Reactome | PPP1R13L [nucleoplasm]

PPP1R13L

Stable Identifier

R-HSA-6799738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RelA-associated inhibitor, iASPP, Inhibitor of ASPP protein

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds PPP1R13L (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUF5 PPP1R13L

Gene Names

PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI

Chain

chain:1-828

Reference Genes

BioGPS Gene:10848 PPP1R13L

COSMIC (genes):PPP1R13L PPP1R13L

CTD Gene:10848 PPP1R13L

dbSNP Gene:10848 PPP1R13L

ENSEMBL:ENSG00000104881 PPP1R13L

HGNC:18838 PPP1R13L

KEGG Gene (Homo sapiens):hsa:10848 PPP1R13L

Monarch:10848 PPP1R13L

NCBI Gene:10848 PPP1R13L

OMIM:607463 PPP1R13L

UCSC:Q8WUF5 PPP1R13L

Reference Transcript

Other Identifiers

0001580131

10848

11750250_a_at

16873296

218849_s_at

2VGE

3865345

3865346

3865347

3865351

3865354

3865355

3865357

3865360

3865365

3865366

3865367

3865368

3865369

3865370

3865371

3865372

3865373

3865374

3865377

41231

5016

55079_at

59883

8037563

A0A024R0Q5

A_23_P119095

CAB005016

CCDS33050

ENSG00000104881

ENSP00000354218

ENSP00000403902

ENST00000360957

ENST00000418234

EntrezGene:10848

g5730000_3p_a_at

GO:0000122

GO:0003215

GO:0003229

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006915

GO:0008134

GO:0009791

GO:0030054

GO:0031076

GO:0035264

GO:0042633

GO:0042802

GO:0045171

GO:0045296

GO:0045597

GO:0048871

GO:0060048

GO:1901796

HGNC:18838

HPA041231

HPA059883

Hs.466937

ILMN_1669390

MIM:607463

NM_001142502

NM_006663

NP_001135974

NP_006654

PF12796

PF14604

PH_hs_0016127

PPP1R13L

PPP1R13L-201

PPP1R13L-202

PR00452

PR01217

SM00248

SM00326

TC19001619.hg

uc002pbn.4

uc002pbo.4

UPI00001400F1

XM_017026177

XM_017026178

XP_016881666

XP_016881667

Participant Of

input

TP53 binds PPP1R13L

hasComponent

(p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm]

Inferred To

PPP1R13L [nucleoplasm] (Bos taurus)

PPP1R13L [nucleoplasm] (Caenorhabditis elegans)

PPP1R13L [nucleoplasm] (Canis familiaris)

PPP1R13L [nucleoplasm] (Drosophila melanogaster)

PPP1R13L [nucleoplasm] (Mus musculus)

PPP1R13L [nucleoplasm] (Rattus norvegicus)

PPP1R13L [nucleoplasm] (Sus scrofa)

PPP1R13L [nucleoplasm] (Xenopus tropicalis)

Homologues of PPP1R13L [nucleoplasm] (Caenorhabditis elegans)

Homologues of PPP1R13L [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_006654.2, NP_001135974.1, XP_016881667.1, XP_016881666.1

GeneCards

Q8WUF5

DOCK Blaster

2VGE

PRO

Q8WUF5

PDB

2VGE

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.856	8
UniProt:P62140 PPP1CB	2	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003)	0.83	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb-TP53 [cytosol] (R-HSA-6793681) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.815	12
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.676	5
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.65	9
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.597	3
UniProt:P15206 CCNB			0.544	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q09472 EP300	2	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072)	0.499	2