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PRKAB2 [cytosol]
Stable Identifier
R-HSA-200413
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AMPK beta 2
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PRKAA2 phosphorylates PLINs (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Thr-180 of ULK1 is phosphorylated (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
ULK complex translocates to the ER (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK:AMP binds the ULK complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
SESN1,2,3 bind AMPK (Homo sapiens)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine metabolism (Homo sapiens)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)
AMPK heterotrimer (active) [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Phosphorylated AMPK binds AMP (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK beta [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43741 PRKAB2
Gene Names
PRKAB2
Chain
chain:1-272
Reference Genes
BioGPS Gene:5565 PRKAB2
COSMIC (genes):PRKAB2 PRKAB2
CTD Gene:5565 PRKAB2
dbSNP Gene:5565 PRKAB2
ENSEMBL:ENSG00000131791.8 PRKAB2
HGNC:9379 PRKAB2
KEGG Gene (Homo sapiens):5565 PRKAB2
Monarch:5565 PRKAB2
NCBI Gene:5565 PRKAB2
OMIM:602741 PRKAB2
UCSC:O43741 PRKAB2
Reference Transcript
RefSeq:NM_005399.4 PRKAB2
Other Identifiers
11718956_a_at
11718957_at
11718958_s_at
1558027_PM_s_at
1558027_s_at
16692297
214474_PM_at
214474_at
225278_PM_at
225278_at
2433210
2433211
2433212
2433213
2433216
2433217
2433219
2433220
2433221
2433224
2433225
36705_at
51254_at
5565
78707_at
7919305
A_23_P350704
A_24_P105564
A_24_P917711
GE55250
GO:0003824
GO:0004679
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006631
GO:0006633
GO:0007165
GO:0016740
GO:0019901
GO:0023052
GO:0031588
GO:0031669
GO:0043226
GO:0050790
GO:0120162
GO:0140096
HMNXSV003016384
Hs.35304.0.S1_3p_at
Hs.50732.0.S1_3p_at
Hs2.399853.1.S1_3p_s_at
ILMN_1786021
PH_hs_0003495
TC01003124.hg
Participates
as a component of
AMPK heterotrimer (active) [cytosol] (Homo sapiens)
as a member of
AMPK beta [cytosol] (Homo sapiens)
Other forms of this molecule
PRKAB2 [nucleoplasm]
Inferred To
MDG1 [cytosol]
(Saccharomyces cerevisiae)
SIP2 [cytosol]
(Saccharomyces cerevisiae)
CRP1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PRKAB2 [cytosol]
(Saccharomyces cerevisiae)
prkab2 [cytosol]
(Xenopus tropicalis)
Prkab2 [cytosol]
(Mus musculus)
Prkab2 [cytosol]
(Rattus norvegicus)
SIP1 [cytosol]
(Saccharomyces cerevisiae)
GAL83 [cytosol]
(Saccharomyces cerevisiae)
PRKAB2 [cytosol]
(Bos taurus)
PRKAB2 [cytosol]
(Canis familiaris)
PRKAB2 [cytosol]
(Danio rerio)
PRKAB2 [cytosol]
(Dictyostelium discoideum)
PRKAB2 [cytosol]
(Gallus gallus)
PRKAB2 [cytosol]
(Schizosaccharomyces pombe)
PRKAB2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005390.1
Guide to Pharmacology - Targets
1544
OpenTargets
ENSG00000131791
HPA
ENSG00000131791-PRKAB2
GeneCards
O43741
Ensembl
ENSP00000254101
,
ENSG00000131791
,
ENST00000254101
PRO
O43741
Pharos - Targets
O43741
Orphanet
24826
PDB
2Y8Q
,
2V8Q
,
4CFH
,
4REW
,
7JHH
,
2YA3
,
7JIJ
,
2V92
,
2V9J
,
2F15
,
6B2E
,
2Y8L
,
4EAJ
,
7JHG
,
7M74
,
4RER
,
4EAI
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.905
14
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.879
10
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.87
9
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.83
8
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.666
4
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.666
4
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.666
4
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.666
4
UniProt:O75928 PIAS2
1
PIAS2 [nucleoplasm]
(R-HSA-2993787)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q8TDS5 OXER1
1
OXER1 [plasma membrane]
(R-HSA-416425)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:P42575 CASP2
3
CASP2(170-325) [cytosol]
(R-HSA-2976746)
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(2-452) [cytosol]
(R-HSA-622412)
0.556
3
UniProt:P04792 HSPB1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
UniProt:Q9NZH6 IL37
6
IL37(?-218) [nucleoplasm]
(R-HSA-9008702)
IL37(1-?) [cytosol]
(R-HSA-9008602)
IL37(?-218) [extracellular region]
(R-HSA-9008607)
IL37 [extracellular region]
(R-HSA-8848334)
IL37(?-218) [cytosol]
(R-HSA-9008584)
IL37 [cytosol]
(R-HSA-9008596)
0.556
5
UniProt:Q01974 ROR2
2
ROR2 [plasma membrane]
(R-HSA-197731)
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
0.556
3
UniProt:P01185 AVP
10
AVP(20-28) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869075)
AVP G23R [extracellular region]
(R-HSA-5621464)
AVP Y2H [extracellular region]
(R-HSA-5621449)
AVP A1T [extracellular region]
(R-HSA-5621473)
AVP V67A [extracellular region]
(R-HSA-5621446)
AVP C67* [extracellular region]
(R-HSA-5621431)
AVP P7L [extracellular region]
(R-HSA-5621460)
AVP E47del [extracellular region]
(R-HSA-5621396)
AVP(20-28) [cytosol]
(R-HSA-879509)
AVP(20-28) [extracellular region]
(R-HSA-388474)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.488
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.488
2
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