Reactome | AURKB [cytosol]

AURKB [cytosol]

Stable Identifier

R-HSA-174231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aurora B

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Chromosome passenger complex [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
        
        (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)
        
        AURKB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96GD4 AURKB

Gene Names

AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5

Chain

chain:1-344

Reference Genes

BioGPS Gene:9212 AURKB

COSMIC (genes):AURKB AURKB

CTD Gene:9212 AURKB

dbSNP Gene:9212 AURKB

ENSEMBL:ENSG00000178999 AURKB

HGNC:11390 AURKB

KEGG:hsa:9212 AURKB

Monarch:9212 AURKB

NCBI Gene:9212 AURKB

OMIM:604970 AURKB

UCSC:Q96GD4 AURKB

Reference Transcript

Other Identifiers

11720203_a_at

16840902

209464_PM_at

209464_at

239219_3p_at

239219_PM_at

239219_at

33266_at

3744271

3744272

3744273

3744274

3744275

3744276

3744277

3744278

3744279

3744280

3744281

3744282

3744283

3744284

3744285

3744286

3744287

3744288

3744289

3744290

3744291

3744292

3744293

3744294

44224_at

8012403

9212

A_23_P130182

GE62547

GE84968

GO:0000122

GO:0000278

GO:0000281

GO:0000775

GO:0000776

GO:0000779

GO:0000910

GO:0002903

GO:0003824

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0006355

GO:0006468

GO:0007010

GO:0007051

GO:0007052

GO:0009838

GO:0010369

GO:0015630

GO:0016740

GO:0019900

GO:0030496

GO:0031117

GO:0031616

GO:0032133

GO:0032206

GO:0032465

GO:0032466

GO:0032467

GO:0034501

GO:0034644

GO:0036089

GO:0043226

GO:0043687

GO:0044839

GO:0044878

GO:0045824

GO:0051233

GO:0051256

GO:0051301

GO:0051983

GO:0061024

GO:0062033

GO:0090267

GO:0090307

GO:0097431

GO:0106310

GO:0140096

GO:0140273

GO:0160049

GO:1901796

GO:1901970

GO:1902425

GO:1903490

GO:1905116

GO:1990023

GO:1990758

HMNXSV003048163

Hs.221197.0.A1_3p_at

Hs.221197.0.A1_3p_x_at

ILMN_1684217

PH_hs_0025861

TC17001109.hg

g5688865_3p_at

Participates

as a member of

(APC/C:Cdh1)-targeted cell cycle proteins [cytosol] (Homo sapiens)

as a component of

Chromosome passenger complex [cytosol] (Homo sapiens)

Other forms of this molecule

AURKB [nucleoplasm]

polySUMO2,3-K202-AURKB [cytosol]

Inferred To

Homologues of AURKB [cytosol] (Drosophila melanogaster)

AURKB [cytosol] (Bos taurus)

AURKB [cytosol] (Canis familiaris)

AURKB [cytosol] (Dictyostelium discoideum)

AURKB [cytosol] (Drosophila melanogaster)

AURKB [cytosol] (Mus musculus)

AURKB [cytosol] (Rattus norvegicus)

AURKB [cytosol] (Sus scrofa)

AURKB [cytosol] (Xenopus tropicalis)

Ghost homologue of AURKB [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001271455.1, XP_016880796.1, XP_011522372.1, NP_001243763.1, NP_004208.2, NP_001300880.1, NP_001300881.1, NP_001300879.1, NP_001300882.1, NP_001300883.1, NP_001300884.1, XP_011522374.1

ZINC - World Drugs

AURKB_HUMAN

Guide to Pharmacology - Targets

1937

OpenTargets

ENSG00000178999

ENSEMBL

ENST00000578549, ENST00000534871, ENSP00000463999, ENST00000316199, ENSP00000462207, ENSP00000313950, ENSP00000443869, ENST00000585124

ZINC - FDA approved

AURKB_HUMAN

ZINC - Substances

AURKB_HUMAN

ZINC - Biogenic

AURKB_HUMAN

ZINC target

Q96GD4

PRO

Q96GD4

GlyGen

Q96GD4

PDB

4AF3

ZINC - Investigational

AURKB_HUMAN

ZINC - Metabolites

AURKB_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000178999-AURKB

Pharos - Targets

Q96GD4

ZINC - Predictions - Purchasable

AURKB_HUMAN

HMDB Protein

HMDBP01421

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQS7 INCENP	2	INCENP [nucleoplasm] (R-HSA-4655393) INCENP [cytosol] (R-HSA-375311)	0.962	22
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.952	13
UniProt:Q53HL2 CDCA8	3	polySUMO2,3-CDCA8 [cytosol] (R-HSA-4655328) CDCA8 [nucleoplasm] (R-HSA-4655357) CDCA8 [cytosol] (R-HSA-375288)	0.868	10
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.834	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.784	5
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.712	6
UniProt:Q8WYJ6 SEPT1			0.704	6
UniProt:Q99986 VRK1	2	VRK1 [cytosol] (R-HSA-2995381) VRK1 [nucleoplasm] (R-HSA-2528998)	0.65	14
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.633	5
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.602	4
UniProt:Q86XJ1 GA2L3			0.584	4
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.569	3
UniProt:Q58FG0 HS905			0.564	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.564	3
UniProt:Q9NQS7-1 INCENP			0.558	2
UniProt:O15392-1 BIRC5			0.544	2
UniProt:O15392-2 BIRC5			0.544	2
UniProt:Q16695 H3-4	3	Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) HIST3H3 [nucleoplasm] (R-HSA-181914)	0.544	8
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:A6NHR9 SMHD1			0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:Q9P2N7 KLHL13	1	KLHL13 [cytosol] (R-HSA-976041)	0.525	2
UniProt:Q9P2J3 KLHL9	1	KLHL9 [cytosol] (R-HSA-976056)	0.525	2
UniProt:Q9HBJ7 UBP29			0.499	3
UniProt:Q8TDD1 DDX54			0.483	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.483	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.463	5
UniProt:O75410 TACC1			0.463	2

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