Reactome | BRAF G466E [cytosol]

BRAF G466E [cytosol]

Stable Identifier

R-HSA-6802374

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

B-RAF

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
        
        chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
        
        chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
        
        mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        kinase dead BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF G466E [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15035987	Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Niculescu-Duvaz, D, Lee, S, Marais, R, Marshall, CJ, Barford, D, Jones, CM, Good, VM, Springer, CJ, Wan, PT, Garnett, MJ, Roe, SM	Cell	2004
12068308	Mutations of the BRAF gene in human cancer Maitland, N, Jayatilake, H, Futreal, PA, Yuen, ST, Marshall, CJ, Menzies, A, Parker, A, Chenevix-Trench, G, Leung, SY, Garnett, MJ, Davis, N, Shipley, J, Cooper, C, Darrow, TL, Marais, R, Paterson, H, Palmieri, G, Floyd, Y, Bottomley, W, Bigner, DD, Bignell, GR, Stevens, C, Cossu, A, Hall, S, Ho, JW, Wilson, R, Mould, C, Gusterson, BA, Watt, S, Cox, C, Riggins, GJ, Flanagan, A, Gray, K, Wooster, R, Hooper, S, Teague, J, Ewing, R, Edkins, S, Seigler, HF, Hargrave, D, Hawes, R, Kosmidou, V, Nicholson, A, Stephens, P, Weber, BL, Hughes, J, Davies, H, Woffendin, H, Stratton, MR, Clegg, S, Dicks, E, Pritchard-Jones, K	Nature	2002

External Reference Information

External Reference

UniProt:P15056 BRAF

Gene Names

BRAF, BRAF1, RAFB1

Chain

initiator methionine:1, chain:2-766

Reference Genes

BioGPS Gene:673 BRAF

COSMIC (genes):BRAF BRAF

CTD Gene:673 BRAF

dbSNP Gene:673 BRAF

ENSEMBL:ENSG00000157764 BRAF

HGNC:1097 BRAF

KEGG Gene (Homo sapiens):673 BRAF

Monarch:673 BRAF

NCBI Gene:673 BRAF

OMIM:164757 BRAF

UCSC:P15056 BRAF

Reference Transcript

RefSeq:NM_004333.4 BRAF

Other Identifiers

11732491_s_at

1654_at

17063631

206044_s_at

3076364

3076365

3076366

3076367

3076368

3076370

3076372

3076374

3076375

3076380

3076381

3076382

3076383

3076384

3076386

3076388

3076392

3076393

3076396

3076399

3076414

3076416

3076439

3076440

3076441

3076442

3982166

3982173

40306_at

673

8143417

86199_r_at

A_23_P42935

GE58163

GE766137

GO:0000165

GO:0000166

GO:0000186

GO:0003674

GO:0003824

GO:0004672

GO:0004674

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007165

GO:0007173

GO:0008150

GO:0008152

GO:0008219

GO:0009887

GO:0010628

GO:0010828

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0033138

GO:0035556

GO:0042802

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0046872

GO:0048856

GO:0055085

GO:0070374

GO:0070413

GO:0071277

GO:0090150

GO:0097110

GO:0106310

GO:0106311

HMNXSV003020754

ILMN_1652472

M95712_at

PH_hs_0027912

TC07001927.hg

g4757867_3p_a_at

Participates

as a member of

kinase dead BRAF mutants [cytosol] (Homo sapiens)

Other forms of this molecule

BRAF-MACF1fusion [cytosol]

p-BRAF-MACF1 fusion [cytosol]

BRAF E501G [cytosol]

BRAF D594N [cytosol]

BRAF D638E [cytosol]

BRAF G596R [cytosol]

BRAF D594V [cytosol]

BRAF G596V [cytosol]

BRAF D594G [cytosol]

BRAF L505H [cytosol]

BRAF F595L [cytosol]

BRAF L597V [cytosol]

BRAF G464E [cytosol]

BRAF N581D [cytosol]

BRAF E586K [cytosol]

BRAF V600K [cytosol]

BRAF A246P [cytosol]

BRAF G469V [cytosol]

BRAF T244P [cytosol]

BRAF G469R [cytosol]

BRAF L597R [cytosol]

BRAF G469E [cytosol]

BRAF L597Q [cytosol]

BRAF G466A [cytosol]

BRAF G466V [cytosol]

BRAF N581S [cytosol]

BRAF G464V [cytosol]

p-BRAF L597V [plasma membrane]

p-BRAF L505H [plasma membrane]

p-BRAF G464E [plasma membrane]

p-BRAF F595L [plasma membrane]

p-BRAF A246P [plasma membrane]

p-BRAF E586K [plasma membrane]

p-BRAF N581D [plasma membrane]

p-BRAF V600K [plasma membrane]

p-BRAF G464V [plasma membrane]

p-BRAF T244P [plasma membrane]

p-BRAF G469E [plasma membrane]

p-BRAF G466V [plasma membrane]

p-BRAF G469V [plasma membrane]

p-BRAF G466A [plasma membrane]

p-BRAF L597Q [plasma membrane]

p-BRAF L597R [plasma membrane]

p-BRAF N581S [plasma membrane]

p-BRAF G469R [plasma membrane]

BRAF 599dupT [cytosol]

BRAF G534R [cytosol]

BRAF S467A [cytosol]

BRAF K601N [cytosol]

BRAF G469A [cytosol]

BRAF L485F [cytosol]

BRAF Q257R [cytosol]

BRAF K499E [cytosol]

BRAF V600E [cytosol]

BRAF K601E [cytosol]

BRAF V600E V169_M438del [cytosol]

BRAF V600E V47_D380del [cytosol]

BRAF V600E V47_M438del [cytosol]

V600E BRAF V169_D380del [cytosol]

p-S445,S729-BRAF [plasma membrane]

p-S,T-BRAF [cytosol]

BRAF [cytosol]

hyperphosphorylated BRAF [plasma membrane]

p-S365,S445,S729 BRAF [cytosol]

p-S445,T599,S602,S729 BRAF [plasma membrane]

p-S445,S729-BRAF [cytosol]

p-S445,T599,S602,S729 BRAF [cytosol]

Modified Residues

Name

glycine 466 replaced with L-glutamic acid

Coordinate

466

PsiMod

glycine removal [MOD:01638]

A protein modification that effectively removes or replaces an glycine.

L-glutamic acid residue [MOD:00015]

A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.

Disease

Name	Identifier	Synonyms
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma

Cross References

RefSeq

NP_004324.2

ZINC - World Drugs

BRAF_HUMAN

Guide to Pharmacology - Targets

1943

OpenTargets

ENSG00000157764

ZINC - FDA approved

BRAF_HUMAN

ZINC - Substances

BRAF_HUMAN

ZINC - Biogenic

BRAF_HUMAN

ZINC target

P15056

PRO

P15056

PDB

4KSP, 4R5Y, 6V2U, 2L05, 6P3D, 4CQE, 6N0Q, 3Q96, 4YHT, 4MNE, 4JVG, 5J2R, 5CSX, 4RZV, 4MBJ, 4FC0, 6U2G, 6V2V, 4KSQ, 4PP7, 4MNF, 3TV6, 6Q0J, 6PP9, 4RZW, 4XV1, 6NYB, 6P7G, 5CT7, 6U2H, 4EHE, 3PRI, 2FB8, 6V31, 5VAM, 3NY5, 5VYK, 4H58, 5ITA, 1UWJ, 5JT2, 5FD2, 5C9C, 6UAN, 3PRF, 4WO5, 6N0P, 6V32, 5VR3, 6UUO, 5JRQ, 4G9R, 3D4Q, 4DBN, 1UWH, 3OG7, 5J18, 6V2Y, 5HID, 4FK3, 6Q0T, 3PPJ, 5HIE, 4XV9, 3C4C, 6NSQ, 6V2Z, 5VAL, 6V30, 6B8U, 6XAG, 3Q4C, 6CAD, 5JSM, 4XV2, 5HI2, 3TV4, 6Q0K, 6V2W, 3II5, 4G9C, 4EHG, 3PSD, 3IDP, 4XV3, 4E26, 4E4X, 6V2X, 3SKC, 3PPK, 5CSW, 5J17, 3PSB

ZINC - Investigational

BRAF_HUMAN

ZINC - Metabolites

BRAF_HUMAN

COSMIC

COSV56059390

HPA

ENSG00000157764-BRAF

GeneCards

P15056

Ensembl

ENSG00000157764, ENST00000646891, ENSP00000493543

Pharos - Targets

P15056

ZINC - Predictions - Purchasable

BRAF_HUMAN

Orphanet

15376

HMDB Protein

HMDBP02597

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02750 MAP2K1	20	MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 P124S [cytosol] (R-HSA-9652062)	0.977	60
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.959	57
UniProt:P15056 BRAF	20	BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF E501G [cytosol] (R-HSA-9651132) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF D594N [cytosol] (R-HSA-6802299) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L505H [cytosol] (R-HSA-9648845) BRAF D594G [cytosol] (R-HSA-6802295) BRAF E586K [cytosol] (R-HSA-6802308) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF N581D [cytosol] (R-HSA-9651152) BRAF G464E [cytosol] (R-HSA-6802369) BRAF L597V [cytosol] (R-HSA-6802397) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469V [cytosol] (R-HSA-9648620) BRAF D638E [cytosol] (R-HSA-9651125) BRAF A246P [cytosol] (R-HSA-9651123) BRAF V600K [cytosol] (R-HSA-6802502) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305)	0.9	13
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.899	10
UniProt:P01112 HRAS	20	HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS [plasma membrane] (R-HSA-62717) HRAS Q61L [plasma membrane] (R-HSA-6802452) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) HRAS G12S [plasma membrane] (R-HSA-6802343) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS K117R [plasma membrane] (R-HSA-9656010)	0.831	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.818	7
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.813	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.813	7
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 [cytosol] (R-HSA-59504)	0.802	9
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646)	0.774	6
UniProt:P01111 NRAS	20	NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS [plasma membrane] (R-HSA-62725) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS Q61R [plasma membrane] (R-HSA-6802461) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61L [plasma membrane] (R-HSA-6802455) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893)	0.68	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.669	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.643	4
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.609	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.589	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.564	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.544	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:Q8N122 RPTOR	3	RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322)	0.527	3
UniProt:P11142 HSPA8	10	HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P38646 HSPA9	6	HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [cytosol] (R-HSA-5251993)	0.527	2
UniProt:Q61097	5	Ksr1 [cytosol] (R-MMU-5672587) phospho-Ksr1 [cytosol] (R-MMU-5672654) phospho-Ksr1 [cytosol] (R-MMU-5672652) phospho-Ksr1 [plasma membrane] (R-MMU-5672659) phospho-Ksr1 [cytosol] (R-MMU-5672656)	0.499	3
UniProt:Q99N57	10	phospho-Raf1 [cytosol] (R-MMU-206028) phospho-Raf1 [plasma membrane] (R-MMU-5675193) phospho-Raf1 [cytosol] (R-MMU-5624469) phospho-Raf1 [cytosol] (R-MMU-5624465) phospho-Raf1 [plasma membrane] (R-MMU-5672665) Raf1 [cytosol] (R-MMU-167205) phospho-Raf1 [cytosol] (R-MMU-5672664) phospho-Raf1 [plasma membrane] (R-MMU-206222) phospho-Raf1 [cytosol] (R-MMU-109786) phospho-Raf1 [plasma membrane] (R-MMU-5675420)	0.499	3
UniProt:P01116 KRAS	20	KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS K5N [plasma membrane] (R-HSA-9651361) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS A146S [plasma membrane] (R-HSA-9649621) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS G12A [plasma membrane] (R-HSA-9649088) S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS P34L [plasma membrane] (R-HSA-9651269)	0.483	3

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