Reactome | CSNK2A2 [cytosol]

CSNK2A2 [cytosol]

Stable Identifier

R-HSA-201721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha' subunit

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Mitophagy (Homo sapiens)
      - Receptor Mediated Mitophagy (Homo sapiens)
        
        FUNDC1 is phosphorylated by CK2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Condensation of Prometaphase Chromosomes (Homo sapiens)
        
        CK2 phosphorylates condensin I subunits (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - CK2 phosphorylates NFE2L2 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Signal transduction by L1 (Homo sapiens)
        
        Phosphorylation of L1 by CK-II (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        pL1:CK-II [plasma membrane] (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - Synthesis of PC (Homo sapiens)
        
        Casein kinase II phosphorylates STARD10 (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Protein folding (Homo sapiens)
  - Chaperonin-mediated protein folding (Homo sapiens)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
      - CK2 phosphorylates PDCL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN stability and activity (Homo sapiens)
        
        Casein kinase II phosphorylates PTEN (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - WNT mediated activation of DVL (Homo sapiens)
      - CSNK2-mediated phosphorylation of DVL (Homo sapiens)
        
        Casein kinase II [cytosol] (Homo sapiens)
        
        CSNK2(A1:A1/A1:A2/A2:A2) [cytosol] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)
        
        CSNK2A2 dimer [cytosol] (Homo sapiens)
        
        CSNK2A2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19784 CSNK2A2

Gene Names

CSNK2A2, CK2A2

Chain

chain:1-350

Reference Genes

BioGPS Gene:1459 CSNK2A2

COSMIC (genes):CSNK2A2 CSNK2A2

CTD Gene:1459 CSNK2A2

dbSNP Gene:1459 CSNK2A2

ENSEMBL:ENSG00000070770.10 CSNK2A2

HGNC:2459 CSNK2A2

KEGG Gene (Homo sapiens):1459 CSNK2A2

Monarch:1459 CSNK2A2

NCBI Gene:1459 CSNK2A2

OMIM:115442 CSNK2A2

UCSC:P19784 CSNK2A2

Reference Transcript

RefSeq:NM_001896.2 CSNK2A2

Other Identifiers

11716807_a_at

1459

16826879

203575_PM_at

203575_at

3693534

3693547

3693549

3693550

3693552

3693553

3693555

3693556

3693561

3693564

3693567

3693569

3693571

3693572

3693573

37629_at

50900_at

8001666

A_23_P14915

GE57970

GO:0000166

GO:0000785

GO:0001669

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0005956

GO:0006468

GO:0006886

GO:0006914

GO:0006915

GO:0007005

GO:0007049

GO:0007059

GO:0007283

GO:0012501

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0021987

GO:0022414

GO:0023052

GO:0030163

GO:0031410

GO:0031519

GO:0032991

GO:0036211

GO:0043226

GO:0047485

GO:0048856

GO:0051726

GO:0097421

GO:0106310

GO:0140096

GO:1903146

GO:1903955

GO:1905818

GO:2000059

GO:2001234

HMNXSV003020620

ILMN_1723843

M55268_at

TC16001148.hg

g4503096_3p_at

Participates

as a component of

Other forms of this molecule

CSNK2A2 [nucleoplasm]

Inferred To

CSNK2A2 [cytosol] (Bos taurus)

CSNK2A2 [cytosol] (Caenorhabditis elegans)

CSNK2A2 [cytosol] (Canis familiaris)

CSNK2A2 [cytosol] (Danio rerio)

CSNK2A2 [cytosol] (Dictyostelium discoideum)

CSNK2A2 [cytosol] (Drosophila melanogaster)

CSNK2A2 [cytosol] (Mus musculus)

CSNK2A2 [cytosol] (Plasmodium falciparum)

CSNK2A2 [cytosol] (Rattus norvegicus)

CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

CSNK2A2 [cytosol] (Schizosaccharomyces pombe)

CSNK2A2 [cytosol] (Sus scrofa)

CSNK2A2 [cytosol] (Xenopus tropicalis)

Homologues of CSNK2A2 [cytosol] (Dictyostelium discoideum)

Homologues of CSNK2A2 [cytosol] (Plasmodium falciparum)

Homologues of CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001887.1

ZINC - World Drugs

CSK22_HUMAN

Guide to Pharmacology - Targets

1550

OpenTargets

ENSG00000070770

ZINC - FDA approved

CSK22_HUMAN

ZINC - Substances

CSK22_HUMAN

ZINC target

P19784

ZINC - Biogenic

CSK22_HUMAN

PRO

P19784

PDB

6QY8, 6HMC, 6TEW, 6QY9, 6HMD, 7ATV, 6TGU, 6L20, 5YF9, 3E3B, 6HMB, 5Y9M, 5M56, 7A1B, 6HMQ, 5M4U, 5OOI, 7A2H, 3OFM, 7AT9, 6TE2, 7A1Z, 5YWM, 7A22, 3U87

ZINC - Investigational

CSK22_HUMAN

HPA

ENSG00000070770-CSNK2A2

GeneCards

P19784

Ensembl

ENSP00000262506, ENST00000262506, ENSG00000070770

Pharos - Targets

P19784

Orphanet

24442

ZINC - Predictions - Purchasable

CSK22_HUMAN

HMDB Protein

HMDBP01476

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.643	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.643	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	5
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	2