavity cancer, malignant tumor of the Floor of the Mouth, malignant neoplasm of lateral portion of floor of mouth, malignant neoplasm of floor of mouth
prostate cancer DOID:10283 NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm
lung cancer DOID:1324
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
seborrheic keratosis DOID:6498
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
cervical cancer DOID:4362 neoplasm of uterine cervix (disorder), tumor of the Cervix Uteri, cervix uteri cancer, cervical neoplasm, cervix cancer
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
brain glioma DOID:0060108
glioblastoma multiforme DOID:3068 GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P27986 PIK3R1  16 0.965 63
 UniProt:O00459 PIK3R2  2 0.864 48
 UniProt:P35568 IRS1  5 0.853 42
 UniProt:Q92569 PIK3R3  2 0.845 45
 UniProt:P62993 GRB2  1 0.742 5
 UniProt:P21860 ERBB3      0.723 18
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:P01100 FOS  2 0.556 3
 UniProt:P54253 ATX1      0.556 3
 UniProt:P54252 ATXN3  2 0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:P03496 NS  2 0.527 7
 UniProt:P42336 PIK3CA  20 0.462 3
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