Reactome | HIF1A [cytosol]

HIF1A [cytosol]

Stable Identifier

R-HSA-1234102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Hypoxia-inducible factor 1-alpha, HIF1A_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)
        
        HIF1A,BIRC2,BIRC3 [cytosol] (Homo sapiens)
        
        HIF1A [cytosol] (Homo sapiens)
        
        USP19:HIF1A,BIRC2,BIRC3 [cytosol] (Homo sapiens)
        
        HIF1A,BIRC2,BIRC3 [cytosol] (Homo sapiens)
        
        HIF1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16665 HIF1A

Gene Names

HIF1A, BHLHE78, MOP1, PASD8

Chain

chain:1-826

Reference Genes

BioGPS Gene:3091 D0VY79

COSMIC (genes):HIF1A HIF1A

CTD Gene:3091 D0VY79

dbSNP Gene:3091 HIF1A

ENSEMBL:ENSG00000100644 HIF1A

HGNC:4910 HIF1A

KEGG:hsa:3091 D0VY79

Monarch:3091 D0VY79

NCBI Gene:3091 D0VY79

OMIM:603348 HIF1A

UCSC:Q16665 HIF1A

Reference Transcript

Other Identifiers

1039_s_at

11718757_s_at

11718758_a_at

11718759_x_at

11747800_a_at

11749123_a_at

11749648_a_at

11749649_x_at

11755737_x_at

16785058

200989_PM_at

200989_at

3091

3539072

3539073

3539074

3539075

3539076

3539077

3539078

3539083

3539084

3539085

3539086

3539087

3539088

3539089

3539090

3539091

3539093

3539094

3539095

3539096

3539097

3539098

3539099

3539100

3539101

3539102

3539103

3539104

3539105

75276_at

7974851

A_14_P117087

A_14_P137044

A_24_P56388

A_33_P3231277

GE59057

GO:0000302

GO:0000785

GO:0000791

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001216

GO:0001217

GO:0001222

GO:0001223

GO:0001228

GO:0001525

GO:0001568

GO:0001666

GO:0001678

GO:0001755

GO:0001837

GO:0001892

GO:0001922

GO:0001938

GO:0001944

GO:0001947

GO:0002039

GO:0002052

GO:0002062

GO:0002067

GO:0002071

GO:0002248

GO:0002376

GO:0003151

GO:0003208

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0005929

GO:0006089

GO:0006110

GO:0006355

GO:0006357

GO:0006879

GO:0006915

GO:0006979

GO:0007018

GO:0007165

GO:0007405

GO:0007595

GO:0008542

GO:0010039

GO:0010468

GO:0010573

GO:0010575

GO:0010628

GO:0010629

GO:0010634

GO:0014850

GO:0016239

GO:0016604

GO:0016607

GO:0016922

GO:0019896

GO:0019899

GO:0019901

GO:0019904

GO:0021502

GO:0021987

GO:0030154

GO:0030279

GO:0030282

GO:0030502

GO:0030949

GO:0031514

GO:0031625

GO:0031929

GO:0032007

GO:0032364

GO:0032722

GO:0032909

GO:0032963

GO:0032991

GO:0034599

GO:0035162

GO:0035773

GO:0035774

GO:0042127

GO:0042541

GO:0042593

GO:0042826

GO:0043066

GO:0043226

GO:0043524

GO:0043536

GO:0043565

GO:0045648

GO:0045766

GO:0045821

GO:0045893

GO:0045926

GO:0045944

GO:0046716

GO:0046886

GO:0046982

GO:0046983

GO:0048514

GO:0048546

GO:0048593

GO:0048856

GO:0048870

GO:0051216

GO:0051402

GO:0051541

GO:0051879

GO:0060574

GO:0061030

GO:0061072

GO:0061298

GO:0061629

GO:0070101

GO:0070243

GO:0070244

GO:0070888

GO:0071347

GO:0071456

GO:0071542

GO:0090575

GO:0097152

GO:0097411

GO:0098586

GO:0140537

GO:1900017

GO:1901135

GO:1902894

GO:1902895

GO:1903377

GO:1904115

GO:1904407

GO:2000434

GO:2001054

HMNXSV003055761

ILMN_1681283

ILMN_1763260

ILMN_2379788

PH_hs_0028366

TC14002197.hg

U22431_s_at

g4504384_3p_at

Participates

as a member of

as an input of

Other forms of this molecule

HIF1A [nucleoplasm]

p-Y565-HIF1A [cytosol]

p-Y565,S797-HIF1A [cytosol]

HN-HIF1A [cytosol]

2xHP-HIF1A [cytosol]

2xHP-HIF1A [nucleoplasm]

Inferred To

sima [cytosol] (Drosophila melanogaster)

HIF1A [cytosol] (Bos taurus)

HIF1A [cytosol] (Canis familiaris)

HIF1A [cytosol] (Gallus gallus)

HIF1A [cytosol] (Sus scrofa)

Hif1a [cytosol] (Mus musculus)

Hif1a [cytosol] (Rattus norvegicus)

hif-1 [cytosol] (Caenorhabditis elegans)

hif1a [cytosol] (Xenopus tropicalis)

hif1ab [cytosol] (Danio rerio)

Cross References

RefSeq

NP_851397.1, NP_001521.1, NP_001230013.1

ZINC - World Drugs

HIF1A_HUMAN

OpenTargets

ENSG00000100644

ENSEMBL

ENSP00000338018, ENST00000539097, ENSG00000100644, ENST00000337138, ENSP00000323326, ENST00000323441, ENSP00000437955

ZINC - FDA approved

HIF1A_HUMAN

ZINC - Substances

HIF1A_HUMAN

ZINC - Biogenic

HIF1A_HUMAN

ZINC target

Q16665

PRO

Q16665

GlyGen

Q16665

PDB

5L9V, 1H2M, 1H2L, 1H2K, 4H6J, 4AJY, 6GFX, 5LA9, 1L3E, 1LQB, 7LVS, 8HE0, 6GMR, 3HQU, 5L9B, 3HQR, 2ILM, 5LAS, 5JWP, 6YW3, 8HE3, 1L8C, 7QGS, 1LM8

ZINC - Metabolites

HIF1A_HUMAN

GeneCards

HIF1A

HPA

ENSG00000100644-HIF1A

Pharos - Targets

Q16665

ZINC - Predictions - Purchasable

HIF1A_HUMAN

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.962	22
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.962	20
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.936	13
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.922	12
UniProt:Q9H6Z9 EGLN3	2	EGLN3 [nucleoplasm] (R-HSA-1234104) EGLN3 [cytosol] (R-HSA-1234115)	0.881	7
UniProt:Q9GZT9 EGLN1	1	EGLN1 [cytosol] (R-HSA-1234108)	0.803	5
UniProt:Q15370 ELOB	2	ELOB [cytosol] (R-HSA-180551) TCEB2 [nucleoplasm] (R-HSA-112423)	0.789	8
UniProt:O60224 SSX4			0.783	6
IntAct:EBI-2895491 VEGFA			0.725	6
UniProt:Q15369 ELOC	2	ELOC [cytosol] (R-HSA-180535) TCEB1 [nucleoplasm] (R-HSA-112422)	0.702	5
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.688	4
UniProt:Q96KS0 EGLN2	1	EGLN2 [nucleoplasm] (R-HSA-1234117)	0.683	3
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.674	15
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105)	0.669	3
UniProt:P41227 NAA10			0.667	3
UniProt:P40337-3 VHL			0.659	6
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.649	9
UniProt:Q8N461 FBXL16	1	FBXL16 [cytosol] (R-HSA-8862609)	0.615	6
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.609	2
UniProt:P09467 FBP1	1	FBP1 [cytosol] (R-HSA-70476)	0.602	5
UniProt:P14618-1 PKM	2	PKM-1 [cytosol] (R-HSA-71667) PolyUb-PKM-1 [cytosol] (R-HSA-9861692)	0.591	7
UniProt:P17861 XBP1			0.591	3
UniProt:P11474 ESRRA	1	ESRRA [nucleoplasm] (R-HSA-446159)	0.576	3
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.576	4
UniProt:MAFG Q9BRP3			0.557	3
UniProt:Q9UHD8-1 SEPTIN9			0.556	4
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.556	6
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.547	2
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.544	2
UniProt:Q8BIF2 Rbfox3	1	Rbfox3 [nucleoplasm] (R-MMU-9770531)	0.544	2
UniProt:P51450-2 Rorc	2	Rorc-2 [nucleoplasm] (R-MMU-8949302) Rorc [nucleoplasm] (R-MMU-446177)	0.544	2
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.544	2
UniProt:P12882 MYH1			0.527	2
UniProt:P13533 MYH6	1	MYH6 [cytosol] (R-HSA-390563)	0.527	2
UniProt:Q9UKX2 MYH2	1	MYH2 [cytosol] (R-HSA-1449561)	0.527	2
UniProt:P11055 MYH3	1	MYH3 [cytosol] (R-HSA-390560)	0.527	2
UniProt:Q9Y623 MYH4			0.527	2
UniProt:P68133 ACTA1	1	ACTA1 [cytosol] (R-HSA-390534)	0.527	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.524	3
UniProt:Q5RIX9	1	e2f7 [nucleoplasm] (R-DRE-6798305)	0.524	2
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.524	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.524	3
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.524	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.499	2
UniProt:Q9Y2N7-4 HIF3A			0.499	2
UniProt:Q61539	1	Esrrb [nucleoplasm] (R-MMU-446173)	0.499	2
UniProt:Q99PV5 Bhlhe41	1	Bhlhe41 [nucleoplasm] (R-MMU-879802)	0.499	3
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.499	3
UniProt:Q9C0J9 BHLHE41	1	BHLHE41 [nucleoplasm] (R-HSA-879703)	0.499	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.463	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.463	6
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-54659) FASN [cytosol] (R-HSA-199233) decanoyl-FASN [cytosol] (R-HSA-5655935)	0.463	4

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