Reactome | DROSHA [nucleoplasm]

DROSHA [nucleoplasm]

Stable Identifier

R-HSA-1482510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ribonuclease 3, RNC_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NRR4 DROSHA

Gene Names

DROSHA, RN3, RNASE3L, RNASEN

Chain

chain:1-1374

Reference Genes

BioGPS Gene:29102 DROSHA

COSMIC (genes):DROSHA DROSHA

CTD Gene:29102 DROSHA

dbSNP Gene:29102 DROSHA

ENSEMBL:ENSG00000113360 DROSHA

HGNC:17904 DROSHA

KEGG Gene (Homo sapiens):29102 DROSHA

Monarch:29102 DROSHA

NCBI Gene:29102 DROSHA

OMIM:608828 DROSHA

UCSC:Q9NRR4 DROSHA

Reference Transcript

Other Identifiers

0002190341

11727107_a_at

11727108_x_at

11727109_a_at

11739629_x_at

11749636_a_at

16994890

218269_at

2851969

2851970

2851971

2851972

2851973

2851974

2851975

2851979

2851982

2851985

2851986

2851988

2851989

2851995

2851997

2851998

2852001

2852003

2852006

2852007

2852008

2852012

2852013

2852014

2852021

2852022

2852024

2852027

2852028

2852033

2852034

2852035

2852040

2852041

2852045

2852049

2852051

2852053

2852054

2852056

2852059

2852060

2852061

2852062

2852063

2852064

2852065

29102

53235_at

62181_at

8111286

88331_at

A_23_P133596

GE55697

GO:0001530

GO:0002376

GO:0003674

GO:0003723

GO:0003725

GO:0004518

GO:0004519

GO:0004521

GO:0004525

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006396

GO:0006950

GO:0008150

GO:0008289

GO:0009056

GO:0010468

GO:0010586

GO:0010628

GO:0014069

GO:0016075

GO:0016787

GO:0017151

GO:0019899

GO:0030154

GO:0030422

GO:0031047

GO:0031053

GO:0031054

GO:0032991

GO:0034641

GO:0034655

GO:0042254

GO:0042803

GO:0043167

GO:0043226

GO:0045589

GO:0046332

GO:0046872

GO:0048856

GO:0050727

GO:0050829

GO:0050830

GO:0070412

GO:0070877

GO:0070878

GO:0090305

GO:0090501

GO:0090502

GO:2000628

HMNXSV003006188

ILMN_1790410

ILMN_2152095

PH_hs_0025710

TC05001223.hg

g7106396_3p_at

Participates

as a component of

MicroProcessor Complex [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005248351.1, NP_001093882.1, XP_005248348.1, NP_037367.3

OpenTargets

ENSG00000113360

IntEnz

3.1.26.3

GeneCards

Q9NRR4

HPA

ENSG00000113360-DROSHA

Ensembl

ENSG00000113360, ENST00000513349, ENST00000511367, ENSP00000425979, ENST00000344624, ENSP00000424161, ENSP00000339845

PRO

Q9NRR4

PDB

2KHX, 6V5B, 6V5C, 6LXD, 2NA2, 6LXE, 5B16

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.929	13
UniProt:P17844 DDX5	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.737	6
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.737	7
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.677	5
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.524	2

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