Reactome | PolyUb,p-S166,S188-MDM2 [nucleoplasm]

PolyUb,p-S166,S188-MDM2 [nucleoplasm]

Stable Identifier

R-HSA-6795669

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PolyUb,p-S166,188-MDM2, PolyUb,p-MDM2, Ub,p-S166,S188-MDM2, Ub,p-S166,188-MDM2, Ub,p-MDM2

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)
        
        PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
        
        PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
        
        USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
        
        PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
        
        PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00987 MDM2

Gene Names

MDM2

Chain

chain:1-491

Reference Genes

BioGPS Gene:4193 MDM2

COSMIC (genes):MDM2 MDM2

CTD Gene:4193 MDM2

dbSNP Gene:4193 MDM2

ENSEMBL:ENSG00000135679 MDM2

ENSEMBL_homo_sapiens_GENE:ENSG00000135679.27 MDM2

HGNC:6973 MDM2

KEGG Gene (Homo sapiens):4193 MDM2

Monarch:4193 MDM2

NCBI Gene:4193 MDM2

OMIM:164785 MDM2

UCSC:Q00987 MDM2

Reference Transcript

Other Identifiers

11731564_x_at

11731565_x_at

11731566_a_at

11731567_a_at

11731568_x_at

11753563_x_at

11753688_a_at

11753689_x_at

11753819_a_at

11753820_x_at

11756046_x_at

16753853

1859_s_at

1880_at

2008_s_at

205386_PM_s_at

205386_s_at

211832_PM_s_at

211832_s_at

217373_PM_x_at

217373_x_at

217542_PM_at

217542_at

225160_PM_x_at

225160_x_at

229711_PM_s_at

229711_s_at

238733_PM_at

238733_at

244616_3p_x_at

244616_PM_x_at

244616_x_at

3421301

3421302

3421303

3421304

3421305

3421306

3421307

3421310

3421311

3421315

3421316

3421322

3421323

3421325

3421328

3421329

3421334

3421335

3421336

3421337

3421338

3421339

3421340

3421341

3421342

3421343

3421344

3421345

3421346

3421347

3421348

3421349

3421350

3421351

3421361

38509_at

3979479

4193

46744_s_at

53464_at

61888_at

62280_at

64992_i_at

64993_r_at

75871_at

7956989

A_14_P118388

A_14_P133404

A_14_P135914

A_23_P139895

A_23_P309545

A_23_P502750

A_24_P925664

A_33_P3361707

GE58146

GE832699

GE83502

GO:0000122

GO:0000209

GO:0000278

GO:0001568

GO:0001974

GO:0002027

GO:0002039

GO:0003013

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003723

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006511

GO:0006886

GO:0006913

GO:0006915

GO:0006977

GO:0007089

GO:0007507

GO:0008097

GO:0008270

GO:0008284

GO:0009410

GO:0009636

GO:0010039

GO:0010468

GO:0010628

GO:0010629

GO:0010955

GO:0010977

GO:0012501

GO:0016567

GO:0016604

GO:0016740

GO:0016874

GO:0016925

GO:0017053

GO:0019789

GO:0019899

GO:0019904

GO:0023052

GO:0030154

GO:0030163

GO:0030666

GO:0031410

GO:0031625

GO:0031648

GO:0032026

GO:0032436

GO:0032991

GO:0033612

GO:0034504

GO:0036211

GO:0042176

GO:0042220

GO:0042802

GO:0042975

GO:0043021

GO:0043066

GO:0043130

GO:0043161

GO:0043226

GO:0043518

GO:0045184

GO:0045472

GO:0045787

GO:0045892

GO:0045931

GO:0046677

GO:0046827

GO:0046872

GO:0048545

GO:0048856

GO:0048870

GO:0051149

GO:0051603

GO:0051604

GO:0051726

GO:0051865

GO:0060411

GO:0061630

GO:0061663

GO:0065003

GO:0065008

GO:0070301

GO:0071236

GO:0071301

GO:0071310

GO:0071312

GO:0071363

GO:0071375

GO:0071391

GO:0071407

GO:0071456

GO:0071480

GO:0071494

GO:0072537

GO:0072717

GO:0097718

GO:0140096

GO:1901797

GO:1902254

GO:1904404

GO:1904707

GO:1904754

GO:1990000

GO:1990785

HMNXSV003000562

HMNXSV003053865

Hs.116932.0.A1_3p_at

Hs.168732.0.A1_3p_at

Hs.168732.0.A1_3p_x_at

Hs.272346.0.S1_3p_s_at

Hs.332938.1.S1_3p_a_at

Hs.37494.0.A1_3p_at

ILMN_1736829

ILMN_1814208

ILMN_2389851

M92424_at

PH_hs_0023082

TC12000606.hg

TC12002437.hg

U33202_s_at

U33203_s_at

g7230489_3p_s_at

Participates

as a component of

Other forms of this molecule

PolyUb-MDM2 [nucleoplasm]

monoSUMO1-K182-MDM2 [nucleoplasm]

MDM2 [plasma membrane]

MDM2 [endocytic vesicle membrane]

p-5S,T-MDM2 [nucleoplasm]

p-S166,S188,T218-MDM2 [nucleoplasm]

MDM2 [nucleoplasm]

MDM2 [cytosol]

p-S166,S188-MDM2 [cytosol]

p-S166,S188-MDM2 [nucleoplasm]

Inferred To

Homologues of PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Xenopus tropicalis)

phospho-mdm2 [nucleoplasm] (Danio rerio)

phospho-mdm2 [nucleoplasm] (Xenopus tropicalis)

phospho-Mdm2 [nucleoplasm] (Mus musculus)

phospho-Mdm2 [nucleoplasm] (Rattus norvegicus)

phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Xenopus tropicalis)

phospho-MDM2 [nucleoplasm] (Bos taurus)

phospho-MDM2 [nucleoplasm] (Canis familiaris)

phospho-MDM2 [nucleoplasm] (Gallus gallus)

phospho-MDM2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 166

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 188

Coordinate

188

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001265391.1, XP_006719462.1, XP_005268929.1, NP_002383.2, NP_001138811.1

Guide to Pharmacology - Targets

3136

OpenTargets

ENSG00000135679

ZINC - Substances

MDM2_HUMAN

ZINC target

Q00987

PRO

Q00987

PDB

6Q96, 2C6A, 4WT2, 8EI9, 6YR6, 3V3B, 7NA3, 2F1Y, 2C6B, 7AD0, 4OCC, 2MPS, 6T2D, 3W69, 8BGU, 3JZK, 4JVR, 5J7G, 4OGV, 6AAW, 6GGN, 6Q9H, 5UMM, 4HG7, 3TJ2, 7BIR, 5Z02, 5MNJ, 1T4E, 2HDP, 2M86, 7BMG, 7BJ0, 8F0Z, 4JWR, 5HMK, 5WTS, 7AI0, 5XXK, 7BJ6, 5LAY, 2VJF, 4UD7, 5HMH, 4JV7, 4OAS, 8AEU, 2GV2, 1T4F, 8EIB, 6SQO, 3LBL, 2VJE, 7QDQ, 6T2F, 4ODF, 3LNJ, 7KJM, 6Q9O, 4ZGK, 8F10, 6I3S, 5ZXF, 4OGN, 3JZR, 4QO4, 5LAZ, 7AYE, 8F13, 6HFA, 6H22, 5LN2, 4OQ3, 4ERE, 5LAV, 6T2E, 4HFZ, 6Q9L, 4UE1, 3IWY, 2AXI, 3G03, 2FOP, 7BIT, 4JVE, 3VBG, 3TPX, 4ZYI, 5AFG, 4OBA, 4XXB, 6I29, 2LZG, 7BIV, 5VK0, 5OAI, 3IUX, 4JV9, 5SWK, 8P0D, 5HMI, 5C5A, 4UMN, 5OC8, 5LAW, 3EQS, 4MDN, 7NA2, 3TU1, 4ZYC, 3LNZ, 2RUH, 4ERF, 8EIA, 5TRF, 7NA4, 4ZFI, 5J7F, 4ODE, 1Z1M, 7NUS, 8EIC, 6IM9, 3LBK, 3MQS, 6KZU, 1RV1, 4DIJ, 3VZV, 4OGT, 4QOC, 4MDQ, 6Y4Q, 3JZS, 8F12, 4HBM, 1YCR, 7AI1, 4ZYF, 7NA1

ZINC - Investigational

MDM2_HUMAN

HPA

ENSG00000135679-MDM2

GeneCards

Q00987

Ensembl

ENST00000299252, ENST00000539479, ENSP00000353611, ENST00000360430, ENSP00000444430, ENST00000258149, ENST00000393413, ENSP00000258149, ENSP00000299252, ENSP00000377065, ENSG00000135679

Pharos - Targets

Q00987

Orphanet

21735

ZINC - Predictions - Purchasable

MDM2_HUMAN

HMDB Protein

HMDBP02432

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.995	117
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.965	34
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.938	15
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.921	13
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.895	18
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.821	6
UniProt:P62081 RPS7	2	RPS7 [nucleoplasm] (R-HSA-6790635) RPS7 [cytosol] (R-HSA-72383)	0.817	17
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.813	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.807	6
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.736	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.734	5
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.718	7
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.71	8
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.709	9
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.708	5
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.697	5
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.686	8
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.669	5
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.66	6
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.641	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.632	5
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.631	4
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.62	5
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.619	6
IntAct:EBI-15762335 PMI			0.618	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.616	11
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.612	8
UniProt:P26447 S10A4			0.611	3
UniProt:P48730 CSNK1D	3	CSNK1D [nucleoplasm] (R-HSA-421305) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [cytosol] (R-HSA-380315)	0.61	6
IntAct:EBI-4399559 UBIQ			0.609	2
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.609	6
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.602	7
UniProt:P42677 RPS27	2	RPS27 [nucleoplasm] (R-HSA-6791190) RPS27 [cytosol] (R-HSA-72361)	0.602	5
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.591	9
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.589	2
UniProt:P29590-5 PML			0.582	6
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.573	3
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.571	2
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.558	4
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.558	2
UniProt:P29034 S10A2			0.558	2
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.558	5
UniProt:P06703 S10A6			0.558	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.558	2
UniProt:Q9NVN8 GNL3L			0.556	8
UniProt:Q9NZM5 NOP53			0.547	2
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.544	4
UniProt:Q9BY89 K1671			0.544	2
UniProt:Q9Y4L5 RNF115	1	RNF115 [cytosol] (R-HSA-8850904)	0.544	2
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.536	2
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.527	2
UniProt:P78352 DLG4	3	DLG4 [cytosol] (R-HSA-6794267) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [plasma membrane] (R-HSA-202135)	0.525	3
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.524	3
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.524	4
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.524	3
UniProt:Q2HR73 VIRF4			0.524	2
UniProt:P48729-2 CSNK1A1			0.524	3
UniProt:Q92736 RYR2	1	RYR2 [sarcoplasmic reticulum membrane] (R-HSA-937283)	0.524	2
UniProt:Q5T7V8 GORAB			0.524	6
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.524	4
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.524	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.524	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.524	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.524	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.524	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.508	2
UniProt:Q00688 FKBP3			0.508	2
UniProt:Q6PCD5 RFWD3			0.499	2
UniProt:Q9NS23 RASF1			0.499	5
UniProt:Q13362-1 PPP2R5C			0.499	3
UniProt:Q6P5F9 Xpo1	2	Xpo1 [nucleoplasm] (R-MMU-9769779) Xpo1 [cytosol] (R-MMU-165539)	0.499	4
UniProt:P0C6X5-PRO_0000283876 REP			0.463	3
IntAct:EBI-1800051 CDKN1A			0.462	2

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