Reactome | PRKAB2 [cytosol]

PRKAB2

Stable Identifier

R-HSA-200413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK beta 2 (inactive)

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:Beclin-1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43741 PRKAB2

Gene Names

PRKAB2

Chain

chain:1-272

Reference Genes

BioGPS Gene:5565 PRKAB2

COSMIC (genes):PRKAB2 PRKAB2

CTD Gene:5565 PRKAB2

dbSNP Gene:5565 PRKAB2

ENSEMBL:ENSG00000131791 PRKAB2

HGNC:9379 PRKAB2

KEGG Gene (Homo sapiens):hsa:5565 PRKAB2

Monarch:5565 PRKAB2

NCBI Gene:5565 PRKAB2

OMIM:602741 PRKAB2

UCSC:O43741 PRKAB2

Reference Transcript

RefSeq:NM_005399.4 PRKAB2

Other Identifiers

0005700671

11718956_a_at

11718957_at

11718958_s_at

1558027_s_at

16692297

214474_at

225278_at

2433210

2433211

2433212

2433213

2433216

2433217

2433219

2433220

2433221

2433224

2433225

2F15

2V8Q

2V92

2V9J

2Y8L

2Y8Q

2YA3

36705_at

44342

4CFH

4EAI

4EAJ

4RER

4REW

51254_at

5565

78707_at

7919305

A_23_P350704

A_24_P105564

A_24_P917711

AAH53610

AAM74153

AF504538

AF504539

AF504540

AF504541

AF504542

AF504543

AJ224538

AK292820

AK294863

AK316005

AL356378

BAF85509

BAG57967

BAH14376

BC053610

CAA12030

CAH72644

CCDS925

CH471223

EAW50945

ENSG00000131791

ENSP00000254101

ENST00000254101

EntrezGene:5565

GE55250

GO:0003674

GO:0004679

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006810

GO:0006853

GO:0006914

GO:0007049

GO:0007050

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0016236

GO:0016241

GO:0016301

GO:0031588

GO:0042304

GO:0042802

GO:0043226

GO:0043234

GO:0044281

GO:0055085

GO:1901796

HGNC:9379

HPA044342

Hs.35304.0.S1_3p_at

Hs.50732.0.S1_3p_at

Hs2.399853.1.S1_3p_s_at

ILMN_1786021

IPR006828

IPR013783

IPR014756

IPR032640

IPR037256

MIM:602741

NM_005399

NP_005390

NR_103870

NR_103871

PF04739

PF16561

PH_hs_0003495

PRKAB2

PRKAB2-201

SM01010

TC01003124.hg

uc001epe.5

UPI00001250AF

XM_011509729

XM_017001697

XP_011508031

XP_016857186

XR_001737291

XR_001737292

Participant Of

hasMember

AMPK beta [cytosol]

Other forms of this molecule

PRKAB2 [nucleoplasm]

PRKAB2 [cytosol]

Inferred To

Homologues of PRKAB2 [cytosol] (Arabidopsis thaliana)

Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAB2 [cytosol] (Canis familiaris)

Homologues of PRKAB2 [cytosol] (Drosophila melanogaster)

Homologues of PRKAB2 [cytosol] (Gallus gallus)

Homologues of PRKAB2 [cytosol] (Rattus norvegicus)

Homologues of PRKAB2 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKAB2 [cytosol] (Sus scrofa)

PRKAB2 [cytosol] (Arabidopsis thaliana)

PRKAB2 [cytosol] (Bos taurus)

PRKAB2 [cytosol] (Caenorhabditis elegans)

PRKAB2 [cytosol] (Canis familiaris)

PRKAB2 [cytosol] (Danio rerio)

PRKAB2 [cytosol] (Dictyostelium discoideum)

PRKAB2 [cytosol] (Drosophila melanogaster)

PRKAB2 [cytosol] (Gallus gallus)

PRKAB2 [cytosol] (Mus musculus)

PRKAB2 [cytosol] (Oryza sativa)

PRKAB2 [cytosol] (Rattus norvegicus)

PRKAB2 [cytosol] (Saccharomyces cerevisiae)

PRKAB2 [cytosol] (Schizosaccharomyces pombe)

PRKAB2 [cytosol] (Sus scrofa)

PRKAB2 [cytosol] (Taeniopygia guttata)

PRKAB2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005390.1

GeneCards

O43741

DOCK Blaster

2YA3, 4CFH, 4EAJ, 2Y8Q, 4REW, 2Y8L, 2V8Q, 2V92, 4RER, 2F15, 4EAI, 2V9J

PRO

O43741

Orphanet

24826

PDB

2V8Q, 4EAI, 4REW, 2Y8Q, 2Y8L, 2F15, 4RER, 2YA3, 2V9J, 4CFH, 2V92, 4EAJ

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P80385 Prkag1	2	KMT2D [nucleoplasm] (R-RNO-1183219) rAMPK gamma2 [nucleoplasm] (R-RNO-164110)	0.826	9
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.781	7
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.764	6
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.696	5
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.556	3
UniProt:O43597 SPRY2	8	p-Y55-SPRY2 [cytosol] (R-HSA-182950) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.488	2
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.488	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.488	2
UniProt:P42575 CASP2	3	CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(170-325) [cytosol] (R-HSA-2976746) CASP2(2-452) [cytosol] (R-HSA-622412)	0.488	2
UniProt:Q01974 ROR2	2	ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729) ROR2 [plasma membrane] (R-HSA-197731)	0.488	2
UniProt:Q9NZH6 IL37	6	IL37(1-?) [cytosol] (R-HSA-9008602) IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37 [cytosol] (R-HSA-9008596) IL37(?-218) [cytosol] (R-HSA-9008584) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [extracellular region] (R-HSA-9008607)	0.488	2
UniProt:Q96RU7 TRIB3	2	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447)	0.488	2
UniProt:P01185 AVP	10	AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated vesicle membrane] (R-HSA-8869075) AVP Y2H [extracellular region] (R-HSA-5621449) AVP A1T [extracellular region] (R-HSA-5621473) AVP V67A [extracellular region] (R-HSA-5621446) AVP C67* [extracellular region] (R-HSA-5621431) AVP P7L [extracellular region] (R-HSA-5621460) AVP E47del [extracellular region] (R-HSA-5621396) AVP(20-28) [cytosol] (R-HSA-879509) AVP(20-28) [extracellular region] (R-HSA-388474)	0.488	2