Reactome | SUMO2-C93-UBE2I [nucleoplasm]

SUMO2-C93-UBE2I

Stable Identifier

R-HSA-3730619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2 S-glycyl-cys93 UBE2I, SUMO-conjugating enzyme UBC9, UBC9_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        PIAS4 SUMOylates MDC1 (Homo sapiens)
        
        SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2-C93-UBE2I [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        SUMO1,2,3:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2-C93-UBE2I [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63279 UBE2I

Gene Names

UBE2I, UBC9, UBCE9

Chain

initiator methionine:1, chain:2-158

Reference Genes

BioGPS Gene:7329 UBE2I

COSMIC (genes):UBE2I UBE2I

CTD Gene:7329 UBE2I

dbSNP Gene:7329 UBE2I

ENSEMBL:ENSG00000103275 UBE2I

HGNC:12485 UBE2I

KEGG Gene (Homo sapiens):hsa:7329 UBE2I

Monarch:7329 UBE2I

NCBI Gene:7329 UBE2I

OMIM:601661 UBE2I

UCSC:P63279 UBE2I

Reference Transcript

Other Identifiers

0001190064

0001190338

0001190446

0006400010

11719281_a_at

11719282_x_at

11742690_a_at

11742691_x_at

11749614_a_at

11749615_x_at

11749763_a_at

11759401_at

11763635_s_at

16814636

1A3S

1KPS

1Z5Q

1Z5S

208760_at

213535_s_at

2GRN

2GRO

2GRP

2GRQ

2GRR

2O25

2PE6

2PX9

2XWU

33136_at

3643706

3643707

3643708

3643709

3643710

3643714

3643715

3643716

3643717

3643724

3643725

3643729

3643736

3643738

3643745

3643746

3643747

38480_s_at

3909

3A4S

3UIN

3UIO

3UIP

4W5V

4Y1L

5D2M

5F6D

5F6E

5F6U

5F6V

5F6W

5F6X

5F6Y

5FQ2

7329

7992205

838_s_at

9021

A_23_P152107

A_24_P227993

AAA86662

AAB02181

AAB09410

AAC50603

AAC50715

AAC50716

AAC51361

AAH00427

AAH04429

AAH51289

AAK61274

AAP35578

AB208988

AE006466

AJ002385

AL031714

BAA08091

BAD92225

BC000427

BC004429

BC051289

BT006932

CAA05359

CAA65287

CAB009021

CCDS10433

CH471112

D45050

EAW85673

EAW85676

EAW85677

EAW85678

EAW85679

ENSG00000103275

ENSP00000324897

ENSP00000348056

ENSP00000380649

ENSP00000380650

ENSP00000384568

ENSP00000385009

ENSP00000457064

ENST00000325437

ENST00000355803

ENST00000397514

ENST00000397515

ENST00000403747

ENST00000406620

ENST00000566587

EntrezGene:7329

GE56096

GE59345

GE86409

GO:0000122

GO:0000166

GO:0000228

GO:0000795

GO:0001650

GO:0003674

GO:0003723

GO:0004842

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006259

GO:0006464

GO:0006511

GO:0006629

GO:0006950

GO:0007049

GO:0007059

GO:0007165

GO:0008022

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0010469

GO:0016032

GO:0016604

GO:0016605

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0030425

GO:0033145

GO:0034641

GO:0042359

GO:0043123

GO:0043161

GO:0043167

GO:0043226

GO:0043234

GO:0043398

GO:0043425

GO:0044281

GO:0044388

GO:0044403

GO:0045202

GO:0045892

GO:0051091

GO:0051301

GO:0061656

GO:0070911

GO:0071535

GO:1903755

GO:1990234

GO:1990356

HGNC:12485

HPA003909

Hs.84285.0.A2_3p_at

Hs.84285.2.S1_3p_a_at

ILMN_1662934

ILMN_1664542

ILMN_1725529

ILMN_1810474

IPR000608

IPR016135

IPR023313

IPR027230

MIM:601661

NM_003345

NM_194259

NM_194260

NM_194261

NP_003336

NP_919235

NP_919236

NP_919237

PF00179

SM00212

TC16000039.hg

U29092

U31882

U31933

U38785

U45328

U45328_s_at

U66818

U66867

UBE2I

UBE2I-201

UBE2I-202

UBE2I-203

UBE2I-204

UBE2I-206

UBE2I-207

UBE2I-213

uc002clc.2

uc002cld.3

uc002clf.3

uc002clg.3

uc059ovm.1

uc059ovp.1

uc059ovq.1

UPI00000010F8

X96427

XM_017023640

XP_016879129

Participant Of

hasComponent

SUMO2:UBE2I [nucleoplasm]

Other forms of this molecule

SUMO1-K14-UBE2I [nucleoplasm]

SUMO1-C93-UBE2I [cytosol]

UBE2I [nuclear envelope]

UBE2I [cytosol]

SUMO3-C93-UBE2I [nucleoplasm]

UBE2I [nucleoplasm]

SUMO1-C93-UBE2I [nucleoplasm]

Inferred To

SUMO2-C93-UBE2I [nucleoplasm] (Drosophila melanogaster)

Homologues of SUMO1-C93-UBE2I [nucleoplasm] (Danio rerio)

Homologues of SUMO1-C93-UBE2I [nucleoplasm] (Oryza sativa)

SUMO1-C93-UBE2I [nucleoplasm] (Arabidopsis thaliana)

SUMO1-C93-UBE2I [nucleoplasm] (Danio rerio)

SUMO1-C93-UBE2I [nucleoplasm] (Dictyostelium discoideum)

SUMO1-C93-UBE2I [nucleoplasm] (Gallus gallus)

SUMO1-C93-UBE2I [nucleoplasm] (Oryza sativa)

SUMO1-C93-UBE2I [nucleoplasm] (Plasmodium falciparum)

SUMO1-C93-UBE2I [nucleoplasm] (Saccharomyces cerevisiae)

SUMO1-C93-UBE2I [nucleoplasm] (Schizosaccharomyces pombe)

SUMO1-C93-UBE2I [nucleoplasm] (Sus scrofa)

SUMO1-C93-UBE2I [nucleoplasm] (Taeniopygia guttata)

SUMO1-C93-UBE2I [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 93 and 93

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_919235.1, NP_919237.1, NP_003336.1, NP_919236.1, XP_016879129.1

GeneCards

P63279

ZINC - Substances

UBC9_HUMAN

DOCK Blaster

4W5V, 2PE6, 2GRN, 1KPS, 3UIN, 5D2M, 5F6D, 5F6Y, 5F6E, 5F6X, 5F6W, 3UIP, 5F6U, 5F6V, 3UIO, 1Z5S, 1A3S, 2GRQ, 3A4S, 2GRR, 2O25, 2GRO, 2GRP, 5FQ2, 4Y1L, 2XWU

ZINC target

P63279

PRO

P63279

BRENDA (Homo sapiens)

2.3.2.23

ZINC - Predictions - Purchasable

UBC9_HUMAN

HMDB Protein

HMDBP00635

PDB

1Z5Q, 5FQ2, 5F6U, 2O25, 3A4S, 1Z5S, 5F6V, 5F6W, 2PE6, 2GRN, 5F6Y, 5F6X, 2GRO, 1A3S, 5F6D, 2GRP, 5F6E, 3UIN, 2GRQ, 5D2M, 3UIO, 2PX9, 1KPS, 2GRR, 2XWU, 3UIP, 4W5V, 4Y1L

Interactors (87)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	154	TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) K239-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085299) K731-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085290) K788-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085308) NPM1-G97-SUMO1 [nucleoplasm] (R-HSA-4086019) NCOR2-G97-SUMO1 [nucleoplasm] (R-HSA-3927883) DDX17-G97-SUMO1 [nucleoplasm] (R-HSA-3900210) PARK7-G97-SUMO1 [nucleoplasm] (R-HSA-4085344) K1033-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927910) K1056-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927954) K998-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927822) K1154-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086067) K756-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086034) DDX5-G97-SUMO1 [nucleoplasm] (R-HSA-3900212) CASP8AP2-G97-SUMO1 [nucleoplasm] (R-HSA-3927863) K1024-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899298) K1020-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899290) CTBP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730764) K231-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085364) K294-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085341) K624-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900128) K576-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900225) K499-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900219) K631-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086044) K630-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086012) SIN3A-G97-SUMO1 [nucleoplasm] (R-HSA-4086058) PPARGC1A-G97-SUMO1 [nucleoplasm] (R-HSA-3903014) HIPK2-G97-SUMO1 [nucleoplasm] (R-HSA-4090362) K774-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085292) K732-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085278) K538-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090416) K499-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090332) ZNF131-G97-SUMO1 [nucleoplasm] (R-HSA-3730875) K90-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755511) K689-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755446) K863-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755412) K298-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755505) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) p-S172-IKBKE-G97-SUMO1 [nucleoplasm] (R-HSA-4755408) K309-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755404) K277-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755531) NFKBIA-G97-SUMO1 [nucleoplasm] (R-HSA-4656987) RANGAP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730796) AURKA-G97-SUMO1 [cytosol] (R-HSA-4655413) TOP2B-G97-SUMO1 [nucleoplasm] (R-HSA-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-HSA-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-HSA-4641341) K254-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615853) K-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615836) K164-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615951) MDC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570527) STAG2-G97-SUMO1 [nucleoplasm] (R-HSA-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-HSA-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568857) K412-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568850) K414-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568900) XRCC4-G97-SUMO1 [nucleoplasm] (R-HSA-4568869) K160-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730884) K490-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730833) K65-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730879) K203-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551625) K486-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551748) K496-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568906) K898-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568893) K356-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568845) RNF168-SUMO1 [nucleoplasm] (R-HSA-4551631) XPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570452) TDG-G97-SUMO1 [nucleoplasm] (R-HSA-4551682) SP100-G97-SUMO1 [nucleoplasm] (R-HSA-3730794) BRCA1-G97-SUMO1 [nucleoplasm] (R-HSA-3730735) RXRA-G97-SUMO1 [nucleoplasm] (R-HSA-4341090) NR5A2-G97-SUMO1 [nucleoplasm] (R-HSA-4755424) K386-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090321) K520-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090352) K293-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341110) K277-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341057) K389-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719415) K283-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719434) K399-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341020) K428-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341035) K494-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341093) K89-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341058) K119-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546379) K194-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546380) NR2C1-G97-SUMO1 [nucleoplasm] (R-HSA-4717492) K303-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090373) K266-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090359) K302-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090363) K299-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090349) K268-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090414) K531-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341021) K7-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341052) K388-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341056) NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4755434) PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717445) K395-PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717446) PPARA-G97-SUMO1 [nucleoplasm] (R-HSA-4341069) K443-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719431) K146-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719410) K50-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719401) RORA-G97-SUMO1 [nucleoplasm] (R-HSA-4719426) HIC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570544) TP53BP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730731) SP3-G97-SUMO1 [nucleoplasm] (R-HSA-3730646) K423-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730755) K289-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730738) K25-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968400) K150-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968382) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570515) K497-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570504) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570462) DNMT3B-G97-SUMO1 [nucleoplasm] (R-HSA-4655444) DNMT3A-G97-SUMO1 [nucleoplasm] (R-HSA-4655383) DNMT1-G97-SUMO1 [nucleoplasm] (R-HSA-4655358) K84-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615838) K-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615955) K476-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4615867) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4616028) CBX4-G97-SUMO1 [nucleoplasm] (R-HSA-4551756) HDAC2-G97-SUMO1 [nucleoplasm] (R-HSA-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-HSA-4615961) SATB1-G97-SUMO1 [nucleoplasm] (R-HSA-4615877) HDAC4-G97-SUMO1 [nucleoplasm] (R-HSA-4615956) K1971-CHD3-G97-SUMO1 [nucleoplasm] (R-HSA-8956370) HIST1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4570549) BMI1-G97-SUMO1 [nucleoplasm] (R-HSA-4551654) TFAP2B-G97-SUMO1 [nucleoplasm] (R-HSA-3730839) TFAP2C-G97-SUMO1 [nucleoplasm] (R-HSA-3730823) TFAP2A-1-G97-SUMO1 [nucleoplasm] (R-HSA-3730825) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) HERC2-SUMO1 [nucleoplasm] (R-HSA-4551761)	0.946	10
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) SUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.932	9
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.853	8
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.742	5
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.734	7
UniProt:Q9H2X6 HIPK2	3	HIPK2 [nucleoplasm] (R-HSA-3215222) SUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405) p-HIPK2 [nucleoplasm] (R-HSA-6799375)	0.721	5
UniProt:Q13485 SMAD4	18	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 R515* [cytosol] (R-HSA-3311012)	0.721	4
UniProt:O94829 IPO13			0.715	6
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.678	3
UniProt:Q9Y4E5 ZN451			0.668	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.666	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.658	3
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.647	3
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.646	4
UniProt:Q92754 TFAP2C	3	TFAP2C [cytosol] (R-HSA-8864579) SUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.646	5
UniProt:Q9Y3V2 RWDD3	1	RWDD3 [nucleoplasm] (R-HSA-8932136)	0.61	5
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.591	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.581	3
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.567	3
UniProt:Q9UBE0 SAE1	1	SAE1 [nucleoplasm] (R-HSA-947697)	0.564	2
UniProt:Q9UBT2 UBA2	4	SUMO2-C173-UBA2 [nucleoplasm] (R-HSA-3730612) SUMO3-C173-UBA2 [nucleoplasm] (R-HSA-3730623) SUMO1-C173-UBA2 [nucleoplasm] (R-HSA-3730628) UBA2 [nucleoplasm] (R-HSA-947696)	0.564	2
UniProt:Q9ERU9 Ranbp2	4	Ranbp2 [nuclear envelope] (R-MMU-5228524) SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-MMU-4551599) RANBP2 [nuclear envelope] (R-MMU-2993756) RANBP2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:P40473 POG1			0.556	3
UniProt:P40151 WRIP1			0.556	3
UniProt:P32458 CDC11			0.556	3
UniProt:P38319 TYDP1			0.556	3
UniProt:P38838 WSS1			0.556	3
UniProt:Q03063 DIG1			0.556	3
UniProt:Q04110 ECM11			0.556	3
UniProt:Q06178	3	NMNAT1 [nucleoplasm] (R-SCE-200484-2) NMNAT2 [Golgi membrane] (R-SCE-197202) NMNAT3 [mitochondrial matrix] (R-SCE-200475-2)	0.556	3
UniProt:Q12206 WTM2			0.556	3
UniProt:P49723 RIR4			0.556	3
UniProt:P25354 YCP7			0.556	3
UniProt:P25515	6	ATP6V0C [tertiary granule membrane] (R-SCE-6800991) ATP6V0C [phagocytic vesicle membrane] (R-SCE-1222603) ATP6V0C [azurophil granule membrane] (R-SCE-6799363) ATP6V0C [plasma membrane] (R-SCE-6806254) ATP6V0C [ficolin-1-rich granule membrane] (R-SCE-6800908) ATP6V0C [endosome membrane] (R-SCE-912591)	0.556	3
UniProt:P40956 GTS1			0.556	3
UniProt:Q12020 SRL2			0.556	3
UniProt:P32502	1	EIF2B2 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P46985 MNN11			0.556	3
UniProt:Q06340 ESC2			0.556	3
UniProt:Q03718 NSE5			0.556	3
UniProt:Q8N3Z6 ZCHC7			0.556	3
UniProt:Q12306	11	SUMO3(1-103) [nucleoplasm] (R-SCE-2990830) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-SCE-4551627) SUMO2(1-95) [nucleoplasm] (R-SCE-2990837) UBE2I-G92-SUMO3 [nucleoplasm] (R-SCE-3730611) SUMO2 [nucleoplasm] (R-SCE-2984281) SUMO3 [nucleoplasm] (R-SCE-2984269) UBE2I-G93-SUMO2 [nucleoplasm] (R-SCE-3730625) SUMO1(2-101) [nucleoplasm] (R-SCE-2990831) SUMO1 [nucleoplasm] (R-SCE-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-SCE-3730616) CTBP1-G97-SUMO1 [nucleoplasm] (R-SCE-4551761)	0.556	3
UniProt:P25611 RDS1			0.556	3
UniProt:P27515	3	UCK 2 [cytosol] (R-SCE-66871) UCKL1 [cytosol] (R-SCE-8954322) UCK1 [cytosol] (R-SCE-73503)	0.556	3
UniProt:P25453 DMC1			0.556	3
UniProt:P53243 YG2A			0.556	3
UniProt:P35192 MAC1			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:P53286 BTN2			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:P38986 ASPG1			0.556	3
UniProt:P60010	6	ACTR1B [extracellular region] (R-SCE-6806503) ACTR1B [ficolin-1-rich granule lumen] (R-SCE-6801063) ACTR1B [secretory granule lumen] (R-SCE-6801082) ACTB(1-375) [nucleoplasm] (R-SCE-3321990) ACTB(1-375) [cytosol] (R-SCE-201858) ACTB(1-375) [plasma membrane] (R-SCE-196016)	0.556	3
UniProt:P17423 KHSE			0.556	3
UniProt:G2XKQ0 G2XKQ0			0.556	3
IntAct:EBI-11522346 CTT1			0.556	3
UniProt:P38703 LAG1			0.556	3
UniProt:P33417 IXR1			0.556	3
UniProt:Q12439 YO21A			0.556	3
UniProt:Q03373 DIG2			0.556	3
UniProt:Q08581 SLK19			0.556	3
UniProt:P04046	1	PPAT [cytosol] (R-SCE-62496)	0.556	3
UniProt:P53252 PIL1			0.556	3
UniProt:P53176 MST27			0.556	3
UniProt:P37263 YC16			0.556	3
UniProt:P53174 PRM8			0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	3
UniProt:P32562	5	phospho-p-T210-PLK1 [nucleoplasm] (R-SCE-3002800) PLK1 [nucleoplasm] (R-SCE-156720) phospho-p-T210-PLK1 [cytosol] (R-SCE-3000318) PLK3 [nucleoplasm] (R-SCE-3222161) PLK1 [cytosol] (R-SCE-164603)	0.556	3
UniProt:P15873	5	K63polyUb-K164-PCNA [nucleoplasm] (R-SCE-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-SCE-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-SCE-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-SCE-5651986) PCNA [nucleoplasm] (R-SCE-68439)	0.556	3
UniProt:P38991	2	AURKA [cytosol] (R-SCE-174254) PolyUb-AURKA [cytosol] (R-SCE-8854040)	0.556	3
UniProt:Q7Z333 SETX			0.553	3
UniProt:Q9H444 CHMP4B	1	CHMP4B [cytosol] (R-HSA-917708)	0.553	3
UniProt:Q06265 EXOSC9	2	EXOSC9 [cytosol] (R-HSA-429984) EXOSC9 [nucleoplasm] (R-HSA-6791577)	0.553	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.553	2
UniProt:Q9UKL3 CASP8AP2	2	CASP8AP2 [nucleoplasm] (R-HSA-3927945) SUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850)	0.553	2
UniProt:Q9UKT9 IKZF3			0.553	2
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:Q01826 SATB1	5	SUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1 [nucleoplasm] (R-HSA-201593) SATB1(1-254) [nucleoplasm] (R-HSA-352269)	0.553	2
UniProt:P03116 VE1			0.527	2
UniProt:P03230 LMP1			0.524	5
UniProt:P56693 SOX10			0.508	2
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.508	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.499	3
UniProt:Q12800 TFCP2			0.488	4
UniProt:Q96IK5 GMCL1			0.488	4
UniProt:P0C206 REX			0.488	2
UniProt:Q969V5 MUL1	2	PolyUb-MUL1 [mitochondrial outer membrane] (R-HSA-6783184) MUL1 [mitochondrial outer membrane] (R-HSA-2993772)	0.462	2