Reactome | SREBF2(1-484) [nucleoplasm]

SREBF2(1-484) [nucleoplasm]

Stable Identifier

R-HSA-1655745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SREBP2(1-484), SREBF2 cleaved by S2P, Sterol regulatory element-binding protein 2, SRBP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q12772 SREBF2

Gene Names

SREBF2, BHLHD2, SREBP2

Chain

chain:1-1141, chain:1-484

Reference Genes

BioGPS Gene:6721 SREBF2

COSMIC (genes):SREBF2 SREBF2

CTD Gene:6721 SREBF2

dbSNP Gene:6721 SREBF2

ENSEMBL:ENSG00000198911 SREBF2

ENSEMBL_homo_sapiens_GENE:ENSG00000198911.13 SREBF2

HGNC:11290 SREBF2

KEGG Gene (Homo sapiens):6721 SREBF2

Monarch:6721 SREBF2

NCBI Gene:6721 SREBF2

OMIM:600481 SREBF2

UCSC:Q12772 SREBF2

Reference Transcript

RefSeq:NM_004599.3 SREBF2

Other Identifiers

11723664_a_at

11752012_a_at

11759548_a_at

16930768

201247_PM_at

201247_at

201248_PM_s_at

201248_s_at

38713_at

3947124

3947125

3947137

3947138

3947142

3947143

3947144

3947148

3947149

3947151

3947154

3947155

3947156

3947158

3947165

3947166

3947179

3947180

3947181

3947183

3947188

3947189

3947192

3947194

3947195

3947196

3947197

3947198

3947199

3947200

6721

78554_at

8073522

A_14_P129067

A_23_P166502

A_23_P419602

GE58852

GE85795

GO:0000122

GO:0000139

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001227

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006351

GO:0006355

GO:0006629

GO:0006886

GO:0006914

GO:0007005

GO:0008202

GO:0008203

GO:0008593

GO:0009267

GO:0010886

GO:0012507

GO:0016020

GO:0023052

GO:0031410

GO:0032933

GO:0032937

GO:0042632

GO:0043226

GO:0043231

GO:0045542

GO:0045944

GO:0046983

GO:0070888

GO:0071404

GO:0071499

GO:0090370

GO:0140110

GO:1901524

GO:1902895

GO:1903955

GO:1990837

HMNXSV003036456

Hs.108689.0.A2_3p_at

ILMN_2217661

PH_hs_0006017

TC22000347.hg

U02031_at

g4759169_3p_s_at

Participates

as a member of

as a component of

SREBF2 dimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SREBF2(1-1141) [Golgi membrane]

SREBF2(1-522) [Golgi membrane]

SREBF2(1-484) [cytosol]

SREBF2(1-1141) [endoplasmic reticulum membrane]

Inferred To

SREBP [nucleoplasm] (Drosophila melanogaster)

sbp-1 [nucleoplasm] (Caenorhabditis elegans)

SREBF2 [nucleoplasm] (Bos taurus)

SREBF2 [nucleoplasm] (Canis familiaris)

SREBF2 [nucleoplasm] (Sus scrofa)

Srebf2 [nucleoplasm] (Mus musculus)

Srebf2 [nucleoplasm] (Rattus norvegicus)

srebf2 [nucleoplasm] (Danio rerio)

srebf2 [nucleoplasm] (Xenopus tropicalis)

SREBF2(1-484) [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_004590.2

OpenTargets

ENSG00000198911

ZINC - Substances

SRBP2_HUMAN

ZINC - Biogenic

SRBP2_HUMAN

ZINC target

Q12772

PRO

Q12772

PDB

1UKL

ZINC - Metabolites

SRBP2_HUMAN

GeneCards

Q12772

HPA

ENSG00000198911-SREBF2

Ensembl

ENST00000361204, ENSP00000354476, ENSG00000198911

Pharos - Targets

Q12772

ZINC - Predictions - Purchasable

SRBP2_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.666	5
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.635	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.499	2
UniProt:Q96RN5 MED15	1	MED15 [nucleoplasm] (R-HSA-556827)	0.499	2

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