Reactome | PPP1R13L [nucleoplasm]

PPP1R13L [nucleoplasm]

Stable Identifier

R-HSA-6799738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RelA-associated inhibitor, iASPP, Inhibitor of ASPP protein

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds PPP1R13L (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUF5 PPP1R13L

Gene Names

PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI

Chain

chain:1-828

Reference Genes

BioGPS Gene:10848 PPP1R13L

COSMIC (genes):PPP1R13L PPP1R13L

CTD Gene:10848 PPP1R13L

dbSNP Gene:10848 PPP1R13L

ENSEMBL:ENSG00000104881 PPP1R13L

HGNC:18838 PPP1R13L

KEGG Gene (Homo sapiens):10848 PPP1R13L

Monarch:10848 PPP1R13L

NCBI Gene:10848 PPP1R13L

OMIM:607463 PPP1R13L

UCSC:Q8WUF5 PPP1R13L

Reference Transcript

Other Identifiers

0001580131

10848

11750250_a_at

16873296

218849_s_at

2VGE

3865345

3865346

3865347

3865351

3865354

3865355

3865357

3865360

3865365

3865366

3865367

3865368

3865369

3865370

3865371

3865372

3865373

3865374

3865377

41231

5016

55079_at

59883

8037563

A0A024R0Q5

A_23_P119095

AAD27004

AAD27005

AAH01475

AAH20589

AAH32298

AAH64913

AAW51146

ABC40745

AF078036

AF078037

AJ888472

AY869712

BC001475

BC020589

BC032298

BC064913

CAB005016

CAI60219

CCDS33050

CH471126

DQ314886

EAW57343

EAW57345

ENSG00000104881

ENSP00000354218

ENSP00000403902

ENST00000360957

ENST00000360957.9

ENST00000418234

ENST00000418234.6

EntrezGene:10848

EntrezGene:PPP1R13L

g5730000_3p_a_at

GO:0000122

GO:0003013

GO:0003215

GO:0003229

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006915

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0009791

GO:0030054

GO:0030154

GO:0031076

GO:0034641

GO:0035264

GO:0040007

GO:0042592

GO:0042633

GO:0042802

GO:0043226

GO:0045171

GO:0045296

GO:0045597

GO:0048856

GO:0048871

GO:0060048

GO:1901796

HGNC:18838

HPA041231

HPA059883

ILMN_1669390

IPR001452

IPR002110

IPR020683

IPR028320

IPR036028

IPR036770

K7EML6

K7EN03

K7EPP1

MIM:607463

NM_001142502

NM_006663

NP_001135974

NP_006654

PF12796

PF14604

PH_hs_0016127

PPP1R13L

PPP1R13L-201

PPP1R13L-202

PR00452

PR01217

SM00248

SM00326

TC19001619.hg

UPI00001400F1

XM_017026177

XM_017026178

XP_016881666

XP_016881667

Participant Of

hasComponent

(p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm]

input

TP53 binds PPP1R13L

Inferred To

PPP1R13L [nucleoplasm] (Bos taurus)

PPP1R13L [nucleoplasm] (Caenorhabditis elegans)

PPP1R13L [nucleoplasm] (Canis familiaris)

PPP1R13L [nucleoplasm] (Danio rerio)

PPP1R13L [nucleoplasm] (Mus musculus)

PPP1R13L [nucleoplasm] (Rattus norvegicus)

PPP1R13L [nucleoplasm] (Sus scrofa)

PPP1R13L [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001135974.1, XP_016881667.1, XP_016881666.1, NP_006654.2

OpenTargets

ENSG00000104881

GeneCards

Q8WUF5

PRO

Q8WUF5

Orphanet

27932

PDB

2VGE, 6DCX

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.892	9
UniProt:P62140 PPP1CB	2	PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB [cytosol] (R-HSA-163405)	0.83	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.815	12
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.676	5
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.65	9
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.597	3
UniProt:P15206 CCNB			0.544	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.499	2