Reactome | p-S351-NR4A1 [nucleoplasm]

p-S351-NR4A1 [nucleoplasm]

Stable Identifier

R-HSA-199846

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-Orphan nuclear receptor NR4A1, NR41_HUMAN, NR4A1

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External Reference Information

External Reference

UniProt:P22736 NR4A1

Gene Names

NR4A1, GFRP1, HMR, NAK1

Chain

chain:1-598

Reference Genes

BioGPS Gene:3164 NR4A1

COSMIC (genes):NR4A1 NR4A1

CTD Gene:3164 NR4A1

dbSNP Gene:3164 NR4A1

ENSEMBL:ENSG00000123358 NR4A1

ENSEMBL_homo_sapiens_GENE:ENSG00000123358.20 NR4A1

HGNC:7980 NR4A1

KEGG Gene (Homo sapiens):3164 NR4A1

Monarch:3164 NR4A1

NCBI Gene:3164 NR4A1

OMIM:139139 NR4A1

UCSC:P22736 NR4A1

Reference Transcript

Other Identifiers

11717994_a_at

11717995_x_at

11749725_a_at

11749726_x_at

11754772_s_at

11759135_x_at

11760979_at

202340_PM_x_at

202340_x_at

210226_PM_at

210226_at

279_at

280_g_at

3164

32265_at

3415233

3415234

3415240

3415241

3415242

3415245

3415248

3415249

3415250

3415251

3415252

3415253

3415254

3415255

3415256

3415257

3415258

3415259

3415260

3415262

3415263

3415265

3415267

3415268

3415269

3415270

3415271

3415272

7955589

A_23_P128230

A_23_P309278

A_33_P3319791

D85245_at

GE57232

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001530

GO:0001938

GO:0001975

GO:0002042

GO:0003012

GO:0003677

GO:0003690

GO:0003700

GO:0004879

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006915

GO:0006954

GO:0007165

GO:0008270

GO:0008289

GO:0012501

GO:0014860

GO:0023052

GO:0030154

GO:0030522

GO:0031965

GO:0032496

GO:0032497

GO:0035259

GO:0035767

GO:0035914

GO:0035924

GO:0042802

GO:0043065

GO:0043226

GO:0043565

GO:0044344

GO:0045444

GO:0045786

GO:0045893

GO:0045944

GO:0046872

GO:0046982

GO:0048856

GO:0048870

GO:0050877

GO:0050896

GO:0051602

GO:0060089

GO:0061469

GO:0071310

GO:0071376

GO:0098793

GO:0140110

GO:0160075

GO:1990837

HMNXSV003049759

ILMN_1661178

ILMN_2408566

ILMN_2410145

L13740_at

PH_hs_0000146

TC12000414.hg

g1339917_3p_at

g1813881_3p_a_at

Participates

as an output of

Other forms of this molecule

NR4A1 [nucleoplasm]

Inferred To

phospho-nhr-6 [nucleoplasm] (Caenorhabditis elegans)

phospho-NR4A1 [nucleoplasm] (Bos taurus)

phospho-NR4A1 [nucleoplasm] (Canis familiaris)

phospho-NR4A1 [nucleoplasm] (Sus scrofa)

phospho-nr4a1 [nucleoplasm] (Danio rerio)

phospho-nr4a1 [nucleoplasm] (Xenopus tropicalis)

phospho-Hr38 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S351-NR4A1 [nucleoplasm] (Gallus gallus)

phospho-Nr4a1 [nucleoplasm] (Mus musculus)

phospho-Nr4a1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 351

Coordinate

351

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_006719427.1, NP_775180.1, NP_001189162.1, XP_005268881.1, NP_002126.2, XP_006719426.1

Guide to Pharmacology - Targets

629

OpenTargets

ENSG00000123358

ZINC - Substances

NR4A1_HUMAN

ZINC target

P22736

ZINC - Biogenic

NR4A1_HUMAN

PRO

P22736

PDB

4KZJ, 2QW4, 3V3E, 6KZ5, 8WUY, 4KZM, 4REE, 4RZE, 6LC1, 4JGV, 4RZG, 4RZF, 3V3Q, 4WHF, 4RE8, 4KZI, 4REF, 4WHG

HPA

ENSG00000123358-NR4A1

GeneCards

P22736

Ensembl

ENSG00000123358, ENST00000394824, ENSP00000243050, ENSP00000353427, ENST00000550082, ENSP00000378301, ENSP00000378302, ENST00000394825, ENSP00000449539, ENST00000548232, ENSP00000449587, ENST00000360284, ENST00000243050

Pharos - Targets

P22736

ZINC - Predictions - Purchasable

NR4A1_HUMAN

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.674	7
UniProt:P55273 CDKN2D	1	CDKN2D [cytosol] (R-HSA-182580)	0.666	4
IntAct:EBI-20568042 NURRE			0.645	5
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.623	6
UniProt:P40305-2 IFI27			0.61	8
UniProt:P32189 GK	1	GK [cytosol] (R-HSA-55717)	0.581	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.581	6
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:Q96JS3 PGBD1			0.556	3
IntAct:EBI-10173330 386677			0.556	3
UniProt:Q13162 PRDX4	3	PRDX4 [secretory granule lumen] (R-HSA-6803305) PRDX4 [extracellular region] (R-HSA-6806512) PRDX4 [ficolin-1-rich granule lumen] (R-HSA-6803286)	0.553	2
UniProt:P03120 VE2			0.553	3
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	2
UniProt:Q504T8 MIDN			0.527	2
UniProt:O60888 CUTA			0.524	2
UniProt:P04350 TUBB4A	6	TUBB4A [cytosol] (R-HSA-190588) TUBB4A [axonemal microtubule] (R-HSA-5610435) Polyglutamyl-TUBB4A [cytosol] (R-HSA-8867425) Polyglycyl-TUBB4A [cytosol] (R-HSA-8867397) TUBB4A unfolded [cytosol] (R-HSA-392778) TUBB4A folding intermediate [cytosol] (R-HSA-392789)	0.524	2
UniProt:Q9P2G1 AKIB1			0.524	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.524	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.508	3
UniProt:Q9Y4D7 PLXND1	1	PLXND1 [plasma membrane] (R-HSA-209637)	0.508	2

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