Reactome | PRKAB2 [cytosol]

PRKAB2

Stable Identifier

R-HSA-200413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK beta 2 (inactive)

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:Beclin-1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43741 PRKAB2

Gene Names

PRKAB2

Chain

chain:1-272

Reference Genes

BioGPS Gene:5565 PRKAB2

COSMIC (genes):PRKAB2 PRKAB2

CTD Gene:5565 PRKAB2

dbSNP Gene:5565 PRKAB2

ENSEMBL:ENSG00000131791 PRKAB2

HGNC:9379 PRKAB2

KEGG Gene (Homo sapiens):hsa:5565 PRKAB2

Monarch:5565 PRKAB2

NCBI Gene:5565 PRKAB2

OMIM:602741 PRKAB2

UCSC:O43741 PRKAB2

Reference Transcript

RefSeq:NM_005399.4 PRKAB2

Other Identifiers

0005700671

11718956_a_at

11718957_at

11718958_s_at

1558027_s_at

16692297

214474_at

225278_at

2433210

2433211

2433212

2433213

2433216

2433217

2433219

2433220

2433221

2433224

2433225

2F15

2V8Q

2V92

2V9J

2Y8L

2Y8Q

2YA3

36705_at

44342

4CFH

4EAI

4EAJ

4RER

4REW

51254_at

5565

78707_at

7919305

A_23_P350704

A_24_P105564

A_24_P917711

AAH53610

AAM74153

AF504538

AF504539

AF504540

AF504541

AF504542

AF504543

AJ224538

AK292820

AK294863

AK316005

AL356378

BAF85509

BAG57967

BAH14376

BC053610

CAA12030

CAH72644

CCDS925

CH471223

EAW50945

ENSG00000131791

ENSP00000254101

ENST00000254101

EntrezGene:5565

GE55250

GO:0003674

GO:0004679

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006914

GO:0007049

GO:0007050

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0016236

GO:0016301

GO:0031588

GO:0032991

GO:0042304

GO:0042802

GO:0043226

GO:0044281

HGNC:9379

HPA044342

Hs.35304.0.S1_3p_at

Hs.50732.0.S1_3p_at

Hs2.399853.1.S1_3p_s_at

ILMN_1786021

IPR006828

IPR013783

IPR014756

IPR032640

IPR037256

MIM:602741

NM_005399

NP_005390

NR_103870

NR_103871

PF04739

PF16561

PH_hs_0003495

PRKAB2

PRKAB2-201

SM01010

TC01003124.hg

uc001epe.5

UPI00001250AF

XM_011509729

XM_017001697

XP_011508031

XP_016857186

XR_001737291

XR_001737292

Participant Of

hasMember

AMPK beta [cytosol]

Other forms of this molecule

PRKAB2 [nucleoplasm]

PRKAB2 [cytosol]

Inferred To

Homologues of PRKAB2 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAB2 [cytosol] (Canis familiaris)

Homologues of PRKAB2 [cytosol] (Drosophila melanogaster)

Homologues of PRKAB2 [cytosol] (Gallus gallus)

Homologues of PRKAB2 [cytosol] (Rattus norvegicus)

Homologues of PRKAB2 [cytosol] (Saccharomyces cerevisiae)

PRKAB2 [cytosol] (Arabidopsis thaliana)

PRKAB2 [cytosol] (Bos taurus)

PRKAB2 [cytosol] (Caenorhabditis elegans)

PRKAB2 [cytosol] (Canis familiaris)

PRKAB2 [cytosol] (Danio rerio)

PRKAB2 [cytosol] (Dictyostelium discoideum)

PRKAB2 [cytosol] (Drosophila melanogaster)

PRKAB2 [cytosol] (Gallus gallus)

PRKAB2 [cytosol] (Mus musculus)

PRKAB2 [cytosol] (Oryza sativa)

PRKAB2 [cytosol] (Rattus norvegicus)

PRKAB2 [cytosol] (Saccharomyces cerevisiae)

PRKAB2 [cytosol] (Schizosaccharomyces pombe)

PRKAB2 [cytosol] (Sus scrofa)

PRKAB2 [cytosol] (Taeniopygia guttata)

PRKAB2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005390.1

GeneCards

O43741

PRO

O43741

Orphanet

24826

PDB

2F15, 2V8Q, 2Y8L, 2Y8Q, 4RER, 4EAJ, 2YA3, 4CFH, 2V92, 4EAI, 2V9J, 4REW

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P80385 Prkag1	2	KMT2D [nucleoplasm] (R-RNO-1183219) rAMPK gamma2 [nucleoplasm] (R-RNO-164110)	0.826	9
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.781	7
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.764	6
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.696	5
UniProt:O43597 SPRY2	8	SPRY2 [plasma membrane] (R-HSA-182924) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [cytosol] (R-HSA-182949) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629)	0.556	3
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q9NZH6 IL37	6	IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [cytosol] (R-HSA-9008596) IL37(1-?) [cytosol] (R-HSA-9008602) IL37(?-218) [cytosol] (R-HSA-9008584)	0.488	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.488	2
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.488	2
UniProt:Q01974 ROR2	2	ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729) ROR2 [plasma membrane] (R-HSA-197731)	0.488	2
UniProt:P42575 CASP2	3	CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(2-452) [cytosol] (R-HSA-622412) CASP2(170-325) [cytosol] (R-HSA-2976746)	0.488	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.488	2
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:P01185 AVP	10	AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated vesicle membrane] (R-HSA-8869075) AVP Y2H [extracellular region] (R-HSA-5621449) AVP A1T [extracellular region] (R-HSA-5621473) AVP V67A [extracellular region] (R-HSA-5621446) AVP C67* [extracellular region] (R-HSA-5621431) AVP P7L [extracellular region] (R-HSA-5621460) AVP E47del [extracellular region] (R-HSA-5621396) AVP(20-28) [cytosol] (R-HSA-879509) AVP(20-28) [extracellular region] (R-HSA-388474)	0.488	2
UniProt:Q96RU7 TRIB3	2	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447)	0.488	2