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p-T32,S253,S315-FOXO3
Stable Identifier
R-HSA-199289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-Forkhead box protein O3A (T32, S253, S315), FOXO3_HUMAN, FOXO3A
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)
p-FOXO1,p-FOXO3,p-FOXO4 [nucleoplasm] (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the nucleus (Homo sapiens)
AKT can phosphorylate forkhead box transcription factors (Homo sapiens)
p-FOXO1,p-FOXO3,p-FOXO4 [nucleoplasm] (Homo sapiens)
p-T32,S253,S315-FOXO3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43524 FOXO3
Gene Names
FOXO3, FKHRL1, FOXO3A
Chain
chain:1-673
Reference Genes
BioGPS Gene:2309 FOXO3
COSMIC (genes):FOXO3 FOXO3
CTD Gene:2309 FOXO3
dbSNP Gene:2309 FOXO3
ENSEMBL:ENSG00000118689 FOXO3
HGNC:3821 FOXO3
KEGG Gene (Homo sapiens):hsa:2309 FOXO3
Monarch:2309 FOXO3
NCBI Gene:2309 FOXO3
OMIM:602681 FOXO3
UCSC:O43524 FOXO3
Reference Transcript
RefSeq:XM_005266868.3 FOXO3
RefSeq:XM_011535628.2 FOXO3
RefSeq:XM_011535629.2 FOXO3
RefSeq:XM_017010586.1 FOXO3
RefSeq:NM_201559.2 FOXO3
RefSeq:NM_001455.3 FOXO3
Other Identifiers
0000050204
0006980288
11718890_x_at
11718891_s_at
11718892_s_at
11737906_x_at
11746522_s_at
11746523_x_at
11749812_s_at
11755663_s_at
204131_s_at
204132_s_at
210655_s_at
217399_3p_s_at
217399_s_at
224889_3p_at
224889_at
224891_at
2309
2K86
2LQH
2LQI
2UZK
34740_at
4074
47893_s_at
49469_at
49651_at
63104
8013307
8121365
A_23_P345575
A_32_P102062
A_33_P3240392
A_33_P3375665
AAC39592
AAH20227
AAH21224
AAH68552
AF032886
AJ001589
AJ001590
AK301304
AL096818
AL365509
AL391646
BAG62858
BC020227
BC021224
BC068552
CAA04860
CAA04861
CAB004074
CAI16295
CAI16405
CCDS5068
CH471051
EAW48373
EAW48374
ENSG00000118689
ENSP00000339527
ENSP00000385824
ENSP00000446316
ENST00000343882
ENST00000406360
ENST00000540898
EntrezGene:2309
FOXO3
FOXO3-201
FOXO3-202
FOXO3-203
g4106722_3p_a_at
GE54251
GE85764
GO:0000003
GO:0000122
GO:0001047
GO:0001071
GO:0001221
GO:0001227
GO:0001228
GO:0001542
GO:0001544
GO:0001547
GO:0001556
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006412
GO:0006417
GO:0006915
GO:0006950
GO:0007165
GO:0007267
GO:0007568
GO:0008013
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0009653
GO:0016020
GO:0019899
GO:0019901
GO:0021700
GO:0030154
GO:0030330
GO:0031490
GO:0031667
GO:0033209
GO:0034599
GO:0034641
GO:0040007
GO:0042493
GO:0042592
GO:0042593
GO:0043065
GO:0043226
GO:0043525
GO:0043565
GO:0045648
GO:0045665
GO:0045893
GO:0045944
GO:0048854
GO:0048856
GO:0071333
GO:0071386
GO:0071456
GO:0071548
GO:0090090
GO:0097150
GO:0097192
GO:1901300
GO:1903428
GO:1904646
GO:1990090
GO:1990785
GO:2000177
GO:2000353
GO:2000377
HGNC:3821
HPA063104
Hs.14845.0.A2_3p_a_at
Hs.214783.0.S1_3p_at
Hs.214783.0.S1_3p_x_at
Hs.214783.0.S2_3p_at
Hs.220950
Hs.274468.0.S1_3p_s_at
Hs.592126
ILMN_1681703
ILMN_1687940
ILMN_1712515
ILMN_1844692
IPR001766
IPR011991
IPR030456
IPR032067
IPR032068
MIM:602681
NM_001455
NM_201559
NP_001446
NP_963853
PF00250
PF16675
PF16676
PH_hs_0028777
PH_hs_0033951
PR00053
SM00339
TC06000868.hg
TC06002977.hg
uc003psk.3
uc003psm.2
uc010kdj.2
UPI000012ADEA
UPI000020E058
XM_005266868
XM_011535628
XM_011535629
XM_017010586
XP_005266925
XP_011533930
XP_011533931
XP_016866075
Participant Of
hasMember
p-FOXO1,p-FOXO3,p-FOXO4 [nucleoplasm]
Other forms of this molecule
FOXO3 [nucleoplasm]
p-S43,S173,S294,S325-FOXO3 [cytosol]
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
FOXO3 [cytosol]
p-S215 FOXO3 [cytosol]
p-S215 FOXO3 [nucleoplasm]
Inferred To
Homologues of p-T32,S253,S315-FOXO3 [nucleoplasm] (Danio rerio)
Homologues of p-T32,S253,S315-FOXO3 [nucleoplasm] (Rattus norvegicus)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Bos taurus)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Caenorhabditis elegans)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Canis familiaris)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Danio rerio)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Drosophila melanogaster)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Gallus gallus)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Mus musculus)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Rattus norvegicus)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Sus scrofa)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Taeniopygia guttata)
phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 32
Coordinate
32
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 315
Coordinate
315
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 253
Coordinate
253
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_011533931.1
,
XP_011533930.1
,
NP_963853.1
,
XP_005266925.1
,
XP_016866075.1
,
NP_001446.1
GeneCards
O43524
DOCK Blaster
2UZK
PRO
O43524
PDB
2UZK
,
2LQI
,
2LQH
,
2K86
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
18
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 [nucleoplasm]
(R-HSA-177103)
SMAD4 [cytosol]
(R-HSA-170862)
RibC-SMAD4 [nucleoplasm]
(R-HSA-2187323)
SMAD4 R361S [cytosol]
(R-HSA-3310994)
SMAD4 R361G [cytosol]
(R-HSA-3310993)
SMAD4 R515* [cytosol]
(R-HSA-3311012)
SMAD4 K428R [cytosol]
(R-HSA-3311001)
0.743
9
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.713
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.704
5
UniProt:P84022 SMAD3
15
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 R268C [cytosol]
(R-HSA-3702149)
SMAD3 D258N [cytosol]
(R-HSA-3702147)
SMAD3 R268H [cytosol]
(R-HSA-3702148)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
0.667
5
IntAct:EBI-1767788 BIM
0.59
2
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.589
2
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.564
2
UniProt:P31946 YWHAB
2
YWHAB [endosome]
(R-HSA-190058)
YWHAB [cytosol]
(R-HSA-48888)
0.564
3
UniProt:Q92793 CREBBP
1
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
3
UniProt:Q60987 FOXG1
0.544
5
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.524
3
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
2
UniProt:P85037 FOXK1
1
FOXK1 [nucleoplasm]
(R-HSA-5689673)
0.499
2
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.499
2
UniProt:O75529 TAF5L
1
TAF5L [nucleoplasm]
(R-HSA-212336)
0.499
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.499
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.499
2
UniProt:P06400 RB1
3
p-S795-RB1 [nucleoplasm]
(R-HSA-69226)
p-RB1 [nucleoplasm]
(R-HSA-188389)
RB1 [nucleoplasm]
(R-HSA-68642)
0.499
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.462
2
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