Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NFYA [nucleoplasm]
Stable Identifier
R-HSA-420841
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NF-YA
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of XBP1(S) (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)
FOXO1,FOXO3,(FOXO4):NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)
FOXO1,FOXO3,(FOXO4):NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:DHCR7 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:GGPS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:IDI1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:CYP51A1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)
SREBP1A,2:NF-Y:SC5DL gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Mevalonate Kinase (MVK) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:MVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)
SREBP1A,2:NF-Y:SP1:PMVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)
SREBP1A,2:SQLE gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of TM7SF2 (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the FASN promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the GPAM promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:CYP51A1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:DHCR7 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the GGPS1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:GGPS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the HMGCR promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the IDI1 promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:IDI1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the MVK promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:MVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the PMVK promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SP1:PMVK gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the SC5DL promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:NF-Y:SC5DL gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2 binds the SQLE promoter (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
SREBP1A,2:SQLE gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
SREBP1A,2:NF-Y:HMGCR gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
NF-Y [nucleoplasm] (Homo sapiens)
NFYA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23511 NFYA
Gene Names
NFYA
Chain
chain:1-347
Reference Genes
BioGPS Gene:4800 NFYA
COSMIC (genes):NFYA NFYA
CTD Gene:4800 NFYA
dbSNP Gene:4800 NFYA
ENSEMBL:ENSG00000001167 NFYA
HGNC:7804 NFYA
KEGG:hsa:4800 NFYA
Monarch:4800 NFYA
NCBI Gene:4800 NFYA
OMIM:189903 NFYA
UCSC:P23511 NFYA
Reference Transcript
RefSeq:NM_002505.4 NFYA
RefSeq:NM_021705.3 NFYA
Participates
as a component of
NF-Y [nucleoplasm] (Homo sapiens)
Inferred To
HAP2 [nucleoplasm]
(Saccharomyces cerevisiae)
nfya-1 [nucleoplasm]
(Caenorhabditis elegans)
NFYA [nucleoplasm]
(Bos taurus)
NFYA [nucleoplasm]
(Canis familiaris)
NFYA [nucleoplasm]
(Gallus gallus)
NFYA [nucleoplasm]
(Sus scrofa)
Nf-YA [nucleoplasm]
(Drosophila melanogaster)
nfyA [nucleoplasm]
(Dictyostelium discoideum)
Nfya [nucleoplasm]
(Mus musculus)
Nfya [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000353205
,
ENSP00000229418
,
ENST00000341376
,
ENSP00000345702
,
ENSG00000001167
OpenTargets
ENSG00000001167
GeneCards
NFYA
HPA
ENSG00000001167-NFYA
PRO
P23511
Pharos - Targets
P23511
GlyGen
P23511
PDB
4AWL
,
8QU2
,
6QMS
,
8QU4
,
8QU3
,
6QMP
,
6QMQ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.666
4
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.599
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.537
11
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
