FXR1(2-784)-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802326
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
23583981 Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

Lu, C, Dooling, DJ, Qaddoumi, I, Parker, M, Ellison, DW, Rusch, M, Easton, J, Miller, CP, Hedlund, E, Vadodaria, B, Downing, JR, Orisme, W, Tatevossian, RG, Wilson, RK, Wang, J, Zhao, D, Sheer, D, Kriwacki, R, Lee, R, Huether, R, Becksfort, J, Shurtleff, S, Wu, G, Boop, FA, Kandoth, C, Chen, X, Ma, J, Boggs, K, Baker, SJ, Gajjar, A, Fulton, RS, Mardis, ER, Fulton, LL, Gilbertson, RJ, Cheng, J, Wei, L, Tang, B, Punchihewa, C, Dalton, JD, Song, G, Mulder, HL, Ochoa, K, Ding, L, Tang, C, Nagahawatte, P, Mullighan, CG, Zhang, J, Li, Y

Nat. Genet. 2013
External Reference Information
External Reference
UniProt:P51114 FXR1
Gene Names
FXR1
Chain
initiator methionine:1, chain:2-621
Reference Genes
BioGPS Gene:8087 FXR1
COSMIC (genes):FXR1 FXR1
CTD Gene:8087 FXR1
dbSNP Gene:8087 FXR1
ENSEMBL:ENSG00000114416 FXR1
ENSEMBL:ENSG00000114416.19 FXR1
HGNC:4023 FXR1
KEGG Gene (Homo sapiens):8087 FXR1
Monarch:8087 FXR1
NCBI Gene:8087 FXR1
OMIM:600819 FXR1
UCSC:P51114 FXR1
Reference Transcript
Other Identifiers
11719715_a_at
11733886_a_at
16948401
201635_PM_s_at
201635_s_at
201636_PM_at
201636_at
201637_PM_s_at
201637_s_at
230201_PM_at
230201_at
235960_PM_at
235960_at
2654395
2654396
2654397
2654405
2654407
2654412
2654413
2654414
2654415
2654417
2654419
2654421
2654423
2654424
2654426
2654427
2654428
2654432
2654433
2654440
2654443
2654444
2654445
2654446
2654448
2654450
2654452
2654453
3451350
3451354
38405_at
47528_at
56014_at
77778_at
77996_at
8084146
8087
A_14_P105619
A_14_P116592
A_24_P345781
A_32_P16954
GE59029
GE841476
GO:0000381
GO:0001934
GO:0003676
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005634
GO:0005635
GO:0005730
GO:0005737
GO:0005829
GO:0005844
GO:0006417
GO:0006915
GO:0006954
GO:0007283
GO:0007286
GO:0007517
GO:0010494
GO:0010608
GO:0012501
GO:0014069
GO:0016020
GO:0016071
GO:0017148
GO:0021542
GO:0022414
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0030426
GO:0031047
GO:0032720
GO:0033592
GO:0035770
GO:0035925
GO:0036211
GO:0036464
GO:0042803
GO:0042995
GO:0043025
GO:0043034
GO:0043197
GO:0043226
GO:0043232
GO:0043488
GO:0044326
GO:0045182
GO:0045187
GO:0045202
GO:0045727
GO:0046982
GO:0048471
GO:0048856
GO:0050728
GO:0050767
GO:0051292
GO:0051489
GO:0051664
GO:0051966
GO:0060090
GO:0060538
GO:0061157
GO:0065003
GO:0098793
GO:0098794
GO:0098978
GO:0140693
GO:0140694
GO:1900272
GO:1902737
GO:2000637
HMNXSV003010732
Hs.244639.0.A1_3p_at
Hs.82712.0.S1_3p_a_at
Hs.82712.0.S3_3p_at
Hs.91789.0.A1_3p_at
ILMN_1679640
ILMN_1704335
ILMN_2389273
PH_hs_0024722
TC03000965.hg
TC03002679.hg
TC03002680.hg
U25165_at
g4826735_3p_a_at
Participates
as a component of
Other forms of this molecule
FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 785 from UniProt:P15056 BRAF
Coordinate
785
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
pilocytic astrocytoma DOID:4851 Piloid astrocytoma, grade I Astrocytic tumor
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04792 HSPB1  3 0.553 2
 UniProt:Q674X7 KAZN  1 0.508 2
 UniProt:P07437 TUBB  3 0.508 2
 UniProt:P21333 FLNA  3 0.508 2
 UniProt:P04637 TP53  20 0.508 2
 UniProt:Q96CW1 AP2M1  6 0.508 2
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