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p-S257-NFATC1 [nucleoplasm]
Stable Identifier
R-HSA-2025935
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear factor of activated T-cells, cytoplasmic 1, NFAC1_HUMAN, NFATC1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S257-NFATC1 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S257-NFATC1 [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S257-NFATC1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [nucleoplasm] (Homo sapiens)
p-S257-NFATC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95644 NFATC1
Gene Names
NFATC1, NFAT2, NFATC
Chain
chain:1-943
Reference Genes
BioGPS Gene:4772 NFATC1
COSMIC (genes):NFATC1 NFATC1
CTD Gene:4772 NFATC1
dbSNP Gene:4772 NFATC1
ENSEMBL:ENSG00000131196 NFATC1
ENSEMBL:ENSG00000131196.18 NFATC1
HGNC:7775 NFATC1
KEGG Gene (Homo sapiens):4772 NFATC1
Monarch:4772 NFATC1
NCBI Gene:4772 NFATC1
OMIM:600489 NFATC1
UCSC:O95644 NFATC1
Reference Transcript
RefSeq:NM_001278673.1 NFATC1
RefSeq:NM_172389.2 NFATC1
RefSeq:NM_172388.2 NFATC1
RefSeq:NM_172387.2 NFATC1
RefSeq:NM_001278672.1 NFATC1
RefSeq:NM_006162.4 NFATC1
RefSeq:NM_001278670.1 NFATC1
RefSeq:NM_001278675.1 NFATC1
RefSeq:NM_172390.2 NFATC1
RefSeq:NM_001278669.1 NFATC1
Other Identifiers
11731281_a_at
11738520_s_at
11746585_a_at
11752395_a_at
11756259_s_at
16853277
208196_PM_x_at
208196_x_at
209664_PM_x_at
209664_x_at
210162_PM_s_at
210162_s_at
211105_PM_s_at
211105_s_at
3795185
3795186
3795188
3795189
3795190
3795191
3795192
3795196
3795197
3795212
3795213
3795214
3795215
3795221
3795227
3795228
3795229
3795230
3795231
3795232
3795233
3795236
3795237
3795238
3795239
3795240
3795268
3795269
3795270
39143_at
39144_at
4772
8021866
A_14_P202048
A_23_P300150
A_24_P258846
GE59468
GE80837
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001223
GO:0001228
GO:0002376
GO:0003180
GO:0003184
GO:0003676
GO:0003677
GO:0003700
GO:0005515
GO:0005528
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0010468
GO:0016604
GO:0023052
GO:0030154
GO:0030178
GO:0033173
GO:0035556
GO:0043226
GO:0045893
GO:0045944
GO:0048273
GO:0048856
GO:0061629
GO:0071356
GO:0071560
GO:0140110
GO:1903131
GO:1905064
GO:1990837
HMNXSV003032262
HMNXSV003054608
Hs.96149.3.S1_3p_a_at
ILMN_1707051
ILMN_1729663
ILMN_1769997
ILMN_2384188
PH_hs_0031424
TC18000263.hg
U08015_at
U59736_at
g4098860_3p_a_at
g500631_3p_at
g5453771_3p_a_at
Participates
as a member of
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
as a component of
NFATC1:CaN:CaM [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S257-NFATC1 [cytosol]
p-12S-NFATC1 [cytosol]
Inferred From
p-S245-Nfatc2 [nucleoplasm]
(Mus musculus)
Inferred To
Ghost homologue of p-S257-NFATC1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-NFAT [nucleoplasm]
(Drosophila melanogaster)
phospho-nfatc1 [nucleoplasm]
(Xenopus tropicalis)
phospho-NFATC1 [nucleoplasm]
(Bos taurus)
phospho-NFATC1 [nucleoplasm]
(Sus scrofa)
phospho-Nfatc1 [nucleoplasm]
(Mus musculus)
phospho-Nfatc1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S257-NFATC1 [nucleoplasm]
(Canis familiaris)
phospho-p-S257-NFATC1 [nucleoplasm]
(Danio rerio)
phospho-p-S257-NFATC1 [nucleoplasm]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at 257
Coordinate
257
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001265601.1
,
NP_001265599.1
,
NP_765975.1
,
NP_006153.2
,
NP_001265602.1
,
NP_765977.1
,
NP_765976.1
,
NP_001265604.1
,
NP_001265598.1
,
NP_765978.1
OpenTargets
ENSG00000131196
HPA
ENSG00000131196-NFATC1
GeneCards
O95644
Ensembl
ENSP00000327850
,
ENST00000318065
,
ENST00000586434
,
ENST00000591814
,
ENSP00000253506
,
ENSP00000316553
,
ENST00000253506
,
ENSG00000131196
,
ENST00000542384
,
ENSP00000466194
,
ENSP00000380892
,
ENSP00000467181
,
ENSP00000466489
,
ENST00000329101
,
ENST00000397790
,
ENST00000427363
,
ENSP00000389377
,
ENST00000592223
,
ENSP00000442435
PRO
O95644
Pharos - Targets
O95644
Orphanet
24757
HMDB Protein
HMDBP01862
PDB
5SVE
,
1A66
,
1NFA
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08209-1 PPP3CA
0.715
4
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.612
5
UniProt:P16220 CREB1
2
p-S119-CREB1 [nucleoplasm]
(R-HSA-111910)
CREB1 [nucleoplasm]
(R-HSA-52777)
0.576
3
UniProt:P18846 ATF1
2
ATF1 [nucleoplasm]
(R-HSA-199900)
p-S63-ATF1 [nucleoplasm]
(R-HSA-199897)
0.576
3
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.499
2
UniProt:P31276 HXC13
0.499
2
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.499
2
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.499
2
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