Reactome | KAT8 [nucleoplasm]

KAT8 [nucleoplasm]

Stable Identifier

R-HSA-3321802

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone acetyltransferase KAT8, KAT8_HUMAN, MYST1, MOF

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H7Z6 KAT8

Gene Names

KAT8, MOF, MYST1, PP7073

Chain

initiator methionine:, chain:2-458

Reference Genes

BioGPS Gene:84148 KAT8

COSMIC (genes):KAT8 KAT8

CTD Gene:84148 KAT8

dbSNP Gene:84148 KAT8

ENSEMBL:ENSG00000103510 KAT8

HGNC:17933 KAT8

Monarch:84148 KAT8

NCBI Gene:84148 KAT8

OMIM:609912 KAT8

UCSC:Q9H7Z6 KAT8

Reference Transcript

Other Identifiers

11720236_a_at

11732338_a_at

16818184

16818204

214885_PM_at

214885_at

221820_PM_s_at

221820_s_at

35986_at

35987_g_at

35988_i_at

3656854

3656856

3656857

3656858

3656859

3656860

3656862

3656863

3656865

3656866

3656867

3656868

3656869

3656870

3656871

3656872

3656873

3656874

3656875

3656876

3656877

3656878

3656879

3656880

3656881

3656882

3656883

7995055

84148

ADDON000298.hg

ADDON001936.hg

A_33_P3287745

GE56306

GE85345

GO:0000123

GO:0000776

GO:0000785

GO:0003682

GO:0003712

GO:0003713

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005739

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0009048

GO:0010485

GO:0010506

GO:0010719

GO:0016363

GO:0016407

GO:0016740

GO:0016746

GO:0019899

GO:0022008

GO:0022414

GO:0030099

GO:0030154

GO:0032480

GO:0035166

GO:0035267

GO:0043226

GO:0043995

GO:0043996

GO:0044545

GO:0045815

GO:0045892

GO:0045893

GO:0046872

GO:0046972

GO:0048477

GO:0048856

GO:0050684

GO:0060090

GO:0060261

GO:0061629

GO:0061733

GO:0061920

GO:0071339

GO:0072487

GO:0140096

GO:0140110

GO:1902726

GO:1903108

GO:1990841

HMNXSV003001058

HMNXSV003020540

Hs.42343.0.S1_3p_a_at

Hs.42343.1.S1_3p_x_at

ILMN_1804679

PH_hs_0003107

TC16000371.hg

p6360

Participates

as a component of

as an input of

Formation of the NSL complex (Homo sapiens)

Inferred To

Ghost homologue of KAT8 [nucleoplasm] (Gallus gallus)

KAT8 [nucleoplasm] (Bos taurus)

KAT8 [nucleoplasm] (Canis familiaris)

KAT8 [nucleoplasm] (Drosophila melanogaster)

KAT8 [nucleoplasm] (Mus musculus)

KAT8 [nucleoplasm] (Rattus norvegicus)

KAT8 [nucleoplasm] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2668

OpenTargets

ENSG00000103510

ENSEMBL

ENSP00000406037, ENSP00000456933, ENST00000219797, ENST00000448516, ENSP00000219797, ENST00000543774

HPA

ENSG00000103510-KAT8

ZINC - Substances

KAT8_HUMAN

ZINC target

Q9H7Z6

PRO

Q9H7Z6

Pharos - Targets

Q9H7Z6

GlyGen

Q9H7Z6

HMDB Protein

HMDBP09985

PDB

6BA4, 6PDF, 6PDA, 6PDG, 6BA2, 3TOB, 6PDE, 6PDD, 2Y0M, 7CMR, 4DNC, 6PDC, 6PDB, 6PD8, 6PD9, 5J8F, 6OIO, 6OIR, 3TOA, 6OIN, 6OIP, 2GIV, 6OIQ, 5J8C, 5H43, 6CT2, 6OWI, 6OWH, 2PQ8, 5WCI, 3QAH

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.69	5
UniProt:Q8N5Y2 MSL3	1	MSL3 [nucleoplasm] (R-HSA-3321863)	0.643	7
UniProt:Q68DK7 MSL1	1	MSL1 [nucleoplasm] (R-HSA-3321894)	0.643	6
UniProt:Q9HCI7 MSL2	1	MSL2 [nucleoplasm] (R-HSA-3321821)	0.643	5
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.591	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	2
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.499	2
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.462	2