Reactome | PRKAB2 [cytosol]

PRKAB2 [cytosol]

Stable Identifier

R-HSA-200413

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK beta 2

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Lipophagy (Homo sapiens)
      - PRKAA2 phosphorylates PLINs (Homo sapiens)
        
        AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK beta [cytosol] (Homo sapiens)
        
        PRKAB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43741 PRKAB2

Gene Names

PRKAB2

Chain

chain:1-272

Reference Genes

BioGPS Gene:5565 PRKAB2

COSMIC (genes):PRKAB2 PRKAB2

CTD Gene:5565 PRKAB2

dbSNP Gene:5565 PRKAB2

ENSEMBL:ENSG00000131791.8 PRKAB2

HGNC:9379 PRKAB2

KEGG Gene (Homo sapiens):5565 PRKAB2

Monarch:5565 PRKAB2

NCBI Gene:5565 PRKAB2

OMIM:602741 PRKAB2

UCSC:O43741 PRKAB2

Reference Transcript

RefSeq:NM_005399.4 PRKAB2

Other Identifiers

11718956_a_at

11718957_at

11718958_s_at

1558027_PM_s_at

1558027_s_at

16692297

214474_PM_at

214474_at

225278_PM_at

225278_at

2433210

2433211

2433212

2433213

2433216

2433217

2433219

2433220

2433221

2433224

2433225

36705_at

51254_at

5565

78707_at

7919305

A_23_P350704

A_24_P105564

A_24_P917711

GE55250

GO:0003824

GO:0004679

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006629

GO:0006631

GO:0006633

GO:0007165

GO:0016740

GO:0019901

GO:0023052

GO:0031588

GO:0031669

GO:0043226

GO:0050790

GO:0120162

GO:0140096

HMNXSV003016384

Hs.35304.0.S1_3p_at

Hs.50732.0.S1_3p_at

Hs2.399853.1.S1_3p_s_at

ILMN_1786021

PH_hs_0003495

TC01003124.hg

Participates

as a component of

AMPK heterotrimer (active) [cytosol] (Homo sapiens)

as a member of

AMPK beta [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAB2 [nucleoplasm]

Inferred To

MDG1 [cytosol] (Saccharomyces cerevisiae)

SIP2 [cytosol] (Saccharomyces cerevisiae)

CRP1 [cytosol] (Saccharomyces cerevisiae)

Homologues of PRKAB2 [cytosol] (Saccharomyces cerevisiae)

prkab2 [cytosol] (Xenopus tropicalis)

Prkab2 [cytosol] (Mus musculus)

Prkab2 [cytosol] (Rattus norvegicus)

SIP1 [cytosol] (Saccharomyces cerevisiae)

GAL83 [cytosol] (Saccharomyces cerevisiae)

PRKAB2 [cytosol] (Bos taurus)

PRKAB2 [cytosol] (Canis familiaris)

PRKAB2 [cytosol] (Danio rerio)

PRKAB2 [cytosol] (Dictyostelium discoideum)

PRKAB2 [cytosol] (Gallus gallus)

PRKAB2 [cytosol] (Schizosaccharomyces pombe)

PRKAB2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005390.1

Guide to Pharmacology - Targets

1544

OpenTargets

ENSG00000131791

HPA

ENSG00000131791-PRKAB2

GeneCards

O43741

Ensembl

ENSP00000254101, ENSG00000131791, ENST00000254101

PRO

O43741

Pharos - Targets

O43741

Orphanet

24826

PDB

2Y8Q, 2V8Q, 4CFH, 4REW, 7JHH, 2YA3, 7JIJ, 2V92, 2V9J, 2F15, 6B2E, 2Y8L, 4EAJ, 7JHG, 7M74, 4RER, 4EAI

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.905	14
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.879	10
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.87	9
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.83	8
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.666	4
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.666	4
UniProt:O43597 SPRY2	8	p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595)	0.666	4
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.666	4
UniProt:O75928 PIAS2	1	PIAS2 [nucleoplasm] (R-HSA-2993787)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P42575 CASP2	3	CASP2(170-325) [cytosol] (R-HSA-2976746) CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(2-452) [cytosol] (R-HSA-622412)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:Q9NZH6 IL37	6	IL37(?-218) [nucleoplasm] (R-HSA-9008702) IL37(1-?) [cytosol] (R-HSA-9008602) IL37(?-218) [extracellular region] (R-HSA-9008607) IL37 [extracellular region] (R-HSA-8848334) IL37(?-218) [cytosol] (R-HSA-9008584) IL37 [cytosol] (R-HSA-9008596)	0.556	5
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.556	3
UniProt:P01185 AVP	10	AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075) AVP G23R [extracellular region] (R-HSA-5621464) AVP Y2H [extracellular region] (R-HSA-5621449) AVP A1T [extracellular region] (R-HSA-5621473) AVP V67A [extracellular region] (R-HSA-5621446) AVP C67* [extracellular region] (R-HSA-5621431) AVP P7L [extracellular region] (R-HSA-5621460) AVP E47del [extracellular region] (R-HSA-5621396) AVP(20-28) [cytosol] (R-HSA-879509) AVP(20-28) [extracellular region] (R-HSA-388474)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.488	2