Reactome | ARIH2 [cytosol]

ARIH2 [cytosol]

Stable Identifier

R-HSA-975987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase ARIH2, ARI2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95376 ARIH2

Gene Names

ARIH2, ARI2, TRIAD1, HT005

Chain

chain:1-493

Reference Genes

BioGPS Gene:10425 ARIH2

COSMIC (genes):ARIH2 ARIH2

CTD Gene:10425 ARIH2

dbSNP Gene:10425 ARIH2

ENSEMBL:ENSG00000177479 ARIH2

HGNC:690 ARIH2

KEGG:hsa:10425 ARIH2

Monarch:10425 ARIH2

NCBI Gene:10425 ARIH2

OMIM:605615 ARIH2

UCSC:O95376 ARIH2

Reference Transcript

Other Identifiers

10425

11717394_at

11717395_a_at

11754979_x_at

16940557

201228_PM_s_at

201228_s_at

201229_PM_s_at

201229_s_at

201230_PM_s_at

201230_s_at

216008_PM_s_at

216008_s_at

227932_PM_at

227932_at

2621828

2621830

2621831

2621832

2621833

2621834

2621835

2621836

2621837

2621838

2621842

2621843

2621846

2621847

2621848

2621849

2621850

2621851

2621852

2621854

2621855

2621857

2621858

2621859

2621862

2621863

2621864

2621865

2621866

2621867

2621868

2621869

2621872

2621873

2621874

2621875

2621876

2621877

3783118

3783119

3783123

39164_at

56846_at

8079662

A_14_P105620

A_23_P61881

A_23_P73279

A_24_P94651

GE61552

GE61709

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006511

GO:0008270

GO:0016567

GO:0016740

GO:0030163

GO:0031466

GO:0031624

GO:0043161

GO:0043226

GO:0046872

GO:0048588

GO:0061630

GO:0070534

GO:0070936

GO:0071425

GO:0140096

GO:1903955

HMNXSV003046972

HMNXSV003056238

Hs.241558.1.S1_3p_at

Hs.241558.2.S1_3p_a_at

ILMN_1792825

PH_hs_0012955

TC03002330.hg

g12653306_3p_a_at

g5453556_3p_a_at

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

ARIH2 [cytosol] (Bos taurus)

ARIH2 [cytosol] (Caenorhabditis elegans)

ARIH2 [cytosol] (Dictyostelium discoideum)

ARIH2 [cytosol] (Drosophila melanogaster)

ARIH2 [cytosol] (Gallus gallus)

ARIH2 [cytosol] (Mus musculus)

ARIH2 [cytosol] (Plasmodium falciparum)

ARIH2 [cytosol] (Saccharomyces cerevisiae)

ARIH2 [cytosol] (Schizosaccharomyces pombe)

ARIH2 [cytosol] (Sus scrofa)

Arih2 [cytosol] (Rattus norvegicus)

Homologues of ARIH2 [cytosol] (Dictyostelium discoideum)

arih2 [cytosol] (Danio rerio)

arih2 [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000356401, ENST00000449376, ENSG00000177479, ENSP00000403222, ENSP00000348769

OpenTargets

ENSG00000177479

GeneCards

ARIH2

HPA

ENSG00000177479-ARIH2

PRO

O95376

Pharos - Targets

O95376

GlyGen

O95376

PDB

7OD1, 7ONI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68036 UBE2L3	4	Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201) UBE2L3 [cytosol] (R-HSA-947631) UBE2L3 [nucleoplasm] (R-HSA-8852056) Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226)	0.884	12
UniProt:O14933 UBE2L6	2	UBE2L6 [cytosol] (R-HSA-936014) UBE2L6 [nucleoplasm] (R-HSA-5653666)	0.879	14
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.691	5
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.677	13
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.623	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P51813 BMX	3	BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875) BMX(1-242) [cytosol] (R-HSA-351899)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q9NPD8 UBE2T	3	UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217)	0.488	2

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