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HIPK1 [nucleoplasm]
Stable Identifier
R-HSA-3215224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2, KIAA0630, MYAK, NBAK2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
TP53 binds HIPK1 (Homo sapiens)
HIPK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:HIPK1 [nucleoplasm] (Homo sapiens)
HIPK1 [nucleoplasm] (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
HIPK1,2 [nucleoplasm] (Homo sapiens)
HIPK1 [nucleoplasm] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
HIPK1,2 [nucleoplasm] (Homo sapiens)
HIPK1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Z02 HIPK1
Gene Names
HIPK1, KIAA0630, MYAK, NBAK2
Chain
chain:1-1210
Reference Genes
BioGPS Gene:204851 HIPK1
COSMIC (genes):HIPK1 HIPK1
CTD Gene:204851 HIPK1
dbSNP Gene:204851 HIPK1
ENSEMBL:ENSG00000163349.22 HIPK1
HGNC:19006 HIPK1
KEGG Gene (Homo sapiens):204851 HIPK1
Monarch:204851 HIPK1
NCBI Gene:204851 HIPK1
OMIM:608003 HIPK1
UCSC:Q86Z02 HIPK1
Reference Transcript
RefSeq:NM_198269.2 HIPK1
RefSeq:NM_152696.3 HIPK1
RefSeq:XM_005270612.4 HIPK1
RefSeq:XM_005270613.4 HIPK1
RefSeq:NM_181358.2 HIPK1
RefSeq:NM_198268.2 HIPK1
Other Identifiers
11715873_a_at
11722239_a_at
11734488_a_at
11744804_a_at
1552515_PM_at
1552515_at
1552516_PM_a_at
1552516_a_at
16668969
16668997
204851
212291_PM_at
212291_at
212293_PM_at
212293_at
218162_PM_at
218162_at
2352759
2352760
2352765
2352767
2352769
2352770
2352772
2352774
2352775
2352776
2352777
2352778
2352780
2352781
2352782
2352784
2352785
2352786
2352788
2352789
2352790
2352791
2352792
2352793
2352794
2352795
2352796
2352798
2352799
2352800
2352801
2352805
2352806
2352807
2352808
2352809
2352810
2352811
2352812
2352813
39376_at
46694_at
7904137
7904158
A_14_P108785
A_14_P126503
A_14_P127912
A_14_P201716
A_24_P11315
A_24_P385336
A_32_P231446
A_32_P24832
GE53345
GE82515
GO:0000166
GO:0001654
GO:0002376
GO:0003677
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006468
GO:0007224
GO:0008283
GO:0008284
GO:0009952
GO:0010803
GO:0010842
GO:0012501
GO:0016301
GO:0016310
GO:0016605
GO:0016607
GO:0016740
GO:0018105
GO:0018107
GO:0018108
GO:0023052
GO:0030154
GO:0030182
GO:0034330
GO:0034333
GO:0036211
GO:0042771
GO:0043226
GO:0045766
GO:0048596
GO:0048856
GO:0060059
GO:0060216
GO:0060235
GO:0061072
GO:0072577
GO:0097191
GO:0106310
GO:0140096
HMNXSV003053160
HMNXSV003056946
Hs.12259.0.A1_3p_at
Hs.12259.0.A2_3p_at
Hs2.12259.1.S1_3p_at
Hs2.12259.1.S1_3p_s_at
ILMN_1660786
ILMN_1661188
ILMN_1690951
ILMN_1727532
ILMN_2412768
PH_hs_0028764
PH_hs_0040191
TC01001003.hg
TC01001004.hg
g9910269_3p_at
Participates
as a member of
HIPK1,2 [nucleoplasm] (Homo sapiens)
as a component of
TP53 Tetramer:HIPK1 [nucleoplasm] (Homo sapiens)
as an input of
TP53 binds HIPK1 (Homo sapiens)
Inferred To
HIPK1 [nucleoplasm]
(Bos taurus)
HIPK1 [nucleoplasm]
(Caenorhabditis elegans)
HIPK1 [nucleoplasm]
(Canis familiaris)
HIPK1 [nucleoplasm]
(Danio rerio)
HIPK1 [nucleoplasm]
(Dictyostelium discoideum)
HIPK1 [nucleoplasm]
(Drosophila melanogaster)
HIPK1 [nucleoplasm]
(Gallus gallus)
HIPK1 [nucleoplasm]
(Mus musculus)
HIPK1 [nucleoplasm]
(Plasmodium falciparum)
HIPK1 [nucleoplasm]
(Rattus norvegicus)
HIPK1 [nucleoplasm]
(Saccharomyces cerevisiae)
HIPK1 [nucleoplasm]
(Schizosaccharomyces pombe)
HIPK1 [nucleoplasm]
(Sus scrofa)
HIPK1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005270670.1
,
NP_938009.1
,
XP_005270669.1
,
NP_852003.1
,
NP_938010.1
,
NP_689909.2
ZINC - World Drugs
HIPK1_HUMAN
Guide to Pharmacology - Targets
2033
OpenTargets
ENSG00000163349
ZINC - FDA approved
HIPK1_HUMAN
ZINC - Substances
HIPK1_HUMAN
ZINC - Biogenic
HIPK1_HUMAN
ZINC target
Q86Z02
PRO
Q86Z02
ZINC - Investigational
HIPK1_HUMAN
GeneCards
Q86Z02
HPA
ENSG00000163349-HIPK1
Ensembl
ENSP00000358571
,
ENST00000369553
,
ENST00000340480
,
ENSG00000163349
,
ENST00000369559
,
ENST00000426820
,
ENSP00000358572
,
ENSP00000407442
,
ENST00000369558
,
ENSP00000340956
,
ENSP00000358566
Pharos - Targets
Q86Z02
ZINC - Predictions - Purchasable
HIPK1_HUMAN
HMDB Protein
HMDBP01404
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13643 FHL3
0.666
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.508
2
UniProt:Q5EBH1 RASF5
0.463
2
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