Reactome | SUMO2-C93-UBE2I [nucleoplasm]

SUMO2-C93-UBE2I [nucleoplasm]

Stable Identifier

R-HSA-3730619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2 S-glycyl-cys93 UBE2I, SUMO-conjugating enzyme UBC9, UBC9_HUMAN

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        PIAS4 SUMOylates MDC1 (Homo sapiens)
        
        SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2-C93-UBE2I [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        SUMO1,2,3:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2:UBE2I [nucleoplasm] (Homo sapiens)
        
        SUMO2-C93-UBE2I [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63279 UBE2I

Gene Names

UBE2I, UBC9, UBCE9

Chain

initiator methionine:1, chain:2-158

Reference Genes

BioGPS Gene:7329 UBE2I

COSMIC (genes):UBE2I UBE2I

CTD Gene:7329 UBE2I

dbSNP Gene:7329 UBE2I

ENSEMBL:ENSG00000103275 UBE2I

HGNC:12485 UBE2I

KEGG Gene (Homo sapiens):7329 UBE2I

Monarch:7329 UBE2I

NCBI Gene:7329 UBE2I

OMIM:601661 UBE2I

UCSC:P63279 UBE2I

Reference Transcript

Other Identifiers

0001190064

0001190338

0001190446

0006400010

11719281_a_at

11719282_x_at

11742690_a_at

11742691_x_at

11749614_a_at

11749615_x_at

11749763_a_at

11759401_at

11763635_s_at

16814636

208760_at

213535_s_at

33136_at

3643706

3643707

3643708

3643709

3643710

3643714

3643715

3643716

3643717

3643724

3643725

3643729

3643736

3643738

3643745

3643746

3643747

3643753

38480_s_at

7329

7992205

838_s_at

A_23_P152107

A_24_P227993

GE56096

GE59345

GE86409

GO:0000122

GO:0000166

GO:0000228

GO:0000795

GO:0001221

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006464

GO:0006511

GO:0007049

GO:0007059

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0016032

GO:0016605

GO:0016740

GO:0016925

GO:0019789

GO:0019899

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0044388

GO:0044403

GO:0045892

GO:0051301

GO:0061656

GO:0071535

GO:1903755

GO:1990234

GO:1990356

HMNXSV003036382

HMNXSV003050289

Hs.84285.0.A2_3p_at

Hs.84285.2.S1_3p_a_at

ILMN_1662934

ILMN_1664542

ILMN_1725529

ILMN_1810474

TC16000039.hg

U45328_s_at

Participates

as a component of

SUMO2:UBE2I [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO1-K14-UBE2I [nucleoplasm]

UBE2I [nuclear envelope]

UBE2I [cytosol]

SUMO1-C93-UBE2I [cytosol]

SUMO3-C93-UBE2I [nucleoplasm]

UBE2I [nucleoplasm]

SUMO1-C93-UBE2I [nucleoplasm]

Inferred To

Ube2i [nucleoplasm] (Mus musculus)

Ube2i [nucleoplasm] (Rattus norvegicus)

lwr [nucleoplasm] (Drosophila melanogaster)

UBE2I [nucleoplasm] (Gallus gallus)

ubc9 [nucleoplasm] (Dictyostelium discoideum)

SUMO2-C93-UBE2I [nucleoplasm] (Dictyostelium discoideum)

SUMO2-C93-UBE2I [nucleoplasm] (Plasmodium falciparum)

ube2ia [nucleoplasm] (Danio rerio)

Homologues of SUMO2-C93-UBE2I [nucleoplasm] (Dictyostelium discoideum)

ube2i [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 93 and 93

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

XP_016879129.1, NP_919236.1, NP_003336.1, NP_919237.1, NP_919235.1

OpenTargets

ENSG00000103275

ZINC - Substances

UBC9_HUMAN

GeneCards

P63279

HPA

ENSG00000103275-UBE2I

ZINC target

P63279

Ensembl

ENST00000403747, ENSG00000103275, ENSP00000380649, ENSP00000348056, ENSP00000324897, ENSP00000385009, ENSP00000384568, ENSP00000380650, ENST00000325437, ENST00000406620, ENST00000397515, ENST00000566587, ENST00000397514, ENSP00000457064, ENST00000355803

PRO

P63279

ZINC - Predictions - Purchasable

UBC9_HUMAN

HMDB Protein

HMDBP00635

PDB

4W5V, 4Y1L, 6SYF, 2XWU, 1Z5Q, 3UIO, 2PX9, 2GRR, 1KPS, 3UIP, 3UIN, 5F6E, 5D2M, 2GRQ, 2GRO, 2GRP, 5F6D, 2PE6, 5F6Y, 1A3S, 5F6X, 2GRN, 5F6V, 1Z5S, 5F6W, 3A4S, 5FQ2, 5F6U, 2O25

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	155	TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) K239-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085299) K731-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085290) K788-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085308) NPM1-G97-SUMO1 [nucleoplasm] (R-HSA-4086019) NCOR2-G97-SUMO1 [nucleoplasm] (R-HSA-3927883) DDX17-G97-SUMO1 [nucleoplasm] (R-HSA-3900210) PARK7-G97-SUMO1 [nucleoplasm] (R-HSA-4085344) K1033-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927910) K1056-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927954) K998-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927822) K1154-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086067) K756-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086034) DDX5-G97-SUMO1 [nucleoplasm] (R-HSA-3900212) CASP8AP2-G97-SUMO1 [nucleoplasm] (R-HSA-3927863) K1024-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899298) K1020-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899290) CTBP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730764) K231-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085364) K294-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085341) K624-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900128) K576-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900225) K499-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900219) K631-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086044) K630-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086012) SIN3A-G97-SUMO1 [nucleoplasm] (R-HSA-4086058) PPARGC1A-G97-SUMO1 [nucleoplasm] (R-HSA-3903014) HIPK2-G97-SUMO1 [nucleoplasm] (R-HSA-4090362) K774-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085292) K732-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085278) K538-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090416) K499-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090332) ZNF131-G97-SUMO1 [nucleoplasm] (R-HSA-3730875) K90-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755511) K689-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755446) K863-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755412) K298-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755505) p-S172-IKBKE-G97-SUMO1 [nucleoplasm] (R-HSA-4755408) K309-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755404) K277-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755531) NFKBIA-G97-SUMO1 [nucleoplasm] (R-HSA-4656987) AURKA-G97-SUMO1 [cytosol] (R-HSA-4655413) TOP2B-G97-SUMO1 [nucleoplasm] (R-HSA-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-HSA-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-HSA-4641341) K254-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615853) K-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615836) K164-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615951) MDC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570527) STAG2-G97-SUMO1 [nucleoplasm] (R-HSA-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-HSA-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568857) K412-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568850) K414-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568900) XRCC4-G97-SUMO1 [nucleoplasm] (R-HSA-4568869) K160-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730884) K490-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730833) K65-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730879) K203-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551625) K486-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551748) K496-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568906) K898-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568893) K356-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568845) RNF168-SUMO1 [nucleoplasm] (R-HSA-4551631) XPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570452) TDG-G97-SUMO1 [nucleoplasm] (R-HSA-4551682) SP100-G97-SUMO1 [nucleoplasm] (R-HSA-3730794) BRCA1-G97-SUMO1 [nucleoplasm] (R-HSA-3730735) RXRA-G97-SUMO1 [nucleoplasm] (R-HSA-4341090) NR5A2-G97-SUMO1 [nucleoplasm] (R-HSA-4755424) K386-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090321) K520-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090352) K293-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341110) K277-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341057) K389-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719415) K283-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719434) K399-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341020) K428-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341035) K494-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341093) K89-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341058) K119-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546379) K194-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546380) NR2C1-G97-SUMO1 [nucleoplasm] (R-HSA-4717492) K303-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090373) K266-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090359) K302-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090363) K299-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090349) K268-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090414) K531-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341021) K7-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341052) K388-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341056) K132-NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-9610527) NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4755434) PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717445) K395-PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717446) PPARA-G97-SUMO1 [nucleoplasm] (R-HSA-4341069) K443-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719431) K146-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719410) K50-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719401) RORA-G97-SUMO1 [nucleoplasm] (R-HSA-4719426) HIC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570544) TP53BP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730731) SP3-G97-SUMO1 [nucleoplasm] (R-HSA-3730646) K423-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730755) K289-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730738) K25-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968400) K150-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968382) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570515) K497-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570504) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570462) DNMT3B-G97-SUMO1 [nucleoplasm] (R-HSA-4655444) DNMT3A-G97-SUMO1 [nucleoplasm] (R-HSA-4655383) DNMT1-G97-SUMO1 [nucleoplasm] (R-HSA-4655358) K84-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615838) K-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615955) K476-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4615867) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4616028) CBX4-G97-SUMO1 [nucleoplasm] (R-HSA-4551756) HDAC2-G97-SUMO1 [nucleoplasm] (R-HSA-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-HSA-4615961) SATB1-G97-SUMO1 [nucleoplasm] (R-HSA-4615877) HDAC4-G97-SUMO1 [nucleoplasm] (R-HSA-4615956) K1971-CHD3-G97-SUMO1 [nucleoplasm] (R-HSA-8956370) HIST1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4570549) BMI1-G97-SUMO1 [nucleoplasm] (R-HSA-4551654) TFAP2B-G97-SUMO1 [nucleoplasm] (R-HSA-3730839) TFAP2C-G97-SUMO1 [nucleoplasm] (R-HSA-3730823) TFAP2A-1-G97-SUMO1 [nucleoplasm] (R-HSA-3730825) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) RANGAP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730796) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) HERC2-SUMO1 [nucleoplasm] (R-HSA-4551761)	0.954	12
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) SUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.946	13
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.853	8
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.835	6
UniProt:Q9UBT2 UBA2	4	SUMO2-C173-UBA2 [nucleoplasm] (R-HSA-3730612) SUMO3-C173-UBA2 [nucleoplasm] (R-HSA-3730623) SUMO1-C173-UBA2 [nucleoplasm] (R-HSA-3730628) UBA2 [nucleoplasm] (R-HSA-947696)	0.806	7
UniProt:P49792 RANBP2	4	SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) RANBP2 [cytosol] (R-HSA-157703) RANBP2 [nuclear envelope] (R-HSA-2993756)	0.752	4
UniProt:P59595 N	11	SUMO1-K62-ADPr-p-S177-Ncap [viral capsid] (R-COV-9685478) p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol] (R-COV-9681626) SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) SUMO1-K62-ADPr-p-S177-Ncap [cytosol] (R-COV-9682916) ADPr-p-S177-Ncap [cytosol] (R-COV-9686058) p-S177-Ncap [cytosol] (R-COV-9683754) Ncap [cytosol] (R-COV-9683625) Ncap [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-Ncap [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane] (R-COV-9686063) N [cytosol] (R-COV-9681657)	0.75	12
UniProt:Q9Y4E5 ZN451			0.747	4
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.742	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.737	5
UniProt:P19419 ELK1	2	p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350) ELK1 [nucleoplasm] (R-HSA-3009346)	0.734	7
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) SUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405) HIPK2 [nucleoplasm] (R-HSA-3215222)	0.721	5
UniProt:O94829 IPO13			0.715	6
UniProt:Q9UBE0 SAE1	1	SAE1 [nucleoplasm] (R-HSA-947697)	0.669	3
UniProt:P54253 ATX1			0.666	7
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.659	4
UniProt:Q9UER7 DAXX	13	DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.647	3
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.646	4
UniProt:Q92754 TFAP2C	3	TFAP2C [cytosol] (R-HSA-8864579) SUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.646	5
UniProt:Q9Y3V2 RWDD3	1	RWDD3 [nucleoplasm] (R-HSA-8932136)	0.61	5
UniProt:P63279 UBE2I	8	UBE2I [nuclear envelope] (R-HSA-4655408) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.591	3
UniProt:P61956 SUMO2	5	UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) MDC1-SUMO2 [nucleoplasm] (R-HSA-5684062)	0.59	7
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.581	3
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.567	3
UniProt:P55854 SUMO3	4	SUMO3 [nucleoplasm] (R-HSA-2984269) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830) UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627)	0.564	2
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:P15873	5	POL30 [nucleoplasm] (R-SCE-8943000) POL30 [nucleoplasm] (R-SCE-4615861) POL30 [nucleoplasm] (R-SCE-68439) POL30 [nucleoplasm] (R-SCE-5651986) POL30 [nucleoplasm] (R-SCE-5653768)	0.556	3
UniProt:P40473 POG1			0.556	3
UniProt:P40151 WRIP1			0.556	3
UniProt:P32458	1	CDC11 [cytosol] (R-SCE-5692671-2)	0.556	3
UniProt:P38319 TYDP1			0.556	3
UniProt:P38838 WSS1			0.556	3
UniProt:Q03063 DIG1			0.556	3
UniProt:Q04110 ECM11			0.556	3
UniProt:Q06178	3	NMA1 [Golgi membrane] (R-SCE-197202-2) NMA1 [mitochondrial matrix] (R-SCE-200475-2) NMA1 [nucleoplasm] (R-SCE-200484)	0.556	3
UniProt:Q12206	1	WTM2 [nucleoplasm] (R-SCE-212227-4)	0.556	3
UniProt:P49723 RIR4			0.556	3
UniProt:P25354 YCP7			0.556	3
UniProt:P25515	7	VMA3 [phagocytic vesicle membrane] (R-SCE-1222603) VMA3 [lysosomal membrane] (R-SCE-9640194) VMA3 [azurophil granule membrane] (R-SCE-6799363) VMA3 [tertiary granule membrane] (R-SCE-6800991) VMA3 [plasma membrane] (R-SCE-6806254) VMA3 [ficolin-1-rich granule membrane] (R-SCE-6800908) VMA3 [endosome membrane] (R-SCE-912591)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P40956 GTS1			0.556	3
UniProt:Q12020 SRL2			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P46985 MNN11			0.556	3
UniProt:Q06340 ESC2			0.556	3
UniProt:Q03718 NSE5			0.556	3
UniProt:Q8N3Z6 ZCHC7			0.556	3
UniProt:Q8WWZ3 EDARADD	1	EDARADD [cytosol] (R-HSA-5675659)	0.556	3
UniProt:P25611 RDS1			0.556	3
UniProt:P27515	5	URK1 [cytosol] (R-SCE-8869620) URK1 [cytosol] (R-SCE-8869628) URK1 [cytosol] (R-SCE-8954322) URK1 [cytosol] (R-SCE-66871) URK1 [cytosol] (R-SCE-73503)	0.556	3
UniProt:P25453 DMC1			0.556	3
UniProt:P53243 YG2A			0.556	3
UniProt:P35192 MAC1			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:P53286 BTN2			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:P38986 ASPG1			0.556	3
UniProt:P60010	5	ACT1 [cytosol] (R-SCE-390536) ACT1 [lysosomal membrane] (R-SCE-196169) ACT1 [extracellular region] (R-SCE-350725) ACT1 [cytosol] (R-SCE-201861) ACT1 [plasma membrane] (R-SCE-196016)	0.556	3
UniProt:P32562	5	phospho-CDC5 [nucleoplasm] (R-SCE-3002800) CDC5 [nucleoplasm] (R-SCE-156720) phospho-CDC5 [cytosol] (R-SCE-3000318) CDC5 [nucleoplasm] (R-SCE-3222161) CDC5 [cytosol] (R-SCE-164603)	0.556	3
UniProt:P17423 KHSE			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
IntAct:EBI-11522346 CTT1			0.556	3
UniProt:P38703	6	LAG1 [endoplasmic reticulum membrane] (R-SCE-428171-2) LAG1 [endoplasmic reticulum membrane] (R-SCE-428168-2) LAG1 [endoplasmic reticulum membrane] (R-SCE-428138-2) LAG1 [endoplasmic reticulum membrane] (R-SCE-428159-2) LAG1 [endoplasmic reticulum membrane] (R-SCE-428145-2) LAG1 [endoplasmic reticulum membrane] (R-SCE-428131-2)	0.556	3
UniProt:P33417	5	IXR1 [secretory granule lumen] (R-SCE-6803337-2) IXR1 [ficolin-1-rich granule lumen] (R-SCE-6803291-2) IXR1 [extracellular region] (R-SCE-879382-2) IXR1 [nucleoplasm] (R-SCE-266221-2) IXR1 [extracellular region] (R-SCE-6797422-2)	0.556	3
UniProt:Q12439 YO21A			0.556	3
UniProt:Q03373 DIG2			0.556	3
UniProt:Q08581 SLK19			0.556	3
UniProt:P04046 PUR1			0.556	3
UniProt:P53252 PIL1			0.556	3
UniProt:P38991	2	IPL1 [cytosol] (R-SCE-174254) IPL1 [cytosol] (R-SCE-8854040)	0.556	3
UniProt:P53176 MST27			0.556	3
UniProt:P37263 YC16			0.556	3
UniProt:P53174 PRM8			0.556	3
UniProt:Q12306	31	SMT3 [nucleoplasm] (R-SCE-3968375) SMT3 [nucleoplasm] (R-SCE-4085334) SMT3 [nuclear envelope] (R-SCE-4551627) SMT3 [nucleoplasm] (R-SCE-4086096) SMT3 [nucleoplasm] (R-SCE-3900210) SMT3 [nucleoplasm] (R-SCE-3900212) SMT3 [nucleoplasm] (R-SCE-4086058) SMT3 [nucleoplasm] (R-SCE-4090362) SMT3 [nucleoplasm] (R-SCE-4641311) SMT3 [nucleoplasm] (R-SCE-4641306) SMT3 [nucleoplasm] (R-SCE-4641341) SMT3 [nucleoplasm] (R-SCE-4615836) SMT3 [nucleoplasm] (R-SCE-3826645) SMT3 [nucleoplasm] (R-SCE-3826574) SMT3 [nucleoplasm] (R-SCE-4568857) SMT3 [nucleoplasm] (R-SCE-4570452) SMT3 [nucleoplasm] (R-SCE-3730731) SMT3 [nucleoplasm] (R-SCE-3730738) SMT3 [nucleoplasm] (R-SCE-3968396) SMT3 [nucleoplasm] (R-SCE-4570515) SMT3 [nucleoplasm] (R-SCE-4570462) SMT3 [nucleoplasm] (R-SCE-4616028) SMT3 [nucleoplasm] (R-SCE-4616032) SMT3 [nucleoplasm] (R-SCE-4615961) SMT3 [nucleoplasm] (R-SCE-4615956) SMT3 [nucleoplasm] (R-SCE-4570549) SMT3 [nucleoplasm] (R-SCE-3730796) SMT3 [nucleoplasm] (R-SCE-2990831) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-3730622)	0.556	3
UniProt:Q7Z333 SETX			0.553	3
UniProt:Q06265 EXOSC9	2	EXOSC9 [cytosol] (R-HSA-429984) EXOSC9 [nucleoplasm] (R-HSA-6791577)	0.553	2
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:Q9UKL3 CASP8AP2	2	CASP8AP2 [nucleoplasm] (R-HSA-3927945) SUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850)	0.553	2
UniProt:Q9UKT9 IKZF3			0.553	2
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.553	2
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.553	3
UniProt:Q01826 SATB1	5	SUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) SATB1(255-763) [nucleoplasm] (R-HSA-352264) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1 [nucleoplasm] (R-HSA-201593)	0.553	2
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.527	2
UniProt:P03116 VE1			0.527	2
UniProt:P03230 LMP1			0.524	5
UniProt:P56693 SOX10	1	SOX10 [nucleoplasm] (R-HSA-9613639)	0.508	2
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.508	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.499	3
UniProt:Q12800 TFCP2			0.488	4
UniProt:Q96IK5 GMCL1			0.488	4
UniProt:P0C206 REX			0.488	2
UniProt:Q969V5 MUL1	2	PolyUb-MUL1 [mitochondrial outer membrane] (R-HSA-6783184) MUL1 [mitochondrial outer membrane] (R-HSA-2993772)	0.462	2

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