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DROSHA [nucleoplasm]
Stable Identifier
R-HSA-1482510
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ribonuclease 3, RNC_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
MicroRNA (miRNA) biogenesis (Homo sapiens)
Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)
MicroProcessor Complex [nucleoplasm] (Homo sapiens)
DROSHA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRR4 DROSHA
Gene Names
DROSHA, RN3, RNASE3L, RNASEN
Chain
chain:1-1374
Reference Genes
BioGPS Gene:29102 DROSHA
COSMIC (genes):DROSHA DROSHA
CTD Gene:29102 DROSHA
dbSNP Gene:29102 DROSHA
ENSEMBL:ENSG00000113360 DROSHA
HGNC:17904 DROSHA
KEGG Gene (Homo sapiens):29102 DROSHA
Monarch:29102 DROSHA
NCBI Gene:29102 DROSHA
OMIM:608828 DROSHA
UCSC:Q9NRR4 DROSHA
Reference Transcript
RefSeq:XM_005248294.3 DROSHA
RefSeq:NM_013235.4 DROSHA
RefSeq:XM_005248291.3 DROSHA
RefSeq:NM_001100412.1 DROSHA
Other Identifiers
0002190341
11727107_a_at
11727108_x_at
11727109_a_at
11739629_x_at
11749636_a_at
16994890
218269_at
2851969
2851970
2851971
2851972
2851973
2851974
2851975
2851979
2851982
2851985
2851986
2851988
2851989
2851995
2851997
2851998
2852001
2852003
2852006
2852007
2852008
2852012
2852013
2852014
2852021
2852022
2852024
2852027
2852028
2852033
2852034
2852035
2852040
2852041
2852045
2852049
2852051
2852053
2852054
2852056
2852059
2852060
2852061
2852062
2852063
2852064
2852065
29102
53235_at
62181_at
8111286
88331_at
A_23_P133596
GE55697
GO:0001530
GO:0002376
GO:0003674
GO:0003723
GO:0003725
GO:0004518
GO:0004519
GO:0004521
GO:0004525
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006396
GO:0006950
GO:0008150
GO:0008289
GO:0009056
GO:0010468
GO:0010586
GO:0010628
GO:0014069
GO:0016075
GO:0016787
GO:0017151
GO:0019899
GO:0030154
GO:0030422
GO:0031047
GO:0031053
GO:0031054
GO:0032991
GO:0034641
GO:0034655
GO:0042254
GO:0042803
GO:0043167
GO:0043226
GO:0045589
GO:0046332
GO:0046872
GO:0048856
GO:0050727
GO:0050829
GO:0050830
GO:0070412
GO:0070877
GO:0070878
GO:0090305
GO:0090501
GO:0090502
GO:2000628
HMNXSV003006188
ILMN_1790410
ILMN_2152095
PH_hs_0025710
TC05001223.hg
g7106396_3p_at
Participates
as a component of
MicroProcessor Complex [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_037367.3
,
XP_005248348.1
,
NP_001093882.1
,
XP_005248351.1
OpenTargets
ENSG00000113360
IntEnz
3.1.26.3
HPA
ENSG00000113360-DROSHA
GeneCards
Q9NRR4
Ensembl
ENSP00000425979
,
ENST00000344624
,
ENSP00000339845
,
ENST00000513349
,
ENSP00000424161
,
ENSG00000113360
,
ENST00000511367
PRO
Q9NRR4
Pharos - Targets
Q9NRR4
PDB
6V5C
,
2NA2
,
6LXE
,
6V5B
,
5B16
,
6LXD
,
2KHX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WYQ5 DGCR8
1
DGCR8 [nucleoplasm]
(R-HSA-1482509)
0.929
13
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.737
6
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.737
7
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.677
5
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.524
2
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