Reactome | p-T32,S253,S315-FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [nucleoplasm]

Stable Identifier

R-HSA-199289

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-Forkhead box protein O3A (T32, S253, S315), FOXO3_HUMAN, FOXO3A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43524 FOXO3

Gene Names

FOXO3, FKHRL1, FOXO3A

Chain

chain:1-673

Reference Genes

BioGPS Gene:2309 FOXO3

COSMIC (genes):FOXO3 FOXO3

CTD Gene:2309 FOXO3

dbSNP Gene:2309 FOXO3

ENSEMBL:ENSG00000118689 FOXO3

ENSEMBL_homo_sapiens_GENE:ENSG00000118689 FOXO3

HGNC:3821 FOXO3

KEGG Gene (Homo sapiens):2309 FOXO3

Monarch:2309 FOXO3

NCBI Gene:2309 FOXO3

OMIM:602681 FOXO3

UCSC:O43524 FOXO3

Reference Transcript

Other Identifiers

0000050204

0006980288

11718890_x_at

11718891_s_at

11718892_s_at

11737906_x_at

11746522_s_at

11746523_x_at

11749812_s_at

11755663_s_at

204131_s_at

204132_s_at

210655_s_at

217399_3p_s_at

217399_s_at

224889_3p_at

224889_at

224891_at

2309

2920476

2920478

2920479

2920480

2920481

2920482

2920483

2920484

2920485

2920486

2920538

2920541

2920542

2920543

2920556

2K86

2LQH

2LQI

2UZK

34740_at

3748537

3748538

3748557

3748558

3748560

3748563

3748564

3748565

3748566

3748567

3748568

3748569

3748570

4074

47893_s_at

49469_at

49651_at

63104

8013307

8121365

A_23_P345575

A_32_P102062

A_33_P3240392

A_33_P3375665

AAC39592

AAH20227

AAH21224

AAH68552

BAG62858

CAA04860

CAA04861

CAB004074

CCDS5068

EAW48373

EAW48374

ENSG00000118689

ENSP00000339527

ENSP00000385824

ENSP00000446316

ENST00000343882

ENST00000406360

ENST00000540898

EntrezGene:2309

FOXO3

FOXO3-201

FOXO3-202

FOXO3-203

g4106722_3p_a_at

GE54251

GE85764

GO:0000003

GO:0000122

GO:0000978

GO:0000981

GO:0000988

GO:0001221

GO:0001227

GO:0001228

GO:0001542

GO:0001544

GO:0001547

GO:0001556

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005759

GO:0005829

GO:0006355

GO:0006357

GO:0006366

GO:0006390

GO:0006412

GO:0006417

GO:0006915

GO:0006950

GO:0007165

GO:0007267

GO:0007568

GO:0008013

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008286

GO:0009058

GO:0016020

GO:0019221

GO:0019899

GO:0019901

GO:0021700

GO:0030154

GO:0030330

GO:0030336

GO:0031490

GO:0031667

GO:0032991

GO:0033209

GO:0034246

GO:0034599

GO:0034641

GO:0040007

GO:0040011

GO:0042493

GO:0042592

GO:0042593

GO:0043065

GO:0043226

GO:0043525

GO:0043565

GO:0045648

GO:0045665

GO:0045893

GO:0045944

GO:0048854

GO:0048856

GO:0048870

GO:0071333

GO:0071386

GO:0071456

GO:0071548

GO:0090090

GO:0097150

GO:0097192

GO:1901300

GO:1903428

GO:1904646

GO:1990090

GO:1990785

GO:2000177

GO:2000353

GO:2000377

HGNC:3821

HPA063104

Hs.14845.0.A2_3p_a_at

Hs.214783.0.S1_3p_at

Hs.214783.0.S1_3p_x_at

Hs.214783.0.S2_3p_at

Hs.274468.0.S1_3p_s_at

ILMN_1681703

ILMN_1687940

ILMN_1712515

ILMN_1844692

IPR001766

IPR030456

IPR032067

IPR032068

IPR036388

IPR036390

MIM:602681

NM_001455

NM_201559

NP_001446

NP_963853

PF00250

PF16675

PF16676

PH_hs_0028777

PH_hs_0033951

PR00053

SM00339

TC06000868.hg

TC06002977.hg

uc003psk.3

uc003psm.2

uc010kdj.2

UPI000012ADEA

UPI000020E058

XM_005266868

XM_011535628

XM_011535629

XM_017010586

XP_005266925

XP_011533930

XP_011533931

XP_016866075

Participant Of

hasMember

Other forms of this molecule

p-S215 FOXO3 [nucleoplasm]

p-S215 FOXO3 [cytosol]

FOXO3 [cytosol]

FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [cytosol]

Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]

p-S43,S173,S294,S325-FOXO3 [cytosol]

p-S43,S173,S294,S325-FOXO3 [nucleoplasm]

Inferred To

Homologues of p-T32,S253,S315-FOXO3 [nucleoplasm] (Danio rerio)

Homologues of p-T32,S253,S315-FOXO3 [nucleoplasm] (Rattus norvegicus)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Bos taurus)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Canis familiaris)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Danio rerio)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Drosophila melanogaster)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Gallus gallus)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Mus musculus)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Rattus norvegicus)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Sus scrofa)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Taeniopygia guttata)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 253

Coordinate

253

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 315

Coordinate

315

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 32

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011533930.1, NP_001446.1, XP_005266925.1, XP_011533931.1, XP_016866075.1, NP_963853.1

OpenTargets

ENSG00000118689

GeneCards

O43524

DOCK Blaster

2UZK

PRO

O43524

PDB

2UZK, 2LQI, 2LQH, 2K86

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012)	0.743	9
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.713	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.704	5
UniProt:P84022 SMAD3	15	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 R268C [cytosol] (R-HSA-3702149) SMAD3 D258N [cytosol] (R-HSA-3702147) SMAD3 R268H [cytosol] (R-HSA-3702148) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.667	5
IntAct:EBI-1767788 BIM			0.59	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.589	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.589	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.564	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	3
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.564	3
UniProt:Q60987 Foxg1	2	FOXG1 [nucleoplasm] (R-MMU-9022629-2) Foxg1 [nucleoplasm] (R-MMU-9022630)	0.544	5
IntAct:EBI-1657542 ERALPHA			0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.524	3
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.499	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.499	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.499	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.499	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.499	2
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) p-RB1 [nucleoplasm] (R-HSA-188389) RB1 [nucleoplasm] (R-HSA-68642)	0.499	2
UniProt:P28749 RBL1	2	p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085) RBL1 [nucleoplasm] (R-HSA-389104)	0.499	3
IntAct:EBI-2678752 ANDR			0.462	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.462	2
IntAct:EBI-2891650 CDKN1B			0.462	2