Reactome | p-T32,S253,S315-FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [nucleoplasm]

Stable Identifier

R-HSA-199289

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-Forkhead box protein O3A (T32, S253, S315), FOXO3_HUMAN, FOXO3A

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External Reference Information

External Reference

UniProt:O43524 FOXO3

Gene Names

FOXO3, FKHRL1, FOXO3A

Chain

chain:1-673

Reference Genes

BioGPS Gene:2309 FOXO3

COSMIC (genes):FOXO3 FOXO3

CTD Gene:2309 FOXO3

dbSNP Gene:2309 FOXO3

ENSEMBL:ENSG00000118689 FOXO3

HGNC:3821 FOXO3

KEGG:hsa:2309 FOXO3

Monarch:2309 FOXO3

NCBI Gene:2309 FOXO3

OMIM:602681 FOXO3

UCSC:O43524 FOXO3

Reference Transcript

Other Identifiers

11718890_x_at

11718891_s_at

11718892_s_at

11737906_x_at

11746522_s_at

11746523_x_at

11749812_s_at

11755663_s_at

204131_PM_s_at

204131_s_at

204132_PM_s_at

204132_s_at

210655_PM_s_at

210655_s_at

217399_3p_s_at

217399_PM_s_at

217399_s_at

224889_3p_at

224889_PM_at

224889_at

224891_PM_at

224891_at

2309

2920476

2920477

2920478

2920479

2920480

2920481

2920482

2920483

2920484

2920485

2920486

2920537

2920538

2920541

2920542

2920543

2920556

2920567

2920568

2920570

2920572

2920574

2920575

34740_at

3748537

3748538

3748557

3748558

3748560

3748563

3748564

3748565

3748566

3748567

3748568

3748569

3748570

47893_s_at

49469_at

49651_at

8013307

8121365

A_23_P345575

A_32_P102062

A_33_P3240392

A_33_P3375665

GE54251

GE85764

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001221

GO:0001227

GO:0001228

GO:0001542

GO:0001544

GO:0001547

GO:0001556

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005759

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006390

GO:0006417

GO:0006915

GO:0008013

GO:0009410

GO:0010508

GO:0012501

GO:0014737

GO:0016020

GO:0019901

GO:0022414

GO:0030330

GO:0030336

GO:0031490

GO:0031667

GO:0032991

GO:0033209

GO:0034246

GO:0034599

GO:0042149

GO:0042593

GO:0042594

GO:0043065

GO:0043226

GO:0043525

GO:0043565

GO:0045591

GO:0045648

GO:0045665

GO:0045893

GO:0045944

GO:0048854

GO:0060070

GO:0070542

GO:0071333

GO:0071386

GO:0071456

GO:0071548

GO:0090090

GO:0090571

GO:0097150

GO:0097192

GO:0140110

GO:1901300

GO:1902895

GO:1903428

GO:1904646

GO:1990090

GO:1990785

GO:1990837

GO:2000177

GO:2000353

GO:2000377

HMNXSV003035668

Hs.14845.0.A2_3p_a_at

Hs.214783.0.S1_3p_at

Hs.214783.0.S1_3p_x_at

Hs.214783.0.S2_3p_at

Hs.274468.0.S1_3p_s_at

ILMN_1681703

ILMN_1687940

ILMN_1712515

ILMN_1844692

PH_hs_0028777

PH_hs_0033951

TC06000868.hg

TC06002977.hg

g4106722_3p_a_at

Participates

as an output of

as an input of

as a member of

Other forms of this molecule

FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [cytosol]

Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]

Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]

FOXO3(?-673) [mitochondrial matrix]

p-S43,S173,S294,S325-FOXO3 [cytosol]

p-S43,S173,S294,S325-FOXO3 [nucleoplasm]

FOXO3 [cytosol]

p-S215 FOXO3 [cytosol]

p-S215 FOXO3 [nucleoplasm]

Inferred To

phospho-Foxo3 [nucleoplasm] (Mus musculus)

phospho-Foxo3 [nucleoplasm] (Rattus norvegicus)

phospho-FOXO3 [nucleoplasm] (Bos taurus)

phospho-FOXO3 [nucleoplasm] (Canis familiaris)

phospho-FOXO3 [nucleoplasm] (Gallus gallus)

phospho-FOXO3 [nucleoplasm] (Sus scrofa)

phospho-foxo3 [nucleoplasm] (Xenopus tropicalis)

phospho-foxo [nucleoplasm] (Drosophila melanogaster)

phospho-foxo3b [nucleoplasm] (Danio rerio)

phospho-daf-16 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 253

Coordinate

253

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 315

Coordinate

315

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 32

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001446.1, XP_005266925.1, NP_001402077.1, NP_001402078.1, NP_001402076.1, NP_963853.1, NP_001402075.1, NP_001402073.1, XP_016866075.1, XP_011533931.1, XP_011533930.1, NP_001402074.1

OpenTargets

ENSG00000118689

ENSEMBL

ENSP00000385824, ENSP00000339527, ENSP00000446316, ENSG00000118689, ENST00000406360, ENST00000540898, ENST00000343882

GeneCards

FOXO3

HPA

ENSG00000118689-FOXO3

PRO

O43524

Pharos - Targets

O43524

GlyGen

O43524

PDB

6MNL, 7V9B, 2UZK, 2K86, 2LQH, 2LQI

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.851	6
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.799	12
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.774	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.753	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.706	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.704	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.695	5
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.667	5
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.632	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.615	3
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.596	5
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787)	0.591	4
IntAct:EBI-1767788 BIM			0.59	2
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.564	3
UniProt:Q60987 Foxg1	2	Foxg1 [nucleoplasm] (R-MMU-9022630) Foxg1 [nucleoplasm] (R-MMU-9022629)	0.544	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.536	2
IntAct:EBI-1657542 ERALPHA			0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.524	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.499	3
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.499	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.499	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.499	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.499	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.499	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.462	2
IntAct:EBI-2891650 CDKN1B			0.462	2
IntAct:EBI-2678752 ANDR			0.462	2

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