Reactome | PPP1R13L [nucleoplasm]

PPP1R13L [nucleoplasm]

Stable Identifier

R-HSA-6799738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RelA-associated inhibitor, iASPP, Inhibitor of ASPP protein

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds PPP1R13L (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)
        
        PPP1R13L [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUF5 PPP1R13L

Gene Names

PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI

Chain

chain:1-828

Reference Genes

BioGPS Gene:10848 PPP1R13L

COSMIC (genes):PPP1R13L PPP1R13L

CTD Gene:10848 PPP1R13L

dbSNP Gene:10848 PPP1R13L

ENSEMBL:ENSG00000104881 PPP1R13L

HGNC:18838 PPP1R13L

KEGG Gene (Homo sapiens):10848 PPP1R13L

Monarch:10848 PPP1R13L

NCBI Gene:10848 PPP1R13L

OMIM:607463 PPP1R13L

UCSC:Q8WUF5 PPP1R13L

Reference Transcript

Other Identifiers

0001580131

10848

11750250_a_at

16873296

218849_s_at

3865345

3865346

3865347

3865351

3865354

3865355

3865357

3865360

3865365

3865366

3865367

3865368

3865369

3865370

3865371

3865372

3865373

3865374

3865377

55079_at

8037563

A_23_P119095

GO:0000122

GO:0003013

GO:0003215

GO:0003229

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006357

GO:0006915

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0009791

GO:0030054

GO:0030154

GO:0031076

GO:0034641

GO:0035264

GO:0040007

GO:0042592

GO:0042633

GO:0042802

GO:0043226

GO:0045171

GO:0045296

GO:0045597

GO:0048856

GO:0048871

GO:0060048

GO:1901796

ILMN_1669390

PH_hs_0016127

TC19001619.hg

g5730000_3p_a_at

Participant Of

hasComponent

(p-S15,S20-TP53,TP63,TP73):PPP1R13L [nucleoplasm]

input

TP53 binds PPP1R13L

Inferred To

PPP1R13L [nucleoplasm] (Bos taurus)

PPP1R13L [nucleoplasm] (Canis familiaris)

PPP1R13L [nucleoplasm] (Sus scrofa)

nfki-1 [nucleoplasm] (Caenorhabditis elegans)

ppp1r13l [nucleoplasm] (Danio rerio)

ppp1r13l [nucleoplasm] (Xenopus tropicalis)

Ppp1r13l [nucleoplasm] (Mus musculus)

Ppp1r13l [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001135974.1, NP_006654.2, XP_016881666.1, XP_016881667.1

OpenTargets

ENSG00000104881

HPA

ENSG00000104881-PPP1R13L

GeneCards

Q8WUF5

Ensembl

ENSG00000104881, ENST00000360957, ENSP00000403902, ENSP00000354218, ENST00000418234

PRO

Q8WUF5

Orphanet

27932

PDB

2VGE, 6DCX, 6RZ3, 6HL6

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.892	9
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.83	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.815	12
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.676	5
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.65	9
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.597	3
UniProt:P15206 CCNB			0.544	2
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
UniProt:Q9WMX2-PRO_0000037551			0.508	2
UniProt:Q15435 PP1R7			0.508	2
UniProt:Q09472 EP300	5	Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) SUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.499	2

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