Reactome | CSNK2A2 [cytosol]

CSNK2A2

Stable Identifier

R-HSA-201721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha' subunit

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Condensation of Prometaphase Chromosomes (Homo sapiens)
        
        CK2 phosphorylates condensin I subunits (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Axon guidance (Homo sapiens)
  - L1CAM interactions (Homo sapiens)
    - Signal transduction by L1 (Homo sapiens)
      - Phosphorylation of L1 by CK-II (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        pL1:CK-II [plasma membrane] (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        Casein kinase II phosphorylates STARD10 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein folding (Homo sapiens)
  - Chaperonin-mediated protein folding (Homo sapiens)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
      - CK2 phosphorylates PDCL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        Casein kinase II phosphorylates PTEN (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - WNT mediated activation of DVL (Homo sapiens)
      - CSNK2-mediated phosphorylation of DVL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19784 CSNK2A2

Gene Names

CSNK2A2, CK2A2

Chain

chain:1-350

Reference Genes

BioGPS Gene:1459 CSNK2A2

CTD Gene:1459 CSNK2A2

dbSNP Gene:1459 CSNK2A2

ENSEMBL:ENSG00000070770 CSNK2A2

HGNC:2459 CSNK2A2

KEGG Gene (Homo sapiens):CSNK2A2 CSNK2A2

KEGG Gene (Homo sapiens):hsa:1459 CSNK2A2

Monarch:1459 CSNK2A2

NCBI Gene:1459 CSNK2A2

OMIM:115442 CSNK2A2

UCSC:P19784 CSNK2A2

Reference Transcript

RefSeq:NM_001896.2 CSNK2A2

Other Identifiers

11716807_a_at

1459

16826879

203575_at

3693534

3693547

3693549

3693550

3693552

3693553

3693555

3693556

3693561

3693564

3693567

3693569

3693571

3693572

37629_at

3E3B

3OFM

3U87

50900_at

5M4U

5M56

5OOI

77719

8001666

A_23_P14915

AAA51548

AAH08812

BC008812

CCDS10794

CSNK2A2

CSNK2A2-201

ENSG00000070770

ENSP00000262506

ENST00000262506

EntrezGene:1459

g4503096_3p_at

GE57970

GO:0000003

GO:0000166

GO:0000785

GO:0001669

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006464

GO:0006468

GO:0006605

GO:0006810

GO:0006914

GO:0006915

GO:0007005

GO:0007049

GO:0007059

GO:0007165

GO:0007267

GO:0007283

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0021987

GO:0031410

GO:0031519

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0047485

GO:0048856

GO:0051726

GO:0097421

GO:1901796

GO:1903146

GO:1903955

GO:1905818

GO:2000059

GO:2001234

H3BNI9

H3BSA1

HGNC:2459

HPA077719

ILMN_1723843

IPR000719

IPR008271

IPR011009

IPR017441

M55268

M55268_at

MIM:115442

NM_001896

NP_001887

PF00069

SM00220

TC16001148.hg

uc002enc.4

UPI0000000C95

XM_005255800

XP_005255857

Participant Of

hasComponent

Other forms of this molecule

CSNK2A2 [nucleoplasm]

Inferred To

CSNK2A2 [cytosol] (Arabidopsis thaliana)

CSNK2A2 [cytosol] (Bos taurus)

CSNK2A2 [cytosol] (Caenorhabditis elegans)

CSNK2A2 [cytosol] (Canis familiaris)

CSNK2A2 [cytosol] (Danio rerio)

CSNK2A2 [cytosol] (Dictyostelium discoideum)

CSNK2A2 [cytosol] (Drosophila melanogaster)

CSNK2A2 [cytosol] (Mus musculus)

CSNK2A2 [cytosol] (Oryza sativa)

CSNK2A2 [cytosol] (Rattus norvegicus)

CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

CSNK2A2 [cytosol] (Schizosaccharomyces pombe)

CSNK2A2 [cytosol] (Sus scrofa)

CSNK2A2 [cytosol] (Xenopus tropicalis)

Homologues of CSNK2A2 [cytosol] (Arabidopsis thaliana)

Homologues of CSNK2A2 [cytosol] (Danio rerio)

Homologues of CSNK2A2 [cytosol] (Oryza sativa)

Homologues of CSNK2A2 [cytosol] (Sus scrofa)

Homologues of CSNK2A2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001887.1

ZINC - World Drugs

CSK22_HUMAN

ZINC - FDA approved

CSK22_HUMAN

GeneCards

P19784

ZINC - Substances

CSK22_HUMAN

ZINC target

P19784

PRO

P19784

BRENDA (Homo sapiens)

2.7.11.1

Orphanet

24442

ZINC - Predictions - Purchasable

CSK22_HUMAN

HMDB Protein

HMDBP01476

PDB

3OFM, 5OOI, 5M56, 3E3B, 5M4U, 3U87

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.488	2