Reactome | CSNK2A2 [cytosol]

CSNK2A2 [cytosol]

Stable Identifier

R-HSA-201721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha' subunit

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Mitophagy (Homo sapiens)
      - Receptor Mediated Mitophagy (Homo sapiens)
        
        FUNDC1 is phosphorylated by CK2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Condensation of Prometaphase Chromosomes (Homo sapiens)
        
        CK2 phosphorylates condensin I subunits (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Signal transduction by L1 (Homo sapiens)
        
        Phosphorylation of L1 by CK-II (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        pL1:CK-II [plasma membrane] (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        Casein kinase II phosphorylates STARD10 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein folding (Homo sapiens)
  - Chaperonin-mediated protein folding (Homo sapiens)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
      - CK2 phosphorylates PDCL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        Casein kinase II phosphorylates PTEN (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - WNT mediated activation of DVL (Homo sapiens)
      - CSNK2-mediated phosphorylation of DVL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19784 CSNK2A2

Gene Names

CSNK2A2, CK2A2

Chain

chain:1-350

Reference Genes

BioGPS Gene:1459 CSNK2A2

COSMIC (genes):CSNK2A2 CSNK2A2

CTD Gene:1459 CSNK2A2

dbSNP Gene:1459 CSNK2A2

ENSEMBL:ENSG00000070770 CSNK2A2

HGNC:2459 CSNK2A2

KEGG Gene (Homo sapiens):1459 CSNK2A2

Monarch:1459 CSNK2A2

NCBI Gene:1459 CSNK2A2

OMIM:115442 CSNK2A2

UCSC:P19784 CSNK2A2

Reference Transcript

RefSeq:NM_001896.2 CSNK2A2

Other Identifiers

11716807_a_at

1459

16826879

203575_at

3693534

3693547

3693549

3693550

3693552

3693553

3693555

3693556

3693561

3693564

3693567

3693569

3693571

3693572

3693573

37629_at

50900_at

8001666

A_23_P14915

GE57970

GO:0000003

GO:0000166

GO:0000785

GO:0001669

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0005956

GO:0006457

GO:0006464

GO:0006468

GO:0006605

GO:0006629

GO:0006656

GO:0006810

GO:0006914

GO:0006915

GO:0007005

GO:0007049

GO:0007059

GO:0007165

GO:0007267

GO:0007283

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0015031

GO:0016055

GO:0016236

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0021987

GO:0031410

GO:0031519

GO:0032991

GO:0043167

GO:0043226

GO:0047485

GO:0048856

GO:0051726

GO:0097421

GO:1901796

GO:1903146

GO:1903955

GO:1905818

GO:2000059

GO:2001234

ILMN_1723843

M55268_at

TC16001148.hg

g4503096_3p_at

Participant Of

hasComponent

Other forms of this molecule

CSNK2A2 [nucleoplasm]

Inferred To

kin-3 [cytosol] (Caenorhabditis elegans)

CKA2 [cytosol] (Saccharomyces cerevisiae)

CSNK2A2 [cytosol] (Canis familiaris)

CSNK2A2 [cytosol] (Plasmodium falciparum)

CSNK2A2 [cytosol] (Sus scrofa)

Homologues of CSNK2A2 [cytosol] (Plasmodium falciparum)

Homologues of CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

csnk2a2b [cytosol] (Danio rerio)

Csnk2a2 [cytosol] (Mus musculus)

Csnk2a2 [cytosol] (Rattus norvegicus)

casK [cytosol] (Dictyostelium discoideum)

cka1 [cytosol] (Schizosaccharomyces pombe)

brca1 [cytosol] (Xenopus tropicalis)

CKA1 [cytosol] (Saccharomyces cerevisiae)

CkIIalpha [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001887.1

ZINC - World Drugs

CSK22_HUMAN

OpenTargets

ENSG00000070770

ZINC - FDA approved

CSK22_HUMAN

ZINC - Substances

CSK22_HUMAN

ZINC - Biogenic

CSK22_HUMAN

ZINC target

P19784

PRO

P19784

PDB

5YF9, 3OFM, 6HMB, 5Y9M, 3U87, 6HMC, 6L20, 6QY9, 5M4U, 6HMQ, 6TEW, 6HMD, 5OOI, 6TGU, 5M56, 5YWM, 3E3B, 6TE2, 6QY8

ZINC - Investigational

CSK22_HUMAN

GeneCards

P19784

HPA

ENSG00000070770-CSNK2A2

Ensembl

ENSP00000262506, ENST00000262506, ENSG00000070770

ZINC - Predictions - Purchasable

CSK22_HUMAN

Orphanet

24442

HMDB Protein

HMDBP01476

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	5
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.527	2
UniProt:P0DTC9 N	10	phospho-SUMO1-K62-ADPr-p-S177-Ncap [cytosol] (R-COV-9694558) phospho-SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694424) phospho-ADPr-p-S177-Ncap [cytosol] (R-COV-9694254) phospho-p-S177-Ncap [cytosol] (R-COV-9694472) Ncap [cytosol] (R-COV-9694300) Ncap [plasma membrane] (R-COV-9694356) phospho-SUMO1-K62-ADPr-p-S177-Ncap [nucleolus] (R-COV-9694318) phospho-SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane] (R-COV-9694764) N [cytosol] (R-COV-9694314) phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol] (R-COV-9694431)	0.527	2