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K6PolyUb-BARD1 [nucleoplasm]
Stable Identifier
R-HSA-9701024
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
BRCA1-A Complex:Histone H2A [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99728 BARD1
Gene Names
BARD1
Chain
chain:1-777
Reference Genes
COSMIC (genes):BARD1 BARD1
dbSNP Gene:580 BARD1
ENSEMBL:ENSG00000138376 BARD1
Participates
as a component of
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
p-T714,T734-BARD1 [nucleoplasm]
BARD1 [nucleoplasm]
BARD1 C83G [nucleoplasm]
BARD1 C50G [nucleoplasm]
BARD1 L44R [nucleoplasm]
BARD1 H68Y [nucleoplasm]
BARD1 W34R [nucleoplasm]
BARD1 G623W [nucleoplasm]
BARD1 C53W [nucleoplasm]
BARD1 C71Y [nucleoplasm]
BARD1 G623E [nucleoplasm]
Inferred To
K6PolyUb-BARD1 [nucleoplasm]
(Gallus gallus)
BARD1 [nucleoplasm]
(Bos taurus)
BARD1 [nucleoplasm]
(Canis familiaris)
BARD1 [nucleoplasm]
(Sus scrofa)
Bard1 [nucleoplasm]
(Mus musculus)
Bard1 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K6-PolyUb [nucleoplasm]) at unknown position
Modification
K6polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.958
20
UniProt:O95751 LDOC1
0.781
7
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:P33240 CSTF2
1
CSTF2 [nucleoplasm]
(R-HSA-72003)
0.702
8
ChEBI:61151 PAR
0.65
9
UniProt:Q05048 CSTF1
1
CSTF1 [nucleoplasm]
(R-HSA-72001)
0.581
4
UniProt:O95453 PARN
1
PARN [cytosol]
(R-HSA-430009)
0.577
4
ChEBI:16864 ADP-RIBOSE
0.558
2
UniProt:O75031 HSF2B
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.556
3
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q8IZU0 FAM9B
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:Q15276 RABEP1
1
RABEP1 [early endosome membrane]
(R-HSA-2029004)
0.556
3
UniProt:P38398-1 BRCA1
0.524
3
UniProt:Q9P2H0 CE126
0.508
2
UniProt:O95251 KAT7
1
KAT7 [nucleoplasm]
(R-HSA-3321823)
0.508
2
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.508
2
UniProt:O14776 TCERG1
1
TCERG1 [nucleoplasm]
(R-HSA-3246027)
0.508
2
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.508
2
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