Reactome | PolyUb-MDM4 [nucleoplasm]

PolyUb-MDM4 [nucleoplasm]

Stable Identifier

R-HSA-6782502

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MDM4, Mdmx

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Homo sapiens)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Homo sapiens)
        
        PolyUb-MDM4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15151 MDM4

Gene Names

MDM4, MDMX

Chain

chain:1-490

Reference Genes

BioGPS Gene:4194 MDM4

COSMIC (genes):MDM4 MDM4

CTD Gene:4194 MDM4

dbSNP Gene:4194 MDM4

ENSEMBL:ENSG00000198625 MDM4

ENSEMBL_homo_sapiens_GENE:ENSG00000198625.14 MDM4

HGNC:6974 MDM4

KEGG Gene (Homo sapiens):4194 MDM4

Monarch:4194 MDM4

NCBI Gene:4194 MDM4

OMIM:602704 MDM4

UCSC:O15151 MDM4

Reference Transcript

Other Identifiers

11721912_at

11721913_x_at

11721914_a_at

11721915_a_at

11721916_at

16676314

1935_at

205655_PM_at

205655_at

225740_PM_x_at

225740_x_at

225742_PM_at

225742_at

235162_PM_at

235162_at

236814_PM_at

236814_at

2376038

2376039

2376040

2376041

2376042

2376044

2376045

2376046

2376054

2376055

2376061

2376062

2376063

2376064

2376065

2376066

2376067

2376068

2376069

2376070

2376071

2376072

2376073

2376074

2376094

2376095

2376096

2376097

4194

44569_at

7909011

83495_at

90290_at

91831_s_at

AF007111_at

A_14_P108985

A_14_P124092

A_19_P00320719

A_19_P00320721

A_19_P00329800

A_23_P103503

A_24_P778649

A_33_P3389376

GE81150

GE88836

GO:0000122

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0008270

GO:0008285

GO:0012501

GO:0016567

GO:0016740

GO:0017053

GO:0019899

GO:0023052

GO:0030163

GO:0030330

GO:0036211

GO:0042177

GO:0043066

GO:0043226

GO:0045892

GO:0046872

GO:0048856

GO:0050821

GO:0051726

GO:0065003

GO:0065008

GO:0071456

GO:0140096

HMNXSV003003592

HMNXSV003055900

Hs.126257.0.A1_3p_at

Hs.154395.0.A1_3p_at

Hs.31433.0.A1_3p_at

Hs.31433.0.A2_3p_at

ILMN_1746020

PH_hs_0025232

TC01004964.hg

g4505138_3p_at

Participates

as a member of

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S403-MDM4 [nucleoplasm]

p-S346,S367,S403-MDM4 [nucleoplasm]

PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]

MDM4 [nucleoplasm]

Inferred To

Mul1 [nucleoplasm] (Drosophila melanogaster)

exc-14 [nucleoplasm] (Caenorhabditis elegans)

MDM4 [nucleoplasm] (Canis familiaris)

Mdm4 [nucleoplasm] (Mus musculus)

Mdm4 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001265448.1, NP_001191101.1, NP_002384.2, NP_001265447.1, NP_001265446.1, NP_001191100.1, NP_001265445.1

OpenTargets

ENSG00000198625

GeneCards

O15151

HPA

ENSG00000198625-MDM4

ZINC - Substances

MDM4_HUMAN

ZINC target

O15151

Ensembl

ENSP00000356150, ENSG00000198625, ENSP00000396840, ENST00000454264, ENST00000367183, ENSP00000356151, ENST00000367182

PRO

O15151

Pharos - Targets

O15151

ZINC - Predictions - Purchasable

MDM4_HUMAN

Orphanet

25627

PDB

6Q9W, 6YR7, 2VYR, 2N06, 7MLA, 6Q9Y, 3LBJ, 2VJE, 3FDO, 6Q9S, 3JZO, 8HDG, 7C44, 6YR5, 7C3Y, 6Q9U, 2CR8, 5MNJ, 2VJF, 3JZQ, 7C3Q, 3FE7, 7EL4, 3DAB, 3JZP, 6Q9Q, 2MWY, 5UML, 3MQR, 2N14, 7KJN, 8IA5, 2N0W, 3FEA, 5VK1, 3U15, 4RXZ, 2N0U, 3EQY

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.966	22
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.938	15
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.758	5
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.758	5
UniProt:O95971 CD160	1	CD160 [plasma membrane] (R-HSA-198014)	0.718	6
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.711	15
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.611	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.556	3
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	3
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.527	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.524	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.499	4

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