p-TRIM24-BRAF fusion

Stable Identifier
R-HSA-6802555
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24345920 BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

Hutchinson, KE, Lipson, D, Stephens, PJ, Otto, G, Lehmann, BD, Lyle, PL, Vnencak-Jones, CL, Ross, JS, Pietenpol, JA, Sosman, JA, Puzanov, I, Miller, VA, Pao, W

Clin. Cancer Res. 2013
External Reference Information
External Reference
Gene Names
TRIM24, RNF82, TIF1, TIF1A
Chain
chain:1-1050
Other Identifiers
0004010687
11729816_x_at
11749468_a_at
11758692_s_at
1569316_at
17052115
204391_x_at
213301_x_at
2YYN
3026603
3026604
3026605
3026606
3026607
3026622
3026626
3026628
3026633
3026636
3026637
3026642
3026643
3026644
3026647
3026648
3026649
3026650
3026651
3026653
3026654
3026656
3026657
3026658
3026660
3026661
3026662
3026663
3026664
3026665
3026666
3026667
3026668
3026670
3026672
39292_r_at
3O33
3O34
3O35
3O36
3O37
43495
4YAB
4YAD
4YAT
4YAX
4YBM
4YBS
4YBT
4YC9
4ZQL
5H1T
5H1U
5H1V
61717
66615_at
8136473
83662_at
8805
A0A024R784
A_14_P124392
A_14_P131860
A_23_P93629
A_33_P3259028
AAB63585
AAD17258
AAH28689
AC008265
AC013429
AF009353
AF119042
AK075306
BAG52105
BC028689
CCDS47720
CCDS5847
CH236950
CH471070
EAL24046
EAL24047
EAW83884
EAW83885
EAW83886
ENSG00000122779
ENSP00000340507
ENSP00000390829
ENST00000343526
ENST00000415680
EntrezGene:8805
g7706233_3p_a_at
GE62625
GE863285
GO:0000228
GO:0000988
GO:0002039
GO:0003674
GO:0003677
GO:0003682
GO:0003713
GO:0004672
GO:0004713
GO:0004842
GO:0005102
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005719
GO:0005726
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0006464
GO:0006468
GO:0007165
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0010628
GO:0016301
GO:0016567
GO:0016740
GO:0016922
GO:0018108
GO:0030163
GO:0031647
GO:0034056
GO:0034641
GO:0042393
GO:0042592
GO:0042981
GO:0043167
GO:0043226
GO:0043565
GO:0045892
GO:0045893
GO:0046777
GO:0046872
GO:0055074
GO:0061630
GO:0070562
GO:0070577
GO:0071391
GO:1901796
HGNC:11812
HPA043495
HPA061717
Hs2.125798.1.S1_3p_at
ILMN_1711247
ILMN_1798032
ILMN_1799642
ILMN_2405031
IPR000315
IPR001487
IPR001841
IPR001965
IPR003649
IPR011011
IPR013083
IPR017907
IPR018359
IPR019786
IPR019787
IPR036427
MIM:603406
NM_003852
NM_015905
NP_003843
NP_056989
PF00439
PF00628
PF00643
PH_hs_0010837
PR00503
SM00184
SM00249
SM00297
SM00336
SM00502
TC07000868.hg
TRIM24
TRIM24-201
TRIM24-202
uc003vub.4
uc003vuc.4
UPI00000012CB
UPI000002B523
Participant Of
Other forms of this molecule
Modified Residues
Name
Insertion of residues 381 to 766 at 511 from UniProt:P15056 BRAF
Coordinate
511
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
ZINC - Substances
GeneCards
DOCK Blaster
ZINC target
PRO
BRENDA (Homo sapiens)
Orphanet
ZINC - Predictions - Purchasable
Interactors (4)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P03372 ESR1  4 0.641 3
 UniProt:Q9UPN9 TRIM33  1 0.597 3
 UniProt:P04637 TP53  27 0.524 3
 UniProt:Q13263 TRIM28  2 0.462 2