Reactome | NCOR2 [nucleoplasm]

NCOR2 [nucleoplasm]

Stable Identifier

R-HSA-442469

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor corepressor 2, NCOR2_HUMAN, Smrt

Icon

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - Fatty acid ligands activate PPARA (Homo sapiens)
        
        Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
        
        NCOR2 [nucleoplasm] (Homo sapiens)
        
        PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
        
        Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
        
        NCOR2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y618 NCOR2

Gene Names

NCOR2, CTG26

Chain

chain:1-2514

Reference Genes

BioGPS Gene:9612 NCOR2

COSMIC (genes):NCOR2 NCOR2

CTD Gene:9612 NCOR2

dbSNP Gene:9612 NCOR2

ENSEMBL:ENSG00000196498 NCOR2

ENSEMBL:ENSG00000196498.14 NCOR2

HGNC:7673 NCOR2

KEGG Gene (Homo sapiens):9612 NCOR2

Monarch:9612 NCOR2

NCBI Gene:9612 NCOR2

OMIM:600848 NCOR2

UCSC:Q9Y618 NCOR2

Reference Transcript

Other Identifiers

11718069_a_at

11718070_x_at

11718071_s_at

11718072_a_at

16772074

207760_PM_s_at

207760_s_at

208888_PM_s_at

208888_s_at

208889_3p_s_at

208889_PM_s_at

208889_s_at

215205_PM_x_at

215205_x_at

3476464

3476465

3476466

3476468

3476469

3476470

3476476

3476478

3476481

3476483

3476486

3476488

3476491

3476492

3476493

3476494

3476496

3476497

3476498

3476499

3476500

3476501

3476503

3476504

3476505

3476507

3476508

3476510

3476511

3476515

3476516

3476517

3476518

3476520

3476522

3476524

3476525

3476528

3476529

3476532

3476533

3476535

3476547

3476548

3476551

3476558

3476559

3476563

3476567

3476568

3476570

3476575

3476584

3476589

3476590

3476592

3476593

3476598

3476599

3476612

3476620

39358_at

39359_s_at

7967493

83991_at

9612

GE62815

GO:0000122

GO:0000785

GO:0003677

GO:0003682

GO:0003714

GO:0005112

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0007595

GO:0010243

GO:0010565

GO:0016020

GO:0016363

GO:0016604

GO:0016922

GO:0017053

GO:0021549

GO:0022414

GO:0023052

GO:0032355

GO:0035259

GO:0042826

GO:0042974

GO:0043226

GO:0044849

GO:0044877

GO:0045892

GO:0046965

GO:0048856

GO:0060766

GO:0140110

GO:1902894

HMNXSV003024183

Hs.287994.1.A1_3p_s_at

Hs.287994.1.A2_3p_s_at

Hs.287994.2.S1_3p_s_at

ILMN_1698419

ILMN_2256868

ILMN_2340052

PH_hs_0014932

S83390_s_at

TC12002096.hg

U37146_at

g5454073_3p_s_at

Participates

as an input of

as an output of

PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)

as a component of

as a member of

Other forms of this molecule

monoSUMO1-K672-NCOR2 [nucleoplasm]

Inferred To

NCOR2 [nucleoplasm] (Bos taurus)

NCOR2 [nucleoplasm] (Canis familiaris)

NCOR2 [nucleoplasm] (Gallus gallus)

NCOR2 [nucleoplasm] (Sus scrofa)

ncor2 [nucleoplasm] (Xenopus tropicalis)

Smr [nucleoplasm] (Drosophila melanogaster)

SNT1 [nucleoplasm] (Saccharomyces cerevisiae)

gei-8 [nucleoplasm] (Caenorhabditis elegans)

Ncor2 [nucleoplasm] (Mus musculus)

Ncor2 [nucleoplasm] (Rattus norvegicus)

SMRT [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001070729.2, NP_001193583.1, NP_006303.4

OpenTargets

ENSG00000196498

GeneCards

Q9Y618

HPA

ENSG00000196498-NCOR2

Ensembl

ENST00000405201, ENSG00000196498, ENSP00000384018

PRO

Q9Y618

Pharos - Targets

Q9Y618

Orphanet

25757

HMDB Protein

HMDBP10865

PDB

6PDZ, 1R2B, 8AQN, 4OAR, 8B8W, 4A69, 6A22, 8B95, 2L5G, 1XC5, 5X8Q, 1KKQ, 8AQM, 8B92, 2LTP, 5ZOO, 3R29, 8B93, 5X8X, 2GPV, 8B94, 2RT5, 3R2A, 8B90, 8B8X, 8B91, 8B8Y, 5ZOP, 2ODD, 8B8Z, 6IVX

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.95	13
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.737	32
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.667	4
UniProt:P10828-1 THRB			0.656	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.647	4
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.646	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.645	7
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.621	3
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.618	5
IntAct:EBI-1264387 AML1			0.618	3
UniProt:O88513	2	Gmnn [nucleoplasm] (R-MMU-68585) Gmnn [nucleoplasm] (R-MMU-113554)	0.602	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.589	2
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.553	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.524	2
UniProt:P35869 AHR	2	AHR [cytosol] (R-HSA-8936842) AHR [nucleoplasm] (R-HSA-8937190)	0.499	2
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.499	2

Cite Us!