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VDR [nucleoplasm]
Stable Identifier
R-HSA-375512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NR1I1, VDR_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
1,25(OH)2D binds VDR (Homo sapiens)
1,25(OH)2D:VDR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11473 VDR
Gene Names
VDR, NR1I1
Chain
chain:1-427
Reference Genes
BioGPS Gene:7421 VDR
COSMIC (genes):VDR VDR
CTD Gene:7421 VDR
dbSNP Gene:7421 VDR
ENSEMBL:ENSG00000111424 VDR
HGNC:12679 VDR
KEGG Gene (Homo sapiens):7421 VDR
Monarch:7421 VDR
NCBI Gene:7421 VDR
OMIM:601769 VDR
UCSC:P11473 VDR
Reference Transcript
RefSeq:NM_001017535.1 VDR
RefSeq:XM_011538720.2 VDR
RefSeq:XM_006719587.3 VDR
RefSeq:NM_001017536.1 VDR
RefSeq:NM_000376.2 VDR
Other Identifiers
0006620095
0106020070
11728776_s_at
11728777_a_at
11750983_a_at
11758546_x_at
1388_g_at
1410_at
16763764
204253_s_at
204254_s_at
204255_s_at
3452817
3452819
3452820
3452821
3452822
3452824
3452825
3452827
3452831
3452833
3452835
3452848
3452849
57460_at
7421
7962689
A_23_P162589
GE57479
GO:0000003
GO:0000122
GO:0000228
GO:0000790
GO:0000902
GO:0000977
GO:0000981
GO:0001501
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006367
GO:0006629
GO:0006810
GO:0006816
GO:0006874
GO:0007165
GO:0007275
GO:0007595
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0008285
GO:0008289
GO:0009058
GO:0009887
GO:0010628
GO:0010629
GO:0010839
GO:0010980
GO:0030154
GO:0030522
GO:0032991
GO:0034641
GO:0038023
GO:0038183
GO:0038186
GO:0042025
GO:0042359
GO:0042592
GO:0042632
GO:0043167
GO:0043226
GO:0043235
GO:0043565
GO:0044281
GO:0045618
GO:0045892
GO:0045944
GO:0046697
GO:0046872
GO:0046965
GO:0048856
GO:0050892
GO:0055088
GO:0060058
GO:0060558
GO:0060745
GO:0070561
GO:0070644
GO:0090575
GO:1902098
GO:1902121
Hs.2062.0.A2_3p_a_at
Hs.2062.0.A3_3p_a_at
ILMN_1794337
ILMN_1869034
ILMN_2319952
J03258_at
PH_hs_0000277
TC12001439.hg
TC12002858.hg
g4507882_3p_a_at
Participant Of
hasMember
NR [nucleoplasm]
input
1,25(OH)2D binds VDR
PIAS4 SUMOylates VDR with SUMO2
hasComponent
1,25(OH)2D:VDR [nucleoplasm]
Other forms of this molecule
SUMO2-VDR [nucleoplasm]
Inferred To
Vdr [nucleoplasm] (Mus musculus)
Vdr [nucleoplasm] (Rattus norvegicus)
nhr-8 [nucleoplasm] (Caenorhabditis elegans)
vdr [nucleoplasm] (Xenopus tropicalis)
daf-12 [nucleoplasm] (Caenorhabditis elegans)
nhr-48 [nucleoplasm] (Caenorhabditis elegans)
vdra [nucleoplasm] (Danio rerio)
EcR [nucleoplasm] (Drosophila melanogaster)
Homologues of VDR [nucleoplasm] (Caenorhabditis elegans)
Homologues of VDR [nucleoplasm] (Drosophila melanogaster)
VDR [nucleoplasm] (Canis familiaris)
VDR [nucleoplasm] (Sus scrofa)
Hr96 [nucleoplasm] (Drosophila melanogaster)
unc-55 [nucleoplasm] (Caenorhabditis elegans)
Cross References
RefSeq
XP_011537022.1
,
XP_006719650.1
,
NP_001017535.1
,
NP_001017536.1
,
NP_000367.1
ZINC - World Drugs
VDR_HUMAN
OpenTargets
ENSG00000111424
ZINC - FDA approved
VDR_HUMAN
ZINC - Substances
VDR_HUMAN
ZINC target
P11473
ZINC - Biogenic
VDR_HUMAN
PRO
P11473
PDB
2HAR
,
1TXI
,
1IE9
,
3X31
,
3A2I
,
3AX8
,
3A78
,
2HAS
,
3M7R
,
3A2J
,
2HB7
,
5YSY
,
3TKC
,
4ITF
,
3A40
,
4G2I
,
5YT2
,
3B0T
,
1KB2
,
5V39
,
1IE8
,
3X36
,
3AUR
,
3W0C
,
1DB1
,
1KB4
,
2HB8
,
3AZ1
,
3OGT
,
3W0A
,
5GT4
,
3WWR
,
3WGP
,
3KPZ
,
1KB6
,
3AZ2
,
3CS4
,
1S0Z
,
3W0Y
,
3AZ3
,
3A3Z
,
3AUQ
,
3P8X
,
3CS6
,
1YNW
,
2HAM
,
4ITE
,
1S19
,
3VHW
ZINC - Investigational
VDR_HUMAN
ZINC - Metabolites
VDR_HUMAN
GeneCards
P11473
HPA
ENSG00000111424-VDR
Ensembl
ENSP00000378734
,
ENST00000395324
,
ENSP00000449573
,
ENSP00000447173
,
ENST00000549336
,
ENST00000550325
,
ENSG00000111424
Orphanet
15707
ZINC - Predictions - Purchasable
VDR_HUMAN
HMDB Protein
HMDBP01798
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19793 RXRA
4
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
SUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.791
6
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.743
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.667
5
UniProt:Q15788 NCOA1
3
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
SUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.656
3
UniProt:Q13501 SQSTM1
2
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
0.591
4
UniProt:P28700 Rxra
5
phospho-Rxra [nucleoplasm]
(R-MMU-5334811)
Rxra [cytosol]
(R-MMU-9619757)
Rxra [nucleoplasm]
(R-MMU-4341130)
Rxra [nucleoplasm]
(R-MMU-442483)
Rxra [nucleoplasm]
(R-MMU-381319)
0.576
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q15645 PCH2
0.556
3
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.547
3
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.537
6
IntAct:EBI-9915211 CO1A1
0.524
2
UniProt:P26045 PTPN3
3
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
PTPN3 [cytosol]
(R-HSA-8867650)
0.524
4
UniProt:Q15596 NCOA2
3
NCOA2 (869-1464) [nucleoplasm]
(R-HSA-5603186)
SUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
(R-HSA-4085305)
NCOA2 [nucleoplasm]
(R-HSA-376398)
0.524
2
UniProt:Q9JLI4 NCOA6
0.508
2
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