Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SMAD2 S296* [cytosol]
Stable Identifier
R-HSA-9668729
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SMAD2 S296TER, SMAD2 Ser296*, SMAD2 Ser296TER
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)
Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
SMAD2/3 Phosphorylation Motif Mutants [cytosol] (Homo sapiens)
SMAD2 Phosphorylation Motif Mutants [cytosol] (Homo sapiens)
SMAD2 S296* [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15796 SMAD2
Gene Names
SMAD2, MADH2, MADR2
Chain
initiator methionine:, chain:2-467
Reference Genes
BioGPS Gene:4087 SMAD2
COSMIC (genes):SMAD2 SMAD2
CTD Gene:4087 SMAD2
dbSNP Gene:4087 SMAD2
ENSEMBL:ENSG00000175387 SMAD2
HGNC:6768 SMAD2
KEGG:hsa:4087 SMAD2
Monarch:4087 SMAD2
NCBI Gene:4087 SMAD2
OMIM:601366 SMAD2
UCSC:Q15796 SMAD2
Reference Transcript
RefSeq:XM_017025745.1 SMAD2
RefSeq:XM_006722451.3 SMAD2
RefSeq:NM_005901.5 SMAD2
RefSeq:XM_017025746.1 SMAD2
RefSeq:NM_001003652.3 SMAD2
RefSeq:XM_005258259.3 SMAD2
Other Identifiers
11729653_a_at
11729654_a_at
11729655_a_at
11729656_s_at
11734014_a_at
11734015_a_at
11746820_a_at
1453_at
16855090
16855093
1928_s_at
203075_PM_at
203075_at
203076_PM_s_at
203076_s_at
203077_PM_s_at
203077_s_at
226563_PM_at
226563_at
235598_PM_at
235598_at
239271_PM_at
239271_at
3096426
3806892
3806894
3806896
3806898
3806900
3806902
3806904
3806906
3806907
3806908
3806909
3806910
3806911
3806912
3806914
3806915
3806916
3806917
3806918
3806919
3806923
3806924
3806926
3806928
3806929
3806931
3806933
3806934
3806935
3806936
3806937
3806938
3806939
3806942
3806946
3806947
3806948
3806952
3806954
3806955
3806956
3806957
3806958
3806959
3806960
3806961
4087
50764_at
53730_at
57493_at
70271_at
8023191
8023195
81545_at
90267_at
A_19_P00331466
A_19_P00811827
A_21_P0009555
A_23_P15937
A_24_P202527
A_32_P109002
A_32_P12580
GE59354
GE846664
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001657
GO:0001701
GO:0001706
GO:0001707
GO:0003140
GO:0003180
GO:0003184
GO:0003203
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007179
GO:0007352
GO:0007369
GO:0007389
GO:0007492
GO:0007507
GO:0008092
GO:0008283
GO:0008285
GO:0009653
GO:0009749
GO:0009791
GO:0009880
GO:0009952
GO:0010468
GO:0010628
GO:0010629
GO:0010718
GO:0016020
GO:0017015
GO:0019902
GO:0023019
GO:0030073
GO:0030154
GO:0030324
GO:0030325
GO:0030513
GO:0031016
GO:0031053
GO:0031625
GO:0032444
GO:0032924
GO:0032991
GO:0034713
GO:0035265
GO:0035556
GO:0038092
GO:0042802
GO:0043226
GO:0045165
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048156
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0051098
GO:0060039
GO:0060395
GO:0061629
GO:0062009
GO:0070410
GO:0070411
GO:0070412
GO:0070723
GO:0071141
GO:0071142
GO:0071144
GO:0071333
GO:0071559
GO:0071560
GO:0071895
GO:0097718
GO:0140110
GO:0140297
HMNXSV003021861
HMNXSV003023211
HMNXSV003024357
Hs.110741.0.A1_3p_at
Hs.12253.0.A1_3p_at
Hs.204129.0.A1_3p_at
Hs.82483.0.A3_3p_at
ILMN_1751036
ILMN_1754521
ILMN_1771203
PH_hs_0020771
PH_hs_0022288
PH_hs_0033969
PH_hs_0038510
TC18000496.hg
TC18000918.hg
TC18000919.hg
U68018_at
g1575529_3p_a_at
g5174510_3p_a_at
p20421
Participates
as a candidate of
SMAD2 Phosphorylation Motif Mutants [cytosol] (Homo sapiens)
Other forms of this molecule
Ub-SMAD2 [cytosol]
p-S465,S467-SMAD2 P305L [cytosol]
p-S465,S467-SMAD2 D300A [cytosol]
p-S465,S467-SMAD2 D300N [cytosol]
p-S465,S467-SMAD2 A354T [cytosol]
p-S465,S467-SMAD2 P305Q [cytosol]
p-S465,S467-SMAD2 [nucleoplasm]
p-S465,S467-SMAD2 [cytosol]
SMAD2 [cytosol]
p-T220,S465,S467-SMAD2 [nucleoplasm]
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
SMAD2 [nucleoplasm]
p-S250-SMAD2 [cytosol]
SMAD2 Q429* [cytosol]
SMAD2 S467P [cytosol]
SMAD2 L315* [cytosol]
SMAD2 E439* [cytosol]
SMAD2 Q455* [cytosol]
SMAD2 S306* [cytosol]
SMAD2 R321* [cytosol]
SMAD2 C463* [cytosol]
SMAD2 S464L [cytosol]
SMAD2 W448* [cytosol]
SMAD2 R427* [cytosol]
SMAD2 S308* [cytosol]
SMAD2 W422* [cytosol]
SMAD2 S464* [cytosol]
p-S465,S467-SMAD2 D300V [cytosol]
Modified Residues
Name
Nonsense mutation at L-serine 296
Coordinate
296
PsiMod
L-serine removal [MOD:01646]
A protein modification that effectively removes or replaces an L-serine.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
large intestine cancer
DOID:5672
malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
RefSeq
XP_006722514.1
,
NP_001003652.1
,
NP_005892.1
,
XP_005258316.1
,
XP_016881235.1
,
XP_016881234.1
COSMIC
COSV51069805
OpenTargets
ENSG00000175387
ENSEMBL
ENST00000586040
,
ENST00000262160
,
ENST00000402690
,
ENST00000356825
,
ENSP00000262160
,
ENSP00000466193
,
ENSP00000384449
,
ENSP00000349282
HPA
ENSG00000175387-SMAD2
PRO
Q15796
Pharos - Targets
Q15796
GlyGen
Q15796
Orphanet
SMAD2
HMDB Protein
HMDBP14506
PDB
6M64
,
6YIA
,
1KHX
,
5ZOJ
,
2LB3
,
5XOD
,
7CO1
,
6ZVQ
,
1DEV
,
1U7V
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.965
24
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.865
11
UniProt:O95405 ZFYVE9
0.832
8
UniProt:Q9HAU4 SMURF2
2
SMURF2 [nucleoplasm]
(R-HSA-178202)
SMURF2 [cytosol]
(R-HSA-173537)
0.811
6
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.678
3
UniProt:O75593 FOXH1
1
FOXH1 [nucleoplasm]
(R-HSA-1225914)
0.675
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.674
7
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.662
6
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.656
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.646
3
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.589
3
UniProt:Q9BZ29 DOCK9
1
DOCK9 [cytosol]
(R-HSA-1012981)
0.576
3
UniProt:Q12955 ANK3
1
ANK3 [cytosol]
(R-HSA-374562)
0.573
2
UniProt:Q9Y2U8 LEMD3
4
LEMD3 [endosome membrane]
(R-HSA-9715091)
LEMD3 [endoplasmic reticulum membrane]
(R-HSA-9714458)
LEMD3 [plasma membrane]
(R-HSA-9715186)
LEMD3 [nuclear envelope]
(R-HSA-2993886)
0.564
3
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.564
3
UniProt:P12757 SKIL
1
SKIL [nucleoplasm]
(R-HSA-2186596)
0.547
3
UniProt:O15198 SMAD9
3
SMAD9 [cytosol]
(R-HSA-201478)
p-S465,S467-SMAD9 [nucleoplasm]
(R-HSA-201474)
p-S465,S467-SMAD9 [cytosol]
(R-HSA-201441)
0.547
2
UniProt:P35813 PPM1A
2
PPM1A [nucleoplasm]
(R-HSA-205813)
PPM1A [cytosol]
(R-HSA-380928)
0.544
2
UniProt:P12757-1 SKIL
0.536
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
SMAD2 [cytosol]
(R-HSA-3006353)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-9773843)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
p-S250-SMAD2 [cytosol]
(R-HSA-9731121)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
0.524
2
UniProt:Q9NYA4 MTMR4
2
MTMR4 [cytosol]
(R-HSA-1604658)
MTMR4 [early endosome membrane]
(R-HSA-2187404)
0.524
2
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.524
2
UniProt:P98082 DAB2
3
DAB2 [cytosol]
(R-HSA-8862456)
DAB2 [lysosomal membrane]
(R-HSA-2980807)
DAB2 [plasma membrane]
(R-HSA-2980808)
0.524
4
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.524
2
UniProt:P70056 FOXH1
0.499
4
UniProt:P36801 VE6
0.488
2
UniProt:P10070 GLI2
11
GLI2 [ciliary tip]
(R-HSA-5610363)
GLI2 [ciliary base]
(R-HSA-5610361)
2p-GLI2 [nucleoplasm]
(R-HSA-5635055)
p-GLI2 [nucleoplasm]
(R-HSA-5635047)
p-GLI2 [ciliary tip]
(R-HSA-5635044)
GLI2 [cytosol]
(R-HSA-445451)
ub-p11S-GLI2 [ciliary base]
(R-HSA-5610501)
p11S-GLI2 [ciliary base]
(R-HSA-5610471)
p8S-GLI2 [ciliary base]
(R-HSA-5610494)
p4S-GLI2 [ciliary base]
(R-HSA-5610487)
ub-2p-GLI2 [nucleoplasm]
(R-HSA-5635059)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text