Reactome | VDR [nucleoplasm]

VDR [nucleoplasm]

Stable Identifier

R-HSA-375512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NR1I1, VDR_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
        
        VDR [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11473 VDR

Gene Names

VDR, NR1I1

Chain

chain:1-427

Reference Genes

BioGPS Gene:7421 VDR

COSMIC (genes):VDR VDR

CTD Gene:7421 VDR

dbSNP Gene:7421 VDR

ENSEMBL:ENSG00000111424 VDR

HGNC:12679 VDR

KEGG Gene (Homo sapiens):7421 VDR

Monarch:7421 VDR

NCBI Gene:7421 VDR

OMIM:601769 VDR

UCSC:P11473 VDR

Reference Transcript

Other Identifiers

0006620095

0106020070

11728776_s_at

11728777_a_at

11750983_a_at

11758546_x_at

1388_g_at

1410_at

16763764

204253_s_at

204254_s_at

204255_s_at

3452817

3452819

3452820

3452821

3452822

3452824

3452825

3452827

3452831

3452833

3452835

3452848

3452849

57460_at

7421

7962689

A_23_P162589

GE57479

GO:0000003

GO:0000122

GO:0000785

GO:0000902

GO:0000978

GO:0000981

GO:0001501

GO:0003674

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0006367

GO:0006629

GO:0006810

GO:0006816

GO:0006874

GO:0007165

GO:0007275

GO:0007595

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0008285

GO:0008289

GO:0009058

GO:0009887

GO:0010628

GO:0010629

GO:0010839

GO:0010980

GO:0030154

GO:0030522

GO:0032991

GO:0034641

GO:0038183

GO:0038186

GO:0042359

GO:0042592

GO:0043167

GO:0043226

GO:0043235

GO:0043565

GO:0044281

GO:0045618

GO:0045892

GO:0045944

GO:0046697

GO:0046872

GO:0046965

GO:0048856

GO:0050892

GO:0060058

GO:0060558

GO:0060745

GO:0070561

GO:0070644

GO:0090575

GO:1902098

GO:1902121

HMNXSV003010726

HMNXSV003043975

Hs.2062.0.A2_3p_a_at

Hs.2062.0.A3_3p_a_at

ILMN_1794337

ILMN_1869034

ILMN_2319952

J03258_at

PH_hs_0000277

TC12001439.hg

TC12002858.hg

g4507882_3p_a_at

Participates

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

1,25(OH)2D:VDR [nucleoplasm] (Homo sapiens)

as an input of

Other forms of this molecule

SUMO2-VDR [nucleoplasm]

Inferred To

Vdr [nucleoplasm] (Mus musculus)

Vdr [nucleoplasm] (Rattus norvegicus)

nhr-8 [nucleoplasm] (Caenorhabditis elegans)

vdrb [nucleoplasm] (Danio rerio)

vdr [nucleoplasm] (Xenopus tropicalis)

daf-12 [nucleoplasm] (Caenorhabditis elegans)

nhr-48 [nucleoplasm] (Caenorhabditis elegans)

EcR [nucleoplasm] (Drosophila melanogaster)

Homologues of VDR [nucleoplasm] (Caenorhabditis elegans)

Homologues of VDR [nucleoplasm] (Drosophila melanogaster)

VDR [nucleoplasm] (Canis familiaris)

VDR [nucleoplasm] (Sus scrofa)

Hr96 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001017536.1, NP_000367.1, NP_001017535.1, XP_011537022.1, XP_006719650.1

ZINC - World Drugs

VDR_HUMAN

Guide to Pharmacology - Targets

605

OpenTargets

ENSG00000111424

ZINC - FDA approved

VDR_HUMAN

ZINC - Substances

VDR_HUMAN

ZINC target

P11473

ZINC - Biogenic

VDR_HUMAN

PRO

P11473

PDB

2HAS, 3W0Y, 3AX8, 3CS4, 1IE9, 3AUQ, 1YNW, 1IE8, 2HAR, 2HAM, 1KB2, 3B0T, 3KPZ, 4G2I, 3X36, 3TKC, 2HB8, 3CS6, 3M7R, 3X31, 2HB7, 4ITF, 3A3Z, 4ITE, 3A40, 3WWR, 3AZ2, 1DB1, 1S0Z, 5V39, 1S19, 3AZ1, 3A78, 1KB6, 3AUR, 1KB4, 3W0C, 5GT4, 3A2J, 3W0A, 1TXI, 3OGT, 3A2I, 3VHW, 3P8X, 5YSY, 3WGP, 3AZ3, 5YT2

ZINC - Investigational

VDR_HUMAN

ZINC - Metabolites

VDR_HUMAN

HPA

ENSG00000111424-VDR

GeneCards

P11473

Ensembl

ENSP00000449573, ENSG00000111424, ENSP00000447173, ENST00000550325, ENSP00000378734, ENST00000395324, ENST00000549336

Pharos - Targets

P11473

Orphanet

15707

ZINC - Predictions - Purchasable

VDR_HUMAN

HMDB Protein

HMDBP01798

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [nucleoplasm] (R-HSA-381319) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130)	0.791	6
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.743	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.667	5
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) SUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230)	0.656	3
UniProt:Q13501 SQSTM1	4	SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954)	0.591	4
UniProt:P28700 Rxra	5	Rxra [nucleoplasm] (R-MMU-381319) phospho-Rxra [nucleoplasm] (R-MMU-5334811) Rxra [nucleoplasm] (R-MMU-4341130) Rxra [cytosol] (R-MMU-9619757) Rxra [nucleoplasm] (R-MMU-442483)	0.576	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q15645 PCH2			0.556	3
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720)	0.547	3
UniProt:P04637 TP53	20	TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 [cytosol] (R-HSA-8869337) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 L348S [nucleoplasm] (R-HSA-9726366) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 K351E [nucleoplasm] (R-HSA-9726258) Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L330R [nucleoplasm] (R-HSA-9726133) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 L344R [nucleoplasm] (R-HSA-9726073)	0.537	6
IntAct:EBI-9915211 CO1A1			0.524	2
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111)	0.524	4
UniProt:Q15596 NCOA2	3	NCOA2 [nucleoplasm] (R-HSA-376398) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) SUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305)	0.524	2
UniProt:Q9JLI4 NCOA6			0.508	2

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