Reactome | CSNK2A2 [cytosol]

CSNK2A2 [cytosol]

Stable Identifier

R-HSA-201721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase alpha' subunit

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P19784 CSNK2A2

Gene Names

CSNK2A2, CK2A2

Chain

chain:1-350

Reference Genes

BioGPS Gene:1459 CSNK2A2

COSMIC (genes):CSNK2A2 CSNK2A2

CTD Gene:1459 CSNK2A2

dbSNP Gene:1459 CSNK2A2

ENSEMBL:ENSG00000070770 CSNK2A2

HGNC:2459 CSNK2A2

KEGG:hsa:1459 CSNK2A2

Monarch:1459 CSNK2A2

NCBI Gene:1459 CSNK2A2

OMIM:115442 CSNK2A2

UCSC:P19784 CSNK2A2

Reference Transcript

Other Identifiers

11716807_a_at

11763321_at

11763322_s_at

1459

16826879

16826892

203575_PM_at

203575_at

224922_PM_at

224922_at

3693534

3693535

3693536

3693537

3693538

3693539

3693540

3693541

3693542

3693543

3693544

3693545

3693546

3693547

3693549

3693550

3693552

3693553

3693554

3693555

3693556

3693557

3693558

3693560

3693561

3693564

3693567

3693569

3693570

3693571

3693572

3693573

37629_at

42076_at

48065_at

50900_at

50902_g_at

64241_r_at

8001666

ADDON000315.hg

ADDON002190.hg

A_21_P0014329

A_23_P14915

A_24_P934809

GE57970

GO:0000166

GO:0000785

GO:0001669

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005956

GO:0006281

GO:0006302

GO:0006468

GO:0006915

GO:0006974

GO:0007283

GO:0016055

GO:0016301

GO:0016740

GO:0021987

GO:0022414

GO:0031519

GO:0032435

GO:0042176

GO:0048856

GO:0051726

GO:0097421

GO:0106310

GO:0140096

GO:1901524

GO:1903955

GO:1905818

GO:2001234

HMNXSV003020620

HMNXSV003037668

Hs.237955.6.S1_3p_at

ILMN_1696468

ILMN_1723843

M55268_at

PH_hs_0039556

TC16001148.hg

TC16001149.hg

g4503096_3p_at

p25966

Participates

as a component of

Other forms of this molecule

CSNK2A2 [nucleoplasm]

Inferred To

kin-3 [cytosol] (Caenorhabditis elegans)

CKA2 [cytosol] (Saccharomyces cerevisiae)

CSNK2A2 [cytosol] (Bos taurus)

CSNK2A2 [cytosol] (Canis familiaris)

CSNK2A2 [cytosol] (Dictyostelium discoideum)

CSNK2A2 [cytosol] (Sus scrofa)

Homologues of CSNK2A2 [cytosol] (Dictyostelium discoideum)

Homologues of CSNK2A2 [cytosol] (Saccharomyces cerevisiae)

csnk2a2b [cytosol] (Danio rerio)

Csnk2a2 [cytosol] (Mus musculus)

Csnk2a2 [cytosol] (Rattus norvegicus)

casK [cytosol] (Dictyostelium discoideum)

cka1 [cytosol] (Schizosaccharomyces pombe)

CKA1 [cytosol] (Saccharomyces cerevisiae)

CkIIalpha [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_054235601.1, XP_047289582.1, NP_001887.1

ZINC - World Drugs

CSK22_HUMAN

Guide to Pharmacology - Targets

1550

OpenTargets

ENSG00000070770

ENSEMBL

ENST00000262506, ENSG00000070770, ENSP00000262506

ZINC - FDA approved

CSK22_HUMAN

ZINC - Substances

CSK22_HUMAN

ZINC - Biogenic

CSK22_HUMAN

ZINC target

P19784

PRO

P19784

GlyGen

P19784

PDB

8Q9S, 5M4U, 5M56, 7AT9, 6QY9, 7A1B, 5OOI, 5YWM, 6L20, 3OFM, 6QY8, 8QCG, 8QF1, 6TEW, 7XYH, 6TGU, 3E3B, 5Y9M, 8QBU, 8Q77, 8QCD, 6HMQ, 5YF9, 7A2H, 6HMD, 6HMC, 3U87, 6HMB, 7A22, 6TE2, 7A1Z, 7ATV

ZINC - Investigational

CSK22_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000070770-CSNK2A2

GeneCards

CSNK2A2

Pharos - Targets

P19784

ZINC - Predictions - Purchasable

CSK22_HUMAN

HMDB Protein

HMDBP01476

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.952	19
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.921	15
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.788	8
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.788	5
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.788	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.725	4
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.725	4
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.643	3
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.643	3
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.643	3
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.643	4
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.643	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	5
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.527	2
UniProt:Q9UPT8 ZC3H4	1	ZC3H4 [nucleoplasm] (R-HSA-9930063)	0.527	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.527	2
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.527	2
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.527	2
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.527	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:O15541 RNF113A	1	RNF113A [nucleoplasm] (R-HSA-9769563)	0.527	2
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2

Cite Us!