Reactome | p-T32,S253,S315-FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [nucleoplasm]

Stable Identifier

R-HSA-199289

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-Forkhead box protein O3A (T32, S253, S315), FOXO3_HUMAN, FOXO3A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43524 FOXO3

Gene Names

FOXO3, FKHRL1, FOXO3A

Chain

chain:1-673

Reference Genes

BioGPS Gene:2309 FOXO3

COSMIC (genes):FOXO3 FOXO3

CTD Gene:2309 FOXO3

dbSNP Gene:2309 FOXO3

ENSEMBL:ENSG00000118689 FOXO3

HGNC:3821 FOXO3

KEGG Gene (Homo sapiens):2309 FOXO3

Monarch:2309 FOXO3

NCBI Gene:2309 FOXO3

OMIM:602681 FOXO3

UCSC:O43524 FOXO3

Reference Transcript

Other Identifiers

0000050204

0006980288

11718890_x_at

11718891_s_at

11718892_s_at

11737906_x_at

11746522_s_at

11746523_x_at

11749812_s_at

11755663_s_at

204131_s_at

204132_s_at

210655_s_at

217399_3p_s_at

217399_s_at

224889_3p_at

224889_at

224891_at

2309

2920476

2920477

2920478

2920479

2920480

2920481

2920482

2920483

2920484

2920485

2920486

2920537

2920538

2920541

2920542

2920543

2920556

2920567

2920568

2920570

2920572

2920574

2920575

2K86

2LQH

2LQI

2UZK

34740_at

3748537

3748538

3748557

3748558

3748560

3748563

3748564

3748565

3748566

3748567

3748568

3748569

3748570

4074

47893_s_at

49469_at

49651_at

63104

6MNL

8013307

8121365

A_23_P345575

A_32_P102062

A_33_P3240392

A_33_P3375665

AAC39592

AAH20227

AAH21224

AAH68552

AF032886

AJ001589

AJ001590

AK301304

AL096818

AL365509

AL391646

BAG62858

BC020227

BC021224

BC068552

CAA04860

CAA04861

CAB004074

CCDS5068

CH471051

EAW48373

EAW48374

ENSG00000118689

ENSP00000339527

ENSP00000385824

ENSP00000446316

ENST00000343882

ENST00000343882.10

ENST00000406360

ENST00000406360.1

ENST00000540898

ENST00000540898.1

EntrezGene:2309

EntrezGene:FOXO3

FOXO3

FOXO3-201

FOXO3-202

FOXO3-203

g4106722_3p_a_at

GE54251

GE85764

GO:0000003

GO:0000122

GO:0000228

GO:0000790

GO:0000978

GO:0000981

GO:0001221

GO:0001227

GO:0001228

GO:0001542

GO:0001544

GO:0001547

GO:0001556

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0005759

GO:0005829

GO:0006355

GO:0006357

GO:0006390

GO:0006412

GO:0006417

GO:0006914

GO:0006915

GO:0006950

GO:0007165

GO:0007267

GO:0007568

GO:0008013

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008286

GO:0009056

GO:0009058

GO:0010508

GO:0014737

GO:0016020

GO:0019221

GO:0019899

GO:0019901

GO:0021700

GO:0030154

GO:0030330

GO:0030336

GO:0031490

GO:0031667

GO:0032991

GO:0033209

GO:0034246

GO:0034599

GO:0034641

GO:0040007

GO:0040011

GO:0042493

GO:0042592

GO:0042593

GO:0042594

GO:0043065

GO:0043226

GO:0043525

GO:0043565

GO:0045648

GO:0045665

GO:0045893

GO:0045944

GO:0048854

GO:0048856

GO:0048870

GO:0071333

GO:0071386

GO:0071456

GO:0071548

GO:0090090

GO:0097150

GO:0097192

GO:1901300

GO:1903428

GO:1904646

GO:1990090

GO:1990785

GO:2000177

GO:2000353

GO:2000377

HGNC:3821

HPA063104

Hs.14845.0.A2_3p_a_at

Hs.214783.0.S1_3p_at

Hs.214783.0.S1_3p_x_at

Hs.214783.0.S2_3p_at

Hs.274468.0.S1_3p_s_at

ILMN_1681703

ILMN_1687940

ILMN_1712515

ILMN_1844692

IPR001766

IPR030456

IPR032067

IPR032068

IPR036388

IPR036390

MIM:602681

NM_001455

NM_201559

NP_001446

NP_963853

PF00250

PF16675

PF16676

PH_hs_0028777

PH_hs_0033951

PR00053

SM00339

TC06000868.hg

TC06002977.hg

UPI000012ADEA

UPI000020E058

XM_005266868

XM_011535628

XM_011535629

XM_017010586

XP_005266925

XP_011533930

XP_011533931

XP_016866075

Participant Of

hasMember

input

AKT-phosphorylated FOXO3 translocates to cytosol

output

AKT phosphorylates FOXO3 downstream of ESR1 and EGFR

Other forms of this molecule

p-S215 FOXO3 [nucleoplasm]

p-S215 FOXO3 [cytosol]

FOXO3 [cytosol]

p-S43,S173,S294,S325-FOXO3 [nucleoplasm]

p-S43,S173,S294,S325-FOXO3 [cytosol]

Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]

FOXO3 [nucleoplasm]

p-T32,S253,S315-FOXO3 [cytosol]

Inferred To

phospho-Foxo3 [nucleoplasm] (Mus musculus)

phospho-Foxo3 [nucleoplasm] (Rattus norvegicus)

phospho-FOXO3 [nucleoplasm] (Bos taurus)

phospho-FOXO3 [nucleoplasm] (Canis familiaris)

phospho-FOXO3 [nucleoplasm] (Sus scrofa)

phospho-foxo3 [nucleoplasm] (Xenopus tropicalis)

phospho-foxo [nucleoplasm] (Drosophila melanogaster)

phospho-foxo3b [nucleoplasm] (Danio rerio)

phospho-p-T32,S253,S315-FOXO3 [nucleoplasm] (Gallus gallus)

phospho-daf-16 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 253

Coordinate

253

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 315

Coordinate

315

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 32

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011533931.1, NP_001446.1, XP_011533930.1, XP_016866075.1, NP_963853.1, XP_005266925.1

OpenTargets

ENSG00000118689

HPA

ENSG00000118689-FOXO3

GeneCards

O43524

Ensembl

ENST00000540898, ENST00000343882, ENSP00000446316, ENST00000406360, ENSG00000118689, ENSP00000339527, ENSP00000385824

PRO

O43524

PDB

2LQI, 2LQH, 2UZK, 2K86, 6MNL

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 K428R [cytosol] (R-HSA-3311001)	0.743	9
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356)	0.713	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.704	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.688	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.669	3
UniProt:P84022 SMAD3	21	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.667	5
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.632	7
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.591	4
IntAct:EBI-1767788 BIM			0.59	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.589	2
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.564	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	3
UniProt:Q60987 Foxg1	2	Foxg1 [nucleoplasm] (R-MMU-9022629) Foxg1 [nucleoplasm] (R-MMU-9022630)	0.544	5
IntAct:EBI-1657542 ERALPHA			0.527	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.524	3
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.499	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.499	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.499	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.499	2
UniProt:P28749 RBL1	2	p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085) RBL1 [nucleoplasm] (R-HSA-389104)	0.499	3
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.499	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.499	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.462	2
IntAct:EBI-2891650 CDKN1B			0.462	2
IntAct:EBI-2678752 ANDR			0.462	2

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